Sulfonamide derivative having PGD2 receptor antagonistic activity

ABSTRACT

The present invention provides an sulfonamide derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases. 
     A compound of the general formula (II): 
     
       
         
         
             
             
         
       
         
         
           
             wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the ring C is an aromatic carbocyclic ring etc.; R1 is carboxy etc.; R2 is independently a halogen atom etc.; R3 is optionally substituted alkyloxy etc.; R4 is independently a halogen atom etc.; R5 is independently optionally substituted alkyl etc.; M is sulfonyl etc.; Y is a single bond etc.; L1 is a single bond etc.; L2 is a single bond etc.; k is 0, 1, 2, 3 or 4; n is 0, 1 or 2; and q is 0, 1, 2 or 3; provided that a) k is not 0 when the ring B is a 6-membered nitrogen-containing heterocyclic ring containing one or two nitrogen atom(s) and the ring C is a benzene ring, etc.; 
             a pharmaceutically acceptable salt or a hydrate thereof.

TECHNICAL FIELD

This invention relates to a sulfonamide derivative having DP receptorantagonistic activity and a medicinal use thereof.

BACKGROUND ART

Prostaglandin D2 (PGD2) is a metabolic product of arachidonic acidthrough PGG2 and PGH2, and known to have various potent physiologicalactivities. For example, in non-patent literature 1 it is described thatPGD2 is involved in sleeping and secretion of hormones in centralnervous system, and in inhibiting activity of platelet aggregation,contraction of bronchial smooth muscle, vasodilation and constriction ofa blood vessel etc. in peripheral system.

Moreover, PGD2 is considered to be involved in forming pathologicalcondition of an allergic disease such as bronchial asthma since it is amajor metabolic product of arachidonic acid produced from a mast cell,and has a potent bronchoconstricting effect, causing an increase ofvascular permeability and migration of inflammatory cell such aseosinophils.

A DP receptor (also called DP1 receptor) or CRTH2 receptor (also calledDP2 receptor) is known as a receptor of PGD2. A phenylacetic acidderivative having a DP receptor antagonistic activity is disclosed inPatent literature 1, a sulfonamide derivative having a CRTH2 receptorantagonistic activity is disclosed in Patent literature 2 and aphenoxyacetic acid derivative having a CRTH2 receptor antagonisticactivity is disclosed in Patent literatures 3-6.

Also, sulfonamide derivatives having an activity other than the PGD2receptor antagonistic activity are disclosed in Patent literatures 7-12and Non-patent literatures 2-3.

-   Patent literature 1: WO 2003/078409 Pamphlet-   Patent literature 2: WO 2003/097598 Pamphlet-   Patent literature 3: WO 2004/089884 Pamphlet-   Patent literature 4: WO 2004/089885 Pamphlet-   Patent literature 5: WO 2005/106302 Pamphlet-   Patent literature 6: WO 2006/056752 Pamphlet-   Patent literature 7: WO 1993/012086 Pamphlet-   Patent literature 8: WO 2004/073606 Pamphlet-   Patent literature 9: EP 76996A Pamphlet-   Patent literature 10: WO 2006/059801 Pamphlet-   Patent literature 11: JP 3-275678A Pamphlet-   Patent literature 12: JP 3-275679A Pamphlet-   Non patent literature 1: Pharmacol. Rev., 1994, Vol. 46, p. 205-22-   Non patent literature 2: Chem. 86 Pharm. Bull., 1994, Vol. 42, p.    521-29-   Non patent literature 3: Chem. & Pharm. Bull., 2000, Vol. 48, p.    1978-85

DISCLOSURE OF INVENTION Problem to be Solved

The present invention provides a sulfonamide derivative having DPreceptor antagonistic activity and a pharmaceutical compositioncomprising the said compound as an active ingredient. The saidpharmaceutical composition is useful as a therapeutic agent for treatingallergic diseases.

Means for Solving Problem

The present inventors have found that the sulfonamide derivative shownbelow has a potent DP receptor antagonistic activity and thepharmaceutical composition comprising the said compound as an activeingredient is useful as a therapeutic agent for treating allergicdiseases.

The present invention relates to

1) a PGD2 receptor antagonist comprising a compound of the generalformula (I):

wherein the ring A is an aromatic carbocyclic ring or an aromaticheterocyclic ring;

the ring B is a nitrogen-containing non-aromatic heterocyclic ring or anitrogen-containing aromatic heterocyclic ring;

the ring C is an aromatic carbocyclic ring or an aromatic heterocyclicring;

R¹ is hydroxyalkyl, carboxy, alkyloxycarbonyl, optionally substitutedcarbamoyl, cyano or a carboxy equivalent;

R² is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted cycloalkenyl,hydroxy, optionally substituted alkyloxy, optionally substitutedalkenyloxy, optionally substituted alkynyloxy, optionally substitutedcycloalkyloxy, optionally substituted cycloalkenyloxy, mercapto,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted cycloalkylthio,optionally substituted cycloalkylsulfinyl, optionally substitutedcycloalkylsulfonyl, optionally substituted cycloalkylsulfonyloxy,optionally substituted cycloalkenylthio, optionally substitutedcycloalkenylsulfinyl, optionally substituted cycloalkenylsulfonyl,optionally substituted cycloalkenylsulfonyloxy, optionally substitutedamino, acyl, optionally substituted alkyloxycarbonyl, optionallysubstituted alkenyloxycarbonyl, optionally substitutedalkynyloxycarbonyl, optionally substituted aryloxycarbonyl, optionallysubstituted carbamoyl, optionally substituted sulfamoyl, cyano, nitro,optionally substituted aryl, optionally substituted aryloxy, optionallysubstituted arylthio, optionally substituted arylsulfinyl, optionallysubstituted arylsulfonyl, optionally substituted arylsulfonyloxy,optionally substituted heteroaryl, optionally substituted heteroaryloxy,optionally substituted heteroarylthio, optionally substitutedheteroarylsulfinyl, optionally substituted heteroarylsulfonyl,optionally substituted heteroarylsulfonyloxy or an optionallysubstituted non-aromatic heterocyclic group;

R³ is a hydrogen atom, optionally substituted alkyloxy, optionallysubstituted alkenyloxy, optionally substituted alkynyloxy, optionallysubstituted cycloalkyloxy, optionally substituted cycloalkenyloxy,optionally substituted aryloxy, optionally substituted heteroaryloxy,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedcycloalkylthio, optionally substituted cycloalkenylthio, optionallysubstituted arylthio or optionally substituted heteroarylthio;

R⁴ is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted cycloalkenyl,hydroxy, optionally substituted alkyloxy, optionally substitutedalkenyloxy, optionally substituted alkynyloxy, optionally substitutedcycloalkyloxy, optionally substituted cycloalkenyloxy, mercapto,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted cycloalkylthio,optionally substituted cycloalkylsulfinyl, optionally substitutedcycloalkylsulfonyl, optionally substituted cycloalkylsulfonyloxy,optionally substituted cycloalkenylthio, optionally substitutedcycloalkenylsulfinyl, optionally substituted cycloalkenylsulfonyl,optionally substituted cycloalkenylsulfonyloxy, optionally substitutedamino, acyl, optionally substituted alkyloxycarbonyl, optionallysubstituted alkenyloxycarbonyl, optionally substitutedalkynyloxycarbonyl, optionally substituted aryloxycarbonyl, optionallysubstituted carbamoyl, optionally substituted sulfamoyl, cyano, nitro,optionally substituted aryl, optionally substituted aryloxy, optionallysubstituted arylthio, optionally substituted arylsulfinyl, optionallysubstituted arylsulfonyl, optionally substituted arylsulfonyloxy,optionally substituted heteroaryl, optionally substituted heteroaryloxy,optionally substituted heteroarylthio, optionally substitutedheteroarylsulfinyl, optionally substituted heteroarylsulfonyl,optionally substituted heteroarylsulfonyloxy or an optionallysubstituted non-aromatic heterocyclic group;

R⁵ is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted alkyloxy, oxo,optionally substituted aryl, optionally substituted heteroaryl or anoptionally substituted non-aromatic heterocyclic group;

M is carbonyl or sulfonyl;

Y is a single bond, optionally substituted alkylene optionallycontaining one or two heteroatom(s), an oxygen atom, a sulfur atom or—N(R⁶)—;

L¹, L² and L³ are independently a single bond, optionally substitutedalkylene optionally containing one or two heteroatom(s), optionallysubstituted alkenylene optionally containing one or two heteroatom(s),optionally substituted alkynylene optionally containing one or twoheteroatom(s) or —N(R⁷)—;

R⁶ and R⁷ are independently a hydrogen atom, optionally substitutedalkyl, optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, acyl, optionally substitutedalkyloxy, optionally substituted aryl, optionally substituted heteroarylor an optionally substituted non-aromatic heterocyclic group;

k is 0, 1, 2, 3 or 4;

n is 0, 1 or 2; and

q is 0, 1, 2 or 3; provided that a) k is not 0 when the ring B is a6-membered nitrogen-containing heterocyclic ring containing one or twonitrogen atom(s), and the ring C is a benzene ring, b) the ring C is notan indole ring or an azaindole ring, c) R¹ is not carboxy when the ringC is a benzene ring, -L³- is —(O-alkylene)-, and the substitutingposition of L³ and Y is an ortho-position each other in the ring C, andd) the substituting position of L³ and Y is not a para-position in thering C when the ring B is a thiazolidine ring and the ring C is abenzene ring;

a pharmaceutically acceptable salt or solvate thereof as an activeingredient,

2) a PGD2 receptor antagonist of 1) wherein R¹ is carboxy and -L³- is—(O-optionally substituted alkylene)-,

3) a PGD2 receptor antagonist of 1) or 2) wherein the ring C is abenzene ring or a pyridine ring,

4) a PGD2 receptor antagonist of any of 1) to 3) wherein R³ isoptionally substituted alkyloxy or optionally substituted alkylthio,

5) a PGD2 receptor antagonist of any of 1) to 4) wherein M is sulfonyl,

6) a PGD2 receptor antagonist of any of 1) to 5) wherein M is sulfonyl,L¹ is a single bond and L² is a single bond,

7) a PGD2 receptor antagonist of any of 1) to 6) wherein Y is a singlebond,

8) a PGD2 receptor antagonist of any of 1) to 7) wherein R² is a halogenatom, optionally substituted alkyl, optionally substituted alkyloxy,optionally substituted amino, optionally substituted carbamoyl,optionally substituted aryl, optionally substituted heteroaryl or anoptionally substituted non-aromatic heterocyclic group, and k is 1 or 2,9) a PGD2 receptor antagonist of any of 1) to 7) wherein R² is a halogenatom, optionally substituted amino, optionally substituted carbamoyl,optionally substituted aryl, optionally substituted heteroaryl or anoptionally substituted non-aromatic heterocyclic group, and k is 1 or 2,10) a PGD2 receptor antagonist of any of 1) to 9) wherein R⁴ is ahalogen atom, optionally substituted alkyl or optionally substitutedalkyloxy, and q is 0 or 1,11) a PGD2 receptor antagonist of any of 1) to 10) wherein thesubstituting position of Y and L³ is a meta-position in the ring C,12) a PGD2 receptor antagonist of any of 1) to 11) which is atherapeutic agent for allegy,13) a PGD2 receptor antagonist of any of 1) to 11) which is atherapeutic agent for asthma,14) a compound of the general formula (II):

wherein the ring A is an aromatic carbocyclic ring or an aromaticheterocyclic ring;

the ring B is a nitrogen-containing non-aromatic heterocyclic ring or anitrogen-containing aromatic heterocyclic ring;

the ring C is an aromatic carbocyclic ring or an aromatic heterocyclicring;

R¹ is hydroxyalkyl, carboxy, alkyloxycarbonyl, optionally substitutedcarbamoyl, cyano or a carboxy equivalent;

R² is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted cycloalkenyl,hydroxy, optionally substituted alkyloxy, optionally substitutedalkenyloxy, optionally substituted alkynyloxy, optionally substitutedcycloalkyloxy, optionally substituted cycloalkenyloxy, mercapto,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted cycloalkylthio,optionally substituted cycloalkylsulfinyl, optionally substitutedcycloalkylsulfonyl, optionally substituted cycloalkylsulfonyloxy,optionally substituted cycloalkenylthio, optionally substitutedcycloalkenylsulfinyl, optionally substituted cycloalkenylsulfonyl,optionally substituted cycloalkenylsulfonyloxy, optionally substitutedamino, acyl, optionally substituted alkyloxycarbonyl, optionallysubstituted alkenyloxycarbonyl, optionally substitutedalkynyloxycarbonyl, optionally substituted aryloxycarbonyl, optionallysubstituted carbamoyl, optionally substituted sulfamoyl, cyano, nitro,optionally substituted aryl, optionally substituted aryloxy, optionallysubstituted arylthio, optionally substituted arylsulfinyl, optionallysubstituted arylsulfonyl, optionally substituted arylsulfonyloxy,optionally substituted heteroaryl, optionally substituted heteroaryloxy,optionally substituted heteroarylthio, optionally substitutedheteroarylsulfinyl, optionally substituted heteroarylsulfonyl,optionally substituted heteroarylsulfonyloxy or an optionallysubstituted non-aromatic heterocyclic group;

R³ is a hydrogen atoms, optionally substituted alkyloxy, optionallysubstituted alkenyloxy, optionally substituted alkynyloxy, optionallysubstituted cycloalkyloxy, optionally substituted cycloalkenyloxy,optionally substituted aryloxy, optionally substituted heteroaryloxy,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedcycloalkylthio, optionally substituted cycloalkenylthio, optionallysubstituted arylthio or optionally substituted heteroarylthio;

R⁴ is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted cycloalkenyl,hydroxy, optionally substituted alkyloxy, optionally substitutedalkenyloxy, optionally substituted alkynyloxy, optionally substitutedcycloalkyloxy, optionally substituted cycloalkenyloxy, mercapto,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted cycloalkylthio,optionally substituted cycloalkylsulfinyl, optionally substitutedcycloalkylsulfonyl, optionally substituted cycloalkylsulfonyloxy,optionally substituted cycloalkenylthio, optionally substitutedcycloalkenylsulfinyl, optionally substituted cycloalkenylsulfonyl,optionally substituted cycloalkenylsulfonyloxy, optionally substitutedamino, acyl, optionally substituted alkyloxycarbonyl, optionallysubstituted alkenyloxycarbonyl, optionally substitutedalkynyloxycarbonyl, optionally substituted aryloxycarbonyl, optionallysubstituted carbamoyl, optionally substituted sulfamoyl, cyano, nitro,optionally substituted aryl, optionally substituted aryloxy, optionallysubstituted arylthio, optionally substituted arylsulfinyl, optionallysubstituted arylsulfonyl, optionally substituted arylsulfonyloxy,optionally substituted heteroaryl, optionally substituted heteroaryloxy,optionally substituted heteroarylthio, optionally substitutedheteroarylsulfinyl, optionally substituted heteroarylsulfonyl,optionally substituted heteroarylsulfonyloxy or an optionallysubstituted non-aromatic heterocyclic group;

R⁵ is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted alkyloxy, oxo,optionally substituted aryl, optionally substituted heteroaryl oroptionally substituted non-aromatic heterocyclic group;

M is carbonyl or sulfonyl;

Y is a single bond, optionally substituted alkylene optionallycontaining one or two heteroatom(s), an oxygen atom, a sulfur atom or—N(R⁶)—;

L¹, L² and L³ are independently a single bond, optionally substitutedalkylene optionally containing one or two heteroatom(s), optionallysubstituted alkenylene optionally containing one or two heteroatom(s),optionally substituted alkynylene optionally containing one or twoheteroatom(s) or —N(R⁷)—;

R⁶ and R⁷ are independently a hydrogen atom, optionally substitutedalkyl, optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, acyl, optionally substitutedalkyloxy, optionally substituted aryl, optionally substituted heteroarylor an optionally substituted non-aromatic heterocyclic group;

k is 0, 1, 2, 3 or 4;

n is 0, 1 or 2; and

q is 0, 1, 2 or 3; provided that a) k is not 0 when the ring B is a6-membered nitrogen-containing heterocyclic ring containing one or twonitrogen atom(s), and the ring C is a benzene ring, b) the ring C is notan indole ring or an azaindole ring, c) Y, L¹ and L² are single bonds,the ring B is piperazine ring and R³ is C2-C4 alkyloxy when the ring Cis a benzene ring, -L³- is —(O-alkylene)-, the substituting position ofL³ and Y is an ortho-position each other in the ring C and R¹ iscarboxy, d) the substituting position of L³ and Y is not a para-positionin the ring C when the ring B is a thiazolidine ring and the ring C is abenzene ring, and e) the group of the formula of

is not a group of the formula of

when the ring C is a benzene ring, -L³- is —(O-alkylene)- and thesubstituting position of L³ and Y is a para-position in the ring C, andf) the ring B is not a diazepindione ring;

a pharmaceutically acceptable salt or solvate thereof,

15) a compound of 14) wherein R¹ is carboxy and -L³- is —(O-optionallysubstituted alkylene)-;

a pharmaceutically acceptable salt or solvate thereof,

16) a compound of 14) or 15) wherein the ring C is a benzene ring or apyridine ring;

a pharmaceutically acceptable salt or solvate thereof,

17) a compound of any of 14) to 16) wherein R³ is optionally substitutedalkyloxy or optionally substituted alkylthio;

a pharmaceutically acceptable salt or solvate thereof,

18) a compound of any of 14) to 17) wherein M is sulfonyl;

a pharmaceutically acceptable salt or solvate thereof,

19) a compound of any of 14) to 17) wherein M is sulfonyl, L¹ is asingle bond and L² is a single bond,

a pharmaceutically acceptable salt or solvate thereof,

20) a compound of any of 14) to 19) wherein Y is a single bond;

a pharmaceutically acceptable salt or solvate thereof,

21) a compound of any of 14) to 20) wherein R² is a halogen atom,optionally substituted alkyl, optionally substituted alkyloxy,optionally substituted amino, optionally substituted carbamoyl,optionally substituted aryl, optionally substituted heteroaryl or anoptionally substituted non-aromatic heterocyclic group, and k is 1 or 2;

a pharmaceutically acceptable salt or solvate thereof,

22) a compound of any of 14) to 20) wherein R² is a halogen atom,optionally substituted amino, optionally substituted carbamoyl,optionally substituted aryl, optionally substituted heteroaryl or anoptionally substituted non-aromatic heterocyclic group, and k is 1 or 2;

a pharmaceutically acceptable salt or solvate thereof,

23) a compound of any of 14) to 22) wherein R⁴ is a halogen atom,optionally substituted alkyl or optionally substituted alkyloxy, and qis 0 or 1,

a pharmaceutically acceptable salt or solvate thereof,

24) a compound of any of 14) to 23) wherein the substituting position ofY and L³ is a meta-position in the ring C,

a pharmaceutically acceptable salt or solvate thereof,

25) a compound of the general formula (III):

wherein the ring D is a benzene ring, a naphthalene ring, a 2-pyridonering, a pyridine ring, a benzoxazolone ring, a benzoxadinone ring or abenzimidazole ring;

R¹ is hydroxyalkyl, carboxy, alkyloxycarbonyl, optionally substitutedcarbamoyl, cyano or a carboxy equivalent;

R² is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted cycloalkenyl,hydroxy, optionally substituted alkyloxy, optionally substitutedalkenyloxy, optionally substituted alkynyloxy, optionally substitutedcycloalkyloxy, optionally substituted cycloalkenyloxy, mercapto,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted cycloalkylthio,optionally substituted cycloalkylsulfinyl, optionally substitutedcycloalkylsulfonyl, optionally substituted cycloalkylsulfonyloxy,optionally substituted cycloalkenylthio, optionally substitutedcycloalkenylsulfinyl, optionally substituted cycloalkenylsulfonyl,optionally substituted cycloalkenylsulfonyloxy, optionally substitutedamino, acyl, optionally substituted alkyloxycarbonyl, optionallysubstituted alkenyloxycarbonyl, optionally substitutedalkynyloxycarbonyl, optionally substituted aryloxycarbonyl, optionallysubstituted carbamoyl, optionally substituted sulfamoyl, cyano, nitro,optionally substituted aryl, optionally substituted aryloxy, optionallysubstituted arylthio, optionally substituted arylsulfinyl, optionallysubstituted arylsulfonyl, optionally substituted arylsulfonyloxy,optionally substituted heteroaryl, optionally substituted heteroaryloxy,optionally substituted heteroarylthio, optionally substitutedheteroarylsulfinyl, optionally substituted heteroarylsulfonyl,optionally substituted heteroarylsulfonyloxy or an optionallysubstituted non-aromatic heterocyclic group;

R³ is optionally substituted C1-C6 alkyloxy, optionally substitutedC2-C6 alkenyloxy, optionally substituted C2-C6 alkynyloxy, optionallysubstituted C3-C6 cycloalkyloxy, optionally substituted C3-C6cycloalkenyloxy, optionally substituted aryloxy, optionally substitutedheteroaryloxy, optionally substituted C1-C6 alkylthio, optionallysubstituted C2-C6 alkenylthio, optionally substituted C2-C6 alkynylthio,optionally substituted C3-C6 cycloalkylthio, optionally substitutedC3-C6 cycloalkenylthio, optionally substituted arylthio or optionallysubstituted heteroarylthio;

R⁴ is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted cycloalkenyl,hydroxy, optionally substituted alkyloxy, optionally substitutedalkenyloxy, optionally substituted alkynyloxy, optionally substitutedcycloalkyloxy, optionally substituted cycloalkenyloxy, mercapto,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted cycloalkylthio,optionally substituted cycloalkylsulfinyl, optionally substitutedcycloalkylsulfonyl, optionally substituted cycloalkylsulfonyloxy,optionally substituted cycloalkenylthio, optionally substitutedcycloalkenylsulfinyl, optionally substituted cycloalkenylsulfonyl,optionally substituted cycloalkenylsulfonyloxy, optionally substitutedamino, acyl, optionally substituted alkyloxycarbonyl, optionallysubstituted alkenyloxycarbonyl, optionally substitutedalkynyloxycarbonyl, optionally substituted aryloxycarbonyl, optionallysubstituted carbamoyl, optionally substituted sulfamoyl, cyano, nitro,optionally substituted aryl, optionally substituted aryloxy, optionallysubstituted arylthio, optionally substituted arylsulfinyl, optionallysubstituted arylsulfonyl, optionally substituted arylsulfonyloxy,optionally substituted heteroaryl, optionally substituted heteroaryloxy,optionally substituted heteroarylthio, optionally substitutedheteroarylsulfinyl, optionally substituted heteroarylsulfonyl,optionally substituted heteroarylsulfonyloxy or optionally substitutednon-aromatic heterocyclic group;

R⁵ is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted alkyloxy, oxo,optionally substituted aryl, optionally substituted heteroaryl or anoptionally substituted non-aromatic heterocyclic group;

M is carbonyl or sulfonyl;

L³ is independently a single bond, optionally substituted alkyleneoptionally containing one or two heteroatom(s), optionally substitutedalkenylene optionally containing one or two heteroatom(s), optionallysubstituted alkynylene optionally containing one or two heteroatom(s) or—N(R⁷)—;

R⁷ is hydrogen atom, optionally substituted alkyl, optionallysubstituted alkenyl, optionally substituted alkynyl, optionallysubstituted cycloalkyl, acyl, optionally substituted alkyloxy,optionally substituted aryl, optionally substituted heteroaryl or anoptionally substituted non-aromatic heterocyclic group;

Y is a single bond or optionally substituted alkylene optionallycontaining one or two heteroatom(s);

Z is CH, C(R⁴) or N;

n is 0, 1 or 2;

p is 1, 2, 3 or 4; and

q is 0, 1, 2 or 3; provided that R¹ is not carboxy when the ring D is abenzene ring, -L³- is —(O-alkylene)-, and the substituting position ofL³ and Y is an ortho-position in the ring D;

a pharmaceutically acceptable salt or hydrate thereof,

26) a compound of 25) wherein R¹ is carboxy and -L³- is —(O-optionallysubstituted alkylene)-;

a pharmaceutically acceptable salt or solvate thereof,

27) a compound of 25) or 26) wherein the ring D is a benzene ring or apyridine ring;

a pharmaceutically acceptable salt or solvate thereof,

28) a compound of any of 25) to 27 wherein R³ is optionally substitutedC1-C6 alkyloxy, or optionally substituted C1-C6 alkylthio;

a pharmaceutically acceptable salt or solvate thereof,

29) a compound of any of 25) to 28) wherein M is sulfonyl;

a pharmaceutically acceptable salt or solvate thereof,

30) a compound of any of 25) to 29) wherein Y is a single bond;

a pharmaceutically acceptable salt or solvate thereof,

31) a compound of any of 25) to 30) wherein R² is a halogen atom,optionally substituted alkyl, optionally substituted alkyloxy,optionally substituted amino, optionally substituted carbamoyl,optionally substituted aryl, optionally substituted heteroaryl or anoptionally substituted non-aromatic heterocyclic group, and p is 1 or 2;

a pharmaceutically acceptable salt or solvate thereof,

32) a compound of any of 25) to 31) wherein R² is a halogen atom,optionally substituted amino, optionally substituted carbamoyl,optionally substituted aryl, optionally substituted heteroaryl or anoptionally substituted non-aromatic heterocyclic group, and p is 1 or 2;

a pharmaceutically acceptable salt or solvate thereof,

33) a compound of any of 25) to 32) wherein R⁴ is a halogen atom,optionally substituted alkyl or optionally substituted alkyloxy, and qis 0 or 1,

a pharmaceutically acceptable salt or solvate thereof,

34) a compound of any of 25) to 33) wherein the substituting position ofY and L³ is a meta-position in the ring D,

a pharmaceutically acceptable salt or solvate thereof,

35) a compound of the general formula (IV):

wherein the ring D is a benzene ring, a naphthalene ring, a 2-pyridonering, a pyridine ring, a benzoxazolone ring, a benzoxadinone ring or abenzimidazole ring;

the ring E is a ring of the formula of

R¹ is hydroxyalkyl, carboxy, alkyloxycarbonyl, optionally substitutedcarbamoyl, cyano or a carboxy equivalent;

R² is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted cycloalkenyl,hydroxy, optionally substituted alkyloxy, optionally substitutedalkenyloxy, optionally substituted alkynyloxy, optionally substitutedcycloalkyloxy, optionally substituted cycloalkenyloxy, mercapto,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted cycloalkylthio,optionally substituted cycloalkylsulfinyl, optionally substitutedcycloalkylsulfonyl, optionally substituted cycloalkylsulfonyloxy,optionally substituted cycloalkenylthio, optionally substitutedcycloalkenylsulfinyl, optionally substituted cycloalkenylsulfonyl,optionally substituted cycloalkenylsulfonyloxy, optionally substitutedamino, acyl, optionally substituted alkyloxycarbonyl, optionallysubstituted alkenyloxycarbonyl, optionally substitutedalkynyloxycarbonyl, optionally substituted aryloxycarbonyl, optionallysubstituted carbamoyl, optionally substituted sulfamoyl, cyano, nitro,optionally substituted aryl, optionally substituted aryloxy, optionallysubstituted arylthio, optionally substituted arylsulfinyl, optionallysubstituted arylsulfonyl, optionally substituted arylsulfonyloxy,optionally substituted heteroaryl, optionally substituted heteroaryloxy,optionally substituted heteroarylthio, optionally substitutedheteroarylsulfinyl, optionally substituted heteroarylsulfonyl,optionally substituted heteroarylsulfonyloxy or an optionallysubstituted non-aromatic heterocyclic group;

R³ is optionally substituted C1-C6 alkyloxy, optionally substitutedC2-C6 alkenyloxy, optionally substituted C2-C6 alkynyloxy, optionallysubstituted C3-C6 cycloalkyloxy, optionally substituted C3-C6cycloalkenyloxy, optionally substituted aryloxy, optionally substitutedheteroaryloxy, optionally substituted C1-C6 alkylthio, optionallysubstituted C2-C6 alkenylthio, optionally substituted C2-C6 alkynylthio,optionally substituted C3-C6 cycloalkylthio, optionally substitutedC3-C6 cycloalkenylthio, optionally substituted arylthio or optionallysubstituted heteroarylthio;

R⁴ is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted cycloalkenyl,hydroxy, optionally substituted alkyloxy, optionally substitutedalkenyloxy, optionally substituted alkynyloxy, optionally substitutedcycloalkyloxy, optionally substituted cycloalkenyloxy, mercapto,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted cycloalkylthio,optionally substituted cycloalkylsulfinyl, optionally substitutedcycloalkylsulfonyl, optionally substituted cycloalkylsulfonyloxy,optionally substituted cycloalkenylthio, optionally substitutedcycloalkenylsulfinyl, optionally substituted cycloalkenylsulfonyl,optionally substituted cycloalkenylsulfonyloxy, optionally substitutedamino, acyl, optionally substituted alkyloxycarbonyl, optionallysubstituted alkenyloxycarbonyl, optionally substitutedalkynyloxycarbonyl, optionally substituted aryloxycarbonyl, optionallysubstituted carbamoyl, optionally substituted sulfamoyl, cyano, nitro,optionally substituted aryl, optionally substituted aryloxy, optionallysubstituted arylthio, optionally substituted arylsulfinyl, optionallysubstituted arylsulfonyl, optionally substituted arylsulfonyloxy,optionally substituted heteroaryl, optionally substituted heteroaryloxy,optionally substituted heteroarylthio, optionally substitutedheteroarylsulfinyl, optionally substituted heteroarylsulfonyl,optionally substituted heteroarylsulfonyloxy or an optionallysubstituted non-aromatic heterocyclic group;

R⁵ is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted alkyloxy, oxo,optionally substituted aryl, optionally substituted heteroaryl or anoptionally substituted non-aromatic heterocyclic group;

M is carbonyl or sulfonyl;

L³ is independently a single bond, optionally substituted alkyleneoptionally containing one or two heteroatom(s), optionally substitutedalkenylene optionally containing one or two heteroatom(s), optionallysubstituted alkynylene optionally containing one or two heteroatom(s) or—N(R⁷)—;

R⁷ is hydrogen atom, optionally substituted alkyl, optionallysubstituted alkenyl, optionally substituted alkynyl, optionallysubstituted cycloalkyl, acyl, optionally substituted alkyloxy,optionally substituted aryl, optionally substituted heteroaryl or anoptionally substituted non-aromatic heterocyclic group,

Y is a single bond or optionally substituted alkylene optionallycontaining one or two heteroatom(s);

Z is CH, C(R⁴) or N;

n is 0, 1 or 2;

p is 1, 2, 3 or 4; and

q is 0, 1, 2 or 3; provided that a) R¹ is not carboxy when the ring D isa benzene ring, -L³- is —(O-alkylene)-, and the substituting position ofL³ and Y is an ortho-position in the ring D, b) the group of the formulaof

is not a group of the formula of

when the ring D is a benzene ring, -L³- is —(O-alkylene)-, and thesubstituting position of L³ and Y is a para-position in the ring D;

a pharmaceutically acceptable salt or solvate thereof,

36) a compound of 35) wherein R¹ is carboxy and -L³- is —(O-optionallysubstituted alkylene)-;

a pharmaceutically acceptable salt or solvate thereof,

37) a compound of 35) or 36) wherein the ring D is a benzene ring or apyridine ring;

a pharmaceutically acceptable salt or solvate thereof,

38) a compound of any of 35) to 37) wherein R³ is optionally substitutedC1-C6 alkyloxy, or optionally substituted C1-C6 alkylthio;

a pharmaceutically acceptable salt or solvate thereof,

39) a compound of any of 35) to 38) wherein M is sulfonyl;

a pharmaceutically acceptable salt or solvate thereof,

40) a compound of any of 35) to 39) wherein Y is a single bond;

a pharmaceutically acceptable salt or solvate thereof,

41) a compound of any of 35) to 40) wherein R² is a halogen atom,optionally substituted alkyl, optionally substituted alkyloxy,optionally substituted amino, optionally substituted carbamoyl,optionally substituted aryl, optionally substituted heteroaryl or anoptionally substituted non-aromatic heterocyclic group, and p is 1 or 2;

a pharmaceutically acceptable salt or solvate thereof,

42) a compound of any of 35) to 41) wherein R² is a halogen atom,optionally substituted amino, optionally substituted carbamoyl,optionally substituted aryl, optionally substituted heteroaryl or anoptionally substituted non-aromatic heterocyclic group, and p is 1 or 2;

a pharmaceutically acceptable salt or solvate thereof,

43) a compound of any of 35) to 42) wherein R⁴ is a halogen atom,optionally substituted alkyl or optionally substituted alkyloxy, and qis 0 or 1,

a pharmaceutically acceptable salt or solvate thereof,

44) a compound of any of 35) to 43) wherein the substituting position ofY and L³ is a meta-position in the ring D,

a pharmaceutically acceptable salt or solvate thereof,

45) a pharmaceutical composition comprising a compound of any of 14) to44), a pharmaceutically acceptable salt or solvate thereof as an activeingredient,

46) a pharmaceutical composition of 45) which is a DP receptorantagonist,

47) a pharmaceutical composition of 45) which is a therapeutic agent forallergy,

48) a pharmaceutical composition of 45) which is a therapeutic agent forasthma,

49) a method for treating a disease related to DP receptor characterizedby administration of the compound of any of 1) to 11) and 14) to 44),pharmaceutically acceptable salt or solvate thereof,

50) a method of 49) wherein the disease related to DP receptor isasthma,

51) use of the compound of any of 1) to 11) and 14) to 44),pharmaceutically acceptable salt or solvate thereof in the manufacturingof a therapeutic agent for treating a disease related to DP receptor,

52) use of the compound of 51), pharmaceutically acceptable salt orsolvate thereof wherein the disease related to DP receptor is asthma,

53) a compound of the general formula (V):

wherein the ring D is a benzene ring, a naphthalene ring, a 2-pyridonering, a pyridine ring, a benzoxazolone ring, a benzoxadinone ring or abenzimidazole ring;

R¹ is hydroxyalkyl, carboxy, alkyloxycarbonyl, optionally substitutedcarbamoyl, cyano or a carboxy equivalent;

R² is independently a hydrogen atoms, a halogen atom, optionallysubstituted alkyl, optionally substituted alkenyl, optionallysubstituted alkynyl, optionally substituted cycloalkyl, optionallysubstituted cycloalkenyl, hydroxy, optionally substituted alkyloxy,optionally substituted alkenyloxy, optionally substituted alkynyloxy,optionally substituted cycloalkyloxy, optionally substitutedcycloalkenyloxy, mercapto, optionally substituted alkylthio, optionallysubstituted alkenylthio, optionally substituted alkynylthio, optionallysubstituted alkylsulfinyl, optionally substituted alkylsulfonyl,optionally substituted alkylsulfonyloxy, optionally substitutedcycloalkylthio, optionally substituted cycloalkylsulfinyl, optionallysubstituted cycloalkylsulfonyl, optionally substitutedcycloalkylsulfonyloxy, optionally substituted cycloalkenylthio,optionally substituted cycloalkenylsulfinyl, optionally substitutedcycloalkenylsulfonyl, optionally substituted cycloalkenylsulfonyloxy,optionally substituted amino, acyl, optionally substitutedalkyloxycarbonyl, optionally substituted alkenyloxycarbonyl, optionallysubstituted alkynyloxycarbonyl, optionally substituted aryloxycarbonyl,optionally substituted carbamoyl, optionally substituted sulfamoyl,cyano, nitro, optionally substituted aryl, optionally substitutedaryloxy, optionally substituted arylthio, optionally substitutedarylsulfinyl, optionally substituted arylsulfonyl, optionallysubstituted arylsulfonyloxy, optionally substituted heteroaryl,optionally substituted heteroaryloxy, optionally substitutedheteroarylthio, optionally substituted heteroarylsulfinyl, optionallysubstituted heteroarylsulfonyl, optionally substitutedheteroarylsulfonyloxy or an optionally substituted non-aromaticheterocyclic group;

L³ is independently a single bond, optionally substituted alkyleneoptionally containing one or two heteroatom(s), optionally substitutedalkenylene optionally containing one or two heteroatom(s), optionallysubstituted alkynylene optionally containing one or two heteroatom(s) or—N(R⁷)—;

R⁷ is a hydrogen atom, optionally substituted alkyl, optionallysubstituted alkenyl, optionally substituted alkynyl, optionallysubstituted cycloalkyl, acyl, optionally substituted alkyloxy,optionally substituted aryl, optionally substituted heteroaryl or anoptionally substituted non-aromatic heterocyclic group;

R⁸ is a halogen atom, trifluoromethanesulfonyloxy or piperazino; and

p is 1, 2, 3 or 4; provided that the substituting position of thepiperidino group and L³ each other is not an ortho-position in the ringD when the ring D is a benzene ring and -L³- is —(O-alkylene)-;

a pharmaceutically acceptable salt or hydrate thereof,

54) a compound of 53) wherein the ring D is a benzene ring and R⁸ is ahalogen atom;

a pharmaceutically acceptable salt or solvate thereof,

55) a compound of 53) wherein the ring D is a benzene ring and R⁸ ispiperazino;

a pharmaceutically acceptable salt or solvate thereof,

56) a compound of any of 53) to 55) wherein R¹ is carboxy oralkyloxycarbonyl and -L3- is —(O-methylene)-;

a pharmaceutically acceptable salt or solvate thereof,

57) a compound of any of 53) to 56) wherein R² is a halogen atom,optionally substituted amino, optionally substituted carbamoyl,optionally substituted aryl, optionally substituted heteroaryl or anoptionally substituted non-aromatic heterocyclic group;

a pharmaceutically acceptable salt or hydrate thereof, and

58) a compound of any of 53) to 57) wherein the substituting position ofR⁸ and L³ each other is a meta-position in the ring D;

a pharmaceutically acceptable salt or solvate thereof.

The present invention also includes the following inventions:

(1) a PGD2 receptor antagonist comprising a compound of the generalformula (I-b):

wherein the ring Ab is an aromatic carbocyclic ring or an aromaticheterocyclic ring;

the ring Bb is a 3- to 8-membered nitrogen-containing heterocyclic ringcontaining one or two nitrogen atom(s);

the ring Cb is a benzene ring, a naphthalene ring, a 2-pyridone ring ora pyridine ring;

R^(1b) is hydroxyalkyl, carboxy, alkyloxycarbonyl, optionallysubstituted carbamoyl or optionally substituted tetrazolyl;

R^(2b) is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, hydroxy, optionally substitutedalkyloxy, optionally substituted alkenyloxy, optionally substitutedalkynyloxy, optionally substituted alkylthio, optionally substitutedalkenylthio, optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted amino, acyl,optionally substituted alkyloxycarbonyl, optionally substitutedalkenyloxycarbonyl, optionally substituted alkynyloxycarbonyl,optionally substituted carbamoyl, cyano, nitro, optionally substitutedaryl, optionally substituted aryloxy, optionally substituted arylthio,optionally substituted arylsulfinyl, optionally substitutedarylsulfonyl, optionally substituted arylsulfonyloxy, optionallysubstituted heteroaryl, optionally substituted heteroaryloxy, optionallysubstituted heteroarylthio, optionally substituted heteroarylsulfinyl,optionally substituted heteroarylsulfonyl, optionally substitutedheteroarylsulfonyloxy or an optionally substituted non-aromaticheterocyclic group;

R^(3b) is optionally substituted alkyloxy, optionally substitutedalkylthio, optionally substituted cycloalkyloxy, optionally substitutedcycloalkylthio, optionally substituted aryloxy, optionally substitutedarylthio, optionally substituted heteroaryloxy or optionally substitutedheteroarylthio;

R^(4b) is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted alkyloxy,optionally substituted alkenyloxy, optionally substituted alkynyloxy,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted amino, acyl,optionally substituted alkyloxycarbonyl, optionally substitutedalkenyloxycarbonyl, optionally substituted alkynyloxycarbonyl,optionally substituted carbamoyl, cyano, nitro, optionally substitutedaryl, optionally substituted aryloxy, optionally substituted arylthio,optionally substituted arylsulfinyl, optionally substitutedarylsulfonyl, optionally substituted arylsulfonyloxy, optionallysubstituted heteroaryl, optionally substituted heteroaryloxy, optionallysubstituted heteroarylthio, optionally substituted heteroarylsulfinyl,optionally substituted heteroarylsulfonyl, optionally substitutedheteroarylsulfonyloxy or an optionally substituted non-aromaticheterocyclic group;

R^(5b) is independently optionally substituted alkyl or optionallysubstituted aryl;

Y^(b) is a single bond, alkylene, alkenylene, alkynylene, —O—, —S—, —O—alkylene- or —S-alkylene-;

Z^(b) is a single bond, alkylene, alkenylene, alkynylene, —O-alkylene-or —S— alkylene-;

kb is 0, 1, 2, 3 or 4;

mb is 0, 1 or 2;

nb is 0, 1 or 2; and

pb is 0 or 1; provided that k is not 0 when the ring B is a 6-memberednitrogen-containing heterocyclic ring containing one or two nitrogenatom(s) and the ring C is a benzene ring;

a pharmaceutically acceptable salt or hydrate thereof,

(2) a PGD2 receptor antagonist of (1) wherein the ring Cb is a benzenering or a pyridine ring,

(3) a PGD2 receptor antagonist of (1) or (2) wherein the ring Bb is aring of the formula of

and nb is 0 or 1,(4) a PGD2 receptor antagonist of any of (1) to (3) wherein the ring Abis a benzene ring or a pyridine ring,(5) a PGD2 receptor antagonist of any of (1) to (4) wherein pb is 1,(6) a PGD2 receptor antagonist of any of (1) to (5) wherein Y^(b) is asingle bond or —O—,(7) a PGD2 receptor antagonist of any of (1) to (6) wherein R^(1b) iscarboxy,(8) a PGD2 receptor antagonist of any of (1) to (7) which is atherapeutic agent for allergy,(9) a PGD2 receptor antagonist of any of (1) to (7) which is atherapeutic agent for asthma,(10) a compound of the general formula (II-b):

wherein the ring Ab is an aromatic carbocyclic ring or an aromaticheterocyclic ring;

the ring Bb is a 3- to 8-membered nitrogen-containing heterocyclic ringcontaining one or two nitrogen atom(s);

the ring Cb is a benzene ring, a naphthalene ring, a 2-pyridone ring ora pyridine ring;

R^(1b) is hydroxyalkyl, carboxy, alkyloxycarbonyl, optionallysubstituted carbamoyl or optionally substituted tetrazolyl;

R^(2b) is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, hydroxy, optionally substitutedalkyloxy, optionally substituted alkenyloxy, optionally substitutedalkynyloxy, optionally substituted alkylthio, optionally substitutedalkenylthio, optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted amino, acyl,optionally substituted alkyloxycarbonyl, optionally substitutedalkenyloxycarbonyl, optionally substituted alkynyloxycarbonyl,optionally substituted carbamoyl, cyano, nitro, optionally substitutedaryl, optionally substituted aryloxy, optionally substituted arylthio,optionally substituted arylsulfinyl, optionally substitutedarylsulfonyl, optionally substituted arylsulfonyloxy, optionallysubstituted heteroaryl, optionally substituted heteroaryloxy, optionallysubstituted heteroarylthio, optionally substituted heteroarylsulfinyl,optionally substituted heteroarylsulfonyl, optionally substitutedheteroarylsulfonyloxy or an optionally substituted non-aromaticheterocyclic group;

R^(3b) is optionally substituted alkyloxy, optionally substitutedalkylthio, optionally substituted cycloalkyloxy, optionally substitutedcycloalkylthio, optionally substituted aryloxy, optionally substitutedarylthio, optionally substituted heteroaryloxy or optionally substitutedheteroarylthio;

R^(4b) is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted alkyloxy,optionally substituted alkenyloxy, optionally substituted alkynyloxy,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted amino, acyl,optionally substituted alkyloxycarbonyl, optionally substitutedalkenyloxycarbonyl, optionally substituted alkynyloxycarbonyl,optionally substituted carbamoyl, cyano, nitro, optionally substitutedaryl, optionally substituted aryloxy, optionally substituted arylthio,optionally substituted arylsulfinyl, optionally substitutedarylsulfonyl, optionally substituted arylsulfonyloxy, optionallysubstituted heteroaryl, optionally substituted heteroaryloxy, optionallysubstituted heteroarylthio, optionally substituted heteroarylsulfinyl,optionally substituted heteroarylsulfonyl, optionally substitutedheteroarylsulfonyloxy or an optionally substituted non-aromaticheterocyclic group;

R^(5b) is independently optionally substituted alkyl or optionallysubstituted aryl;

Y^(b) is a single bond, alkylene, alkenylene, alkynylene, —O—, —S—, —O—alkylene- or —S-alkylene-;

Z^(b) is a single bond, alkylene, alkenylene, alkynylene, —O-alkylene-or —S-alkylene-;

kb is 0, 1, 2, 3 or 4;

mb is 0, 1 or 2; and

nb is 0, 1 or 2; provided that a) k is not 0 when the ring B is a6-membered nitrogen-containing heterocyclic ring containing one or twonitrogen atom(s) and the ring C is a benzene ring, b) the group of theformula of

is not a group of the formula of

when Z is —O-alkylene;

a pharmaceutically acceptable salt or hydrate thereof,

(11) a compound of (10) wherein the ring Bb is a group of the formula of

and n is 0 or 1;

a pharmaceutically acceptable salt or hydrate thereof,

(12) a compound of (10) or (11) wherein the ring C is a benzene ring ora pyridine ring;

a pharmaceutically acceptable salt or hydrate thereof,

(13) a compound of any of (10) to (12) wherein R^(3b) is optionallysubstituted alkyloxy or optionally substituted alkylthio;

a pharmaceutically acceptable salt or hydrate thereof,

(14) a compound of any of (10) to (13) wherein R^(1b) is carboxy;

a pharmaceutically acceptable salt or hydrate thereof,

(15) a compound of the general formula (III-b):

wherein the ring Cb is a benzene ring, a naphthalene ring, a 2-pyridonering or a pyridine ring;

R^(1b) is hydroxyalkyl, carboxy, alkyloxycarbonyl, optionallysubstituted carbamoyl or optionally substituted tetrazolyl;

R^(2b) is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, hydroxy, optionally substitutedalkyloxy, optionally substituted alkenyloxy, optionally substitutedalkynyloxy, optionally substituted alkylthio, optionally substitutedalkenylthio, optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted amino, acyl,optionally substituted alkyloxycarbonyl, optionally substitutedalkenyloxycarbonyl, optionally substituted alkynyloxycarbonyl,optionally substituted carbamoyl, cyano, nitro, optionally substitutedaryl, optionally substituted aryloxy, optionally substituted arylthio,optionally substituted arylsulfinyl, optionally substitutedarylsulfonyl, optionally substituted arylsulfonyloxy, optionallysubstituted heteroaryl, optionally substituted heteroaryloxy, optionallysubstituted heteroarylthio, optionally substituted heteroarylsulfinyl,optionally substituted heteroarylsulfonyl, optionally substitutedheteroarylsulfonyloxy or an optionally substituted non-aromaticheterocyclic group;

R^(3b) is optionally substituted alkyloxy, optionally substitutedalkylthio, optionally substituted cycloalkyloxy, optionally substitutedcycloalkylthio, optionally substituted aryloxy, optionally substitutedarylthio, optionally substituted heteroaryloxy or optionally substitutedheteroarylthio,

R^(4b) is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted alkyloxy,optionally substituted alkenyloxy, optionally substituted alkynyloxy,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted amino, acyl,optionally substituted alkyloxycarbonyl, optionally substitutedalkenyloxycarbonyl, optionally substituted alkynyloxycarbonyl,optionally substituted carbamoyl, cyano, nitro, optionally substitutedaryl, optionally substituted aryloxy, optionally substituted arylthio,optionally substituted arylsulfinyl, optionally substitutedarylsulfonyl, optionally substituted arylsulfonyloxy, optionallysubstituted heteroaryl, optionally substituted heteroaryloxy, optionallysubstituted heteroarylthio, optionally substituted heteroarylsulfinyl,optionally substituted heteroarylsulfonyl, optionally substitutedheteroarylsulfonyloxy or an optionally substituted non-aromaticheterocyclic group;

R^(5b) is independently optionally substituted alkyl and optionallysubstituted aryl;

X^(b) is CH or N;

Y^(b) is a single bond, alkylene, alkenylene, alkynylene, —O—, —S—, —O—alkylene- or —S-alkylene-;

Z^(b) is a single bond, alkylene, alkenylene, alkynylene, —O-alkylene-or —S— alkylene-;

mb is 0, 1 or 2;

nb is 0, 1 or 2; and

qb is 1, 2, 3 or 4;

a pharmaceutically acceptable salt or hydrate thereof,

(16) a compound of 15) wherein the ring Cb is a benzene ring or apyridine ring;

a pharmaceutically acceptable salt or hydrate thereof,

(17) a compound of (15) or (16) wherein R^(3b) is optionally substitutedalkyloxy(the substituent is a halogen atom, alkyloxy, aryl orheteroaryl), optionally substituted alkylthio(the substituent is ahalogen atom, alkyloxy, aryl or heteroaryl), optionally substitutedcycloalkyloxy(the substituent is a halogen atom, alkyl, aryl orheteroaryl), optionally substituted cycloalkylthio(the substituent is ahalogen atom, alkyloxy, aryl or heteroaryl), optionally substitutedaryloxy(the substituent is a halogen atom, alkyl or alkyloxy),optionally substituted arylthio(the substituent is a halogen atom, alkylor alkyloxy), optionally substituted heteroaryloxy(the substituent is ahalogen atom, alkyl or haloalkyl), or optionally substitutedheteroarylthio(the substituent is a halogen atom, alkyl or haloalkyl);

a pharmaceutically acceptable salt or hydrate thereof,

(18) a compound of (15) or (16) wherein R^(3b) is optionally substitutedalkyloxy(the substituent is a halogen atom, alkyloxy, aryl orheteroaryl) or alkylthio(the substituent is a halogen atom, alkyloxy,aryl or heteroaryl);

a pharmaceutically acceptable salt or hydrate thereof,

(19) a compound of any of (15) to (18) wherein R^(2b) is a halogen atom,cyano, nitro or optionally substituted heteroaryl;

a pharmaceutically acceptable salt or hydrate thereof,

(20) a compound of any of (15) to (19) wherein R^(2b) is optionallysubstituted 5-membered heteroaryl;

a pharmaceutically acceptable salt or hydrate thereof,

(21) a compound of any of (15) to (20) wherein R^(1b) is carboxy;

a pharmaceutically acceptable salt or hydrate thereof,

(22) a compound of the general formula (IV-b):

wherein the ring Cb is a benzene ring, a naphthalene ring, a 2-pyridonering or a pyridine ring;

the ring Db is a ring of the formula of

R^(1b) is hydroxyalkyl, carboxy, alkyloxycarbonyl, optionallysubstituted carbamoyl or optionally substituted tetrazolyl;

R^(2b) is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, hydroxy, optionally substitutedalkyloxy, optionally substituted alkenyloxy, optionally substitutedalkynyloxy, optionally substituted alkylthio, optionally substitutedalkenylthio, optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted amino, acyl,optionally substituted alkyloxycarbonyl, optionally substitutedalkenyloxycarbonyl, optionally substituted alkynyloxycarbonyl,optionally substituted carbamoyl, cyano, nitro, optionally substitutedaryl, optionally substituted aryloxy, optionally substituted arylthio,optionally substituted arylsulfinyl, optionally substitutedarylsulfonyl, optionally substituted arylsulfonyloxy, optionallysubstituted heteroaryl, optionally substituted heteroaryloxy, optionallysubstituted heteroarylthio, optionally substituted heteroarylsulfinyl,optionally substituted heteroarylsulfonyl, optionally substitutedheteroarylsulfonyloxy or an optionally substituted non-aromaticheterocyclic group;

R^(3b) is optionally substituted alkyloxy, optionally substitutedalkylthio, optionally substituted cycloalkyloxy, optionally substitutedcycloalkylthio, optionally substituted aryloxy, optionally substitutedarylthio, optionally substituted heteroaryloxy or optionally substitutedheteroarylthio;

R^(4b) is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted alkyloxy,optionally substituted alkenyloxy, optionally substituted alkynyloxy,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted amino, acyl,optionally substituted alkyloxycarbonyl, optionally substitutedalkenyloxycarbonyl, optionally substituted alkynyloxycarbonyl,optionally substituted carbamoyl, cyano, nitro, optionally substitutedaryl, optionally substituted aryloxy, optionally substituted arylthio,optionally substituted arylsulfinyl, optionally substitutedarylsulfonyl, optionally substituted arylsulfonyloxy, optionallysubstituted heteroaryl, optionally substituted heteroaryloxy, optionallysubstituted heteroarylthio, optionally substituted heteroarylsulfinyl,optionally substituted heteroarylsulfonyl, optionally substitutedheteroarylsulfonyloxy or an optionally substituted non-aromaticheterocyclic group;

R^(5b) is independently optionally substituted alkyl or optionallysubstituted aryl;

X^(b) is CH or N;

Y^(b) is a single bond, alkylene, alkenylene, alkynylene, —O—, —S—,—O-alkylene- or —S-alkylene-;

Z^(b) is a single bond, alkylene, alkenylene, alkynylene, —O-alkylene-or —S— alkylene-;

mb is 0, 1 or 2

nb is 0, 1 or 2; and

sb is 1, 2, 3 or 4;

a pharmaceutically acceptable salt or hydrate thereof,

(23) a compound of 22) wherein the ring Cb is a benzene ring or apyridine ring;

a pharmaceutically acceptable salt or hydrate thereof,

(24) a compound of (22) or (23) wherein R^(3b) is optionally substitutedalkyloxy(the substituent is a halogen atom, alkyloxy, aryl orheteroaryl), optionally substituted alkylthio(the substituent is ahalogen atom, alkyloxy, aryl or heteroaryl), optionally substitutedcycloalkyloxy(the substituent is a halogen atom, alkyl, aryl orheteroaryl), optionally substituted cycloalkylthio(the substituent is ahalogen atom, alkyloxy, aryl or heteroaryl), optionally substitutedaryloxy(the substituent is a halogen atom, alkyl or alkyloxy),optionally substituted arylthio(the substituent is a halogen atom, alkylor alkyloxy), optionally substituted heteroaryloxy(the substituent is ahalogen atom, alkyl or haloalkyl), or optionally substitutedheteroarylthio(the substituent is a halogen atom, alkyl or haloalkyl);

a pharmaceutically acceptable salt or hydrate thereof,

(25) a compound of (22) or (23) wherein R^(3b) is optionally substitutedalkyloxy(the substituent is a halogen atom, alkyloxy, aryl orheteroaryl), optionally substituted alkylthio(the substituent is ahalogen atom, alkyloxy, aryl or heteroaryl);

a pharmaceutically acceptable salt or hydrate thereof,

(26) a compound of any of (22) to (25) wherein R^(1b) is carboxy;

a pharmaceutically acceptable salt or hydrate thereof,

(27) a compound of the general formula (V-b)

wherein the ring Cb is a benzene ring, a naphthalene ring or a pyridinering;

the ring Eb is a ring of the formula of

R^(1b) is hydroxyalkyl, carboxy, alkyloxycarbonyl, optionallysubstituted carbamoyl or optionally substituted tetrazolyl;

R^(2b) is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, hydroxy, optionally substitutedalkyloxy, optionally substituted alkenyloxy, optionally substitutedalkynyloxy, optionally substituted alkylthio, optionally substitutedalkenylthio, optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted amino, acyl,optionally substituted alkyloxycarbonyl, optionally substitutedalkenyloxycarbonyl, optionally substituted alkynyloxycarbonyl,optionally substituted carbamoyl, cyano, nitro, optionally substitutedaryl, optionally substituted aryloxy, optionally substituted arylthio,optionally substituted arylsulfinyl, optionally substitutedarylsulfonyl, optionally substituted arylsulfonyloxy, optionallysubstituted heteroaryl, optionally substituted heteroaryloxy, optionallysubstituted heteroarylthio, optionally substituted heteroarylsulfinyl,optionally substituted heteroarylsulfonyl, optionally substitutedheteroarylsulfonyloxy or an optionally substituted non-aromaticheterocyclic group;

R^(3b) is optionally substituted alkyloxy, optionally substitutedalkylthio, optionally substituted cycloalkyloxy, optionally substitutedcycloalkylthio, optionally substituted aryloxy, optionally substitutedarylthio, optionally substituted heteroaryloxy or optionally substitutedheteroarylthio;

R^(4b) is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted alkyloxy,optionally substituted alkenyloxy, optionally substituted alkynyloxy,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted amino, acyl,optionally substituted alkyloxycarbonyl, optionally substitutedalkenyloxycarbonyl, optionally substituted alkynyloxycarbonyl,optionally substituted carbamoyl, cyano, nitro, optionally substitutedaryl, optionally substituted aryloxy, optionally substituted arylthio,optionally substituted arylsulfinyl, optionally substitutedarylsulfonyl, optionally substituted arylsulfonyloxy, optionallysubstituted heteroaryl, optionally substituted heteroaryloxy, optionallysubstituted heteroarylthio, optionally substituted heteroarylsulfinyl,optionally substituted heteroarylsulfonyl, optionally substitutedheteroarylsulfonyloxy or an optionally substituted non-aromaticheterocyclic group;

X^(b) is CH or N;

W^(b) is a single bond, alkylene or —O—;

Z^(b) is a single bond, alkylene, alkenylene, alkynylene, —O-alkylene-or —S— alkylene-;

mb is 0, 1 or 2; and

sb is 1, 2, 3 or 4;

a pharmaceutically acceptable salt or hydrate thereof,

(28) a compound of (27) wherein the ring Cb is a benzene ring or apyridine ring; a pharmaceutically acceptable salt or hydrate thereof,

(29) a compound of (27) or (28) wherein R^(3b) is optionally substitutedalkyloxy(the substituent is a halogen atom, alkyloxy, aryl orheteroaryl), optionally substituted alkylthio(the substituent is ahalogen atom, alkyloxy, aryl or heteroaryl), optionally substitutedcycloalkyloxy(the substituent is a halogen atom, alkyl, aryl orheteroaryl), optionally substituted cycloalkylthio(the substituent is ahalogen atom, alkyloxy, aryl or heteroaryl), optionally substitutedaryloxy(the substituent is a halogen atom, alkyl or alkyloxy),optionally substituted arylthio(the substituent is a halogen atom, alkylor alkyloxy), optionally substituted heteroaryloxy(the substituent is ahalogen atom, alkyl or haloalkyl), or optionally substitutedheteroarylthio(the substituent is a halogen atom, alkyl or haloalkyl);

a pharmaceutically acceptable salt or hydrate thereof,

(30) a compound of (27) or (28) wherein R^(3b) is optionally substitutedalkyloxy(the substituent is a halogen atom, alkyloxy, aryl orheteroaryl), optionally substituted alkylthio(the substituent is ahalogen atom, alkyloxy, aryl or heteroaryl);

a pharmaceutically acceptable salt or hydrate thereof,

(31) a compound of any of (27) to (30) wherein R^(1b) is carboxy;

a pharmaceutically acceptable salt or hydrate thereof,

(32) a pharmaceutical composition comprising a compound of any of (10)to (31), a pharmaceutically acceptable salt or hydrate thereof as anactive ingredient,

(33) a pharmaceutical composition of (32) which is a DP receptorantagonist,

(34) a pharmaceutical composition of (32) which is a therapeutic agentfor allergy,

(35) a pharmaceutical composition of (32) which is a therapeutic agentfor asthma,

(36) a method for treating a disease related to DP receptorcharacterized by administration of the compound of any of (1) to (7) and(10) to (31), pharmaceutically acceptable salt or hydrate thereof,

(37) a method of (36) wherein the disease related to DP receptor isasthma,

(38) use of the compound of any of (1) to (7) and (10) to (31),pharmaceutically acceptable salt or hydrate thereof in the manufacturingof a therapeutic agent for treating a disease related to DP receptor,and

(39) use of the compound of (38), pharmaceutically acceptable salt orhydrate thereof wherein the disease related to DP receptor is asthma.

The present invention also includes the following inventions:

[1] a PDG2 antagonist comprising a compound of the general formula(I-a):

wherein the ring A-a is an aromatic carbocyclic ring or an aromaticheterocyclic ring;

the ring B-a is a 4- to 8-membered nitrogen-containing heterocyclic ringcontaining one or two nitrogen atom(s);

the ring C-a is a benzene ring, a naphthalene ring or a pyridine ring;

R^(1a) is hydroxyalkyl, carboxy, alkyloxycarbonyl, optionallysubstituted carbamoyl or optionally substituted tetrazolyl;

R^(2a) is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted alkyloxy,optionally substituted alkenyloxy, optionally substituted alkynyloxy,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted amino, acyl,optionally substituted alkyloxycarbonyl, optionally substitutedalkenyloxycarbonyl, optionally substituted alkynyloxycarbonyl,optionally substituted carbamoyl, cyano, nitro, optionally substitutedaryl, optionally substituted aryloxy, optionally substituted arylthio,optionally substituted arylsulfinyl, optionally substitutedarylsulfonyl, optionally substituted arylsulfonyloxy, optionallysubstituted heteroaryl, optionally substituted heteroaryloxy, optionallysubstituted heteroarylthio, optionally substituted heteroarylsulfinyl,optionally substituted heteroarylsulfonyl, optionally substitutedheteroarylsulfonyloxy or an optionally substituted non-aromaticheterocyclic group;

R^(3a) is optionally substituted alkyloxy, optionally substitutedalkylthio, optionally substituted cycloalkyloxy, optionally substitutedcycloalkylthio, optionally substituted aryloxy, optionally substitutedarylthio, optionally substituted heteroaryloxy or optionally substitutedheteroarylthio;

R^(4a) is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted alkyloxy,optionally substituted alkenyloxy, optionally substituted alkynyloxy,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted amino, acyl,optionally substituted alkyloxycarbonyl, optionally substitutedalkenyloxycarbonyl, optionally substituted alkynyloxycarbonyl,optionally substituted carbamoyl, cyano, nitro, optionally substitutedaryl, optionally substituted aryloxy, optionally substituted arylthio,optionally substituted arylsulfinyl, optionally substitutedarylsulfonyl, optionally substituted arylsulfonyloxy, optionallysubstituted heteroaryl, optionally substituted heteroaryloxy, optionallysubstituted heteroarylthio, optionally substituted heteroarylsulfinyl,optionally substituted heteroarylsulfonyl, optionally substitutedheteroarylsulfonyloxy or an optionally substituted non-aromaticheterocyclic group;

R^(5a) is independently optionally substituted alkyl or optionallysubstituted aryl;

Y^(a) is a single bond, alkylene, alkenylene, alkynylene, —O—, —S—, —O—alkylene- or —S-alkylene-;

Z^(a) is a single bond, alkylene, alkenylene, alkynylene, —O-alkylene-or —S— alkylene-;

ka is 0, 1, 2, 3 or 4;

ma is 0, 1 or 2;

na is 0, 1 or 2; and

pa is 0 or 1; provided that ka is not 0 when the ring B-a is a6-membered nitrogen-containing heterocyclic ring containing one or twonitrogen atom(s) and the ring C-a is a benzene ring;

a pharmaceutically acceptable salt or hydrate thereof as an activeingredient,

[2] a PGD2 antagonist of [1] wherein the ring C-a is a benzene ring or apyridine ring,

[3] a PGD2 antagonist of [1] or [2] wherein the ring B-a is a ring ofthe formula of

and n is 0,[4] a PGD2 antagonist of any of [1] to [3] wherein the ring A-a is abenzene ring or a pyridine ring,[5] a PGD2 antagonist of any of [1] to [4] wherein pa is 1,[6] a PGD2 antagonist of any of [1] to [5] wherein Y^(a) is a singlebond or —O—,[7] a PGD2 antagonist of any of [1] to [6] wherein R^(1a) is carboxy,[8] a PGD2 antagonist of any of [1] to [7] which is a therapeutic agentfor allergy,[9] a PGD2 antagonist of any of [1] to [7] which is a therapeutic agentfor asthma,[10] a compound of the general formula (II-a)

wherein the ring B-a is a 4- to 8-membered nitrogen-containingheterocyclic ring containing one or two nitrogen atom(s);

the ring C-a is a benzene ring, a naphthalene ring or a pyridine ring;

R^(1a) is hydroxyalkyl, carboxy, alkyloxycarbonyl, optionallysubstituted carbamoyl or optionally substituted tetrazolyl;

R^(2a) is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted alkyloxy,optionally substituted alkenyloxy, optionally substituted alkenyloxy,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted amino, acyl,optionally substituted alkyloxycarbonyl, optionally substitutedalkenyloxycarbonyl, optionally substituted alkynyloxycarbonyl,optionally substituted carbamoyl, cyano, nitro, optionally substitutedaryl, optionally substituted aryloxy, optionally substituted arylthio,optionally substituted arylsulfinyl, optionally substitutedarylsulfonyl, optionally substituted arylsulfonyloxy, optionallysubstituted heteroaryl, optionally substituted heteroaryloxy, optionallysubstituted heteroarylthio, optionally substituted heteroarylsulfinyl,optionally substituted heteroarylsulfonyl, optionally substitutedheteroarylsulfonyloxy or an optionally substituted non-aromaticheterocyclic group;

R^(3a) is optionally substituted alkyloxy, optionally substitutedalkylthio, optionally substituted cycloalkyloxy, optionally substitutedcycloalkylthio, optionally substituted aryloxy, optionally substitutedarylthio, optionally substituted heteroaryloxy or optionally substitutedheteroarylthio;

R^(4a) is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted alkyloxy,optionally substituted alkenyloxy, optionally substituted alkynyloxy,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted amino, acyl,optionally substituted alkyloxycarbonyl, optionally substitutedalkenyloxycarbonyl, optionally substituted alkynyloxycarbonyl,optionally substituted carbamoyl, cyano, nitro, optionally substitutedaryl, optionally substituted aryloxy, optionally substituted arylthio,optionally substituted arylsulfinyl, optionally substitutedarylsulfonyl, optionally substituted arylsulfonyloxy, optionallysubstituted heteroaryl, optionally substituted heteroaryloxy, optionallysubstituted heteroarylthio, optionally substituted heteroarylsulfinyl,optionally substituted heteroarylsulfonyl, optionally substitutedheteroarylsulfonyloxy or an optionally substituted non-aromaticheterocyclic group;

R^(5a) is independently optionally substituted alkyl or optionallysubstituted aryl;

Y^(a) is a single bond, alkylene, alkenylene, alkynylene, —O—, —S—, —O—alkylene- or —S-alkylene-;

Z^(a) is a single bond, alkylene, alkenylene, alkynylene, —O-alkylene-or —S— alkylene-;

ka is 0, 1, 2, 3 or 4;

ma is 0, 1 or 2; and

na is 0, 1 or 2; provided that a) ka is not 0 when the ring B-a is a6-membered nitrogen-containing heterocyclic ring containing one or twonitrogen atom(s) and the ring C-a is a benzene ring and b) the group ofthe formula of

is not a group of the formula of

when Z^(a) is —O-alkylene;

a pharmaceutically acceptable salt or hydrate thereof,

[11] a compound of [11] wherein the ring B-a is a ring of the formula of

and na is 0;

a pharmaceutically acceptable salt or hydrate thereof,

[12] a compound of [10] or [11] wherein the ring C-a is a benzene ringor a pyridine ring;

a pharmaceutically acceptable salt or hydrate thereof,

[13] a compound of any of [10] to [12] wherein R^(3a) is optionallysubstituted alkyloxy or optionally substituted alkylthio;

a pharmaceutically acceptable salt or hydrate thereof,

[14] a compound of any of [10] to [13] wherein R^(1a) is carboxy;

a pharmaceutically acceptable salt or hydrate thereof,

[15] a compound of the general formula (III-a):

wherein the ring C-a is a benzene ring, a naphthalene ring or a pyridinering;

R^(1a) is hydroxyalkyl, carboxy, alkyloxycarbonyl, optionallysubstituted carbamoyl or optionally substituted tetrazolyl;

R^(2a) is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted alkyloxy,optionally substituted alkenyloxy, optionally substituted alkynyloxy,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted amino, acyl,optionally substituted alkyloxycarbonyl, optionally substitutedalkenyloxycarbonyl, optionally substituted alkynyloxycarbonyl,optionally substituted carbamoyl, cyano, nitro, optionally substitutedaryl, optionally substituted aryloxy, optionally substituted arylthio,optionally substituted arylsulfinyl, optionally substitutedarylsulfonyl, optionally substituted arylsulfonyloxy, optionallysubstituted heteroaryl, optionally substituted heteroaryloxy, optionallysubstituted heteroarylthio, optionally substituted heteroarylsulfinyl,optionally substituted heteroarylsulfonyl, optionally substitutedheteroarylsulfonyloxy or an optionally substituted non-aromaticheterocyclic group;

R^(3a) is optionally substituted alkyloxy, optionally substitutedalkylthio, optionally substituted cycloalkyloxy, optionally substitutedcycloalkylthio, optionally substituted aryloxy, optionally substitutedarylthio, optionally substituted heteroaryloxy or optionally substitutedheteroarylthio;

R^(4a) is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted alkyloxy,optionally substituted alkenyloxy, optionally substituted alkynyloxy,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted amino, acyl,optionally substituted alkyloxycarbonyl, optionally substitutedalkenyloxycarbonyl, optionally substituted alkynyloxycarbonyl,optionally substituted carbamoyl, cyano, nitro, optionally substitutedaryl, optionally substituted aryloxy, optionally substituted arylthio,optionally substituted arylsulfinyl, optionally substitutedarylsulfonyl, optionally substituted arylsulfonyloxy, optionallysubstituted heteroaryl, optionally substituted heteroaryloxy, optionallysubstituted heteroarylthio, optionally substituted heteroarylsulfinyl,optionally substituted heteroarylsulfonyl, optionally substitutedheteroarylsulfonyloxy or an optionally substituted non-aromaticheterocyclic group;

R^(5a) is independently optionally substituted alkyl or optionallysubstituted aryl;

Y^(a) is a single bond, alkylene, alkenylene, alkynylene, —O—, —S—, —O—alkylene- or —S-alkylene-;

Z^(a) is a single bond, alkylene, alkenylene, alkynylene, —O-alkylene-or —S— alkylene-;

ma is 0, 1 or 2;

na is 0, 1 or 2; and

qa is 1, 2, 3 or 4;

a pharmaceutically acceptable salt or hydrate thereof,

[16] a compound of [15] wherein the ring C-a is a benzene ring or apyridine ring; a pharmaceutically acceptable salt or hydrate thereof,

[17] a compound of [15] or [16] wherein R^(3a) is alkyloxy which may besubstituted with one to three substituent(s) selected from thesubstituent group Q-a comprising a halogen atom, alkyloxy, aryl andheteroaryl or optionally substituted alkylthio;

a pharmaceutically acceptable salt or hydrate thereof,

[18] a compound of any of [15] to [17] wherein R^(1a) is carboxy;

a pharmaceutically acceptable salt or hydrate thereof,

[19] a compound of the general formula (IV-a):

wherein the ring C-a is a benzene ring, a naphthalene ring or a pyridinering;

the ring D-a is a ring of the formula of

R^(1a) is hydroxyalkyl, carboxy, alkyloxycarbonyl, optionallysubstituted carbamoyl or optionally substituted tetrazolyl;

R^(2a) is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted alkyloxy,optionally substituted alkenyloxy, optionally substituted alkynyloxy,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted amino, acyl,optionally substituted alkyloxycarbonyl, optionally substitutedalkenyloxycarbonyl, optionally substituted alkynyloxycarbonyl,optionally substituted carbamoyl, cyano, nitro, optionally substitutedaryl, optionally substituted aryloxy, optionally substituted arylthio,optionally substituted arylsulfinyl, optionally substitutedarylsulfonyl, optionally substituted arylsulfonyloxy, optionallysubstituted heteroaryl, optionally substituted heteroaryloxy, optionallysubstituted heteroarylthio, optionally substituted heteroarylsulfinyl,optionally substituted heteroarylsulfonyl, optionally substitutedheteroarylsulfonyloxy or an optionally substituted non-aromaticheterocyclic group;

R^(3a) is optionally substituted alkyloxy, optionally substitutedalkylthio, optionally substituted cycloalkyloxy, optionally substitutedcycloalkylthio, optionally substituted aryloxy, optionally substitutedarylthio, optionally substituted heteroaryloxy or optionally substitutedheteroarylthio;

R^(4a) is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted alkyloxy,optionally substituted alkenyloxy, optionally substituted alkynyloxy,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted amino, acyl,optionally substituted alkyloxycarbonyl, optionally substitutedalkenyloxycarbonyl, optionally substituted alkynyloxycarbonyl,optionally substituted carbamoyl, cyano, nitro, optionally substitutedaryl, optionally substituted aryloxy, optionally substituted arylthio,optionally substituted arylsulfinyl, optionally substitutedarylsulfonyl, optionally substituted arylsulfonyloxy, optionallysubstituted heteroaryl, optionally substituted heteroaryloxy, optionallysubstituted heteroarylthio, optionally substituted heteroarylsulfinyl,optionally substituted heteroarylsulfonyl, optionally substitutedheteroarylsulfonyloxy or an optionally substituted non-aromaticheterocyclic group;

R^(5a) is independently optionally substituted alkyl or optionallysubstituted aryl;

Y^(a) is a single bond, alkylene, alkenylene, alkynylene, —O—, —S—, —O—alkylene- or —S-alkylene-;

Z^(a) is a single bond, alkylene, alkenylene, alkynylene, —O-alkylene-or —S— alkylene-;

ma is 0, 1 or 2;

na is 0, 1 or 2;

sa is 1, 2, 3 or 4

a pharmaceutically acceptable salt or hydrate thereof,

[20] a compound of [19] wherein the ring C-a is a benzene ring or apyridine ring; a pharmaceutically acceptable salt or hydrate thereof,

[21] a compound of [19] or [20] wherein R^(3a) is alkyloxy which may besubstituted with one to three substituent(s) selected from thesubstituent group Q-a comprising a halogen atom, alkyloxy, aryl andheteroaryl or optionally substituted alkylthio;

a pharmaceutically acceptable salt or hydrate thereof,

[22] a compound of any of [19] to [21] wherein R^(1a) is carboxy;

a pharmaceutically acceptable salt or hydrate thereof,

[23] a compound of the general formula (V-a)

wherein the ring C-a is a benzene ring, a naphthalene ring or a pyridinering;

the ring D-a is a ring of the formula of

R^(3a) is hydroxyalkyl, carboxy, alkyloxycarbonyl, optionallysubstituted carbamoyl or optionally substituted tetrazolyl;

R^(2a) is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted alkyloxy,optionally substituted alkenyloxy, optionally substituted alkynyloxy,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted amino, acyl,optionally substituted alkyloxycarbonyl, optionally substitutedalkenyloxycarbonyl, optionally substituted alkynyloxycarbonyl,optionally substituted carbamoyl, cyano, nitro, optionally substitutedaryl, optionally substituted aryloxy, optionally substituted arylthio,optionally substituted arylsulfinyl, optionally substitutedarylsulfonyl, optionally substituted arylsulfonyloxy, optionallysubstituted heteroaryl, optionally substituted heteroaryloxy, optionallysubstituted heteroarylthio, optionally substituted heteroarylsulfinyl,optionally substituted heteroarylsulfonyl, optionally substitutedheteroarylsulfonyloxy or an optionally substituted non-aromaticheterocyclic group;

R^(3a) is optionally substituted alkyloxy, optionally substitutedalkylthio, optionally substituted cycloalkyloxy, optionally substitutedcycloalkylthio, optionally substituted aryloxy, optionally substitutedarylthio, optionally substituted heteroaryloxy or optionally substitutedheteroarylthio;

R^(4a) is independently a halogen atom, optionally substituted alkyl,optionally substituted alkenyl, optionally substituted alkynyl,optionally substituted cycloalkyl, optionally substituted alkyloxy,optionally substituted alkenyloxy, optionally substituted alkynyloxy,optionally substituted alkylthio, optionally substituted alkenylthio,optionally substituted alkynylthio, optionally substitutedalkylsulfinyl, optionally substituted alkylsulfonyl, optionallysubstituted alkylsulfonyloxy, optionally substituted amino, acyl,optionally substituted alkyloxycarbonyl, optionally substitutedalkenyloxycarbonyl, optionally substituted alkynyloxycarbonyl,optionally substituted carbamoyl, cyano, nitro, optionally substitutedaryl, optionally substituted aryloxy, optionally substituted arylthio,optionally substituted arylsulfinyl, optionally substitutedarylsulfonyl, optionally substituted arylsulfonyloxy, optionallysubstituted heteroaryl, optionally substituted heteroaryloxy, optionallysubstituted heteroarylthio, optionally substituted heteroarylsulfinyl,optionally substituted heteroarylsulfonyl, optionally substitutedheteroarylsulfonyloxy or an optionally substituted non-aromaticheterocyclic group;

R^(5a) is independently optionally substituted alkyl or optionallysubstituted aryl;

W^(a) is a single bond, alkylene, alkenylene, alkynylene, —O— or —S—;

Z^(a) is a single bond, alkylene, alkenylene, alkynylene, —O-alkylene-or —S— alkylene-;

ma is 0, 1 or 2;

na is 0, 1 or 2;

sa is 1, 2, 3 or 4;

a pharmaceutically acceptable salt or hydrate thereof,

[24] a compound of [23] wherein the ring C-a is a benzene ring or apyridine ring; a pharmaceutically acceptable salt or hydrate thereof,

[25] a compound of [23] or [24] wherein R^(3a) is alkyloxy which may besubstituted with one to three substituent(s) selected from thesubstituent group Q-a comprising a halogen atom, alkyloxy, aryl andheteroaryl or optionally substituted alkylthio;

a pharmaceutically acceptable salt or hydrate thereof,

[26] a compound of any of [23] to [25] wherein R^(1a) is carboxy;

a pharmaceutically acceptable salt or hydrate thereof,

[27] a pharmaceutical composition comprising a compound of any of [10]to [26] a pharmaceutically acceptable salt or hydrate thereof as anactive ingredient,

[28] a pharmaceutical composition of [27] which is a DP receptorantagonist,

[29] a pharmaceutical composition of [27] which is a therapeutic agentfor allergy,

[30] a pharmaceutical composition of [27] which is a therapeutic agentfor asthma,

[31] a method for treating a disease related to DP receptorcharacterized by administration of the compound of any of [1] to [7] and[10] to [26], pharmaceutically acceptable salt or hydrate thereof,

[32] a method of [31] wherein the disease related to DP receptor isasthma,

[33] use of the compound of any of [1] to [7] and [10] to [26],pharmaceutically acceptable salt or hydrate thereof in the manufacturingof a therapeutic agent for treating a disease related to DP receptor,

[34] use of the compound of [33], pharmaceutically acceptable salt orhydrate thereof wherein the disease related to DP receptor is asthma,

Terms herein used are explained below. In the present specification eachterm is used under the unified definition and has the same meaning whenused alone or in combination with other terms.

In the present specification, a term of “halogen atom” means a fluorineatom, a chlorine atom, a bromine atom and an iodine atom. A fluorineatom, a chlorine atom and a bromine atom are preferable.

In the present specification, a term of “hetero atom” means an oxygenatom, a sulfur atom and a nitrogen atom.

In the present specification, a term of “alkyl” includes a monovalentstraight or branched hydrocarbon group having one to eight carbonatom(s). For example, methyl, ethyl, n-propyl, isopropyl, n-butyl,isobutyl, sec-butyl, tert-butyl, n-pentyl, isopentyl, neo-pentyl,n-hexyl, isohexyl, n-heptyl, n-octyl and the like are exemplified. C1-C6alkyl is preferred. C1-C4 alkyl is further preferred. When a number ofcarbon is specified, it means “alkyl” having the carbon number withinthe range.

In the present specification, a term of “hydroxyalkyl” includes a“alkyl” above, a hydrogen atom of which is substituted with a hydroxygroup. For example, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl,1-hydroxypropyl, 2-hydroxypropyl and the like are exemplified.Hydroxymethyl is preferred.

In the present specification, a term of “alkenyl” includes a monovalentstraight or branched hydrocarbon group having two to eight carbon atomsand one or more double bond(s). For example, vinyl, allyl, 1-propenyl,2-butenyl, 2-pentenyl, 2-hexenyl, 2-heptenyl, 2-octenyl and the like areexemplified. C2-C6 alkenyl is preferred. Moreover, C2-C4 alkenyl isfurther preferred.

In the present specification, a term of “alkynyl” includes a monovalentstraight or branched hydrocarbon group having two to eight carbon atomsand one or more triple bond(s). For example, ethynyl, 1-propynyl,2-propynyl, 2-butynyl, 2-pentynyl, 2-hexynyl, 2-heptynyl, 2-octynyl andthe like are exemplified. C2-C6 alkynyl is preferred. Moreover, C2-C4alkynyl is further preferred.

In the present specification, a term of “cycloalkyl” includes acycloalkyl having three to eight carbon atoms and for example,cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl,cyclooctyl and the like are exemplified. C3-C6 cycloalkyl is preferred.

In the present specification, a term of “cycloalkenyl” includes acycloalkenyl having three to eight carbon atoms and for example,cyclopropenyl, cyclobutenyl, cyclopentenyl, cyclohexenyl, cycloheptenyl,cycloocentyl and the like are exemplified. C3-C6 cycloalkenyl ispreferred.

In the present specification, a term of “alkyloxy” includes a groupwherein an oxygen atom is substituted with one “alkyl” above and forexample, methyloxy, ethyloxy, n-propyloxy, isopropyloxy, n-butyloxy,isobutyloxy, sec-butyloxy, tert-butyloxy, n-pentyloxy, isopentyloxy,2-pentyloxy, 3-pentyloxy, n-hexyloxy, isohexyloxy, 2-hexyloxy,3-hexyloxy, n-heptyloxy, n-octyloxy, and the like are exemplified. C1-C6alkyloxy is preferred. Moreover, C1-C4 alkyloxy is further preferred.When a number of carbon is specified, it means “alkyloxy” having thecarbon number within the range.

In the present specification, a term of “alkenyloxy” includes a groupwherein an oxygen atom is substituted with one “alkenyl” above and forexample, vinyloxy, allyloxy, 1-propenyloxy, 2-butenyloxy, 2-pentenyloxy,2-hexenyloxy, 2-heptenyloxy, 2-octenyloxy and the like are exemplified.C2-C6 alkenyloxy is preferred. Moreover, C2-C4 alkenyloxy is furtherpreferred. When a number of carbon is specified, it means “alkenyloxy”having the carbon number within the range.

In the present specification, a term of “alkynyloxy” includes a groupwherein an oxygen atom is substituted with one “alkynyl” above and forexample, ethynyloxy, 1-propynyloxy, 2-propynyloxy, 2-butynyloxy,2-pentynyloxy, 2-hexynyloxy, 2-heptynyloxy, 2-octynyloxy and the likeare exemplified. C2-C6 alkynyloxy is preferred. Moreover, C2-C4alkynyloxy is further preferred. When a number of carbon is specified,it means “alkynyloxy” having the carbon number within the range.

In the present specification, a term of “cycloalkyloxy” includes a groupwherein an oxygen atom is substituted with one “cycloalkyl” above andfor example, cyclopropyloxy, cyclobutyloxy, cyclopentyloxy,cyclohexyloxy, cycloheptyloxy and cyclooctyloxy are exemplified. C3-C6cycloalkyloxy is preferred. When a number of carbon is specified, itmeans “cycloalkyloxy” having the carbon number within the range.

In the present specification, a term of “cycloalkenyloxy” includes agroup wherein an oxygen atom is substituted with one “cycloalkenyl”above and for example, cyclopropenyloxy, cyclobutenyloxy,cyclopentenyloxy, cyclohexenyloxy, cycloheptenyloxy and cyclooctenyloxyare exemplified. C3-C6 cycloalkenyloxy is preferred. When a number ofcarbon is specified, it means “cycloalkenyloxy” having the carbon numberwithin the range.

In the present specification, a term of “alkylthio” includes a groupwherein a sulfur atom is substituted with one “alkyl” above, and forexample, methylthio, ethylthio, n-propylthio, isopropylthio,n-butylthio, isobutylthio, sec-butylthio, tert-butylthio, n-pentylthio,isopentylthio, 2-pentylthio, 3-pentylthio, n-hexylthio, isohexylthio,2-hexylthio, 3-hexylthio, n-heptylthio, n-octylthio, and the like areexemplified. C1-C6 Alkylthio is preferred. Moreover, C1-C4 alkylthio isfurther preferred. When a number of carbon is specified, it means“alkylthio” having the carbon number within the range.

In the present specification, a term of “alkenylthio” includes a groupwherein a sulfur atom is substituted with one “alkenyl” above, and forexample, vinylthio, allylthio, 1-propenylthio, 2-butenylthio,2-pentenylthio, 2-hexenylthio, 2-heptenylthio, 2-octenylthio and thelike are exemplified. C2-C6 Alkenylthio is preferred. Moreover, C2-C4alkylthio is further preferred. When a number of carbon is specified, itmeans “alkenylthio” having the carbon number within the range.

In the present specification, a term of “alkynylthio” includes a groupwherein a sulfur atom is substituted with one “alkynyl” above and forexample, ethynylthio, 1-propynylthio, 2-propynylthio, 2-butynylthio,2-pentynylthio, 2-hexynylthio, 2-heptynylthio, 2-octynylthio and thelike are exemplified. C2-C6 alkynylthio is preferred. Moreover, C2-C4alkynylthio is further preferred. When a number of carbon is specified,it means “alkynylthio” having the carbon number within the range.

In the present specification, a term of “alkylsulfinyl” includes a groupwherein sulfinyl is substituted with one “alkyl” above and for example,methylsulfinyl, ethylsulfinyl, n-propylsulfinyl, isopropylsulfinyl,n-butylsulfinyl, isobutylsulfinyl, sec-butylsulfinyl,tert-butylsulfinyl, n-pentylsulfinyl, isopentylsulfinyl,2-pentylsulfinyl, 3-pentylsulfinyl, n-hexylsulfinyl, isohexylsulfinyl,2-hexylsulfinyl, 3-hexylsulfinyl, n-heptylsulfinyl, n-octylsulfinyl andthe like are exemplified. C1-C6 alkylsulfinyl is preferred. Moreover,C1-C4 alkylsulfinyl is further preferred.

In the present specification, a term of “alkylsulfonyl” includes a groupwherein sulfonyl is substituted with one “alkyl” above and for example,methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl,n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl,tert-butylsulfonyl, n-pentylsulfonyl, isopentylsulfonyl,2-pentylsulfonyl, 3-pentylsulfonyl, n-hexylsulfonyl, isohexylsulfonyl,2-hexylsulfonyl, 3-hexylsulfonyl, n-heptylsulfonyl, n-octylsulfonyl andthe like are exemplified. C1-C6 alkylsulfonyl is preferred. Moreover,C1-C4 alkylsulfonyl is further preferred.

In the present specification, a term of “alkylsulfonyloxy” includes agroup wherein an oxygen atom is substituted with one “alkylsulfonyl”above and for example, methylsulfonyloxy, ethylsulfonyloxy,n-propylsulfonyloxy, isopropylsulfonyloxy, n-butylsulfonyloxy,isobutylsulfonyloxy, sec-butylsulfonyloxy, tert-butylsulfonyloxy,n-pentylsulfonyloxy, isopentylsulfonyloxy, 2-pentylsulfonyloxy,3-pentylsulfonyloxy, n-hexylsulfonyloxy, isohexylsulfonyloxy,2-hexylsulfonyloxy, 3-hexylsulfonyloxy, n-heptylsulfonyloxy,n-octylsulfonyloxy and the like are exemplified. C1-C6 alkylsulfonyl ispreferred. Moreover, C1-C4 alkylsulfonyl is further preferred.

In the present specification, a term of “cycloalkylthio” includes agroup wherein a sulfur atom is substituted with one “cycloalkyl” aboveand for example, cyclopropylthio, cyclobutylthio, cyclopentylthio,cyclohexylthio, cycloheptylthio, cyclooctylthio and the like areexemplified. C3-C6 cycloalkylthio is preferred. When a number of carbonis specified, it means “cycloalkylthio” having the carbon number withinthe range.

In the present specification, a term of “cycloalkylsulfinyl” includes agroup in which sulfinyl is substituted with one “cycloalkyl” above. Forexample, cyclopropylsulfinyl, cyclobutylsulfinyl, cyclopentylsulfinyl,cyclohexylsulfinyl, cycloheptylsulfinyl, and cyclooctylsulfinyl areexemplified. Preferably C3-C6 cycloalkylsulfinyl is exemplified.

In the present specification, a term of “cycloalkylsulfonyl” includes agroup in which sulfonyl is substituted with one “cycloalkyl” above. Forexample, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl,cyclohexylsulfonyl, cycloheptylsulfonyl, and cyclooctylsulfonyl areexemplified. Preferably C3-C6 cycloalkylsulfonyl is exemplified.

In the present specification, a term of “cycloalkylsulfonyloxy” includesa group in which an oxygen atom is substituted with one“cycloalkylsulfonyl” above. For example, cyclopropylsulfonyloxy,cyclobutylsulfonyloxy, cyclopentylsulfonyloxy, cyclohexylsulfonyloxy,cycloheptylsulfonyloxy, and cyclooctylsulfonyloxy are exemplified.Preferably C3-C6 cycloalkylsulfonyloxy is exemplified.

In the present specification, a term of “cycloalkenylthio” includes agroup in which a sulfur atom is substituted with one “cycloalkenyl”above. For example, cyclopropenylthio, cyclobutenylthio,cyclopentenylthio, cyclohexenylthio, cycloheptenylthio, andcyclooctenylthio are exemplified. Preferably C3-C6 cycloalkenylthio isexemplified. When a number of carbon is specified, it means“cycloalkenylthio” having the carbon number within the range.

In the present specification, a term of “cycloalkenylsulfinyl” includesa group in which sulfinyl is substituted with one “cycloalkenyl” above.For example, cyclopropenylsulfinyl, cyclobutenylsulfinyl,cyclopentenylsulfinyl, cyclohexenylsulfinyl, cycloheptenylsulfinyl, andcyclooctenylsulfinyl are exemplified. Preferably C3-C6cycloalkenylsulfinyl is exemplified.

In the present specification, a term of “cycloalkenylsulfonyl” includesa group in which sulfonyl is substituted with one “cycloalkenyl” above.For example, cyclopropenylsulfonyl, cyclobutenylsulfonyl,cyclopentenylsulfonyl, cyclohexenylsulfonyl, cycloheptenylsulfonyl, andcyclooctenylsulfonyl are exemplified. Preferably C3-C6cycloalkenylsulfonyl is exemplified.

In the present specification, a term of “cycloalkenylsulfonyloxy”includes a group in which an oxygen atom is substituted with one“cycloalkenylsulfonyl” described above. For example,cyclopropenylsulfonyloxy, cyclobutenylsulfonyloxy,cyclopentenylsulfonyloxy, cyclohexenylsulfonyloxy,cycloheptenylsulfonyloxy, and cyclooctenylsulfonyloxy are exemplified.Preferably C3-C6 cycloalkenylsulfonyloxy is exemplified.

In the present specification, a term of “alkyloxycarbonyl” includes agroup in which carbonyl is substituted with one “alkyloxy” above. Forexample, methyloxycarbonyl, ethyloxycarbonyl, n-propyloxycarbonyl,isopropyloxycarbonyl, n-butyloxycarbonyl, tert-butyloxycarbonyl andn-pentyloxycarbonyl are exemplified. Preferably C1-C4 alkyloxycarbonylis exemplified. Moreover, C1-C2 alkyloxycarbonyl is further preferable.

In the present specification, a term of “alkenyloxycarbonyl” includes agroup in which carbonyl is substituted with one “alkenyloxy” above. Forexample, vinyloxycarbonyl, allyloxycarbonyl, 1-propenyloxycarbonyl,2-butenyloxycarbonyl and 2-pentenyloxyarbonyl are exemplified.Preferably C2-C4 alkyloxycarbonyl is exemplified.

In the present specification, a term of “alkynyloxycarbonyl” includes agroup in which carbonyl is substituted with one “alkynyloxy” above. Forexample, ethynyloxycarbonyl, 1-propynyloxycarbonyl,2-propynyloxycarbonyl, 2-butynyloxyarbonyl and 2-pentynyloxycarbonyl areexemplified. Preferably C2-C4 alkynyloxycarbonyl is exemplified.

In the present specification, a term of “acyl” includes alkylcarbonylwherein the part of alkyl is “alkyl” before, alkenylcarbonyl wherein thepart of alkenyl is “alkenyl” before, alkynylcarbonyl wherein the part ofalkynyl is “alkynyl” before, cycloalkylcarbonyl wherein the part ofcycloalkyl is “cycloalkyl” before, arylcarbonyl wherein the part of arylis “aryl” below, heteroarylcarbonyl wherein the part of heteroaryl is“heteroaryl” below and non-aromatic heterocycliccarbonyl wherein thepart of non-aromatic heterocyclic group is “non-aromatic heterocyclicgroup” below. “Alkyl”, “alkenyl”, “alkynyl”, “cycloalkyl”, “aryl”,“heteroaryl” and “non-aromatic heterocyclic group” may be substitutedrespectively with substituent groups exemplified in “optionallysubstituted alkyl”, “optionally substituted alkenyl”, “optionallysubstituted alkynyl”, “optionally substituted cycloalkyl”, “optionallysubstituted aryl”, “optionally substituted heteroaryl” and “optionallysubstituted non-aromatic heterocyclic group” below. Examples of the acylgroup include acetyl, propionyl, butyroyl, cyclohexylcarbonyl, benzoyl,pyridinecarbonyl and the like.

In the present specification, a term of “optionally substituted amino”includes an amino group which may be substituted with one or twogroup(s) of “alkyl” before, “alkenyl” before, “alkynyl” before,“cycloalkyl” before, “cycloalkynyl” before, “aryl” below, “heteroaryl”below, “acyl” before, “alkyloxycarbonyl” before, “alkenyloxycarbonyl”before, “alkynyloxycarbonyl” before, “alkylsulfonyl”, “alkenylsulfonyl”,“alkynylsulfonyl”, “arylsulfonyl” and/or “heteroarylsulfonyl” before.Examples of the optionally substituted amino group include amino,methylamino, dimethylamino, ethylamino, diethylamino, ethylmethylamino,benzylamino, acetylamino, benzoylamino, methyloxycarbonylamino andmethanesulfonylamino. Preferably, amino, methylamino, dimethylamino,ethylmethylamino, diethylamino, acetylamino and methanesulfonylamino areexemplified.

In the present specification, a term of “optionally substitutedcarbamoyl” includes an aminocarbonyl group wherein the part ofoptionally substituted amino is “optionally substituted amino” beforeand examples of the optionally substituted carbamoyl group includescarbamoyl, N-methylcarbamoyl, N,N-dimethylcarbarnoyl,N-ethyl-N-methylcarbamoyl, N,N-diethylcarbamoyl, N-phenylcarbamoyl,N-benzylcarbamoyl, N-acetylcarbamoyl and N-methylsulfonylcarbamoyl etc.Preferably, carbamoyl, N-methylcarbamoyl, N,N-dimethylcarbarnoyl andN-methylsulfonylcarbamoyl etc. are exemplified.

In the present specification, a term of “optionally substitutedsulfamoyl” includes an aminosulfonyl group wherein the part ofoptionally substituted amino is “optionally substituted amino” beforeand examples of the optionally substituted sulfamoyl group includesulfamoyl, N-methylsulfamoyl, N,N-dimethylsulfamoyl,N-ethyl-N-methylsulfarnoyl, N,N-diethylsulfarnoyl, N-phenylsulfamoyl,N-benzylsulfamoyl, N-acetylsulfamoyl and N-methylsulfonylsulfamoyl etc.Preferably, sulfamoyl, N-methylsulfamoyl, N,N-dimethylsulfamoyl andN-methylsulfonylsulfamoyl etc. are exemplified.

In the present specification, a term of “alkylene” means a straight orbranched alkylene group having one to ten carbon atom(s) and forexample, methylene, 1-methylmethylene, 1,1-dimethylmethylene, ethylene,1-methylethylene, 1-ethylethylene, 1,1-dimethylethylene,1,2-dimethylethylene, 1,1-diethylethylene, 1,2-diethylethylene,1-ethyl-2-methylethylene, trimethylene, 1-methyltrimethylene,2-methyltrimethylene, 1,1-dimethyltrimethylene,1,2-dimethyltrimethylene, 2,2-dimethyltrimethylene, 1-ethyltrimethylene,2-ethyltrimethylene, 1,1-diethyltrimethylene, 1,2-diethyltrimethylene,2,2-diethyltrimethylene, 2-ethyl-2-methyltrimethylene, tetramethylene,1-methyltetramethylene, 2-methyltetramethylene,1,1-dimethyltetramethylene, 1,2-dimethyltetramethylene,2,2-dimethyltetramethylene, 2,2-di-n-propyltrimethylene etc. areexemplified. Especially, a straight or branched alkylene groups havingtwo to six carbon atom(s) are preferred.

In the present specification, a term of “alkenylene” means a straight orbranched alkenylene group having two to ten carbon atom(s) and forexample, ethenylene, 1-methylethenylene, 1-ethylethenylene,1,2-dimethylethenylene, 1,2-diethylethenylene,1-etnyl-2-methylethenylene, propenylene, 1-methyl-2-propenylene,2-methyl-2-propenylene, 1,1-dimethyl-2-propenylene,1,2-dimethyl-2-propenylene, 1-ethyl-2-propenylene,2-ethyl-2-propenylene, 1,1-dietnyl-2-propenylene,1,2-diethyl-2-propenylene, 1-butenylene, 2-butenylene,1-methyl-2-butenylene, 2-methyl-2-butenylene, 1,1-dimethyl-2-butenylene,1,2-dimethyl-2-butenylene etc, are exemplified. Especially, a straightor branched alkenylene groups having two to six carbon atom(s) arepreferred.

In the present specification, a term of “alkynylene” means a straight orbranched alkynylene group having two to ten carbon atom(s) and forexample, ethynylene, propynylene, 1-methyl-2-propynylene,1-ethyl-2-propynylene, butynylene, 1-methyl-2-butynylene,2-methyl-3-butynylene, 1,1-dimethyl-2-butynylene,1,2-dimethyl-3-butynylene, 2,2-dimethyl-3-butynylene etc, areexemplified. Especially, a straight or branched alkynylene groups havingtwo to six carbon atom(s) are preferred.

In the present specification, a term of “—O-alkylene” in Y includes agroup of “alkylene” above, a terminal of which is linked to —O— and forexample, —O-methylene-, —O-1-methylethylene-, —O-1,1-dimethylmethylene-,—O-ethylene-, —O-1-methylethylene-, —O-trimethylene etc are exemplified.Preferably, O-methylene-, —O-1-methylethylene- and—O-1,1-dimethylmethylene- are exemplified. In addition, the ring C andthe ring B are linked in a manner of “the ring C—O-alkylene the ring B”.

In the present specification, a term of “—O-alkylene” of“—O-alkylene-R1” in —Z—R¹ includes a group of “alkylene” above, aterminal of which is linked to —O— and for example, —O-methylene-,—O-1-methylethylene-, —O-1,1-dimethylmethylene-, —O-ethylene-,—O-1-methylethylene-, —O-trimethylene etc are exemplified.—O-Methylene-, —O-1-methylethylene- and —O-1,1-dimethylmethylene- arepreferred.

In the present specification, a term of “—S-alkylene” in Y includes agroup of “alkylene” above, a terminal of which is linked to —S— and forexample, —S-methylene-, —S-1-methylethylene-, —S-1,1-dimethylmethylene-,—S-ethylene-, —S-1-methylethylene-, —S-trimethylene etc are exemplified.Preferably, —S— methylene-, —S-1-methylethylene-,—S-1,1-dimethylmethylene- are exemplified. In addition, the ring C andthe ring B are linked in a manner of “the ring C—S-alkylene the ring B”.

In the present specification, a term of “—S-alkylene” of“—S-alkylene-R¹” in —Z—R¹ includes a group of “alkylene” above, aterminal of which is linked to —S— and for example, —S-methylene-,—S-1-methylethylene-, —S-1,1-dimethylmethylene-, —S-ethylene-,—S-1-methylethylene-, —S-trimethylene etc are exemplified.—S-Methylene-, —S-1-methylethylene- and —S-1,1-dimethylmethylene- arepreferred.

In the present specification, a term of “aryl” includes an aromaticmonocyclic or aromatic fused cyclic hydrocarbons and it may be fusedwith “cycloalkyl” before, “cycloalkenyl” before or “non-aromaticheterocyclic group” below at any possible position. Both of monocyclicring and fused ring may be substituted at any position and for example,phenyl, 1-naphthyl, 2-naphthyl, anthryl, tetrahydronaphthyl,1,3-benzodioxolyl, 1,4-benzodioxanyl etc. are exemplified. Phenyl,1-naphthyl and 2-naphthyl are preferred. Moreover, phenyl is furtherpreferred.

In the present specification, a term of “non-aromatic heterocyclicgroup” includes a 5- to 7-membered non-aromatic heterocyclic ringcontaining one or more of heteroatom(s) selected independently fromoxygen, sulfur and nitrogen atoms or a multicyclic ring formed by fusingthe two or more rings thereof. For example, pyrrolidinyl (e.g.,1-pyrrolidinyl, 2-pyrrolidinyl), pyrrolinyl (e.g., 3-pyrrolinyl),imidazolidinyl (e.g., 2-imidazolidinyl), imidazolinyl (e.g.,imidazolinyl), pyrazolidinyl (e.g., 1-pyrazolidinyl, 2-pyrazolidinyl),pyrazolinyl (e.g., pyrazolinyl), piperidyl (e.g., piperidino,2-piperidyl), piperazinyl (e.g., 1-piperazinyl), indolinyl (e.g.,1-indolinyl), isoindolinyl (e.g., isoindolinyl), morpholinyl (e.g.,morpholino, 3-morpholinyl) etc. are exemplified.

In the present specification, a term of “heteroaryl” in R², R^(2a) andR^(2b) includes a 5- to 6-membered aromatic ring containing one or moreof heteroatom(s) selected independently from oxygen, sulfur and nitrogenatoms and it may be fused with “cycloalkyl” before, “aryl” before,“non-aromatic heterocyclic group” or other heteroaryl at any possibleposition. The heteroaryl group may be substituted at any positionwhenever it is a monocyclic ring or a fused ring. For example, pyrrolyl(e.g., 1-pyrrolyl, 2-pyrrolyl, 3-pyrrolyl), furyl (e.g., 2-furyl,3-furyl), thienyl (e.g., 2-thienyl, 3-thienyl), imidazolyl (e.g.,2-imidazolyl, 4-imidazolyl), pyrazolyl (e.g., 1-pyrazolyl, 3-pyrazolyl),isothiazolyl (e.g., 3-isothiazolyl), isoxazolyl (e.g., 3-isoxazolyl),oxazolyl (e.g., 2-oxazolyl), thiazolyl (e.g., 2-thiazolyl), pyridyl(e.g., 2-pyridyl, 3-pyridyl, 4-pyridyl), pyrazinyl (e.g., 2-pyrazinyl),pyrimidinyl (e.g., 2-pyrimidinyl, 4-pyrimidinyl), pyridazinyl (e.g.,3-pyridazinyl), tetrazolyl (e.g., 1H-tetrazolyl), oxadiazolyl (e.g.,1,3,4-oxadiazolyl), thiadiazolyl (e.g., 1,3,4-thiadiazolyl), indolidinyl(e.g., 2-indolidinyl, 6-indolidinyl), isoindolynyl (e.g.,2-isoindolynyl), indolyl (e.g., 1-indolyl, 2-indolyl, 3-indolyl),indazolyl (e.g., 3-indazolyl), purinyl (e.g., 8-purinyl), quinolidinyl(e.g., 2-quinolidinyl), isoquinolyl (e.g., 3-isoquinolyl), quinolyl(e.g., 2-quinolyl, 5-quinolyl), phtharazinyl (e.g., 1-phtharazinyl),naphthylidinyl (e.g., 2-naphthylidinyl), quinolanyl (e.g.,2-quinolanyl), quinazolinyl (e.g., 2-quinazolinyl), cinnolinyl (e.g.,3-cinnolinyl), pteridinyl (e.g., 2-pteridinyl), carbazolyl (e.g.,2-carbazolyl, 4-carbazolyl), phenanthridinyl (e.g., 2-phenanthridinyl,3-phenanthridinyl), acridinyl (e.g., 1-acridinyl, 2-acridinyl),dibenzofuranyl (e.g., 1-dibenzofuranyl, 2-dibenzofuranyl),benzoimidazolyl (e.g., 2-benzoimidazolyl), benzoisoxazolyl (e.g.,3-benzoisoxazolyl), benzooxazolyl (e.g., 2-benzooxazolyl),benzooxadiazolyl (e.g., 4-benzooxadiazolyl), benzoisothiazolyl (e.g.,3-benzoisothiazolyl), benzothiazolyl (e.g., 2-benzothiazolyl),benzofuryl (e.g., 3-benzofuryl), benzothienyl (e.g., 2-benzothienyl),dibenzothienyl (e.g., 2-dibenzothienyl) and benzodioxolyl (e.g.,1,3-benzodioxolyl) etc. are exemplified.

In the present specification, a term of “heteroaryl” in R³, R^(3a),R^(3b), R⁴, R^(4a), R^(4b), R⁵, R^(5a), R^(5b), R⁶ and R⁷ includes a 5-to 6-membered aromatic ring containing one or more of heteroatom(s)selected independently from oxygen, sulfur and nitrogen atoms and it maybe fused with “cycloalkyl” before, “aryl” before, “non-aromaticheterocyclic group” or other heteroaryl at any possible position. Theheteroaryl group may be substituted at any position whenever it is amonocyclic ring or a fused ring. For example, furyl (e.g., 2-furyl,3-furyl), thienyl (e.g., 2-thienyl, 3-thienyl), imidazolyl (e.g.,2-imidazolyl, 4-imidazolyl), pyrazolyl (e.g., 1-pyrazolyl, 3-pyrazolyl),isothiazolyl (e.g., 3-isothiazolyl), isoxazolyl (e.g., 3-isoxazolyl),oxazolyl (e.g., 2-oxazolyl), thiazolyl (e.g., 2-thiazolyl), pyridyl(e.g., 2-pyridyl, 3-pyridyl, 4-pyridyl), pyrazinyl (e.g., 2-pyrazinyl),pyrimidinyl (e.g., 2-pyrimidinyl, 4-pyrimidinyl), pyridazinyl (e.g.,3-pyridazinyl), oxadiazolyl (e.g., 1,3,4-oxadiazolyl), thiadiazolyl(e.g., 1,3,4-thiadiazolyl), benzoimidazolyl (e.g., 2-benzoimidazolyl),benzoisoxazolyl (e.g., 3-benzoisoxazolyl), benzooxazolyl (e.g.,2-benzooxazolyl), benzofuryl (e.g., 3-benzofuryl), benzothienyl (e.g.,2-benzothienyl) etc. are exemplified.

In the present specification, “2-pyridone” means pyridine-2-one.

In the present specification, a term of “aryloxy” includes a group inwhich an oxygen atom is substituted with one “aryl” before and forexample, phenyloxy and naphthyloxy etc. are exemplified.

In the present specification, a term of “arylthio” includes a group inwhich a sulfur atom is substituted with one “aryl” before and forexample, phenylthio and naphthylthio etc. are exemplified.

In the present specification, a term of “arylsulfinyl” includes a groupin which sulfinyl is substituted with one “aryl” before and for example,phenylsulfinyl and naphthylsulfinyl etc. are exemplified.

In the present specification, a term of “arylsulfonyl” includes a groupin which sulfonyl is substituted with one “aryl” before and for example,phenylsulfonyl and naphthylsulfinyl etc. are exemplified.

In the present specification, examples of “arylsulfonyloxy includephenylsulfonyloxy and naphthylsulfonyloxy etc.

In the present specification, a term of “aryloxycarbonyl” includes agroup in which carbonyl is substituted with one “aryloxy” before and forexample, phenyloxycarbonyl, 1-naphthyloxycarbonyl and1-naphthyloxycarbonyl etc. are exemplified.

In the present specification, a term of “heteroaryloxy” includes a groupin which an oxygen atom is substituted with one “heteroaryl” before. Forexample, pyrrolyloxy, furyloxy, thienyloxy, imidazolyloxy, pyrazolyloxy,isothiazolyloxy, isoxazolyloxy, oxazolyloxy, thiazolyloxy, pyridyloxy,pyrazinyloxy, pyrimidinyloxy, pyridazinyloxy, tetrazolyloxy,oxadiazolyloxy, thiadiazolyloxy, indolidinyloxy, isoindolynyloxy,indolyloxy, indazolyloxy, purinyloxy, quinolidinyloxy, isoquinolyloxy,quinolyloxy, phtharazinyloxy, naphthylidinyloxy, quinolanyloxy,quinazolinyloxy, cinnolinyloxy, pteridinyloxy, carbazolyloxy,phenanthridinyloxy, acridinyloxy, dibenzofuranyloxy, benzoimidazolyloxy,benzoisoxazolyloxy, benzooxazolyloxy, benzooxadiazolyloxy,benzoisothiazolyloxy, benzothiazolyloxy, benzofuryloxy, benzothienyloxy,dibenzothienyloxy and benzodioxolyloxy are exemplified. Preferablyfuryloxy, thienyloxy, imidazolyloxy, pyrazolyloxy, isothiazolyloxy,isoxazolyloxy, oxazolyloxy, thiazolyloxy, pyridyloxy, pyrazinyloxy,pyrimidinyloxy and pyridazinyloxy are exemplified

In the present specification, a term of “heteroarylthio” includes agroup in which a sulfur atom is substituted with one “heteroaryl”before. For example, pyrrolylthio, furylthio, thienylthio,imidazolylthio, pyrazolylthio, isothiazolylthio, isoxazolylthio,oxazolylthio, thiazolylthio, pyridylthio, pyrazinylthio,pyrimidinylthio, pyridazinylthio, tetrazolylthio, oxadiazolylthio,thiadiazolylthio, indolidinylthio, isoindolynylthio, indolylthio,indazolylthio, purinylthio, quinolidinylthio, isoquinolylthio,quinolylthio, phtharazinylthio, naphthylidinylthio, quinolanylthio,quinazolinylthio, cinnolinylthio, pteridinylthio, carbazolylthio,phenanthridinylthio, acridinylthio, dibenzofuranylthio,benzoimidazolylthio, benzoisoxazolylthio, benzooxazolylthio,benzooxadiazolylthio, benzoisothiazolylthio, benzothiazolylthio,benzofurylthio, benzothienylthio, dibenzothienylthio andbenzodioxolylthio etc. are exemplified. Preferably furylthio,thienylthio, imidazolylthio, pyrazolylthio, isothiazolylthio,isoxazolylthio, oxazolylthio, thiazolylthio, pyridylthio, pyrazinylthio,pyrimidinylthio, and pyridazinylthio etc. are exemplified.

In the present specification, a term of “heteroarylsulfinyl” includes agroup in which sulfinyl is substituted with one “heteroaryl” before. Forexample, pyrrolylsulfinyl, furylsulfinyl, thienylsulfinyl,imidazolylsulfinyl, pyrazolylsulfinyl, isothiazolylsulfinyl,isoxazolylsulfinyl, oxazolylsulfinyl, thiazolylsulfinyl,pyridylsulfinyl, pyrazinylsulfinyl, pyrimidinylsulfinyl,pyridazinylsulfinyl, tetrazolylsulfinyl, oxadiazolylsulfinyl,thiadiazolylsulfinyl, indolidinylsulfinyl, isoindolylsulfinyl,indolylsulfinyl, indazolylsulfinyl, purinylsulfinyl,quinolidinylsulfinyl, isoquinolylsulfinyl, quinolylsulfinyl,phtharazinylsulfinyl, naphthylidinylsulfinyl, quinolanylsulfinyl,quinazolinylsulfinyl, cinnolinylsulfinyl, pteridinylsulfinyl,carbazolylsulfinyl, phenanthridinylsulfinyl, acridinylsulfinyl,dibenzofuranylsulfinyl, benzoimidazolylsulfinyl,benzoisoxazolylsulfinyl, benzooxazolylsulfinyl,benzooxadiazolylsulfinyl, benzoisothiazolylsulfinyl,benzothiazolylsulfinyl, benzofurylsulfinyl, benzothienylsulfinyl,dibenzothienylsulfinyl and benzodioxolylsulfinyl etc. are exemplified.Preferably furylsulfinyl, thienylsulfinyl, imidazolylsulfinyl,pyrazolylsulfinyl, isothiazolylsulfinyl, isoxazolylsulfinyl,oxazolylsulfinyl, thiazolylsulfinyl, pyridylsulfinyl, pyrazinylsulfinyl,pyrimidinylsulfinyl and pyridazinylsulfinyl etc. are exemplified.

In the present specification, a term of “heteroarylsulfonyl” includes agroup in which sulfonyl is substituted with one “heteroaryl” before. Forexample, pyrrolylsulfonyl, furylsulfonyl, thienylsulfonyl,imidazolylsulfonyl, pyrazolylsulfonyl, isothiazolylsulfonyl,isoxazolylsulfonyl, oxazolylsulfonyl, thiazolylsulfonyl,pyridylsulfonyl, pyrazinylsulfonyl, pyrimidinylsulfonyl,pyridazinylsulfonyl, tetrazolylsulfonyl, oxadiazolylsulfonyl,thiadiazolylsulfonyl, indolizinylsulfonyl, isoindolylsulfonyl,indolylsulfonyl, indazolylsulfonyl, purinylsulfonyl,quinolidinylsulfonyl, isoquinolylsulfonyl, quinolylsulfonyl,phtharazinylsulfonyl, naphthilidinylsulfonyl, quinolanyl sulfonyl,quinazolinylsulfonyl, cinnolinylsulfonyl, pteridinylsulfonyl,carbazolylsulfonyl, phenanthridinylsulfonyl, acridinylsulfonyl,dibenzofuranylsulfonyl, benzoimidazolylsulfonyl,benzoisoxazolylsulfonyl, benzooxazolylsulfonyl,benzooxadiazolylsulfonyl, benzoisothiazolylsulfonyl,benzothiazolylsulfonyl, benzofurylsulfonyl, benzothienylsulfonyl,dibenzothienylsulfonyl and benzodioxolylsulfonyl are exemplified.Preferably furylsulfonyl, thienylsulfonyl, imidazolylsulfonyl,pyrazolylsulfonyl, isothiazolylsulfonyl, isoxazolylsulfonyl,oxazolylsulfonyl, thiazolylsulfonyl, pyridylsulfonyl, pyrazinylsulfonyl,pyrimidinylsulfonyl and pyridazinylsulfonyl are exemplified.

In the present specification, a term of “heteroarylsulfonyloxy” includesa group in which an oxygen atom is substituted with one“heteroarylsulfonyl” before. For example, pyrrolylsulfonyloxy,furylsulfonyloxy, thienylsulfonyloxy, imidazolylsulfonyloxy,pyrazolylsulfonyloxy, isothiazolylsulfonyloxy, isoxazolylsulfonyloxy,oxazolylsulfonyloxy, thiazolylsulfonyloxy, pyridylsulfonyloxy,pyrazinylsulfonyloxy, pyrimidinylsulfonyloxy, pyridazinylsulfonyloxy,tetrazolylsulfonyloxy, oxadiazolylsulfonyloxy, thiadiazolylsulfonyloxy,indolizinylsulfonyloxy, isoindolylsulfonyloxy, indolylsulfonyloxy,indazolylsulfonyloxy, purinylsulfonyloxy, quinolidinylsulfonyloxy,isoquinolylsulfonyloxy, quinolylsulfonyloxy, phtharazinylsulfonyloxy,naphthilidinylsulfonyloxy, quinolanylsulfonyloxy,quinazolinylsulfonyloxy, cinnolinylsulfonyloxy, pteridinylsulfonyloxy,carbazolylsulfonyloxy, phenanthridinylsulfonyloxy, acridinylsulfonyloxy,dibenzofuranylsulfonyloxy, benzoimidazolylsulfonyloxy,benzoisoxazolylsulfonyloxy, benzooxazolylsulfonyloxy,benzooxadiazolylsulfonyloxy, benzoisothiazolylsulfonyloxy,benzothiazolylsulfonyloxy, benzofurylsulfonyloxy,benzothienylsulfonyloxy, dibenzothienylsulfonyloxy andbenzodioxolylsulfonyloxy etc. are exemplified. Preferably,furylsulfonyloxy, thienylsulfonyloxy, imidazolylsulfonyloxy,pyrazolylsulfonyloxy, isothiazolylsulfonyloxy, isoxazolylsulfonyloxy,oxazolylsulfonyloxy, thiazolylsulfonyloxy, pyridylsulfonyloxy,pyrazinylsulfonyloxy, pyrimidinylsulfonyloxy and pyridazinylsulfonyloxyetc. are exemplified.

In the present specification, a term of “aromatic carbocyclic ring”includes an aromatic monocyclic or aromatic fused carbocyclic ring andfor example, a benzene ring, a naphthalene ring and an anthracene ringare exemplified. A benzene ring is preferred.

In the present specification, a term of “aromatic heterocyclic ring”includes an aromatic monocyclic or aromatic fused heterocyclic ring. Forexample, a pyrrole ring, a furan ring, a thiophen ring, a pyrazole ring,an imidazole ring, an isothiazole ring, an isoxazole ring, an oxazolering, a thiazole ring, a pyrazine ring, a pyrimidine ring, a pyridazinering, a tetrazole ring, an oxadiazole ring, a thiadiazole ring, anindolizine ring, an isoindole ring, an indole ring, an indazole ring, apurine ring, a quinolidine ring, an isoquinoline ring, a quinoline ring,a phtharazine ring, a naphthyridine ring, a quinolane ring, aquinazoline ring, a cinnoline ring, a pteridine ring, a carbazole ring,a phenanthridine ring, an acridine ring, a dibenzofuran ring, abenzoxazolon ring, a benzoxadinone ring, a benzoimidazole ring, abenzoisoxazole ring, a benzooxazole ring, a benzooxadiazole ring, abenzoisothiazole ring, a benzothiazole ring, a benzofuran ring, abenzothiophen ring, a dibenzothiophen ring and a benzodixolane ring areexemplified. Preferably a pyridine ring, a furan ring and a thiophenring are exemplified.

In the present specification, a term of “azaindole” includes4-azaindole, 5-azaindole, 6-azaindole, 7-azaindole, 4,5-diazaindole-,4,6-diazaindole, 4,7-diazaindole, 5,6-diazaindole, 5,7-diazaindole,6,7-diazaindole, 4,5,6-triazaindole, 4,5,7-triazaindole and5,6,7-triazaindole.

In the present specification, a term of “C1-C6 alkylene” includes astraight or branched alkylene group having one to six carbon atom(s),and for example, —CH₂—, —CH(CH₃)—, —C(CH₃)₂—, —CH₂CH₂—, —CH(CH₃)CH₂—,—C(CH₃)₂CH₂—, —CH₂CH₂CH₂—, —CH₂CH₂CH₂CH₂—, —CH₂CH₂CH₂CH₂CH₂— and—CH₂CH₂CH₂CH₂CH₂CH₂— are exemplified. Preferably, —CH₂—, —CH₂CH₂—,—CH₂CH₂CH₂— and —CH₂CH₂CH₂CH₂— are exemplified.

In the present specification, a term of “alkylene optionally containingone or two heteroatom(s)” of “optionally substituted alkylene optionallycontaining one or two heteroatom(s)” includes a straight or branchedalkylene group having one to six carbon atoms, optionally containing oneor two heteroatom(s) which may be substituted with “alkyl” above, andfor example, —CH₂—, —CH₂CH₂—, —CH₂CH₂CH₂—, —CH₂CH₂CH₂CH₂—,—CH₂CH₂CH₂CH₂CH₂—, —CH₂CH₂CH₂CH₂CH₂CH₂—, —CH₂O—, —OCH₂—, —CH₂CH₂O—,—OCH₂CH₂—, —CH₂S—, —SCH₂—, —CH₂CH₂S—, —SCH₂CH₂—, —CH₂CH₂OCH₂CH₂—,—OCH₂CH₂O—, —OCH₂O—, —NHCH₂—, —N(CH₃)CH₂—, —N⁺(CH₃)₂CH₂—, —NHCH₂CH₂CH₂—and —N(CH₃)CH₂CH₂CH₂— etc. are exemplified. Preferably, —CH₂—, —CH₂CH₂—,—CH₂CH₂CH₂—, —CH₂CH₂CH₂CH₂—, —OCH₂CH₂O—, —OCH₂O— and —N(CH₃)CH₂CH₂CH₂—are exemplified.

In the present specification, a term of “alkenylene optionallycontaining one or two heteroatom(s)” of “optionally substituted alkyleneoptionally containing one or two heteroatom(s)” includes a straight orbranched alkenylene group having two to six carbon atoms, optionallycontaining one or two heteroatom(s) which may be substituted with“alkyl” above, and for example, —CH═CHCH═CH—, —CH═CHO—, —OCH═CH—,—CH═CHS—, —SCH═CH—, —CH═CHNH—, —NHCH═CH—, —CH═CH—CH═N— and —N═CH—CH═CH—are exemplified. Preferably, —CH═CHCH═CH—, —CH═CHCH═N— and —N═CHCH═CH—are exemplified.

In the present specification, a term of “alkynylene optionallycontaining one or two heteroatom(s)” includes a straight or branchedalkynylene group having two to six carbon atoms, optionally containingone or two heteroatom(s) which may be substituted with “alkyl” above,and for example, —C≡CCH₂—, —CH₂C≡CCH₂—, —CH₂C≡CCH₂O—, —CH₂C≡CCH₂S—,—SCH₂C≡CH—, —CH₂C≡CCH₂NH—, —NHCH₂C≡CH—, —CH₂C≡CCH₂N(CH₃)— and—N(CH₃)CH₂C≡CH— are exemplified. Especially, —CH₂C≡CCH₂— and —OCH₂C≡CH—are preferred.

In the present specification, a term of “nitrogen-containingnon-aromatic heterocyclic ring” includes a 3- to 12-memberednon-aromatic heterocyclic ring containing one or more of nitrogenatom(s), and further optionally containing an oxygen atom and/or asulfur atom, and a formula of

exemplified.

In the present specification, a term of “nitrogen-containing aromaticheterocyclic ring” includes a 3- to 12-membered aromatic heterocyclicring containing one or more of nitrogen atom(s), and further optionallyan oxygen atom and/or sulfur atom in the ring. For example, pyrrolyl(e.g., 1-pyrrolyl, 2-pyrrolyl, 3-pyrrolyl), imidazolyl (e.g.,2-imidazolyl, 4-imidazolyl), pyrazolyl (e.g., 1-pyrazolyl, 3-pyrazolyl),isothiazolyl (e.g., 3-isothiazolyl), isoxazolyl (e.g., 3-isoxazolyl),oxazolyl (e.g., 2-oxazolyl), thiazolyl (e.g., 2-thiazolyl), pyridyl(e.g., 2-pyridyl, 3-pyridyl, 4-pyridyl), pyrazinyl (e.g., 2-pyrazinyl),pyrimidinyl (e.g., 2-pyrimidinyl, 4-pyrimidinyl), pyridazinyl (e.g.,3-pyridazinyl), tetrazolyl (e.g., 1H-tetrazolyl), oxadiazolyl (e.g.,1,3,4-oxadiazolyl) and thiadiazolyl (e.g., 1,3,4-thiadiazolyl) areexemplified.

In the present specification, examples of “3- to 8-memberednitrogen-containing aromatic heterocyclic ring containing one or twonitrogen atom(s)” includes a ring shown in the formula of

In the present specification, examples of “4- to 8-memberednitrogen-containing aromatic heterocyclic ring containing one or twonitrogen atom(s)” includes a ring shown in the formula of

In the present specification, ortho-, meta- and para-substitutingposition of L³ and Y mean the relationship of the formula:

when the ring C is a benzene ring.

In the present specification, examples of substituents in “optionallysubstituted alkyl”, “optionally substituted alkyloxy”, “optionallysubstituted alkylthio”, “optionally substituted alkylsulfinyl”,“optionally substituted alkylsulfonyl”, “optionally substitutedalkylsulfonyloxy” and “the optionally substituted alkyloxycarbonyl”include cycloalkyl, alkylene optionally containing one or twoheteroatom(s), hydroxy, oxo, alkyloxy optionally substituted with asubstituent group A at one to three position(s), mercapto, alkylthio, ahalogen atom, nitro, cyano, carboxy, alkyloxycarbonyl, optionallysubstituted amino, optionally substituted carbamoyl, acyl, aryloptionally substituted with a substituent group B at one to threeposition(s) (e.g., phenyl), heteroaryl optionally substituted with asubstituent group C at one to three position(s) (e.g., pyridyl, furyl,thienyl, imidazolyl, oxazolyl, thiazolyl, pyrazolyl), an optionallysubstituted non-aromatic heterocyclic ring group which may besubstituted with a substituent group C at one to three position(s)(e.g., morpholinyl, pyrrolidinyl, piperazinyl), aryloxy optionallysubstituted with a substituent group B at one to three position(s)(e.g., phenyloxy), alkylsulfonyl and the like. These can be substitutedwith one to three substituent(s) at any possible position.

In the present specification, examples of substituents in “optionallysubstituted alkenyl”, “optionally substituted alkynyl”, “optionallysubstituted alkenyloxy”, “optionally substituted alkynyloxy”,“optionally substituted alkenylthio”, “optionally substitutedalkynylthio”, “optionally substituted alkenyloxycarbonyl”, “optionallysubstituted alkynyloxycarbonyl”, “optionally substituted cycloalkyl”,“optionally substituted cycloalkenyl”, “optionally substitutedcycloalkyloxy, “optionally substituted cycloalkenyloxy”, “optionallysubstituted cycloalkylthio”, “optionally substituted cycloalkenylthio”,“optionally substituted cycloalkylsulfinyl”, “optionally substitutedcycloalkenylsulfinyl”, “optionally substituted cycloalkylsulfonyl”,“optionally substituted cycloalkenylsulfonyl”, “optionally substitutedcycloalkylsulfonyloxy”, “optionally substitutedcycloalkenylsulfonyloxy”, “optionally substituted alkenyloxycarbonyl”,“optionally substituted C1-C6 alkylene”, “optionally substitutedalkylene”, “optionally substituted alkenylene” and “the optionallysubstituted alkynylene” include alkyl optionally substituted with asubstituent group D at one to three position(s), cycloalkyl, alkyleneoptionally containing one or two heteroatom(s), hydroxy, oxo, alkyoxyloptionally substituted with a substituent group A at one to threeposition(s), mercapto, alkylthio, a halogen atom, nitro, cyano, carboxy,alkyloxycarbonyl, optionally substituted amino, optionally substitutedcarbamoyl, acyl acyloxy, aryl optionally substituted with a substituentgroup B at one to three position(s) (e.g., phenyl), heteroaryloptionally substituted with a substituent group C at one to threeposition(s) (e.g., pyridyl, furyl, thienyl, imidazolyl, oxazolyl,thiazolyl, pyrazolyl), non-aromatic heterocyclic group optionallysubstituted with a substituent group C at one to three position(s)(e.g., morpholinyl, pyrrolidinyl, piperazinyl), aryloxy optionallysubstituted with a substituent group C at one to three position(s)(e.g., phenyloxy), alkylsulfonyl and the like. These can be substitutedwith one or more substituent(s) at any possible position.

In the present specification, examples of substituents in “optionallysubstituted aryl”, “optionally substituted phenoxy”, “optionallysubstituted aryloxy”, “optionally substituted phenylthio”, “optionallysubstituted arylthio”, “optionally substituted arylsulfinyl”,“optionally substituted arylsulfonyl”, “optionally substitutedarylsulfonyloxy”, “optionally substituted heteroaryl”, “optionallysubstituted heteroaryloxy”, “optionally substituted heteroarylthio”,“optionally substituted heteroarylsulfinyl”, “optionally substitutedheteroarylsulfonyl”, “optionally substituted heteroarylsulfonyloxy” and“optionally substituted non-aromatic heterocyclic group” include alkyloptionally substituted with a substituent group D at one to threeposition(s), cycloalkyl, alkenyl, alkynyl, hydroxy, alkyloxy optionallysubstituted with a substituent group A at one to three position(s),aryloxy optionally substituted with a substituent group B at one tothree position(s) (e.g., phenoxy), mercapto, alkylthio, a halogen atom,nitro, cyano, carboxy, alkyloxycarbonyl, acyl, alkylsulfonyl, optionallysubstituted amino, optionally substituted carbamoyl, aryl optionallysubstituted with a substituent group B at one to three position(s)(e.g., phenyl), heteroaryl optionally substituted with a substituentgroup C at one to three position(s) (e.g., pyridyl, furyl, thienyl,imidazolyl, oxazolyl, thiazolyl, pyrazolyl), non-aromatic heterocyclicgroup optionally substituted with a substituent group C at one to threeposition(s) (e.g., morpholinyl, pyrrolidinyl, piperazinyl) and the like.These can be substituted with one or more substituent(s) at any possibleposition.

Substituent group A is comprised of a halogen atom and phenyl optionallysubstituted with one to three substituent(s) selected from theSubstituent group B.

Substituent group B is comprised of a halogen atom, alkyl, alkyloxy,cyano and nitro.

Substituent group C is comprised of a halogen atom and alkyl.

Substituent group D is comprised of a halogen atom and alkyloxy.

In the specification a term of “carboxy equivalent” means a biologicalequivalent and includes substituents having the same polar effect as acarboxy group. For example, —CONHCN, —CONHOH, —CONHOMe, —CONHOt-Bu,—CONHOCH₂Ph, —SO₃H, —SO₂NH₂, —SO₂NHMe, —NHCONH₂, —NHCONMe₂, —P(═O)(OH)₂,—P(═O)(OH)(OEt), —P(═O)(OH)NH₂, —P(═O)(OH)NHMe, —CONHSO₂Ph, —SO₂NHCOMe,—SO₂NHCOPh, and the formulae of;

are exemplified.

Preferably, —CONHOt-Bu, —CONHOCH₂Ph, —SO₃H, —CONHSO₂Ph, —SO₂NHCOMe,—SO₂NHCOPh, and the formulae of;

are exemplified.

A compound of the general formula (I) includes a compound of the generalformula of

wherein R^(2A), R^(2B), R^(2C), R^(2D) and R^(2E) are independently ahydrogen atom, a halogen atom, optionally substituted alkyl, optionallysubstituted alkenyl, optionally substituted alkynyl, optionallysubstituted cycloalkyl, optionally substituted cycloalkenyl, hydroxy,optionally substituted alkyloxy, optionally substituted alkenyloxy,optionally substituted alkynyloxy, optionally substituted cycloalkyloxy,optionally substituted cycloalkenyloxy, mercapto, optionally substitutedalkylthio, optionally substituted alkenylthio, optionally substitutedalkynylthio, optionally substituted alkylsulfinyl, optionallysubstituted alkylsulfonyl, optionally substituted alkylsulfonyloxy,optionally substituted cycloalkylthio, optionally substitutedcycloalkylsulfinyl, optionally substituted cycloalkylsulfonyl,optionally substituted cycloalkylsulfonyloxy, optionally substitutedcycloalkenylthio, optionally substituted cycloalkenylsulfinyl,optionally substituted cycloalkenylsulfonyl, optionally substitutedcycloalkenylsulfonyloxy, optionally substituted amino, acyl, optionallysubstituted alkyloxycarbonyl, optionally substituted alkenyloxycarbonyl,optionally substituted alkynyloxycarbonyl, optionally substitutedaryloxycarbonyl, optionally substituted carbamoyl, optionallysubstituted sulfamoyl, cyano, nitro, optionally substituted aryl,optionally substituted aryloxy, optionally substituted arylthio,optionally substituted arylsulfinyl, optionally substitutedarylsulfonyl, optionally substituted arylsulfonyloxy, optionallysubstituted heteroaryl, optionally substituted heteroaryloxy, optionallysubstituted heteroarylthio, optionally substituted heteroarylsulfinyl,optionally substituted heteroarylsulfonyl, optionally substitutedheteroarylsulfonyloxy or an optionally substituted non-aromaticheterocyclic group; L³ is the same meaning as 1) before;

wherein R^(2A), R^(2B), R^(2C), R^(2D) and R^(2E) are the same asbefore; R³ is the same as 1) before; R^(4A), R^(4B), R^(4C) and R^(4D)are the same as before; L³ is the same as 1) before;

wherein R^(2A), R^(2B), R^(2C), R^(2D) and R^(2E) are the same asbefore; R³ is the same as 1) before; R^(4A), R^(4B), R^(4C) and R^(4D)are the same as before; L³ is the same as 1) before;

wherein R^(2A), R^(2B), R^(2C), R^(2D) and R^(2E) are the same asbefore; R³ is the same as 1) before; R^(4A), R^(4B), R^(4C) and R^(4D)are the same as before; L³ is the same as 1) before;

wherein R^(2A), R^(2B), R^(2C), R^(2D) and R^(2E) are the same asbefore; R³ is the same as 1) before; R^(4A), R^(4B), R^(4C) and R^(4D)are the same as before; L³ is the same as 1) before;

wherein R^(2A), R^(2B), R^(2C), R^(2D) and R^(2E) are the same asbefore; R³ is the same as 1) before; R^(4A), R^(4B), R^(4C) and R^(4D)are the same as before; L³ is the same as 1) before.

Among the compounds of the general formulae above, compounds of thegeneral formulae of

wherein R^(2A), R^(2B), R^(2C), R^(2D) and R^(2E) are the same asbefore; R³ is the same as 1) before; R^(4A), R^(4B), R^(4C) and R^(4D)are the same as before; L³ is the same as 1) before;

are preferred, and compounds of the general formulae of

wherein R^(2A), R^(2B), R^(2C), R^(2D) and R^(2E) are the same asbefore; R³ is the same as 1) before; R^(4A), R^(4B), R^(4C) and R^(4D)are the same as before; L³ is the same as 1) before;

are most preferred.

In the general formula (I), examples of the group of the formula:

include groups of the formulae of

wherein R³ is the same as 1) before; R^(4A) and R^(4B) are the same asbefore; and groups of the formulae of

wherein R³ is the same as 1) before; R^(4A) is the same as before.

Among the groups above, a group of the formula of

wherein R³ is the same as 1) before; R^(4A) and R^(4B) are the same asbefore; is preferred.

Groups of preferred substituents in the ring A, ring B, ring C, R¹ toR⁵, M, Y, L¹, L², L³, k, n and q of the compound of general formula (I)are shown with (Ia) to (IIl). Compounds having possible combination ofthem are preferable.

In the ring A, (Ia) a benzen ring, a furan ring, a thiophen ring or apyridine ring is preferable, and further (Ib) a benzene ring or apyridine ring is more preferable.

In the ring B, (Ic) a group of the formula of

is preferable, (Id) a group of the formula of

is more preferable, and (Ie) a group of the formula of

is most preferable.

In the ring C, (If) a benzene ring, a naphthalene ring, a pyridine ringor a benzimidazole ring is preferable, and further (Ig) a benzene ringis more preferable.

In R¹, (Ih) carboxy, alkoxycarbonyl, optionally substituted carbamoyl ora carboxy equivalent is preferable, and (Ii) carboxy is more preferable.

In R², (Ij) a halogen atom, optionally substituted alkyl, optionallysubstituted alkyloxy, optionally substituted amino, optionallysubstituted carbamoyl, cyano, nitro, optionally substituted aryl,optionally substituted heteroaryl or an optionally substitutednon-aromatic heterocyclic ring is preferable, further (Ik) a halogenatom, optionally substituted alkyl, optionally substituted alkyloxy,optionally substituted amino, optionally substituted carbamoyl,optionally substituted aryl, optionally substituted heteroaryl or anoptionally substituted non-aromatic heterocyclic ring is morepreferable, and (Il) a halogen atom, optionally substituted alkyl,optionally substituted alkyloxy, optionally substituted aryl oroptionally substituted heteroaryl is most preferable.

In R³, (Im) optionally substituted alkyloxy, optionally substitutedalkylthio, optionally substituted cycloalkyloxy or optionallysubstituted aryloxy is preferable, further (In) optionally substitutedC1-C6 alkyloxy or optionally substituted C1-C6 alkylthio is morepreferable, and (Io) optionally substituted C2-C4 alkyloxy or optionallysubstituted C2-C4 alkylthio is most preferable.

In R⁴, (Ip) a halogen atom, optionally substituted alkyl, optionallysubstituted alkyloxy, cyano, nitro, optionally substituted aryl oroptionally substituted heteroaryl is preferable, further (Iq) a halogenatom, optionally substituted alkyl or optionally substituted alkyloxy ismore preferable, and (Ir) a halogen atom or optionally substituted alkylis most preferable.

In R⁵, (Is) optionally substituted alkyl or oxo is preferable, andfurther (It) alkyl is more preferable.

In M, (Iu) sulfonyl or carbonyl is preferable, and further (Iv) sulfonylis more preferable.

In Y, (Iw) a single bond or optionally substituted alkylene optionallycontaining one or two heteroatom(s) is preferable, and further (Ix) asingle bond is more preferable.

In L¹, (Iy) a single bond or optionally substituted alkylene optionallycontaining one or two heteroatom(s) or —NH— is preferable, and further(Iz) a single bond is more preferable.

In L², (IIa) a single bond or optionally substituted alkylene optionallycontaining one or two heteroatom(s) or —NH— is preferable, and further(IIb) a single bond is more preferable.

In L³, (IIc) a single bond, methylene, —O-methylene or —NH-methylene ispreferable, further (IId) —O-methylene or —NH-methylene is morepreferable, and (IIe) —O-methylene is most preferable.

In k, (IIf) 0, 1 or 2 is preferable, and further (IIg) 1 or 2 is morepreferable.

In n, (IIh) 0, 1 or 2 is preferable, and further (IIi) 0 is morepreferable.

In q, (IIj) 0 or 1 is preferable, and further (IIk) 1 or (II l) 0 ismore preferable.

Groups of preferred substituents in the ring A, ring B, ring C, R¹ toR⁵, M, Y, L¹, L², L³, k, n and q of the compound of general formula (II)are shown with (Ia) to (IIl). Compounds having possible combination ofthem are preferable.

In the ring A, (Ia) above is preferable, and further (Ib) above is morepreferable.

In the ring B, a ring of the formula (Ic) above is preferable, further aring of the formula (Id) above is more preferable, and a ring of theformula (Ie) above is most preferable.

In the ring C, (If) above is preferable, and further (Ig) above is morepreferable.

In R¹, (Ih) above is preferable, and further (Ii) above is morepreferable.

In R², (Ij) above is preferable, further (Ik) above is more preferableand (Il) above is most preferable.

In R³, (Im) above is preferable, further (In) above is more preferableand (Io) above is most preferable.

In R⁴, (Ip) above is preferable, further (Iq) above is more preferableand (Ir) above is most preferable.

In R⁵, (Is) above is preferable, and further (It) above is morepreferable.

In M, (Iu) above is preferable, and further (Iv) above is morepreferable.

In Y, (Iw) above is preferable, and further (Ix) above is morepreferable.

In L¹, (Iy) above is preferable, and further (Iz) above is morepreferable.

In L², (IIa) above is preferable, and further (IIb) above is morepreferable.

In L³, (IIc) above is preferable, further (IId) above is more preferableand (IIe) above is most preferable.

In k, (IIf) above is preferable, and further (IIg) above is morepreferable.

in n, (IIh) above is preferable, and further (IIi) above is morepreferable.

in q, (IIj) above is preferable, and further (IIk) above or (IIl) aboveis more preferable.

Groups of preferred substituents in the ring D, R¹ to R⁵, M, Y, Z, L³,p, n and q of the compound of general formula (III) are shown with (If)to (Ix), (IIc) to (IIe) and (IIg) to (IIn). Compounds having possiblecombination of them are preferable.

In the ring D, (If) above is preferable, and further (Ig) above is morepreferable.

In R¹, (Ih) above is preferable, and further (Ii) above is morepreferable.

In R², (Ij) above is preferable, further (Ik) above is more preferableand (Il) above is most preferable.

In R³, (Im) above is preferable, further (In) above is more preferableand (Io) above is most preferable.

In R⁴, (Ip) above is preferable, further (Iq) above is more preferableand (Ir) above is most preferable.

In R⁵, (Is) above is preferable, and further (It) above is morepreferable.

In M, (Iu) above is preferable, and further (Iv) above is morepreferable.

In Y, (Iw) above is preferable, and further (Ix) above is morepreferable.

In Z, (IIm) CH, C—R⁴ or N is preferable, and further (IIn) CH above ismore preferable.

In L³, (IIc) above is preferable, further (IId) above is more preferableand (IIe) above is most preferable.

In n, (IIh) above is preferable, and further (IIi) above is morepreferable.

In q, (IIj) above is preferable, and further (IIk) above or (IIl) aboveis more preferable.

In p, (IIg) above is preferable.

Groups of preferred substituents in the ring D, the ring E, R¹ to R⁵, M,Y, Z, L³, p, n and q of the compound of general formula (IV) are shownwith (If) to (Ix), (IIc) to (IIe) and (IIg) to (IIp). Compounds havingpossible combination of them are preferable.

In the ring D, (If) above is preferable, and further (Ig) above is morepreferable.

In R¹, (Ih) above is preferable, and further (Ii) above is morepreferable.

In R², (Ij) above is preferable, further (Ik) above is more preferableand (II) above is most preferable.

In R³, (Im) above is preferable, further (In) above is more preferableand (Io) above is most preferable.

In R⁴, (Ip) above is preferable, further (Iq) above is more preferableand (Ir) above is most preferable.

In R⁵, (Is) above is preferable, and further (It) above is morepreferable.

In M, (Iu) above is preferable, and further (Iv) above is morepreferable.

In Y, (Iw) above is preferable, and further (Ix) above is morepreferable.

In Z, (IIm) CH, C—R4 or N is preferable, and further (IIn) CH above ismore preferable.

In L³, (IIc) above is preferable, further (IId) above is more preferableand (IIe) above is most preferable.

In n, (IIh) above is preferable, and further (IIi) above is morepreferable.

In q, (IIj) above is preferable, and further (IIk) above or (IIl) aboveis more preferable.

In p, (IIg) above is preferable.

In the ring E, (IIo) a ring of the formula of

is preferable, and further (IIp) a ring of the formula of

is more preferable.

Groups of preferred substituents in the ring Ab, the ring Bb, the ringCb, R^(1b) to R^(5b), Yb, Zb, kb, mb, nb and p of the compound ofgeneral formula (I-b) are shown with (IIIa) to (IVc). Compounds havingpossible combination of them are preferable.

In the ring Ab, (IIIa) a benzene ring, a furan ring, a thiophen ring ora pyridine ring is preferable, and further (IIIb) a benzene ring or apyridine ring is more preferable.

In the ring Bb, (IIIc) a ring of the formula of

is preferable, further (IIId) a ring of the formula of

is more preferable and (IIIe) a ring of the formula of

is most preferable.

In the ring Cb, (MI) a benzene ring, a naphthalene ring or a pyridinering is preferable, and further (IIIg) a benzene ring is morepreferable.

In R^(1b), (IIIh) hydroxyalkyl, carboxy or alkoxycarbonyl is preferable,and further (IIIi) carboxy is more preferable.

In R^(2b), (IIIj) a halogen atom, optionally substituted alkyl,optionally substituted alkyloxy, optionally substituted amino, cyano,nitro, optionally substituted aryl or optionally substituted heteroarylis preferable, and further (IIIk) a halogen atom, optionally substitutedalkyl, optionally substituted alkloxy, optionally substituted aryl oroptionally substituted heteroaryl is more preferable.

In R^(3b), (IIIl), optionally substituted alkyloxy, optionallysubstituted alkylthio, optionally substituted cycloalkyloxy oroptionally substituted aryloxy is preferable, and further (IIIm)optionally substituted C2-C4 alkyloxy or optionally substituted C2-C4alkylthio is more preferable.

In R^(4b), (IIIn) a halogen atom, optionally substituted alkyl, cyano,nitro, optionally substituted aryl or optionally substituted heteroarylis preferable, and further (IIIo) a halogen atom or optionallysubstituted alkyl is more preferable.

In R^(5b), (IIIp) optionally substituted alkyl is preferable, andfurther (IIIq) alkyl is more preferable.

In Y^(b), (IIIr) a single bond, alkylene or —O— is preferable, andfurther (IIIs) a single bond or —O— is preferable.

In Z^(b), (IIIt) alkylene, alkenylene or —O-alkylene is preferable, andfurther (IIIu) methylene or —O-alkylene is more preferable.

In kb, (IIIv) 1, 2 or 3 is preferable, and further (IIIw) 1 or 2 is morepreferable.

In mb, (IIIx) 0, 1 or 2 is preferable, and further (IIIy) 0 or 1 is morepreferable.

In nb, (IIIz) 0, 1 or 2 is preferable, and further (IVa) 0 is morepreferable.

In pb, (IVb) 0 or 1 is preferable, and further (IVc) 1 is morepreferable.

Groups of preferred substituents in the ring Ab, the ring Bb, the ringCb, R^(1b) to R^(5b), Y^(b), Z^(b), kb, mb and nb of the compound ofgeneral formula (II-b) are shown with (IIIa) to (IVa). Compounds havingpossible combination of them are preferable.

In the ring Ab, (IIIa) above is preferable, and further (IIIb) above ismore preferable.

In the ring Bb, a ring of the formula (IIIc) above is preferable,further a ring of the formula (IIId) above is more preferable, and aring of the formula (IIIe) is most preferable.

In the ring Cb, (IIIf) above is preferable, and further (IIIg) above ismore preferable.

In R^(1b), (IIIh) above is preferable, and further (IIIi) above is morepreferable.

In R^(2b), (IIIj) above is preferable, and further (IIIk) above is morepreferable.

In R^(3b), (IIIl) above is preferable, and further (IIIm) above is morepreferable.

In R^(4b), (IIIn) above is preferable, and further (IIIo) above is morepreferable.

In R^(5b), (IIIp) above is preferable, and further (IIIq) above is morepreferable.

In Y^(b), (IIIr) above is preferable, and further (IIIs) above is morepreferable.

In Z^(b), (IIIt) above is preferable, and further (IIIu) above is morepreferable.

In kb, (IIIv) above is preferable, and further (IIIw) above is morepreferable.

In mb, (IIIx) above is preferable, and further (IIIy) above is morepreferable.

In nb, (IIIz) above is preferable, and further (IVa) above is morepreferable.

Groups of preferred substituents in the ring Cb, R^(1b) to R^(5b),X^(b), Y^(b), Z^(b), mb, nb and qb of the compound of general formula(III-b) are shown with (IIIf) to (IIIIu), (IIIx) to (IVa) and (IVd) to(IVg). Compounds having possible combination of them are preferable.

In the ring Cb, (IIIf) above is preferable, and further (IIIg) above ismore preferable.

In R^(1b), (IIIh) above is preferable, and further (IIIi) above is morepreferable.

In R^(2b), (IIIj) above is preferable, and further (IIIk) above is morepreferable.

In R^(3b), (IIIl) above is preferable, and further (IIIm) above is morepreferable.

In R^(4b), (IIIn) above is preferable, and further (IIIo) above is morepreferable.

In R^(5b), (IIIp) above is preferable, and further (IIIq) above is morepreferable.

In Y^(b), (IIIr) above is preferable, and further (IIIs) above is morepreferable.

In Z^(b), (IIIt) above is preferable, and further (IIIu) above is morepreferable.

In mb, (IIIx) above is preferable, and further (IIIy) above is morepreferable.

In nb, (IIIz) above is preferable, and further (IVa) above is morepreferable.

In qb, (IVd) above 1, 2 or 3 is preferable, and further (IVe) 1 or 2 ismore preferable.

In X^(b), (IVf) CH or (IVg) N is preferable.

Groups of preferred substituents in the ring Cb, the ring Db, R^(1b) toR^(5b), X^(b), Y^(b), Z^(b), mb, nb and sb of the compound of generalformula (IV-b) are shown with (IIIf) to (IIIu), (IIIx) to (IVa) and(IVf) to (IVk). Compounds having possible combination of them arepreferable.

In the ring Cb, (IIIf) above is preferable, and further (IIIg) above ismore preferable.

In R^(1b), (IIIh) above is preferable, and further (IIIi) above is morepreferable.

In R^(2b), (IIIj) above is preferable, and further (IIIk) above is morepreferable.

In R^(3b), (IIIl) above is preferable, and further (IIIm) above is morepreferable.

In R^(4b), (IIIn) above is preferable, and further (IIIo) above is morepreferable.

In R^(5b), (IIIp) above is preferable, and further (IIIq) above is more

In Y^(b), (IIIr) above is preferable, and further (IIIs) above is morepreferable.

In Z^(b), (IIIt) above is preferable, and further (IIIu) above is morepreferable.

In mb, (IIIx) above is preferable, and further (IIIy) above is morepreferable.

In nb, (IIIz) above is preferable, and further (IVa) above is morepreferable.

In X^(b), (IVf) above or (IVg) above is preferable.

In the ring Db, (IVh) a ring of the formula of

is preferable, and further (IVi) a ring of the formula of

is more preferable.

In sb, (IVj) 1, 2 or 3 is preferable, and further (IVk) 1 or 2 is morepreferable.

Groups of preferred substituents in the ring Cb, the ring Eb, R^(1b) toR^(4b), X^(b), W^(b), Z^(b), mb, nb and sb of the compound of generalformula (V-b) are shown with (IIIf) to (IIIo), (IIIt) to (IIIu), (IIIx)to (IVa), (IVf) to (IVg) and (IVj) to (IVo). Compounds having possiblecombination of them are preferable.

In the ring Cb, (IIIf) above is preferable, and further (IIIg) above ismore preferable.

In R^(1b), (IIIh) above is preferable, and further (IIIi) above is morepreferable.

In R^(2b), (IIIj) above is preferable, and further (IIIk) above is morepreferable.

In R^(3b), (IIIl) above is preferable, and further (IIIm) above is morepreferable.

In R^(4b), (IIIn) above is preferable, and further (IIIo) above is morepreferable.

In Z^(b), (IIIt) above is preferable, and further (IIIu) above is morepreferable.

In mb, (IIIx) above is preferable, and further (IIIy) above is morepreferable.

In nb, (IIIz) above is preferable, and further (IVa) above is morepreferable.

In X^(b), (IVf) above or (IVg) above is preferable.

In sb, (IVj) above is preferable, and further (IVk) above is morepreferable.

In the ring Eb, (IVl) a ring of the formula of

is preferable, and further (IVm) a ring of the formula of

is more preferable.

In W^(b), (IVn) a single bond, alkylene or —O— is preferable, andfurther (IVo) a single bond or —O— is more preferable.

Effect of Invention

The compounds of the present invention are useful as a therapeuticagent, especially for treating allergic diseases, since they have anexcellent DP receptor antagonistic activity and high safety.

BEST MODE FOR CARRYING OUT THE INVENTION

The compounds of the present invention can be prepared by the method A,B or C set forth below. In addition, a racemate or an optical isomer isincluded in structural formulae of (IV) to (XV), (XVII), (XVIII), (XIX)and (XX).

Method A is set forth below,

wherein the ring A, the ring B, the ring C, R¹, R², R³, R⁴, R⁵, M, Y,L¹, L², L³, k, n and q are the same as 1) above; La is a halogen atom ora hydroxy group; Lb is a hydrogen atom, a halogen atom, a hydroxy group,methylsulfonyloxy, p-toluenesulfonyloxy or tert-butyloxycarbonyl.

A starting compound of the formula (VI) is available from commercialproducts or by chemical modification of the substituent on the compoundof the formula (VI) such as general alkylation, esterification,amidation, hydrolysis, reductive reaction, oxdative reaction,Suzuki-coupling reaction, protection and de-protection reaction and thelike.

Step 1 is a process in which a compound of the formula (VI) is reactedwith a compound of the formula (VII) to give a compound of the formula(VIII).

The reaction can be carried out by reacting 0.5 to 5 equivalents of thecompound (VII) compared to the compound (VI) in a solvent at 0° C. to150° C. for 5 minutes to 48 hours.

The reaction may be conducted under the presence of 1 to 5 equivalentsof a base. Examples of the preferable base include sodium hydride,potassium carbonate, sodium carbonate, potassium bicarbonate, sodiumbicarbonate, triethylamine and the like.

Examples of the preferable solvent include tetrahydrofuran,N,N-dimethylformamide, dimethylsulfoxide, water and the like, which canbe used alone or as a mixed solvent.

When Lb is tert-butyloxycarbonyl, the compound can be de-protected in asolvent such as ethyl acetate etc. at 0° C. to 150° C. for 5 minutes to48 hours using hydrochloric acid.

Step 2 is a process in which a compound of the formula (VIII) iscondensed with a compound of the formula (IX), and the product ishydrolyzed under basic condition if necessary, to give a compound of theformula (I).

The reaction can be carried out by reacting 0.5 to 5 equivalents of thecompound (IX) compared to the compound (VIII) in a solvent at 0° C. to150° C. for 5 minutes to 48 hours.

Examples of the preferable solvent include ethyl acetate, methylenechloride, tetrahydrofuran, toluene, N,N-dimethylformamide, methanol,dioxane, water and the like, which can be used alone or as a mixedsolvent.

If necessary, 0.05 to 5 equivalents of a)1,1′-(azodicarbonyl)dipiperidine and tributylphosphine or b)tris(dibenzylideneacetone)-dipalladium(0), xantophos and sodiumtert-butoxide respectively compared to the compound of the formula(VIII) can be used as a condensing agent.

Hydrolysis can be conducted by reacting 1 to 5 equivalent(s) of a basecompared to the compound of the formula (VII) at 0° C. to 150° C. for 5minutes to 48 hours.

Examples of the preferable solvent include tetrahydrofuran, methanol,N,N-dimethylformamide, water and the like, which can be used alone or asa mixed solvent.

Examples of the preferable base include sodium hydroxide, potassiumhydroxide, potassium carbonate, sodium carbonate, potassium bicarbonate,sodium bicarbonate and the like.

In addition, each substituent may be converted to the other substituentusing a general reaction such as alkylation, esterification, amidation,hydrolysis, reductive reaction, oxdative reaction, Suzuki-couplingreaction, protection and de-protection reaction and the like. A product(VIII) and (I) of each step may be purified by a usual method such ascolumn chromatography or re-crystalization.

Method B is set forth below,

wherein the ring A, the ring C, R¹, R², R³, R⁴, R⁵, L³, k, n and q arethe same as 1) above.

Step 1 is a process in which a compound of the formula (X) is reactedwith a compound of the formula (XI) to give a compound of the formula(XII).

The reaction can be carried out by reacting 0.5 to 5 equivalents of thecompound (XI) compared to the compound (X) in a solvent at 0° C. to 150°C. for 5 minutes to 48 hours.

The reaction may be conducted under the presence of 1 to 5 equivalent(s)of a base. Examples of the preferable base include sodium hydride,potassium carbonate, sodium carbonate, potassium bicarbonate, sodiumbicarbonate, triethylamine and the like.

Examples of the preferable solvent include tetrahydrofuran,N,N-dimethylformamide, dimethylsulfoxide, water and the like, which canbe used alone or as a mixed solvent.

Step 2 is a process in which a compound of the formula (XII) is reactedwith a compound of the formula (XIII), and the product is hydrolyzedunder basic condition if necessary, to give a compound of the formula(XIV).

The reaction can be carried out by reacting 0.5 to 5 equivalents of thecompound (XIII) compared to the compound (XII) in a solvent at 0° C. to150° C. for 5 minutes to 48 hours.

Examples of the preferable solvent include ethyl acetate, methylenechloride, tetrahydrofuran, N,N-dimethylformamide, methanol, dioxane,water and the like, which can be used alone or as a mixed solvent.

If necessary, the reaction may be carried out under the presence of 1 to5 equivalent(s) of a base. Examples of the preferable base includesodium hydride, potassium carbonate, sodium carbonate, potassiumbicarbonate, sodium bicarbonate, triethylamine and the like.

Further, 0.2 to 4 equivalents of potassium iodide can be used comparedto the compound of the formula (XIII).

Hydrolysis can be conducted by reacting 1 to 5 equivalent(s) of a basecompared to the compound of the formula (MI) at 0° C. to 150° C. for 5minutes to 48 hours.

Examples of the preferable solvent include tetrahydrofuran, methanol,N,N-dimethylformamide, water and the like, which can be used alone or asa mixed solvent.

Examples of the preferable base include sodium hydroxide, potassiumhydroxide, potassium carbonate, sodium carbonate, potassium bicarbonate,sodium bicarbonate and the like.

In addition, each substituent may be converted to the other substituentusing a general reaction such as alkylation, esterification, amidation,hydrolysis, reductive reaction, oxdative reaction, Suzuki-couplingreaction, protection and de-protection reaction and the like. A product(XII) and (XIV) of each step may be purified by a usual method such ascolumn chromatography or re-crystalization.

Method C is set forth below,

wherein the ring A, the ring B, the ring C, R¹, R², R³, R⁴, R⁵, Y, L³,k, n and q are the same as 1) above; and Lb is a hydrogen atom, ahalogen atom, a hydroxyl group, methylsulfonyloxy, p-toluenesulfonyloxyor tert-butyloxycarbonyl.

Step 1 is a process in which a compound of the formula (X) is reactedwith a compound of the formula (XV) to give a compound of the formula(XVI).

The reaction can be carried out by reacting 0.5 to 5 equivalents of thecompound (XV) compared to the compound (X) in a solvent at 0° C. to 150°C. for 5 minutes to 48 hours.

The reaction may be conducted under the presence of 1 to 5 equivalent(s)of a base. Examples of the preferable base include sodium hydride,potassium carbonate, sodium carbonate, potassium bicarbonate, sodiumbicarbonate, triethylamine and the like.

Examples of the preferable solvent include tetrahydrofuran,N,N-dimethylformamide, dimethylsulfoxide, water and the like, which canbe used alone or as a mixed solvent.

When Lb is tert-butyloxycarbonyl, the compound can be de-protected in asolvent such as ethyl acetate etc. at 0° C. to 150° C. for 5 minutes to48 hours using hydrochloric acid.

Step 2 is a process in which a compound of the formula (XVI) iscondensed with a compound of the formula (XVII) to give a compound ofthe formula (XVIII).

The reaction can be carried out by reacting 0.5 to 5 equivalents of thecompound (XVII) compared to the compound (XVI) in a solvent at 0° C. to150° C. for 5 minutes to 48 hours.

Examples of the preferable solvent include ethyl acetate, methylenechloride, tetrahydrofuran, N,N-dimethylformamide, methanol, dioxane,water and the like, which can be used alone or as a mixed solvent.

If necessary, 0.5 to 5 equivalents of 1,1′-(azodicarbonyl)dipiperidineand tributylphosphine compared to the compound of the formula (XVI) canbe used as a condensing agent.

Step 3 is a process in which a compound of the formula (XVIII) iscondensed, and if necessary further reduced and/or hydrolyzed under abasic condition to give a compound of the formula (XIX).

The condensation reaction can be carried out by reacting 0.5 to 5equivalents of a condensing agent compared to the compound (XVIII) in asolvent at 0° C. to 150° C. for 5 minutes to 48 hours.

Examples of the preferable solvent include ethyl acetate, methylenechloride, tetrahydrofuran, N,N-dimethylformamide, dimethylsulfoxide,water and the like, which can be used alone or as a mixed solvent.

As a condensing agent, carboethoxymethylenetriphenylphosphorane and thelike can be used.

A double bond or triple bond formed by the condensation reaction can bereduced to a saturated bond by a usual reductive reaction.

Hydrolysis can be conducted by reacting 1 to 5 equivalent(s) of a basecompared to the compound of the formula (XVIII) in a solvent at 0° C. to150° C. for 5 minutes to 48 hours.

Examples of the preferable solvent include tetrahydrofuran, methanol,N,N-dimethylformamide, water and the like, which can be used alone or asa mixed solvent.

Examples of the preferable base include sodium hydroxide, potassiumhydroxide, potassium carbonate, sodium carbonate, potassium bicarbonate,sodium bicarbonate and the like.

In addition, each substituent may be converted to the other substituentusing a general reaction such as alkylation, esterification, amidation,hydrolysis, reductive reaction, oxdative reaction, Suzuki-couplingreaction and the like.

The product (XVI), (XVIII) or (XIX) of each step can be purified ifnecessary by usual methods such as column chromatography andre-crystallization etc.

In addition, a compound of the general formula (X) can be prepared bythe next method;

wherein the ring A, R³, R⁴ and q are the same as 1) before, and W³ is ahalogen atom.

In a method for preparing the compound of the formula (X) from thecompound of the formula (XX), the compound of the formula (XX) is 1)converted to a SO₃H derivative by treating with ClSO₃Cl, and 2) followedby chlorination of the hydroxy group by the reaction with POCl₃ or PCl₅to give the compound of the formula (X).

In a method for preparing the compound of the formula (X) from thecompound of the formula (XXI), the compound of the formula (XIX) is 1)lithiated by n-BuLi, and 2) follwed by conversion to a SO₂Li derivativeby the reaction with SO₂, and finally 3) reacted with SO₂Cl₂ to give thecompound of the formula (XX). A bromine atom or an iodine atom ispreferable as W³.

In addition, each substituent may be converted to the other substituentin each step using a general reaction such as alkylation,esterification, amidation, hydrolysis, reductive reaction, oxdativereaction, Suzuki-coupling reaction and the like.

In this specification, a term of “solvate” includes, for example, asolvate with an organic solvent, a hydrate and the like. In a case offorming the solvate with an organic solvent, any number of molecules ofthe organic solvent may be coordinated. In a case of forming thehydrate, any number of water molecules may be coordinated. A hydrate isusually preferred.

A term of “compound of the present invention” includes apharmaceutically acceptable salt and a solvate thereof. Examples of thesalt include salts with alkaline metal (lithium, sodium and potassiumetc.), alkaline earth metal (magnesium and calcium etc.), ammonium,organic bases and amino acids and salts with inorganic acids(hydrochloric acid, hydrobromic acid, phosphoric acid and sulfuric acid,etc.) and organic acids (acetic acid, citric acid, maleic acid, fumaricacid, benzenesulfonic acid and p-toluenesulfonic acid etc.). These saltscan be formed by the usual method.

A compound of the present invention is not limited to the specifiedisomer but includes all possible isomers and racemates.

A compound of the present invention shows an excellent DP receptorantagonistic activity as described in the following examples.Accordingly, a pharmaceutical composition of the present invention canbe used as a therapeutic agent for preventing and/or treating allergicdiseases such as asthma, allergic rhinitis, allergic dermatitis,allergic conjunctivitis, food allergy and the like; systemicmastocytosis; systemic disorder of mastcell-activation; lung emphysema;chronic bronchitis; chronic obstructive lung disease; skin disordercharacterized by pruritus such as atopic dermatitis and hives; diseasesoccurring secondarily due to behavior accompanied by pruritus such ascataract and retinal detachment; brain damages such as cerebrovasculardisorder, degenerative brain disorder and demyelinating disease;sleep-waking disorder; Churg-Strauss syndrome; papular dermatitis suchas filariasis; vasculitis; polyarteritis; cutaneous eosoiophilicgranuloma; autoimmune diseases such as multiple sclerosis and transplantrejection; eosoiophilic pneumonopathy; histiocytosis; pneumonia;aspergillosis; pleurisy; sarcoidosis; pulmonary fibrosis; eosinophilia;skin flush such as face flush by nicotinic acid; filariasis;schistosomiasis; trichinelliasis; coccidioidomycosis; tuberculosis;bronchial cancer; lymphoma; Hodgkin's disease and the like.

When a compound of the present invention is administered to a human inorder to treat the diseases above, oral administration through a powder,granule, tablet, capsule, pill, liquid formulation and the like, orparenteral administration through an injection, suppository, transdermalformulation, inhalant and the like is possible.

A pharmaceutical composition can be obtained by mixing a therapeuticallyeffective amount of a compound of the present invention with apharmaceutical additives such as an excipient, binder, wetting agent,disintegrating agent, lubricant and the like, which is suitable to theselected formulation. An injection can be formulated by sterilizationtogether with a suitable carrier.

In the treatment of the diseases related to PGD2 receptor above, it ispossible to use the compound of the present invention combined with orin a coupled formulation with the other therapeutic agent. In the caseof treating inflammatory diseases including allergy, the compound can beused combined with or in a coupled formulation with leukotriene receptorantagonist (e.g., montelukast sodium, zafirlukast, pranlukast hydrate,leukotriene B4 receptor antagonist); leukotriene synthesis inhibitorsuch as zileuton, PDE IV inhibitor (e.g., theophylline, cilomilast,roflumilast), corticosteroid (e.g., prednisolone, fluticasone,budesonide, ciclesonide), β2-agonist (e.g., salbutamol, salmeterol,formoterol), anti IgE antibody (e.g., omalizumab), histamine H1 receptorantagonist (e.g., chlorpheniramine, loratadine, cetirizine), immunosuppressant (tacrolimus, cyclosporin), thromboxane A2 receptorantagonist (e.g., ramatroban), chemokine receptor (especially CCR-1,CCR-2, CCR-3) antagonist, other prostanoid receptor antagonist (e.g.,CRTH2 antagonist), adhesion molecule antagonist (e.g., VLA-4antagonist), cytokine antagonist (e.g., anti-IL-4 antibody, anti-IL-3antibody), Non-steroidal anti-inflammatory agent (e.g., propionic acidderivative such as ibuprofen, ketoprofen, and naproxen etc.; acetic acidderivative such as indomethacin, and diclofenac etc.; salicylic acidsuch as acetyl salicylic acid; cyclooxigenase-2 inhibitor such ascelecoxib and etoricoxib).

Further, uses combined with or in a coupled formulation with antitussiveagent (e.g., codein, hydrocodein), cholesterol lowering agent(lovastatin, simvastatin, fluvastatin. rosuvastatin), anticholinergicdrug (e.g., tiotropium, ipratropium, flutropium, oxitropium) are alsopossible.

Dose of the compounds of the present invention depends on condition ofdiseases, route of administration, age and body weight of a patient. Inthe case of oral administration to an adult, the dose range is usually0.1 to 100 mg/kg/day, preferably 1 to 20 mg/kg/day.

EXAMPLE

The present invention is illustrated more in detail below by examplesand test examples, but not limited to these examples.

In examples, the following abbreviations are used;

Me: methyl

Et: ethyl

n-Pr: n-propyl

i-Pr: isopropyl

Ac: acetyl

Ph: phenyl

Bn: benzyl

Boc: tert-butyloxycarbonyl

MOM: methyloxymethyl

THF: tetrahydrofuran

DMF: N,N-dimethylformamide

MeOH: methanol

HOBt: 1-hydroxybenzotriazole

WSCD HCl: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride

Example 1 Preparation of the Compound I-1

Step 1

4-Isopropoxybenzenesulfonyl chloride (2.34 g, 10.0 mmol) andtriethylamine (4.2 mL, 30.0 mmol) were added at 0° C. to a solution of4-hydroxypiperidine (1.01 g, 10.0 mmol) in THF (20 mL) and the mixturewas stirred for an hour. Diluted hydrochloric acid (60 mL) and ethylacetate (60 mL) were added to the reaction solution, the mixture wasextracted and the organic layer was washed with a saturated aqueoussolution of sodium bicarbonate and saturated brine successively, driedand concentrated. n-Hexane was added to the residue and the resultingcrystalline was filtered to give the compound (2) (2.8 g, 94% yield).

¹H-NMR (CDCl₃) δ ppm: 1.36 (d, J=6.0 Hz, 6H), 1.71 (m, 2H), 1.93 (m,2H), 2.84 (m, 2H), 3.23 (m, 2H), 3.77 (m, 1H), 4.06 (m, 1H), 6.95 (d,J=8.7 Hz, 2H), 7.66 (d, J=8.7 Hz, 2H).

Step 2

Carboethoxymethylenetriphenylphosphorane (920 mg, 2.6 mmol) was added toa solution of 2-hydroxy-4-methylbenzaldehyde (3) (300 mg, 2.2 mmol) inTHF (5 mL) and the mixture was heated under reflux for an hour. Afterthe reaction mixture was cooled down, the solvent was evaporated. Theresulting residue was purified by a silica gel column chromatography(hexane:ethyl acetate=5:1) and concentrated to give the compound (4)(320 mg, 70% yield).

¹H-NMR (CDCl₃) δ ppm: 1.34 (t, J=7.2 Hz, 3H), 2.28 (s, 3H), 4.27 (m,2H), 6.09 (s, 1H), 6.60 (d, J=16.2 Hz, 1H), 6.74 (d, J=8.1 Hz, 1H), 7.04(dd, J=2.1, 8.1 Hz, 1H), 7.27 (d, J=2.1 Hz, 1H), 8.00 (d, J=16.2 Hz,1H).

Step 3

The compound (2) (218 mg, 0.7 mmol) obtained in step 1,1,1′-(azodicarbonyl)dipiperidine (238 mg, 0.9 mmol) andtributylphosphine (0.57 mL, 2.2 mmol) were added to a solution of thecompound (4) (150 mg, 0.7 mmol) in THF (10 mL), and the mixture wasstirred at room temperature for 4 hours. Water was added to the reactionsolution, the mixture was extracted with ethyl acetate and the organiclayer was washed with a saturated aqueous solution of sodium bicarbonateand saturated brine successively, dried and concentrated. The resultingresidue was purified by a silica gel column chromatography (hexane:ethylacetate=3:1) to give the compound (5) (130 mg, 37% yield).

Step 4

A 2M aqueous solution of sodium hydroxide (0.4 mL, 0.8 mmol) was addedto a solution of the compound (5) (40 mg, 0.08 mmol) in THF (6 mL) andMeOH (2 mL) and the mixture was stirred at room temperature for 18hours. After the reaction solution was acidified by adding dilutedhydrochloric acid, the mixture was extracted with ethyl aetate, and theextract was washed with water, dried and concentrated. The residue wascrystallized from hexane-ethyl acetate to give the compound I-1 (15 mg,40% yield).

¹H-NMR (CDCl₃) δ ppm: 1.35 (d, 6H, J=9.0 Hz), 2.01 (m, 4H), 2.28 (s,3H), 3.15 (m, 4H), 4.62 (m, 1H), 6.38 (d, J=16.2 Hz, 1H), 6.74 (d, J=8.4Hz, 1H), 6.96 (d, J=9.0 Hz, 2H), 7.11 (dd, J=1.8, 8.4 Hz, 1H), 7.31 (d,J=1.8 Hz, 1H), 7.68 (d, J=9.0 Hz, 2H), 7.89 (d, J=16.2 Hz, 1H).

Example 2 Preparation of the Compound II-9 and III-1

Step 1

4-Isopropoxybenzenesulfonyl chloride (2.35 g, 10.0 mmol) andtriethylamine (3.7 mL, 22.0 mmol) were added to a solution ofbis(2-chloroethyl)amine hydrochloride (6) (1.78 g, 10.0 mmol) in DMF (20mL) and the mixture was stirred at room temperature for 2 hours. Dilutedhydrochloric acid (200 mL) was added to the reaction solution, themixture was extracted with ethyl acetate (200 mL) and the organic layerwas washed with a saturated aqueous solution of sodium bicarbonate andsaturated brine successively, dried and concentrated. The resultingresidue was purified by a silica gel column chromatography (hexane:ethylacetate=8:1) to give the compound (7) (1.79 g, 53% yield).

¹H-NMR (CDCl₃) δ ppm: 1.37 (d, J=6.3 Hz, 6H), 2.98 (m, 4H), 3.74 (m,4H), 4.64 (m, 1H), 6.97 (d, J=9.0 Hz, 2H), 7.66 (d, J=9.0 Hz, 2H).

Step 2

Methyl bromoacetate (7.1 mL, 75.0 mmol), potassium carbonate (13.8 g,100.0 mmol) and potassium iodide (0.83 g, 5.0 mmol) were added to asolution of 2-methoxy-5-nitrophenol (8) (8.46 g, 50.0 mmol) in DMF (80mL) and the mixture was stirred at 30° C. for 2 hours. Water was addedto the reaction mixture and the precipitated crystalline was washed withwater and dried to give the compound (9) (11.9 g, 99.9% yield).

¹H-NMR (CDCl₃) δ ppm: 3.83 (s, 3H), 3.99 (s, 3H), 4.78 (s, 2H), 6.96 (d,J=9.0 Hz, 1H), 7.69 (d, J=2.4 Hz, 1H), 7.98 (dd, J=2.4, 9.0 Hz, 1H).

Step 3

To a solution of the compound (9) (5.95 g, 25.0 mmol) in a mixture ofTHF (60 mL) and MeOH (60 mL) was added 10% palladium carbon (1.2 g) andthe mixture was stirred under hydrogen atmosphere at room temperaturefor 5 hours. The reaction mixture was filtered through Celite and thefiltrate was concentrated to give the compound (10) (5.28 g, 99.9%yield).

¹H-NMR (CDCl₃) δ ppm: 3.20 (brs, 2H), 3.79 (s, 3H), 3.81 (s, 3H), 4.65(s, 3H), 6.28-6.34 (m, 2H), 6.73 (d, J=8.4 Hz, 1H).

Step 4

The compound (7) (749 mg, 2.2 mmol), potassium carbonate (1.11 g, 8.0mmol) and potassium iodide (66.4 mg, 0.4 mmol) were added to a solutionof the compound (10) (422 mg, 2.0 mmol) in DMF (5 mL) and the mixturewas stirred at room temperature for 18 hours. Diluted hydrochloric acid(50 mL) was added to the reaction solution and the mixture was extractedwith ethyl acetate (50 mL), and the organic layer was washed with asaturated aqueous solution of sodium bicarbonate and saturated brine,dried and concentrated. The resulting residue was purified by a silicagel column chromatography (hexane:ethyl acetate=2:1) to give thecompound III-1 (43 mg, 5% yield)

¹H-NMR (CDCl₃) δ ppm: 1.37 (d, J=6.0 Hz, 6H), 3.15 (brs, 8H), 3.78 (s,3H), 3.83 (s, 3H), 4.60 (m, 1H), 4.65 (s, 2H), 6.60-6.63 (m, 2H), 6.81(d, J=7.8 Hz, 1H), 6.96 (d, J=9.0 Hz, 2H), 7.69 (d, J=9.0 Hz, 2H).

Step 5

The compound III-1 (40 mg, 0.084 mmol) was dissolved in MeOH (1.0 mL)and THF (1.0 mL). A 2M aqueous solution of sodium hydroxide (0.12 mL,0.25 mmol) was added and the mixture was stirred at room temperature for2 hours.

After the reaction solution was diluted with water and acidified byadding diluted hydrochloric acid, the mixture was extracted with ethylacetate and the extract was washed with water, dried and concentrated.The residue was crystallized from hexane-ethyl acetate to give thecompound II-9 (35 mg, 91% yield).

¹H-NMR (CDCl₃) δ ppm: 1.38 (d, J=6.0 Hz, 6H), 1.95 (brs, 1H), 3.16 (brs,8H), 3.86 (s, 3H), 4.60-4.69 (m, 3H), 6.60-6.63 (m, 2H), 6.85 (d, J=9.0Hz, 1H), 6.98 (d, J=9.0 Hz, 2H), 7.70 (d, J=9.0 Hz, 2H).

Example 3 Preparation of the Compound II-6 and III-2

Step 1

4-Isopropoxybenzenesulfonyl chloride (4.46 g, 19.0 mmol) andtriethylamine (5.6 mL, 40.0 mmol) were added to a solution of1-(tert-butoxycarbonyl)piperazine (11) (3.73 g, 20.0 mmol) in THF (40mL) and the mixture was stirred at room temperature for 2 hours. Dilutedhydrochloric acid (200 mL) was added to the reaction solution and themixture was extracted with ethyl acetate (200 mL), and the organic layerwas washed with a saturated aqueous solution of sodium bicarbonate andsaturated brine successively, dried and concentrated. The residue wascrystallized from hexane-ethyl acetate to give the compound (12) (6.78g, 88% yield)

¹H-NMR (CDCl₃) δ ppm: 1.37 (d, J=6.0 Hz, 6H), 1.41 (s, 9H), 2.95 (m,4H), 3.51 (m, 4H), 4.63 (m, 1H), 6.96 (d, J=8.7 Hz, 2H), 7.65 (d, J=8.7Hz, 2H).

Step 2

A 4M solution of hydrochloric acid in ethyl acetate was added to asolution of the compound (12) (6.78 g, 17.6 mmol) in ethyl acetate (30mL) and the mixture was stirred at room temperature for 2 hours and thestirring was further continued at 50° C. for 1 hour. Water (200 mL) wasadded to the reaction solution and extracted with ethyl acetate (200mL). After the aqueous layer was adjusted to pH=11 by adding a 2Maqueous solution of sodium hydroxide, the mixture was extracted withethyl acetate (400 mL). The organic layer was washed with water andsaturated brine successively, dried and concentrated. The residue wascrystallized from hexane-ethyl acetate to give the compound (13) (4.58g, 92% yield).

¹H-NMR (CDCl₃) δ ppm: 1.37 (d, J=6.0 Hz, 6H), 2.95 (m, 8H), 4.63 (m,1H), 6.94 (d, J=8.7 Hz, 2H), 7.65 (d, J=8.7 Hz, 2H).

Step 3

Tris(dibenzylideneacetone)-dipalladium(0)(71 mg, 0.08 mmol), xanthophos(134 mg, 0.23 mmol) and sodium tert-butoxide (288 mg, 3.0 mmol) wereadded to a solution of 3-bromo-2-chloropyridine (14) (192.4 mg, 1.0mmol) and the compound (3) (219 mg, 0.77 mmol) in toluene (10 mL) andthe mixture was heated under reflux under nitrogen atmosphere for 3hours. After being cooled, water (40 mL) was poured to the reactionsolution and extracted with ethyl acetate (100 mL). The organic layerwas washed with diluted hydrochloric acid, a saturated aqueous solutionof sodium bicarbonate and saturated brine successively, dried andconcentrated. The resulting residue was purified by a silica gel columnchromatography (hexane:ethyl acetate=3:1) to give the compound (15) (189mg, 62% yield).

¹H-NMR (CDCl₃) δ ppm: 1.39 (d, J=6.0 Hz, 6H), 3.17 (m, 8H), 4.65 (m,1H), 6.98 (d, J=8.7 Hz, 2H), 7.19-7.34 (m, 2H), 7.65 (d, J=8.7 Hz, 2H),8.08 (dd, J=1.5, 4.5 Hz, 1H).

Step 4

60% Sodium hydride (150 mg, 3.7 mmol) was added to a solution of benzylalcohol (0.35 mL, 3.4 mmol) in DMF (10 mL) at 0° C., and the mixture wasstirred for 30 minutes. To the reaction solution was added dropwise asolution of the compound (15) (673 mg, 3.4 mmol) in DMF (5 mL) at 0° C.and the mixture was stirred at 90° C. After being cooled, water (100 mL)was poured to the reaction solution and extracted with ethyl acetate(100 mL). The organic layer was washed with diluted hydrochloric acid, asaturated aqueous solution of sodium bicarbonate and saturated brinesuccessively, dried and concentrated. The resulting residue was purifiedby a silica gel column chromatography (hexane:ethyl acetate=3:1) andconcentrated to give the residue, which was used in the next stepwithout further purification.

¹H-NMR (CDCl₃) δ ppm: 1.37 (d, J=6.0 Hz, 6H), 3.17 (brs, 8H), 4.63 (m,1H), 4.70 (s, 2H), 6.87 (dd, J=2.4, 7.8 Hz, 1H), 6.96 (d, J=9.0 Hz, 2H),7.09 (m, 1H), 7.28-7.34 (m, 5H), 7.68 (d, J=9.0 Hz, 2H), 8.08 (dd,J=1.5, 4.8 Hz, 1H).

Step 5

To the residue obtained in the step 4 were added THF (2 mL) and MeOH (2mL), and further 10% palladium carbon (150 mg), and the mixture wasstirred under hydrogen atmosphere at room temperature for 1.5 hours. Thereaction solution was filtered through Celite and the filtrate wasconcentrated. The residue was crystallized from hexane-ethyl acetate togive the compound (17) (365 mg, 57% yield/two steps).

¹H-NMR (CDCl₃) δ ppm: 1.37 (d, J=6.0 Hz, 6H), 3.25 (m, 8H), 4.63 (m,1H), 6.26 (m, 1H), 6.94-7.04 (m, 4H), 7.67 (d, J=8.7 Hz, 2H).

Step 6

Ethyl iodoacetate (0.95 mL, 0.8 mmol) and silver carbonate (166 mg, 0.6mmol) were added to a solution of the compound (17) (151 mg, 0.4 mmol)in toluene (20 mL) and the mixture was heated under reflux for 3 hoursunder nitrogen atmosphere. After being cooled, the reaction solution wasfiltered through a glass filter. The filtrate was concentrated and theresulting residue was purified by a silica gel column chromatography(hexane:ethyl acetate=5:1) to give the compound III-2 (83 mg, 45%yield).

¹H-NMR (CDCl₃) δ ppm: 1.25 (t, J=7.2 Hz, 3H), 1.38 (d, J=6.0 Hz, 6H),3.23 (brs, 8H), 4.20 (m, 2H), 4.63 (m, 1H), 4.93 (s, 2H), 6.85-6.98 (m,3H), 7.18 (m, 1H), 7.68-7.76 (m, 3H).

Step 7

The compound III-2 (80 mg, 0.17 mmol) was dissolved in MeOH (1.0 mL) andTHF (1.0 mL). A 2M aqueous solution of sodium hydroxide (0.34 mL, 0.69mmol) was added thereto and the mixture was stirred at room temperaturefor 2 hours. The reaction solution was diluted with water and acidifiedby adding diluted hydrochloric acid. The mixture was extracted withethyl acetate and the extract was washed with water, dried andconcentrated. The residue was crystallized from hexane-ethyl acetate togive the compound II-6 (53 mg, 70% yield).

¹H-NMR (DMSO-d₆) δ ppm: 1.31 (d, J=6.0 Hz, 6H), 2.99 (brs, 4H), 3.13(brs, 4H), 4.72-4.79 (m, 3H), 6.92 (dd, J=5.1, 7.5 Hz, 1H), 7.15 (d,J=8.7 Hz, 2H), 7.23 (d, J=7.8 Hz, 1H), 7.67-7.70 (m, 3H), 12.75 (brs,1H).

Example 4 Preparation of the Compound I-3, I-4, III-3 and III-4

Step 1

Sodium hydride (5.6 mL, 40.0 mmol) was added to a solution of2-bromophenol (18) (5.19 g, 30.0 mmol) in DMF (50 mL) at 0° C. and themixture was stirred for 0.5 hours. Thereto was added chloromethyl methylether (3.4 mL, 45.0 mmol) dropwise at 0° C. and the mixture was stirredat room temperature for an hour. Water (300 mL) was added to thereaction solution and extracted with diethyl ether (300 mL). The extractwas washed with water and saturated brine successively, dried andconcentrated to give the compound (19) (6.6 g, 99% yield)

¹H-NMR (CDCl₃) δ ppm: 3.52 (s, 3H), 5.25 (s, 2H), 6.89 (m, 1H),7.13-7.28 (m, 2H), 7.55 (m, 1H).

Step 2

A solution of the compound (19) (2.17 g, 10.0 mmol) in THF (125 mL) wascooled to −78° C., thereto was added a hexane solution of n-butyllithium (7.5 mL, 12.0 mmol) dropwise during 10 minutes and the mixturewas stirred at the same temperature for 30 minutes. The solution waswarmed up to −50° C., a solution of 1-(tert-butoxycarbonyl)piperidone(3.79 g, 19.0 mmol) in THF (100 mL) was added dropwise at −50° C. andthen the mixture was stirred at −20° C. for 30 minutes. A saturatedaqueous solution of NH₄Cl (300 mL) was poured to the reaction solutionand the mixture was extracted with diethyl ether (300 mL). The extractwas washed with water and saturated brine successively, dried andconcentrated. The resulting residue was purified by a silica gel columnchromatography (hexane:ethyl acetate=2:1) to give the compound (20) (650mg, 19% yield).

¹H-NMR (CDCl₃) δ ppm: 1.48 (s, 9H), 2.00 (m, 4H), 3.28 (m, 2H), 3.51 (s,3H), 4.01 (m, 2H), 5.30 (s, 2H), 7.01 (m, 1H), 7.14-7.30 (m, 3H).

Step 3

Trifluoroacetic acid (3.0 mL) was added to a solution of the compound(20) (650 mg, 10.0 mmol) in dichloromethane (10 mL) cooled to 0° C., andthe mixture was stirred at room temperature for 18 hours. The reactionsolution was cooled to 0° C., adjusted to pH=7 by adding a saturatedaqueous solution of sodium bicarbonate and extracted with ethyl acetate(100 mL). The extract was washed with water and saturated brinesuccessively, dried and concentrated. The resulting residue [thecompound (21)] was directly used in the next step.

Step 4

THF (7 mL) was added to the residue obtained in step 3, and4-isopropoxybenzenesulfonyl chloride (435 mg, 1.85 mmol) andtriethylamine (1.03 mL, 7.4 mmol) were added and stirred at roomtemperature for 2 hours. Diluted hydrochloric acid (200 mL) was added tothe reaction solution and extracted with ethyl acetate (200 mL). Theorganic layer was washed with a saturated aqueous solution of sodiumbicarbonate and saturated brine successively, dried and concentrated.The resulting residue was purified by a silica gel column chromatography(hexane:ethyl acetate=5:1) to give the compound (22) (150 mg, 21%yield/two steps).

¹H-NMR (CDCl₃) δ ppm: 1.37 (d, J=6.3 Hz, 6H), 2.33 (m, 2H), 3.35 (t,J=5.7 Hz, 2H), 3.77 (m, 2H), 4.64 (m, 1H), 5.79 (m, 1H), 6.83-7.00 (m,5H), 7.14 (m, 1H), 7.73 (d, J=9.0 Hz, 2H).

Step 5

Methyl bromoacetate (29 μL, 0.31 mmol), potassium carbonate (70 mg, 0.51mmol) and potassium iodide (4.2 mg, 0.025 mmol) were added to a solutionof the compound (22) (95 mg, 0.25 mmol) in DMF (1 mL) and the mixturewas stirred at room temperature for 2 hours. Water (200 mL) was added tothe reaction solution and extracted with ethyl acetate (20 mL). Theorganic layer was washed with saturate brine, dried and concentrated.The residue was crystallized from hexane-ethyl acetate to give thecompound III-3 (90.7 mg, 80% yield).

Step 6

The compound I-3 (25 mg, 0.06 mmol) was dissolved in MeOH (1.0 mL)-THF(1.0 mL). An 2M aqueous solution of sodium hydroxide (84 μL) was addedand the solution was stirred at room temperature for 2 hours. Thereaction solution was diluted with water, acidified by adding dilutedhydrochloric acid and extracted with ethyl acetate. The extract waswashed with water, dried and concentrated. The residue was crystallizedfrom hexane-ethyl acetate to give the compound I-XX (15 mg, 62% yield).

¹H-NMR (DMSO-d6) δ ppm: 1.30 (d, J=4.5 Hz, 6H), 2.50 (brs, 2H), 3.14(brs, 2H), 3.61 (brs, 2H), 4.63 (s, 2H), 4.74 (brs, 1H), 5.72 (s, 1H),6.82-6.92 (m, 2H), 7.02-7.19 (m, 4H), 7.71 (d, J=7.5 Hz, 2H), 13.01(brs, 1H).

Step 7

THF (1 mL) and MeOH (1 mL) were added to the compound III-3 (61.6 mg,0.138 mmol) and then 10% palladium carbon (18 mg) was added, and themixture was stirred under hydrogen atmosphere at room temperature for1.5 hours. The reaction mixture was filtered through Celite and thefiltrate was concentrated The residue was crystallized from hexane-ethylacetate to give the compound III-4 (62 mg, 99% yield).

Step 8

The compound III-4 (62 mg, 0.138 mmol) was dissolved in MeOH (1.0 mL)and THF (1.0 mL). A 2M aqueous solution of sodium hydroxide (207 μL) wasadded and the solution was stirred at room temperature for 2 hours. Thereaction solution was diluted with water, acidified by adding dilutedhydrochloric acid and extracted with ethyl acetate. The extract waswashed with water, dried and concentrated. The residue was crystallizedfrom hexane-ethyl acetate to give the compound I-4 (20 mg, 33% yield).

¹H-NMR (DMSO-d6) δ ppm: 1.32 (d, J=6.0 Hz, 6H), 1.60-1.71 (m, 2H), 1.82(d, J=11.7 Hz, 2H), 2.26 (t, J=10.5 Hz, 2H), 2.84 (t, J=11.7 Hz, 1H),3.75 (d, J=11.4 Hz, 2H), 4.64 (s, 2H), 4.72-4.80 (m, 1H), 6.80 (d, J=8.4Hz, 1H), 6.90 (t, J=7.2 Hz, 1H), 7.11-7.15 (m, 4H), 7.67 (d, J=8.7 Hz,2H), 13.00 (brs, 1H).

Example 5 Preparation of the Compound II-13, III-13 and (26)

Step 1

1-(t-Butylcarbonyl)piperadine (46.6 g, 250 mmol) was added to thecompound (23) (15.7 g, 100 mmol) and stirred at 80° C. for an hour. Thereaction solution was poured into water and extracted with ethylacetate. The organic layer was washed with 2N hydrochloric acid andwater, and dried over anhydrous magnesium sulfate. The solvent wasevaporated to give the product (24) (28.4 g, 88% yield) as a yellowpowder.

Step 2

Potassium carbonate (5.53 g, 40.0 mmol), potassium iodide (0.33 g, 2.0mmol) and methyl bromoacetate (2.8 mL, 30.0 mmol) were added to asolution of the compound (24) (6.47 g, 20.0 mmol) obtained in step 1 inDMF (60.0 mL) and stirred at room temperature for an hour. The reactionsolution was poured into water and the precipitated crystalline wascollected by filtration and washed with water. The obtained crudecrystalline was washed with hexane to give the product (25) (9.9 g) as ayellow powder.

Step 3

4N Hydrochloric acid/dioxane (40.0 mL) was added to a solution of thecompound (25) (9.9 g) obtained in step 2 in ethyl acetate (50.0 mL) andstirred at 50° C. for 0.5 hour. The reaction solution was filtered andthe crude crystalline was washed with hexane and ethyl acetate to givethe product (26) (6.38 g, 96% yield) as a yellow powder.

Step 4

A solution of the compound (26) (3.32 g, 10.0 mmol) obtained in step 3in THF (10.0 mL) was cooled to 0° C., and triethylamine (4.2 mL, 30.0mmol) and 4-isopropoxybenzenesulfonyl chloride (2.58 g, 11.0 mmol) wereadded thereto. After stirring at room temperature for 15 hours, thereaction solution was poured into water and extracted with ethylacetate. The organic layer was washed with 2N hydrochloric acid, waterand saturated brine successively, and dried over anhydrous magnesiumsulfate. The solvent was evaporated in vacuo to give the product III-13(4.17 g, 85% yield) as a yellow powder.

Step 5

A 2M aqueous solution of sodium hydroxide (0.60 mL, 1.2 mmol) was addedto a solution of the compound III-13 (197 mg, 0.40 mmol) obtained instep 4 in MeOH (2.0 mL)-THF (2.0 mL) and stirred at room temperature for2 hours. The reaction solution was poured into water and washed withether. The aqueous layer was acidified by adding 2N hydrochloric acid,an extracted with ethyl acetate. The organic layer was washed withwater, dried over anhydrous magnesium sulfate and concentrated in vacuo.The crude crystalline was re-crystallized from hexane-ethyl acetate togive the product II-13 (166 mg, 87% yield) as a yellow powder.

¹H-NMR (CDCl₃) δ ppm: 1.37 (d, 6H, J=6.3 Hz), 3.15 (brt, 4H, J=4.8 Hz),3.50 (brt, 4H, J=4.2 Hz), 4.60-4.70 (m, 1H), 4.75 (s, 2H), 6.24, (s,1H), 6.49 (dd, 1H, J=2.1, 9.3 Hz), 6.98 (d, 2H, J=9.0 Hz), 7.69 (d, 2H,J=8.7 Hz), 8.06 (d, 2H, J=9.6 Hz).

Example 6 Preparation of the Compound II-24 and III-24

Step 1

Triethylamine (5.6 mL, 40.0 mmol) and p-isopropoxybenzenesulfonylpiperazine (8.53 g, 30.0 mmol) were added to a solution of the compound(23)(3.14 g, 20.0 mmol) in DMF (150 mL) and stirred at 80° C. for 4hours. 2N Hydrochloric acid was added to the reaction solution at roomtemperature. The precipitated crystalline was collected by filtrationand washed with water. The crude crystalline was washed with hexane togive the product (27) (9.06 g) as a yellow powder.

Step 2

10% Palladium-carbon (1.35 g) was added to a solution of the compound(27) (9.0 g) obtained in step 1 in MeOH (90.0 mL)-THF (90.0 mL) andhydrogenated at room temperature for 2 hours. The catalyst was filteredthrough Celite and the filtrate was concentrated in vacuo. The resultingcrude crystalline was washed with ether to give the product (28) (5.00g, 77% yield) as a purple powder.

Step 3

A solution of the compound (28) (1.17 g, 3.0 mmol) obtained in step 2 inpyridine (5.0 mL) was cooled to 0° C. and 2-furilic acid chloride (0.28mL, 2.85 mmol) was added thereto. After stirring at room temperature for18 hours, the reaction solution was poured into water and extracted withethyl acetate. The organic layer was washed with a 0.5M citric acidsolution and water, and dried over anhydrous magnesium sulfate. Thesolvent was evaporated in vacuo to give the product (29) (660 mg, 45%yield) as a purple powder.

Step 4

Potassium carbonate (370 mg, 2.68 mmol) and methyl bromoacetate (0.19mL, 2.01 mmol) were added to a solution of the compound (29) (650 mg,1.34 mmol) obtained in step 3 in DMF (5.0 mL) and stirred at roomtemperature for 2 hours. The reaction solution was poured into water andextracted with ethyl acetate. The organic layer was washed with a 0.5Mcitric acid solution and water, dried over anhydrous magnesium sulfateand concentrated in vacuo. The residue was purified by a silica gelcolumn chromatography (chloroform:methanol=500:1) and the crudecrystalline obtained was re-crystallized to give the compound III-24(360 mg, 48% yield) as a pale purple powder.

Step 5

A 2M solution of sodium hydroxide (2.39 mL, 4.77 mmol) was added to asolution of the compound III-24 (350 mg, 1.59 mmol) obtained in step 4in MeOH (3.5 mL)-THF (3.5 mL) and stirred at room temperature for 2hours. The reaction solution was poured into water and washed withether. 2N Hydrochloric acid was added to the aqueous layer and theprecipitated crystalline was collected by filtration. The obtained crudecrystalline was re-crystallized from MeOH and further re-crystallizedfrom ethyl acetate to give the product II-24 (120 mg, 14% yield) as apale green powder.

¹H-NMR (DMSO-d₆) δ ppm: 1.30 (d, J=6.0 Hz, 6H), 2.97 (brs, 4H), 3.20(brs, 4H), 4.71-4.79 (m, 3H), 6.55 (dd, J=2.4, 8.7 Hz, 1H), 6.68-6.70(m, 2H), 7.15 (d, J=8.7 Hz, 2H), 7.23 (dd, J=0.6, 2.2 Hz, 1H), 7.68 (d,J=9.0 Hz, 2H), 7.81 (d, J=8.7 Hz, 1H), 7.89-7.90 (m, 1H), 9.30 (s, 1H).

Example 7 Preparation of the Compound II-33 and III-33

Step 1

Iron (5.59 g, 100 mmol), ammonium chloride (5.35 g, 100 mmol) and water(75.0 mL) were added to a solution of the compound (30) (11.6 g, 50.0mmol) in MeOH (150 mL) and stirred at 100° C. for 6 hours. The reactionsolution was filtered through Celite to remove iron and the filtrate waspoured into water. The reaction solution was acidified by adding 2Nhydrochloric acid and washed with ether. The reaction solution was madealkaline by adding a 2M solution of sodium hydroxide and extracted withethyl acetate. The organic layer was dried over anhydrous magnesiumsulfate and the solvent was evaporated in vacuo to give the product (31)(4.20 g, 42% yield) as a brown powder.

Step 2

Concentrated hydrochloric acid (32.0 mL) was added to the compound (31)(4.12 g, 20.4 mmol) obtained in step 1 and stirred at room temperaturefor 18 hours. The reaction solution was cooled to 0° C. and an aqueoussolution (10.0 mL) of sodium nitrate (3.37 g, 48.8 mmol) was addeddropwise during 20 minutes. Then, an aqueous solution (10.0 mL) ofpotassium iodide (9.96 g, 61.0 mmol) was added dropwise during 20minutes. After stirring at 0° C. for an hour, the reaction solution wasextracted with ether. The organic layer was washed with a saturatedaqueous solution of sodium thiosulfate and water and dried overanhydrous magnesium sulfate. The solvent was evaporated in vacuo to givethe product (32) (5.00 g, 65% yield).

Step 3

A solution of the compound (32) (5.00 g, 16.0 mmol) obtained in step 2in dichloromethylane (10.0 mL) was cooled to 0° C. and a 1M solution ofboron tribromide in dichloromethylane (32.0 mL) was added dropwiseduring 30 minutes. After stirring at 0° C. for an hour, it was stirredat room temperature for 3 hours. The reaction solution was poured intoice-water, concentrated hydrochloric acid was added and the mixture wasstirred at room temperature for an hour. The mixture was extracted withether and the organic layer was extracted with a 2M aqueous solution ofsodium hydroxide. The aqueous layer was acidified by adding 2Nhydrochloric acid and extracted with ethyl acetate. The organic layerwas washed with water and dried over anhydrous magnesium sulfate. Thesolvent was evaporated in vacuo to give the product (33) (4.30 g, 90%yield)

Step 4

Potassium carbonate (3.98, 28.8 mmol) and chloromethyl methyl ether (2.2mL, 28.8 mmol) were added to a solution of the compound (33) (4.30 g,14.4 mmol) obtained in step 3 in DMF (40.0 mL) and stirred at roomtemperature for 18 hours. The reaction solution was poured into waterand extracted with ether. The organic layer was washed with water, driedover anhydrous magnesium sulfate and concentrated in vacuo. The residuewas purified by a silica gel column chromatography (hexane) to give theproduct (34) (5.42 g, 99% yield).

Step 5

p-Isopropyloxybenzenesulfonyl piperazine (683 mg, 2.4 mmol),tris(dibenzylideneacetone)dipalladium(91.8 mg, 0.1 mmol),rac-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl(249 mg, 0.4 mmol) andsodium t-butoxide (384 mg, 4.0 mmol) were added to a solution of thecompound (34) (686 mg, 2.0 mmol) obtained in step 4 in toluene (3.4 mL)and stirred at 50° C. for 4 hours. The reaction solution was poured intowater and extracted with ethyl acetate. The organic layer was washedwith water, dried over anhydrous magnesium sulfate and concentrated invacuo. The residue was purified by a silica gel column chromatography(ethyl acetate:hexane=2:1) and the crude crystalline was re-crystallizedto give the product (35) (412 mg, 41% yield).

Step 6

2N Hydrochloric acid was added to a solution of the compound (35) (300mg, 0.60 mmol) obtained in step 5 in MeOH (2.0 mL)-THF (2.0 mL) andstirred at room temperature for 18 hours. The reaction solution waspoured into water and extracted with ethyl acetate. The organic layerwas washed with water, and concentrated in vacuo. The resulting residuewas dissolved in ether and extracted with a 2M aqueous solution ofsodium hydroxide. The aqueous layer was acidified by adding 2Nhydrochloric acid and extracted with ethyl acetate. The organic layerwas dried over anhydrous magnesium sulfate, and the solvent wasevaporated in vacuo to give the product (36) (179 mg, 66% yield) as acolorless powder.

Step 7

Potassium carbonate (103 mg, 0.75 mmol) and methyl bromoacetate (0.042mL, 0.45 mmol) were added to a solution of the compound (36) (170 mg,0.37 mmol) obtained in step 6 in DMF (2.0 mL) and stirred at roomtemperature for 18 hours. The reaction solution was poured into waterand extracted with ethyl acetate. The organic layer was washed with 2Nhydrochloric acid and water, and dried over anhydrous magnesium sulfate.The solvent was evaporated in vacuo to give the product III-33 (150 mg,76% yield) as a colorless powder.

Step 8

A 2M aqueous solution of sodium hydroxide (0.43 mL, 0.85 mmol) was addedto a solution of the compound III-33 (150 mg, 0.28 mmol) obtained instep 7 in MeOH (2.0 mL)-THF (2.0 mL) and stirred at room temperature for3 hours. The reaction solution was poured into water and extracted withether. The aqueous layer was acidified by adding 2N hydrochloric acidand extracted with ethyl acetate. The organic layer was washed withwater, dried over anhydrous magnesium sulfate and concentrated in vacuo.The obtained crude crystalline was re-crystallized from ethylacetate/hexane to give the product II-33 (142 mg, 97% yield) as acolorless powder.

¹H-NMR (DMSO-d₆) δ ppm: 1.30 (d, J=6.0 Hz, 6H), 2.95 (brs, 4H), 3.02(brs, 4H), 4.71-4.79 (m, 3H), 6.42 (dd, J=2.4, 9.0 Hz, 1H), 6.54 (d,J=2.4 Hz, 1H), 7.13 (d, J=9.0 Hz, 2H), 7.32 (d, J=8.7 Hz, 1H), 7.66 (d,J=8.7 Hz, 2H).

Example 8 Preparation of the Compound II-54 and III-54

Step 1

A solution of the compound (35) (350 mg, 0.70 mmol), 3-furyl boric acid(94.1 mg, 0.84 mmol), palladium acetate (7.9 mg, 0.035 mmol),triphenylphosphine (36.8 mg, 0.14 mmol) and a 2M aqueous solution ofpotassium carbonate (2.1 mL) in DMF (6.3 mL) were stirred at 80° C. for4 hours. The reaction solution was poured into water and extracted withethyl acetate. The aqueous layer was washed with a 0.5M aqueous solutionof citric acid and water, dried over anhydrous magnesium sulfate andconcentrated in vacuo. The residue was purified by a silica gel columnchromatography (ethyl acetate:hexane=3:1) to give the product (37) (266mg, 78% yield) as a yellow powder.

Step 2

6N Hydrochloric acid (0.35 mL) was added to a solution of the compound(37) (200 mg, 0.41 mmol) obtained in step 1 in MeOH (3.0 mL)-THF (3.0mL) and stirred at room temperature for 6 hours. The reaction solutionwas poured into water and extracted with ethyl acetate. The organiclayer was washed with water and dried over anhydrous magnesium sulfate.The solvent was evaporated in vacuo to give the product (38) (151 mg,67% yield) as a gray powder.

Step 3

Potassium carbonate (87.3 g, 0.63 mmol) and methyl bromoacetate (0.036mL, 0.38 mmol) were added to a solution of the compound (38) (140 mg,0.32 mmol) obtained in step 2 in DMF (2.0 mL) and stirred at roomtemperature for 18 hours. The reaction solution was poured into waterand extracted with ethyl acetate. The organic layer was washed with 2Nhydrochloric acid and water, and dried over anhydrous magnesium sulfate.The solvent was evaporated in vacuo to give the product III-54 (110 mg,68% yield) as a colorless powder.

Step 4

A 2M solution of sodium hydroxide (0.29 mL, 0.58 mmol) was added to asolution of the compound III-54 (100 mg, 0.19 mmol) obtained in step 3in MeOH (2.0 mL)-THF (2.0 mL) and stirred at room temperature for 2hours. The reaction solution was poured into water and extracted withether. The aqueous layer was acidified by adding 2N hydrochloric acidand extracted with ethyl acetate. The organic layer was washed withwater, dried over anhydrous magnesium sulfate and concentrated in vacuo.The obtained crude crystalline was re-crystallized from ethylacetate/hexane to give the compound II-54 (85 mg, 88% yield) as acolorless powder.

¹H-NMR (DMSO-d₆) δ ppm: 1.29 (d, J=6.0 Hz, 6H), 2.97 (brs, 4H), 3.26(brs, 4H), 4.79-4.70 (m, 3H), 6.52 (d, J=9.0 Hz, 1H), 6.55 (s, 1H), 6.97(s, 1H), 7.14 (d, J=9.0 Hz, 2H), 7.44 (d, J=9.0 Hz, 1H), 7.66 (s, 1H),7.67 (d, J=9.0 Hz, 2H), 8.36 (s, 1H).

Example 9 Preparation of the Compound II-63 and III-63

Step 1

A solution of the compound (39) (5.0 g, 32.6 mmol) in 15% sulfuric acid(45 mL) was stirred at 5° C. A solution of sodium nitrate (2.25 g, 32.6mmol) in water (10 mL) and a solution of potassium iodide (8.13 g) in 1Nsulfuric acid (20 mL) were added to the reaction solution. Afterstirring at 5° C. for 10 minutes, the reaction solution was furtherstirred at 90° C. for 30 minutes. After being cooled to roomtemperature, the precipitated solid was collected by filtration anddried. The obtained solid was dissolved in THF (20 mL)-MeOH (20 mL) andthereto was added a 2M solution of TMSCH₂N₂ in hexane (40 mL) andstirred for 2 hours. The reaction solution was concentrated in vacuo,the resulting residue was purified by a silica gel column chromatography(ethyl acetate/hexane=1/10), and the obtained crude product wasre-crystallized from hexane to give the product (40) (3.95 g, 44% yield)as a white powder.

Step 2

A solution of the compound (40) (1.8 g, 6.48 mmol) obtained in step 1,the compound (13) (2.03 g, 7.12 mmol) obtained in step 2 of Example 3,palladium acetate (58 mg, 0.26 mmol),rac-2,2′-bis(diphenylphosohino)-1,1′-binaphthyl(242 mg, 0.39 mmol) andcesium carbonate (2.95 g, 9.07 mmol) in toluene (20 mL) was stirred at100° C. under nitrogen atmosphere for 12 hours. After being cooled toroom temperature, the reaction solution was extracted with chloroform.The organic layer was washed with water and 2N hydrochloric acid, andconcentrated in vacuo. The residue was crystallized fromethanol-chloroform to give the product (41) (1.35 g, 48% yield).

Step 3

A solution of the compound (41) (380 mg, 0.875 mmol) obtained in step 2,potassium t-butoxide (980 mg, 8.75 mmol) and water (63 μL, 3.5 mmol) inTHF (5 mL) was stirred at room temperature for 1.5 hours. The reactionsolution was extracted with ethyl acetate and the organic layer waswashed with water, 2N hydrochloric acid and saturated brine. The solventwas evaporated in vacuo and the residue was crystallized from ethylacetate-hexane to give the product (42) (353 mg, 96% yield).

Step 4

A solution of the compound (42) (250 mg, 0.59 mmol) obtained in step 3,WSCD HCl (137 mg, 0.71 mmol), HOBt (97 mg, mmol), isopropylamine (61 μL,0.71 mmol) in DMF (2 mL) was stirred at room temperature for 2 hours.The reaction solution was extracted with ethyl acetate and the organiclayer was washed with water and 2N hydrochloric acid. The solvent wasevaporated in vacuo and the residue was purified by a silica gel columnchromatography (ethyl acetate/hexane=1/4) to give the product (43) (177mg, 64% yield).

Step 5

A solution of the compound (43) (170 mg, 0.37 mmol) obtained in step 4,cesium carbonate (180 mg, 0.55 mmol) and methyl bromoacetate (0.052 mL,0.55 mmol) in DMF (2 mL) was stirred at room temperature for 3 hours.The reaction solution was extracted with ethyl acetate and the organiclayer was washed with water, 2N hydrochloric acid and saturated brine.The solvent was evaporated in vacuo and the residue was purified by asilica gel column chromatography (ethyl acetate/hexane=1/1) to give theproduct III-63 (195 mg, quant.)

Step 6

A solution of the compound III-63 (190 mg, 0.36 mmol) obtained in step 5and a 4N aqueous solution of sodium hydroxide (220 μL, 0.89 mmol) in THF(1 mL)-MeOH (1 mL) was stirred overnight. 2N Hydrochloric acid was addedto the reaction solution and extracted with ethyl acetate. The organiclayer was washed with water and saturated brine. The solvent wasevaporated in vacuo to give the product III-63 (165 mg, 89% yield).

¹H-NMR (CDCl₃) δ ppm: 1.24 (d, 6H, J=6.3 Hz), 1.37 (d, 6H, J=6.0 Hz),3.14 (t, 4H), 3.35 (t, 4H), 4.65 (m, 1H), 4.71 (s, 2H), 6.29 (d, 1H,J=2.4 Hz), 6.53 (dd, 1H, J=8.7 Hz, 2.1 Hz), 6.97 (d, 2H, J=3.0 Hz)),7.66-7.72 (m, 3H), 7.84 (d, 1H, J=8.7 Hz).

Example 10 Preparation of the Compound II-74 and III-74

Step 1

A solution of the compound (44) (15.0 g, 86.92 mmol), WSCD HCl (20.0 g,104.32 mmol), HOBt (11.70 g, 86.57 mmol), 2,2′-dimethyloxyethylamine(13.70 g, 130.30 mmol) in THF (75 mL) was stirred for 2 hours. Water wasadded to the reaction solution and the reaction solution was extractedwith ethyl acetate. The organic layer was washed with saturated brineand the solvent was evaporated in vacuo. A solution of the resultingsolid, potassium carbonate (18.0 g, 130.23 mmol) and benzyl bromide(19.20 g, 112.25 mmol) in DMF (50 mL)-ethyl acetate (50 mL) was stirredat 60° C. for 2 hours. Water was added to the reaction solution and thereaction solution was extracted with ethyl acetate. The organic layerwas washed with saturated brine and the solvent was evaporated in vacuo.The obtained crystalline was washed with 10% ethyl acetate-hexane togive the product (45) (23.40 g, 76% yield).

Step 2

2N Hydrochloric acid (15 mL) was added to a solution of the compound(45) (5.0 g, 14.29 mmol) obtained in step 1 in TH (20 mL) and stirred at70° C. for 2 hours. After being cooled to room temperature, the reactionmixture was extracted with ethyl acetate, the organic layer was washedwith saturated brine and the solvent was evaporated in vacuo.Acetonitrile (15 mL) was added to the resulting residue and the solutionwas used in the next step.

A solution of triphenylphosphine (7.45 g, 28.40 mmol) andhexachloroethane (6.72 g, 28.40 mmol) in acetonitrile was stirred for 30minutes, the solution of the obtained residue in acetonitrile (15 mL)and pyridine (4.6 mL, 56.80 mmol) were added thereto and the mixture wasstirred at room temperature for 30 minutes. Further, it was stirred at60° C. for a hour. Water was added to the reaction solution and thereaction solution was extracted with ethyl acetate. The organic layerwas washed with water and 10% aqueous solution of citric acid, and thesolvent was evaporated in vacuo. The residue was purified by a silicagel column chromatography (ethyl acetate/hexane=1/4) to give the product(46) (3.35 g, 83% yield).

Step 3

A solution of the compound (46) (200 mg, 0.70 mmol) obtained in step 2,the compound (13) (239 mg, 0.84 mmol) obtained in step 2 of Example 3,lead tetraacetate (3.1 mg, 0.014 mmol), butyldiadamantylphosphine (10.0mg, 0.028 mmol) and sodium t-butoxide (94.2 mg, 0.98 mmol) in toluene (2mL) was stirred at 110° C. under nitrogen atmosphere for 15 hours. Afterbeing cooled to room temperature, the reaction solution was extractedwith chloroform, citric acid (147 mg, 0.70 mmol) was added to theorganic layer and the organic layer was washed with water and saturatedbrine. The solvent was evaporated in vacuo and crystallized from ethylacetate-hexane to give the product (47) (331 mg, 89% yield).

Step 4

A solution of the compound (47) (100 mg, 0.187 mmol) obtained in step 3and 10% palladium carbon (30 mg) in THF (15 mL)-MeOH (15 mL) was stirredunder hydrogen atmosphere for 2 hours. After filtration, the filtratewas concentrated in vacuo to give the product (48) (81.3 mg, 98% yield)as a white solid.

Step 5

A solution of the compound (48) (200 mg, 0.45 mmol) obtained in step 4,potassium carbonate (93 mg, 0.67 mmol), potassium iodide (15 mmol) andmethyl bromoacetate (0.064 mL, 0.68 mmol) in DMF (1.6 mL) was stirred at90° C. for an hour. After being cooled to 0° C., 2N hydrochloric acid(0.23 mL), MeOH (5.0 mL) and water (5.0 mL) were added. The obtainedcrystalline was collected by filtration to give the product III-74 (212mg, 91% yield) as a white crystalline.

Step 6

A solution of the compound III-74 (65 mg, 0.126 mmol) obtained in step 5and 4N aqueous solution of sodium hydroxide (80 μL, 0.315 mmol) in DMF(1 mL) was stirred overnight. After 2N hydrochloric acid (315 μL) wasadded to the reaction solution and stirred, water (20. mL) was added tothe reaction mixture and stirred at 0° C. for 30 minutes. Theprecipitated crystalline was collected by filtration to give the productII-74 (50.6 mg, 80% yield) as a white crystalline.

¹H-NMR (CDCl₃) δ ppm: 1.37 (d, 6H, J=6.0 Hz), 3.16 (t, 4H), 3.42 (t,4H), 4.63 (m, 1H), 4.77 (s, 2H), 6.40 (d, 1H, J=2.7 Hz), 6.62 (dd, 1H,J=9.0 Hz, 2.4 Hz), 6.98 (d, 2H, J=3.0 Hz), 7.27 (d, 1H), 7.67-7.72 (m,3H), 7.79 (d, 1H, J=3.0 Hz).

Example 11 Preparation of the Compound II-96 and III-96

Step 1

The compound (49) (19.0 g, 110 mmol) was cooled to 0° C., aceticanhydrous (12.5 mL, 132 mmol) was added. A drop of sulfuric acid wasadded thereto. After stirring at room temperature for an hour, asaturated aqueous solution of sodium bicarbonate was poured into thesolution. The reaction solution was extracted with ether, the extractwas washed with a saturated aqueous solution of sodium bicarbonate andwater, and dried over anhydrous magnesium sulfate. The solvent wasevaporated in vacuo to give the product (50) (24.3 g, 99% yield)(2).

Step 2

The compound (50) (21.5 g, 100 mmol) obtained in step 1 was cooled to 0°C., aluminium chloride(III) (24.0 g, 180 mmol) was added in two portionsand the mixture was stirred at 165° C. for 2 hours. The reactionsolution was cooled to room temperature, and water was added. Thereaction solution was extracted with chloroform, the organic layer waswashed with water, dried over anhydrous magnesium sulfate andconcentrated in vacuo. The residue was re-crystallized from hexane togive the product (51) (22.9 g, 97% yield) as a yellow powder.

Step 3

Potassium carbonate (18.7 g, 50.0 mmol), potassium iodide (0.83 g, 5.0mmol) and benzyl bromide (3.21 mL, 65.0 mmol) were added to a solutionof the compound (51) (10.8 g, 50.0 mmol) obtained in step 2 in DMF (50.0mL) and stirred at 60° C. for 18 hours. After being cooled to roomtemperature, water was added to the reaction solution. The precipitatedcrystalline was collected by filtration and washed with water. Theresulting crude crystalline was washed with hexane to give the product(52) (13.8 g, 90% yield).

Step 4

A solution of bromine (2.1 mL, 40.0 mmol) in dioxane (40.0 mL) was addedat 15° C. during 30 minutes to a solution of the compound (52) (12.5 g,41.0 mmol) obtained in step 3 in dioxane (20 mL). After being warmed upto 20° C. and stirred for 30 minutes, the reaction solution was stirredat 25° C. for 3 hours. The reaction solution was concentrated in vacuoand the resulting residue was re-crystallizesd from dioxane/hexane togive the product (53) (9.84 g, 64% yield) as a brown powder.

Step 5

Ammonium formate (10.3 g, 180 mmol) was added to a solution of thecompound (53) (9.84 g, 35.9 mmol) obtained in step 4 in formic acid(40.0 mL) and heated under reflux for 12 hours. The reaction solutionwas poured into a 2M aqueous solution of sodium hydroxide and made to bebasic, and extracted with chloroform. The organic layer was washed withwater, dried over anhydrous magnesium sulfate and concentrated in vacuo.The residue was purified by a silica gel column chromatography (ethylacetate/hexane=10/1) to give the product (54) (1.19 g, 10% yield) as ayellow powder.

Step 6

p-Isopropyloxybenzenesulfonylpiperazine (1.23 g, 4.33 mmol),tris(dibenzylideneacetone)dipalladium(152 mg, 0.17 mmol),rac-2,2′-bis(diphenylphosohino)-1,1′-binaphthyl(414 mg, 0.67 mmol) andsodium t-butoxide (640 mg, 6.66 mmol) were added to a solution of thecompound (54) (1.10 g, 3.33 mmol) obtained in step 5 in toluene (3.4 mL)and stirred at 100° C. for 12 hours. Water was added to the reactionsolution and extracted with ethyl acetate. The organic layer wasfiltered through Celite, washed with 2N hydrochloric acid and water,dried over anhydrous magnesium sulfate and concentrated in vacuo. Theresidue was purified by a silica gel column chromatography (ethylacetate/hexane=2/1) to give the product (55) (450 mg, 25% yield) as ayellow powder.

Step 7

10% Palladium carbon (20 mg) was added to a solution of the compound(55) (200 mg, 0.38 mmol) obtained in step 6 in THF (2.0 mL) andhydrogenated. After stirring at room temperature for 2 hours, themixture was filtered through Celite and the filtrate was concentrated invacuo. The residue was dissolved in MeOH (2.0 mL), 20% palladiumhydroxide carbon (20 mg) was added and the mixture was hydrogenated.After stirring at room temperature for 3 hours, 2N hydrochloric acid(0.20 mL) was added and further hydrogenated. After stirring at roomtemperature for 9 hours, the reaction solution was filtered throughCelite. The solvent of the filtrate was evaporated in vacuo to give theproduct (56) (135 mg, 81% yield) as a yellow powder.

Step 8

Potassium carbonate (81.0 g, 0.59 mmol) and methyl bromoacetate (0.097mL, 0.35 mmol) were added to a solution of the compound (56) (130 mg,0.29 mmol) obtained in step 7 in DMF (2.0 mL) and stirred at roomtemperature for 2 hours. The reaction solution was poured into water,the precipitated crystalline was collected by filtration and washed withwater. The obtained crude product was washed with hexane to give theproduct III-96 (75% yield) as a colorless powder.

Step 9

A 2M aqueous solution of sodium hydroxide (0.33 mL, 0.66 mmol) was addedto a solution of the compound (9), III-96 (114 mg, 0.22 mmol) obtainedin step 8 in MeOH (2.0 mL)-THF (2.0 mL) and stirred at room temperaturefor 2 hours. The reaction solution was poured into water and extractedwith ether. The organic layer was washed with water, dried overanhydrous magnesium sulfate and concentrated in vacuo. The resultingcrude crystalline was re-crystallized from ethyl acetate-hexane to givethe product III-96 (15 mg, 14%) as a colorless powder.

¹H-NMR (DMSO-d₆) δ ppm: 1.29 (d, J=6.0 Hz, 6H), 2.96 (brs, 4H), 3.26(brs, 4H), 4.30 (s, 2H), 4.69-4.77 (m, 1H), 6.50 (s, 1H), 6.53 (d, J=9.0Hz, 1H), 7.12 (d, J=8.7 Hz, 2H), 7.65 (d, J=9.0 Hz, 2H), 7.78 (d, J=8.7Hz, 1H), 8.31 (s, 1H), 9.13 (s, 1H).

The compounds I-2, I-5 to I-31, II-1 to II-5, II-7 to II-8, II-10 toII-12, II-14 to II-23, II-25 to II-32, II-34 to II-53, II-55 to II-62,II-64 to II-73, II-75 to II-95, II-99 to II-103, II-105 to II-106,II-108 to II-118, II-122 to II-123, II-127 to II-131, II-133 to II-135,and II-140 to II-143 were prepared in the same manner as set forthabove. The structures and physical properties thereof were shown inTables 1-41.

TABLE 1

Comd. No. R^(2A) R^(2B) R^(2C) R^(2D) R^(2E) I-1

H Me H H I-2

H Me H H I-5

H OMe H H I-6

H Cl H H I-7

H H H H I-8

OMe H H H I-9

H OMe H H I-10

H Cl H H I-11

H H H H I-12

OMe H H H I-17

H F H H I-18

H F H H

TABLE 2

Comd. No. R^(2A) R^(2B) R^(2C) R^(2D) R^(2E) I-19

H H OMe H I-20

H H OMe H I-21

H H H OMe I-22

H H H OMe I-25 H

H H H I-26 H

H H H I-27

H Cl H Cl I-28

H Cl H Cl

TABLE 3

Comd. No. R^(2A) R^(2B) R^(2C) R^(2D) R^(2E) I-29 H

Cl H H

TABLE 4

Comd. No. R^(2A) R^(2B) R^(2C) R^(2D) R^(2E) I-3

H H H H I-30 H

Cl H H

TABLE 5

Comd. No. R^(2A) R^(2B) R^(2C) R^(2D) R^(2E) I-4

H H H H I-31 H

Cl H H

TABLE 6

Comd. No. R^(2A) R^(2C) R^(2D) R^(2E) I-13

H H H I-14

Me H H I-15

H H H I-16

Me H H

TABLE 7

Comd. No. R^(2A) R^(2B) R^(2C) R^(2D) R^(2E) I-23

H H H H I-24

H H H H

TABLE 8

Comd. No. R^(2A) R^(2B) R^(2C) R^(2D) R^(2E) II-1

H H H H II-3 H

H H H II-4 H H

H H II-7

H F H H II-8 H

Me H H II-9 H

OMe H H II-10 H

Cl H H II-13 H

NO₂ H H II-15 H

Cl H H II-16 H

F F H II-17 H

H Br H II-18 H

Cl H H II-19 H

H CF₃ H

TABLE 9

Comd. No. R^(2A) R^(2B) R^(2C) R^(2D) R^(2E) II-20 H

Cl H H II-21 H

Cl H H II-22 H

H H H II-23 H

H H II-24 H

H H II-25 H

H F H II-26 H

H Cl H II-28 H

H H II-32 H

H H II-33 H

Br H H II-37 H

H

H II-38 H

H

H

TABLE 10

Comd. No. R^(2A) R^(2B) R^(2C) R^(2D) R^(2E) II-39 H

H

H II-40 H

H

H II-41 H

H Me H II-45

H H Cl H II-46 H

H H II-47 H

H H II-48 H

H H II-49 H

H H II-50 H

Cl H H II-51 H

H

H

TABLE 11

Comd. No. R^(2A) R^(2B) R^(2C) R^(2D) R^(2E) II-52 H

Cl H H II-53 H

H H II-54 H

H H II-56 H

Cl H H II-57 H

H

H II-58 H

H H II-59 H

H H II-60 H

H H II-61 H

H H II-62 H

H H II-63 H

H H

TABLE 12

Comd. No. R^(2A) R^(2B) R^(2C) R^(2D) R^(2E) II-64 H

H

H II-65 H

H H II-66 H

H

H II-67 H

H H II-68 H

H H II-69 H

H H Cl II-70 H

H H II-71 H

H H II-72 H

H H II-73 H

II-74 H

II-75 H

TABLE 13

Comd. No. R^(2A) R^(2B) R^(2C) R^(2D) R^(2E) II-76 H

OH H H II-77 H

H H II-78 H

H H II-79 H

H H II-80 H

CN H H II-81 H

H H II-82 H

H H II-83 H

H H II-84 H

H H II-86 H

OH H H II-87 H

H H II-88 H

H H

TABLE 14

Comd. No. R^(2A) R^(2B) R^(2C) R^(2D) R^(2E) II-89 H

H H II-91 H

H H II-92 H

H H II-93 H

H H II-95 H

H H II-96 H

H H II-99 H

H H II-100 H

H H II-101 H

H H

TABLE 15

Comd. No. R^(2A) R^(2B) R^(2C) R^(2D) R^(2E) II-102

H

H H II-105 H

H H II-106 H

H H II-108 H

H H II-109 H

H H II-110 H

H H II-111 H

H H II-112 H

H H II-113 H

H H

TABLE 16

Comd. No. R^(2A) R^(2B) R^(2C) R^(2D) R^(2E) II-114 H

H H II-115 H

H H II-118 H

H H II-122 H

H H II-123 H

H H II-127 H

H H II-129 H

H H

TABLE 17

Comd. No. R^(2A) R^(2B) R^(2C) R^(2D) R^(2E) II-133 H

H H II-135 H

H H II-140 H

H H II-141 H

H H II-143 H

H H

TABLE 18

Comd. No. R^(2B) R^(2C) R^(2D) R^(2E) II-11

H H H II-12 H H

H II-90

Br H H

TABLE 19

Comd. No. R^(2A) R^(2C) R^(2D) R^(2E) II-6

H H H II-42 H H

H

TABLE 20

Comd. No. R^(2A) R^(2B) R^(2D) R^(2E) II-14 H

H H

TABLE 21

Comd. No. R^(2A) R^(2B) R^(2C) R^(2D) R^(2E) II-2

H H H H II-27 H

Cl H H II-55 H

F F H II-85 H

H H II-94 H

H H

TABLE 22 Comd. No. Structure II-5

II-29

II-30

II-31

II-34

II-35

II-36

TABLE 23 Comd. No. Structure II-43

II-44

II-103

II-116

II-117

TABLE 24 Comd. No. Structure II-128

II-130

II-131

II-134

TABLE 25 Comd. No. Structure II-138

II-139

II-142

TABLE 26 Comd. No. ¹H-NMR (Solvent)δ I-1 (CDCl3) 1.35 (d, 6H, J = 9.0Hz), 2.01 (m, 4H), 2.28 (s, 3H), 3.15 (m, 4H), 4.62 (m, 1H), 6.38 (d, J= 16.2 Hz, 1H), 6.74 (d, J = 8.4 Hz, 1H), 6.96 (d, J = 9.0 Hz, 2H), 7.11(dd, J = 1.8, 8.4 Hz, 1H), 7.31 (d, J = 1.8 Hz, 1H), 7.68 (d, J = 9.0Hz, 2H), 7.89 (d, J = 16.2 Hz, 1H) I-2 (CDCl3) 1.35 (d, 6H, J = 9.0 Hz),1.98 (m, 4H), 2.28 (s, 3H), 2.28 (m, 2H), 2.70 (m, 2H), 3.15 (m, 4H),4.62 (m, 1H), 6.74 (d, J = 9.0 Hz, 1H), 6.94 (m, 4H), 7.68 (d, J = 9.0Hz, 2H) I-3 (DMSO-d6) 1.30 (d, 6H, J = 4.5 Hz), 2.50 (brs, 2H), 3.14(brs, 2H), 3.61 (brs, 2H), 4.63 (s, 2H), 4.74 (brs, 1H), 5.72 (s, 1H),6.82-6.92 (m, 2H), 7.02-7.19 (m, 4H), 7.71 (d, 2H, J = 7.5 Hz), 13.01(brs, 1H) I-4 (DMSO-d6) 1.32 (d, 6H, J = 6.0 Hz), 1.60-1.71 (m, 2H),1.82 (d, 2H, J = 11.7 Hz), 2.26 (t, 2H, J = 10.5 Hz), 2.84 (t, 1H, J =11.7 Hz), 3.75 (d, 2H, J = 11.4 Hz), 4.64 (s, 2H), 4.72-4.80 (m, 1H),6.80 (d, 1H, J = 8.4 Hz), 6.90 (t, 1H, J = 7.2 Hz), 7.11-7.15 (m, 4H),7.67 (d, 2H, J = 8.7 Hz), 13.00 (brs, 1H) I-5 (CDCl3) 1.37 (d, 6H, J =6.3 Hz), 1.90-2.10 (m, 4H), 3.05-3.20 (m, 4H), 3.78 (s, 3H), 4.26-4.35(m, 1H), 4.63-4.70 (m, 1H), 6.37 (d, 1H, J = 15.9 Hz), 6.80 (d, 1H, J =9.0 Hz), 6.87 (dd, 1H, J = 9.0, 2.0 Hz), 6.95 (d, 2H, J = 9.0 Hz), 7.02(d, 1H, J = 2.0 Hz), 7.67 (d, 2H, J = 9.0 Hz), 7.86 (d, 1H, J = 15.9 Hz)I-6 (CDCl3) 1.35 (d, 6H, J = 6.0 Hz), 1.90-2.10 (m, 4H), 3.05-3.20 (m,4H), 4.36-4.45 (m, 1H), 4.63-4.70 (m, 1H), 6.37 (d, 1H, J = 15.9 Hz),6.78 (d, 1H, J = 9.0 Hz), 6.95 (d, 2H, J = 9.0 Hz), 7.20-7.30 (m, 1H),7.47 (d, 1H, J = 2.0 Hz), 7.67 (d, 2H, J = 9.0 Hz), 7.83 (d, 1H, J =15.9 Hz) I-7 (CDCl3) 1.35 (d, 6H, J = 6.0 Hz), 1.90-2.10 (m, 4H),3.05-3.20 (m, 4H), 4.40-4.48 (m, 1H), 4.63-4.70 (m, 1H), 6.37 (d, 1H, J= 15.9 Hz), 6.80 (d, 1H, J = 9.0 Hz), 6.92 (d, 1H, J = 9.0 Hz), 6.95 (d,2H, J = 9.0 Hz), 7.33 (t, 1H, J = 9.0 Hz), 7.53 (d, 1H, J = 9.0 Hz),7.70 (d, 2H, J = 9.0 Hz), 7.89 (d, 1H, J = 15.9 Hz) I-8 (CDCl3) 1.33 (d,6H, J = 6.3 Hz), 1.90-2.10 (m, 4H), 3.05-3.30 (m, 4H), 3.85 (s, 3H),4.50-4.57 (m, 1H), 4.60-4.70 (m, 1H), 6.47 (d, 1H, J = 9.0 Hz), 6.52 (d,1H, J = 9.0 Hz), 6.78 (d, 1H, J = 15.9 Hz), 6.95 (d, 2H, J = 9.0 Hz),7.20 (t, 1H, J = 9.0 Hz), 7.67 (d, 2H, J = 9.0 Hz), 8.02 (d, 1H, J =15.9 Hz) I-9 (CDCl3) 1.37 (d, 6H, J = 6.1 Hz), 1.85-2.05 (m, 4H), 2.49(t, 2H, J = 7.5 Hz), 2.72 (t, 2H, J = 7.5 Hz), 3.05-3.20 (m, 4H), 3.74(s, 3H), 4.26-4.35 (m, 1H), 4.63-4.70 (m, 1H), 6.65 (d, 1H, J = 2.0 Hz),6.67 (s, 1H), 6.95 (d, 1H, J = 2.0 Hz), 6.95 (d, 2H, J = 9.0 Hz), 7.86(d, 2H, J = 9.0 Hz).

TABLE 27 Comd. No. ¹H-NMR (Solvent)δ I-10 (CDCl3) 1.36 (d, 6H, J = 6.1Hz), 1.85-2.05 (m, 4H), 2.46 (t, 2H, J = 7.5 Hz), 2.70 (t, 2H, J = 7.5Hz), 3.05-3.20 (m, 4H), 4.35-4.42 (m, 1H), 4.60-4.70 (m, 1H), 6.65 (d,1H, J = 8.0 Hz), 6.95 (d, 2H, J = 9.0 Hz), 7.05 (d, 1H, J = 8.0 Hz),7.10 (s, 1H), 7.68 (d, 2H, J = 9.0 Hz). I-11 (CDCl3) 1.35 (d, 6H, J =6.1 Hz), 1.85-2.05 (m, 4H), 2.47 (t, 2H, J = 7.5 Hz), 2.75 (t, 2H, J =7.5 Hz), 3.00-3.20 (m, 4H), 4.40-4.50 (m, 1H), 4.63-4.70 (m, 1H), 6.75(d, 1H, J = 8.0 Hz), 6.84 (t, 1H, J = 8.0 Hz), 6.95 (d, 2H, J = 9.0 Hz),7.13 (d, 1H, J = 8.0 Hz), 7.15 (t, 1H, J = 8.0 Hz), 7.68 (d, 2H, J = 9.0Hz). I-12 (CDCl3) 1.37 (d, 6H, J = 6.1 Hz), 1.85-2.05 (m, 4H), 2.38 (t,2H, J = 7.5 Hz), 2.79 (t, 2H, J = 7.5 Hz), 3.00-3.20 (m, 4H), 3.78 (s,3H), 4.40-4.50 (m, 1H), 4.63-4.70 (m, 1H), 6.43 (d, 1H, J = 8.0 Hz),6.50 (d, 1H, J = 8.0 Hz), 6.95 (d, 2H, J = 9.0 Hz), 7.05 (t, 1H, J = 8.0Hz), 7.68 (d, 2H, J = 9.0 Hz). I-13 (CDCl3) 1.33 (d, 6H, J = 6.0 Hz),1.90-2.10 (m, 4H), 3.05-3.20 (m, 4H), 4.40-4.48 (m, 1H), 4.63-4.70 (m,1H), 6.92 (d, 1H, J = 15.9 Hz), 6.95 (d, 2H, J = 9.0 Hz), 7.15-7.23 (m,2H), 7.68 (d, 2H, J = 9.0 Hz), 7.95 (d, 1H, J = 15.9 Hz), 8.25 (d, 1H, J= 3.4 Hz). I-14 (CDCl3) 1.33 (d, 6H, J = 6.0 Hz), 1.90-2.10 (m, 4H),2.50 (s, 3H), 3.05-3.20 (m, 4H), 4.40-4.48 (m, 1H), 4.63-4.70 (m, 1H),6.92 (d, 1H, J = 15.9 Hz), 6.95 (d, 2H, J = 9.0 Hz), 7.15 (s, 2H), 7.68(d, 2H, J = 9.0 Hz), 7.95 (d, 1H, J = 15.9 Hz). I-15 (CDCl3) 1.37 (d,6H, J = 6.1 Hz), 1.95-2.15 (m, 4H), 2.67 (t, 2H, J = 7.5 Hz), 2.95 (t,2H, J = 7.5 Hz), 3.00-3.25 (m, 4H), 4.42-4.50 (m, 1H), 4.63-4.70 (m,1H), 6.95 (d, 2H, J = 9.0 Hz), 7.15-7.22 (m, 2H), 7.68 (d, 2H, J = 9.0Hz), 8.25 (d, 1H, J = 3.4 Hz). I-16 (CDCl3) 1.37 (d, 6H, J = 6.1 Hz),1.95-2.15 (m, 4H), 2.50 (s, 3H), 2.67 (t, 2H, J = 7.5 Hz), 2.95 (t, 2H,J = 7.5 Hz), 3.00-3.25 (m, 4H), 4.42-4.50 (m, 1H), 4.63-4.70 (m, 1H),6.95 (d, 2H, J = 9.0 Hz), 7.05 (d, 1H, J = 8.8 Hz), 7.13 (d, 1H, J = 8.8Hz), 7.68 (d, 2H, J = 9.0 Hz). I-17 (CDCl3) 1.37 (d, 6H, J = 6.1 Hz),1.85-2.05 (m, 4H), 2.47 (t, 2H, J = 7.5 Hz), 2.72 (t, 2H, J = 7.5 Hz),3.05-3.20 (m, 4H), 4.35-4.42 (m, 1H), 4.60-4.70 (m, 1H), 6.62-6.67 (m,1H), 6.78-6.97 (m, 2H), 7.68 (d, 2H, J = 9.0 Hz). I-18 (CDCl3) 1.35 (d,6H, J = 6.3 Hz), 1.90-2.10 (m, 4H), 3.05-3.20 (m, 4H), 3.80 (s, 3H),4.40-4.45 (m, 1H), 4.63-4.70 (m, 1H), 6.37 (d, 1H, J = 15.9 Hz), 6.37(d, 1H, J = 2.0 Hz), 6.55 (dd, 1H, J = 8.0, 2.0 Hz), 6.95 (d, 2H, J =9.0 Hz), 7.45 (d, 1H, J = 8.0 Hz), 7.67 (d, 2H, J = 9.0 Hz), 7.82 (d,1H, J = 15.9 Hz). I-19 (CDCl3) 1.35 (d, 6H, J = 6.3 Hz), 1.90-2.10 (m,4H), 3.05-3.20 (m, 4H), 3.80 (s, 3H), 4.40-4.45 (m, 1H), 4.63-4.70 (m,1H), 6.37 (d, 1H, J = 15.9 Hz), 6.37 (d, 1H, J = 2.0 Hz), 6.55 (dd, 1H,J = 8.0, 2.0 Hz), 6.95 (d, 2H, J = 9.0 Hz), 7.45 (d, 1H, J = 8.0 Hz),7.67 (d, 2H, J = 9.0 Hz), 7.82 (d, 1H, J = 15.9 Hz).

TABLE 28 Comd. No. ¹H-NMR (Solvent)δ I-20 (CDCl3) 1.37 (d, 6H, J = 6.1Hz), 1.85-2.05 (m, 4H), 2.42 (t, 2H, J = 7.5 Hz), 2.66 (t, 2H, J = 7.5Hz), 3.05-3.20 (m, 4H), 3.74 (s, 3H), 4.36-4.45 (m, 1H), 4.63-4.70 (m,1H), 6.32 (d, 1H, J = 2.0 Hz), 6.38 (dd, 1H, J = 8.0, 2.0 Hz), 6.95 (d,2H, J = 9.0 Hz), 7.02 (d, 1H, J = 8.0 Hz), 7.86 (d, 2H, J = 9.0 Hz).I-21 (CDCl3) 1.35 (d, 6H, J = 6.3 Hz), 1.90-2.10 (m, 4H), 2.85-2.95 (m,2H), 3.35-3.45 (m, 2H), 3.80 (s, 3H), 4.06-4.15 (m, 1H), 4.60-4.71 (m,1H), 6.37 (d, 1H, J = 16.2 Hz), 6.90 (t, 1H, J = 8.1 Hz), 6.95 (d, 2H, J= 9.0 Hz), 7.05 (t, 1H, J = 8.1 Hz), 7.17 (d, 1H, J = 8.1 Hz), 7.67 (d,2H, J = 9.0 Hz), 7.82 (d, 1H, J = 16.2 Hz). I-22 (CDCl3) 1.37 (d, 6H, J= 6.1 Hz), 1.85-2.05 (m, 4H), 2.52 (t, 2H, J = 7.5 Hz), 2.76 (t, 2H, J =7.5 Hz), 2.78-2.85 (m, 2H), 3.33-3.40 (m, 2H), 3.74 (s, 3H), 4.16-4.25(m, 1H), 4.63-4.70 (m, 1H), 6.75 (d, 2H, J = 8.0 Hz), 6.95 (d, 2H, J =9.0 Hz), 6.97 (t, 1H, J = 8.0 Hz), 7.67 (d, 2H, J = 9.0 Hz). I-23(CDCl3) 1.35 (d, 6H, J = 6.0 Hz), 2.06-2.14 (m, 2H), 3.35-3.50 (m, 2H),3.60-3.80 (m, 2H), 4.50-4.60 (m, 1H), 4.90-4.98 (m, 1H), 6.37 (d, 1H, J= 16.1 Hz), 6.72 (d, 1H, J = 9.0 Hz), 6.80 (d, 2H, J = 9.0 Hz), 6.99 (t,1H, J = 9.0 Hz), 7.35 (t, 1H, J = 9.0 Hz), 7.53 (d, 1H, J = 9.0 Hz),7.65 (d, 2H, J = 9.0 Hz), 7.67 (d, 1H, J = 16.1 Hz). I-24 (CDCl3) 1.35(d, 6H, J = 6.0 Hz), 2.06-2.14 (m, 2H), 2.43 (t, 2H, J = 7.5 Hz), 2.60(t, 2H, J = 7.5 Hz), 3.35-3.50 (m, 2H), 3.60-3.80 (m, 2H), 4.50-4.60 (m,1H), 4.90-4.98 (m, 1H), 6.62 (d, 1H, J = 8.0 Hz), 6.85 (d, 2H, J = 9.0Hz), 6.88 (t, 1H, J = 8.0 Hz), 7.15 (d, 1H, J = 8.0 Hz), 7.18 (d, 1H, J= 8.0 Hz), 7.71 (d, 2H, J = 9.0 Hz). I-25 (CDCl3) 1.39 (d, 6H, J = 6.0Hz), 1.90-2.10 (m, 4H), 3.05-3.20 (m, 4H), 4.35-4.45 (m, 1H), 4.62-4.68(m, 1H), 6.39 (d, 1H, J = 15.9 Hz), 6.84 (d, 1H, J = 8.0 Hz), 6.92 (d,1H, J = 8.0 Hz), 6.95 (d, 2H, J = 9.0 Hz), 7.13 (d, 1H, J = 8.0 Hz),7.33 (t, 1H, J = 8.0 Hz), 7.67 (d, 2H, J = 9.0 Hz), 7.70 (d, 1H, J =15.9 Hz). I-26 (CDCl3) 1.35 (d, 6H, J = 6.1 Hz), 1.85-2.05 (m, 4H), 2.60(t, 2H, J = 7.5 Hz), 2.85 (t, 2H, J = 7.5 Hz), 3.00-3.20 (m, 4H),4.30-4.40 (m, 1H), 4.60-4.65 (m, 1H), 6.67 (d, 1H, J = 8.2 Hz), 6.69 (s,1H), 6.95 (d, 2H, J = 9.0 Hz), 7.18 (t, 1H, J = 8.2 Hz), 7.68 (d, 2H, J= 9.0 Hz). I-27 (DMSO-d6) 1.35 (d, 6H, J = 6.0 Hz), 1.70-2.00 (m, 4H),2.60-2.75 (m, 2H), 3.40-3.55 (m, 2H), 4.05-4.15 (m, 1H), 4.68-4.75 (m,1H), 6.35 (d, 1H, J = 15.9 Hz), 7.50-7.70 (m, 4H), 7.33 (t, 1H, J = 8.0Hz), 7.89 (d, 1H, J = 15.9 Hz). I-28 (CDCl3) 1.35 (d, 6H, J = 6.0 Hz),1.90-2.10 (m, 4H), 2.60 (t, 2H, J = 7.5 Hz), 2.60-2.75 (m, 2H), 2.85 (t,2H, J = 7.5 Hz), 3.45-3.55 (m, 2H), 4.05-4.15 (m, 1H), 4.68-4.75 (m,1H), 6.95 (d, 2H, J = 9.0 Hz), 7.08 (d, 1H, J = 2.0 Hz), 7.20 (d, 1H, J= 2.0 Hz), 7.68 (d, 2H, J = 9.0 Hz).

TABLE 29 Comd. No. ¹H-NMR (Solvent) δ I-29 (DMSO-d6) 1.32 (d, J = 6.0Hz, 6H), 1.59 (brd, 2H), 1.94-2.08 (m, 2H), 2.54 (brt, 2H), 3.51 (brd,2H), 4.76 (m, 1H), 4.82 (s, 2H), 5.06 (s, 1H), 7.04 (dd, J = 1.8, 8.1Hz, 1H), 7.09 (d, J = 1.8 Hz, 1H), 7.15 (d-like, 2H), 7.35 (d, J = 8.1Hz, 1H), 7.67 (d-like, 2H), 13.08 (br, 1H) I-30 (DMSO-d6) 1.28 (d, J =6.0 Hz, 6H), 2.50 (brd, 2H), 3.18 (brt, 2H), 3.65 (brd, 2H), 4.73 (m,1H), 4.83 (s, 2H), 6.11 (brt, 1H), 6.94 (dd, J = 1.8, 8.1 Hz, 1H), 7.00(d, J = 1.8 Hz, 1H), 7.11 (d- like, 2H), 7.36 (d, J = 8.1 Hz, 1H), 7.71(d-like, 2H), 13.06 (br, 1H) I-31 (DMSO-d6) 1.31 (d, J = 6.0 Hz, 6H),1.60-1.80 (m, 4H), 2.20-2.29 (m, 2H), 2.47 (m, 1H), 3.72 (brd, 2H), 4.75(m, 1H), 4.79 (s, 2H), 6.78 (dd, J = 1.8, 8.4 Hz, 1H), 6.90 (d, J = 1.8Hz, 1H), 7.13 (d-like, 2H), 7.30 (d, J = 8.4 Hz, 1H), 7.66 (d-like, 2H),13.04 (br, 1H) II-1 (DMSO-d6) 1.31 (d, 6H, J = 6.0 Hz), 2.99 (brs, 4H),3.08 (brs, 4H), 4.61 (s, 2H), 4.72-4.80 (m, 1H), 6.78 (d, 1H, J = 6.9Hz), 6.87-6.95 (m, 3H), 7.15 (d, 2H, J = 9.0 Hz), 7.67 (d, 2H, J = 9.0Hz) II-2 (DMSO-d6) 1.34 (d, 6H, J = 6.3 Hz), 3.07 (brd, 8H, J = 5.4 Hz),4.61 (s, 2H), 5.34-5.40 (m, 1H), 6.79 (d, 1H, J = 7.8 Hz), 6.85-6.95 (m,3H), 6.98 (d, 1H, J = 9.0 Hz), 8.01 (dd, 2H, J = 2.4, 8.7 Hz), 8.55 (d,1H, J = 2.1 Hz), 13.01 (brs, 1H) II-3 (DMSO-d6) 1.30 (d, 6H, J = 6.0Hz), 2.93-2.99 (brm, 4H), 3.17-3.22 (brm, 4H), 4.59 (s, 2H), 4.71-4.79(m, 1H), 6.33 (dd, 1H, J = 2.4, 8.1 Hz), 6.43 (t, 1H, J = 2.4 Hz), 6.50(dd, 1H, J = 2.4, 8.1 Hz), 7.08 (t, 1H, J = 8.1 Hz), 7.14 (d, 2H, J =9.0 Hz), 7.67 (d, 2H, J = 9.0 Hz), 12.90 (brs, 1H) II-4 (DMSO-d6) 1.30(d, 6H, J = 6.3 Hz), 2.94-3.00 (brm, 4H), 3.02-3.08 (brm, 4H), 4.55 (s,2H), 4.71-4.80 (m, 1H), 6.78 (d, 2H, J = 9.3 Hz), 6.85 (d, 2H, J = 9.3Hz), 7.15 (d, 2H, J = 9.0 Hz), 7.67 (d, 2H, J = 9.0 Hz), 12.89 (brs, 1H)II-5 (DMSO-d6) 1.30 (d, 6H, J = 6.0 Hz), 2.94 (brs, 4H), 3.10 (brs, 4H),4.55 (s, 2H), 4.72-4.81 (m, 1H), 6.16 (t, 1H, J = 7.2 Hz), 6.74 (dd, 1H,J = 1.5, 7.5 Hz), 7.15 (d, 2H, J = 9.0 Hz), 7.30 (dd, 1H, J = 1.5, 6.6Hz), 7.67 (d, 2H, J = 9.0 Hz), 12.87 (brs, 1H) II-6 (DMSO-d6) 1.31 (d,6H, J = 6.0 Hz), 2.99 (brs, 4H), 3.13 (brs, 4H), 4.72-4.79 (m, 3H), 6.92(dd, 1H, J = 5.1, 7.5 Hz), 7.15 (d, 2H, J = 8.7 Hz), 7.23 (d, 1H, J =7.8 Hz), 7.67-7.70 (m, 3H), 12.75 (brs, 1H) II-7 (DMSO-d6) 1.31 (d, 6H,J = 6.0 Hz), 2.98 (brs, 4H), 3.02 (brs, 4H), 4.67 (s, 2H), 4.72-4.80 (m,1H), 6.66-6.76 (m, 2H), 6.90 (dd, 1H, J = 6.3, 8.7 Hz), 7.15 (d, 2H, J =9.0 Hz), 7.67 (d, 2H, J = 8.7 Hz) II-8 (CDCl3) 1.37 (d, 6H, J = 6.3 Hz),2.20 (s, 3H), 2.50 (brs, 1H), 3.20 (brs, 8H), 4.61-4.67 (m, 3H), 6.43(s, 1H), 6.51 (d, 1H, J = 8.1 Hz), 6.97 (d, 2H, J = 9.0 Hz), 7.05 (d,1H, J = 7.8 Hz), 7.69 (d, 2H, J = 9.0 Hz)

TABLE 30 Comd. No. ¹H-NMR (Solvent)δ II-9 (CDCl3) 1.38 (d, 6H, J = 6.0Hz), 1.95 (brs, 1H), 3.16 (brs, 8H), 3.86 (s, 3H), 4.60-4.69 (m, 3H),6.60-6.63 (m, 2H), 6.85 (d, 1H, J = 9.0 Hz), 6.98 (d, 2H, J = 9.0 Hz),7.70 (d, 2H, J = 9.0 Hz) II-10 (CDCl3) 1.37 (d, 6H, J = 6.0 Hz),3.16-3.23 (brs, 8H), 3.73 (brs, 1H), 4.60-4.71 (m, 3 H), 6.49-6.54 (m,2H), 6.98 (d, 2H, J = 9.0 Hz), 7.24 (d, 1H, J = 8.7 Hz), 7.69 (d, 2H, J= 9.0 Hz) II-11 (CDCl3) 1.37 (d, J = 6.3 Hz, 6H), 3.00 (brs, 1H), 3.08(brt, J = 4.8 Hz, 4H), 3.57 (brt, J = 4.8, 4H), 4.58-4.66 (m, 1H), 4.77(s, 2H), 6.19-6.25 (m, 2H), 6.96 (d, J = 9.0 Hz, 2H), 7.44 (t, J = 7.8Hz, 1H), 7.67 (d, J = 9.0 Hz, 2H) II-12 (CDCl3) 1.35 (d, J = 5.7 Hz,6H), 3.08 (brs, 4H), 3.68 (brs, 4H), 4.58-4.66 (m, 1H), 4.79 (s, 2H),5.64 (brs, 1H), 6.29 (brs, 1H), 6.39 (d, J = 6.0 Hz, 1H), 6.95 (d, J =9.0 Hz, 2H), 7.63 (t, J = 9.0 Hz, 2H), 7.92 (d, J = 6.9 Hz, 1H) II-13(CDCl3) 1.37 (d, 6H, J = 6.3 Hz), 3.15 (brt, 4H, J = 4.8 Hz), 3.50 (brt,4H, J = 4.2 Hz), 4.60-4.70 (m, 1H), 4.75 (s, 2H), 6.24, (s, 1H), 6.49(dd, 1H, J = 2.1, 9.3 Hz), 6.98 (d, 2H, J = 9.0 Hz), 7.69 (d, 2H, J =8.7 Hz), 8.06 (d, 2H, J = 9.6 Hz) II-14 (CDCl3) 1.36 (d, J = 5.7 Hz,6H), 3.10 (brs, 4H), 3.39 (brs, 1H), 3.74 (brs, 4H), 4.60-4.68 (m, 1H),4.73 (s, 2H), 6.33 (brs, 1H), 6.43 (brs, 1H), 6.95 (brd, J = 8.7 Hz,2H), 7.63 (brd, J = 7.8 Hz, 1H), 7.91 (brs, 1H) II-15 (CDCl3) 1.37 (d,6H, J = 6.0 Hz), 3.17 (m, 4H), 3.25 (m, 4H), 4.63 (m, 1H), 6.92 (dd, 1H,J = 9.0, 3.0 Hz), 6.97 (d, 2H, J = 9.9 Hz), 7.26-7.30 (m, 2H), 7.69 (d,2H). II-16 (CDCl3) 1.38 (d, J = 6.0 Hz, 6H), 3.00 (brs, 1H), 3.15 (s,8H), 4.60-4.68 (m, 1H), 4.71 (s, 2H), 6.27 (brs, 1H), 6.32-6.39 (m, 1H),6.98 (d, J = 8.7 Hz, 2H), 7.69 (d, J = 8.7 Hz, 2H) II-17 (CDCl3) 1.37(d, 6H, J = 6.1 Hz), 3.09-3.13 (m, 4H), 4.62 (s, 2H), 4.63-4.69 (m, 1H),6.35 (s, 1H), 6.51 (s, 1H), 6.65 (s, 1H), 6.98 (d, 2H, J = 8.7 Hz), 7.69(d, 2H, J = 8.7 Hz). II-18 (DMSO-d6) 1.30 (d, 6H, J = 5.7 Hz), 2.97 (t,4H), 3.38 (t, 4H), 4.75 (m, 1H), 6.65 (d, 1H, J = 16.2 Hz), 6.99 (dd,1H, J = 9.0, 2.7 Hz), 7.14 (d, 2H, J = 9.0 Hz), 7.32 (d, 1H), 7.35 (d,1H), 7.68 (d, 2H), 7.78 (d, 1H). II-19 (DMSO-d6) 1.38 (d, J = 5.7 Hz,6H), 2.96 (brs, 4H), 3.29 (brs, 4H), 4.61 (s, 2H), 4.71-4.79 (m, 1H),6.57 (s, 1H), 6.67 (s, 1H), 6.76 (s, 1H), 7.14 (d, J = 8.7 Hz, 2H), 7.66(d, J = 8.7 Hz, 2H) II-20 (CDCl3) 1.38 (d, 6H, J = 6.3 Hz), 3.25-3.26(m, 8H), 3.75 (s, 2H), 4.64 (m, 1H), 6.87-6.99 (m, 4H), 7.28 (d, 1H),7.69 (d, 2H, J = 9.0 Hz). II-21 (CDCl3) 1.38 (d, 6H, J = 6.0 Hz), 2.67(t, 2H, J = 7.8 Hz), 3.00 (t, 2H), 3.18-3.21 (m, 8H), 4.63 (m, 1H),6.71-6.82 (m, 3H), 6.97 (d, 2H, J = 9.0 Hz), 7.21 (d, 1H, J = 8.4 Hz),7.69 (d, 2H). II-22 (CDCl3) 1.38 (d, 6H, J = 6.3 Hz), 2.65 (t, 2H, J =7.8 Hz), 2.92 (t, 2H), 3.29-3.30 (m, 8H), 4.64 (m, 1H), 6.86-6.99 (m,5H), 7.23 (d, 1H, J = 7.8 Hz), 7.70 (d, 2H, J = 8.7 Hz).

TABLE 31 Comd. No. ¹H-NMR (Solvent)δ II-23 (DMSO-d6) 1.30 (d, J = 6.0Hz, 6H), 2.02 (s, 3H), 2.96 (brs, 4H), 3.14 (brs, 4H), 4.69 (s, 2H),4.71-4.79 (m, 1H), 6.45 (dd, J = 2.4, 9.0 Hz, 1H), 6.54 (d, J = 2.4 Hz,1H), 7.14 (d, J = 8.7 Hz, 2H), 7.65-7.68 (m, 3H), 9.02 (s, 1H) II-24(DMSO-d6) 1.30 (d, J = 6.0 Hz, 6H), 2.97 (brs, 4H), 3.20 (brs, 4H),4.71-4.79 (m, 3H), 6.55 (dd, J = 2.4, 8.7 Hz, 1H), 6.68-6.70 (m, 2H),7.15 (d, J = 8.7 Hz, 2H), 7.23 (dd, J = 0.6, 2.2 Hz, 1H), 7.68 (d, J =9.0 Hz, 2H), 7.81 (d, J = 8.7 Hz, 1H), 7.89-7.90 (m, 1H), 9.30 (s, 1H)II-25 (CDCl3) 1.37 (d, 6H, J = 6.0 Hz), 3.08-3.17 (m, 4H), 3.20-3.30 (m,4H), 4.59 (s, 2H), 4.57-4.65 (m, 1H), 6.07 (d, 1H, J = 8.8 Hz), 6.21 (s,1H), 6.22 (d, 1H, J = 8.8 Hz), 6.98 (d, 2H, J = 9.0 Hz), 7.69 (d, 2H, J= 9.0 Hz) II-26 (CDCl3) 1.37 (d, 6H, J = 6.0 Hz), 3.08-3.17 (m, 4H),3.20-3.30 (m, 4H), 4.60 (s, 2H), 4.58-4.65 (m, 1H), 6.31 (s, 1H), 6.33(s, 1H), 6.49 (s, 1H), 6.98 (d, 2H, J = 9.0 Hz), 7.69 (d, 2H, J = 9.0Hz) II-27 (CDCl3) 1.32 (d, J = 6.3 Hz, 6H), 3.01-3.04 (m, 4H), 3.20-3.23(m, 4H), 4.76 (s, 2H), 5.34 (sep, J = 6.3 Hz, 1H), 6.48 (dd, J = 2.7,8.7 Hz, 1H), 6.58 (d, J = 2.7 Hz, 1H), 6.96 (d, J = 8.7 Hz, 1H), 7.20(d, J = 8.7 Hz, 1H), 8.00 (dd, J = 2.7, 8.7 Hz, 1H), 8.55 (d, J = 2.7Hz, 1H), 13.03 (br, 1H) II-28 (DMSO-d6) 1.30 (d, J = 6.0 Hz, 6H), 2.98(brs, 4H), 3.21 (brs, 4H), 4.72-4.80 (m, 3H), 6.57 (dd, J = 2.4, 8.7 Hz,1H), 6.71 (d, J = 2.4 Hz, 1H), 7.15 (d, J = 8.7 Hz, 2H), 7.49-7.61 (m,3H), 7.68 (d, J = 8.7 Hz, 2H), 7.74 (d, J = 8.7 Hz, 1H), 7.95 (d, J =8.4 Hz, 2H), 9.51 (s, 1H) II-29 (DMSO-d6) 0.91 (t, J = 7.2 Hz, 3H), 1.26(d, J = 6.0 Hz, 6H), 1.53-1.76 (m, 2H), 2.91-2.99 (m, 4H), 3.16-3.24 (m,4H), 4.51 (m, 1H), 4.75 (s, 2H), 6.47 (dd, J = 2.4, 8.7 Hz, 1H), 6.58(d, J = 2.4 Hz, 1H), 7.15 (d-like, 2H), 7.19 (d, J = 8.7 Hz, 1H), 7.66(d- like, 2H), 13.02 (br, 1H) II-30 (DMSO-d6) 2.91-2.99 (m, 4H),3.16-3.24 (m, 4H), 3.86 (s, 3H), 4.75 (s, 2H), 6.46 (dd, J = 2.4, 8.7Hz, 1H), 6.57 (d, J = 2.4 Hz, 1H), 7.17 (d-like, 2H), 7.18 (d, J = 8.7Hz, 1H), 7.70 (d-like, 2H), 13.01 (br, 1H) II-31 (DMSO-d6) 1.33 (d, J =6.0 Hz, 6H), 2.95-3.04 (m, 4H), 3.16-3.24 (m, 4H), 4.76 (s, 2H), 4.81(m, 1H), 6.47 (dd, J = 2.4, 8.7 Hz, 1H), 6.58 (d, J = 2.4 Hz, 1H), 7.20(d, J = 8.7 Hz, 1H), 7.43 (t, J = 8.4 Hz, 1H), 7.54 (dd, J = 2.1, 9.0Hz, 1H), 7.60 (dd, J = 2.1, 10.5 Hz, 1H), 13.01 (brs, 1H) II-32(DMSO-d6) 1.30 (d, J = 6.0 Hz, 6H), 2.97 (brs, 4H), 3.16 (brs, 4H), 3.39(s, 3H), 3.96 (s, 2H), 4.70-4.80 (m, 3H), 6.49 (d, J = 8.4 Hz, 1H), 6.64(s, 1H), 7.14 (d, J = 8.7 Hz, 2H), 7.67 (d, J = 8.4 Hz, 2H), 7.91 (d, J= 8.7 Hz, 1H), 8.92 (s, 1H)

TABLE 32 Comd. No. ¹H-NMR (Solvent)δ II-33 (DMSO-d6) 1.30 (d, J = 6.0Hz, 6H), 2.95 (brs, 4H), 3.02 (brs, 4H), 4.71-4.79 (m, 3H), 6.42 (dd, J= 2.4, 9.0 Hz, 1H), 6.54 (d, J = 2.4 Hz, 1H), 7.13 (d, J = 9.0 Hz, 2H),7.32 (d, J = 8.7 Hz, 1H), 7.66 (d, J = 8.7 Hz, 2H) II-34 (DMSO-d6)2.97-3.04 (m, 4H), 3.17-3.24 (m, 4H), 4.76 (s, 2H), 6.47 (dd, J = 2.7,8.7 Hz, 1H), 6.58 (d, J = 2.7 Hz, 1H), 7.19 (d, J = 8.7 Hz, 1H),7.47-7.55 (m, 2H), 7.82-7.89 (m, 2H), 13.00 (br, 1H) II-35 (DMSO-d6)1.31 (d, J = 6.6 Hz, 6H), 2.94-3.03 (m, 4H), 3.15-3.23 (m, 4H), 3.73 (m,1H), 4.75 (s, 2H), 6.47 (dd, J = 2.7, 8.7 Hz, 1H), 6.58 (d, J = 2.7 Hz,1H), 7.19 (d, J = 8.7 Hz, 1H), 7.54 (d-like, 2H), 7.67 (d-like, 2H),13.02 (br, 1H) II-36 (DMSO-d6) 0.98 (d, J = 6.6 Hz, 6H), 2.04 (sep, J =6.6 Hz, 1H), 2.91-2.99 (m, 4H), 3.16-3.24 (m, 4H), 3.85 (d, J = 6.6 Hz,2H), 4.75 (s, 2H), 6.47 (dd, J = 2.4, 8.7 Hz, 1H), 6.57 (d, J = 2.4 Hz,1H), 7.17 (d-like, 2H), 7.19 (d, J = 8.7 Hz, 1H), 7.65 (d-like, 2H),13.00 (br, 1H) II-37 (CDCl3) 1.37 (d, 6H, J = 6.0 Hz), 3.08-3.17 (m,4H), 3.20-3.30 (m, 4H), 3.43 (s, 3H), 4.29 (s, 2H), 4.60 (s, 2H),4.58-4.65 (m, 1H), 6.31 (s, 1H), 6.33 (s, 1H), 6.49 (s, 1H), 6.98 (d,2H, J = 9.0 Hz), 7.69 (d, 2H, J = 9.0 Hz) II-38 (CDCl3) 1.37 (d, 6H, J =6.0 Hz), 3.18-3.22 (m, 4H), 3.25-3.30 (m, 4H), 4.58-4.65 (m, 1H), 4.70(s, 2H), 6.44 (s, 1H), 6.57 (s, 1H), 6.61 (s, 1H), 6.68 (s, 1H), 6.98(d, 2H, J = 8.6 Hz), 7.45 (s, 1H), 7.69 (d, 2H, J = 8.6 Hz). II-39(DMSO-d6) 1.37 (d, 6H, J = 6.0 Hz), 2.98-3.07 (m, 4H), 3.20-3.30 (m,4H), 4.60 (s, 2H), 4.58-4.65 (m, 1H), 6.55 (s, 1H), 6.75 (s, 1H), 6.95(s, 1H), 7.18 (d, 2H, J = 9.0 Hz), 7.69 (d, 2H, J = 9.0 Hz), 7.65-7.75(m, 2H), 8.60-8.64 (2H). II-40 (DMSO-d6) 1.37 (d, 6H, J = 6.0 Hz),2.98-3.07 (m, 4H), 3.20-3.30 (m, 4H), 4.64 (s, 2H), 4.68-4.75 (m, 1H),6.45 (s, 1H), 6.65 (s, 1H), 6.80 (s, 1H), 7.18 (d, 2H, J = 9.0 Hz),7.39-7.45 (m, 1H), 7.69 (d, 2H, J = 9.0 Hz), 8.00 (d, 1H, J = 8.0 Hz),8.53 (d, 1H, J = 4.8 Hz), 8.80 (brs, 1H). II-41 (CDCl3) 1.37 (d, 6H, J =6.0 Hz), 2.23 (s, 3H), 3.08-3.17 (m, 4H), 3.20-3.30 (m, 4H), 4.60 (s,2H), 4.58-4.65 (m, 1H), 6.47 (s, 2H), 6.65 (s, 1H), 6.98 (d, 2H, J = 9.0Hz), 7.69 (d, 2H, J = 9.0 Hz). II-42 (DMSO-d6) 1.30 (d, 6H, J = 5.7 Hz),2.96 (t, 4H), 3.28 (t, 4H), 4.71 (s, 2H), 4.75 (m, 1H), 6.87 (dd, 1H, J= 2.1 Hz), 7.14 (d, 2H, J = 9.0 Hz), 7.67 (d, 2H), 7.71 (d, 1H), 7.88(d, 1H). II-43 (DMSO-d6) 1.08 (d, 3H, J = 6.6 Hz), 1.29 (d, 6H, J = 6.0Hz), 2.42-2.76 (m, 2H), 3.20-3.59 (m, 4H), 4.01 (m, 1H), 4.68-4.76 (m,3H), 6.43 (m, 2H), 7.08 (d, 2H, J = 9.0 Hz), 7.18 (d, 1H, J = 8.7 Hz),7.73 (d, 2H). II-44 (DMSO-d6) 0.98 (d, 3H, J = 6.3 Hz), 1.30 (d, 6H, J =6.0 Hz), 2.35-2.56 (m, 2H), 3.00-3.59 (m, 4H), 4.03 (m, 1H), 4.71-4.79(m, 3H), 6.44 (dd, 1H, J = 8.7, 2.1 Hz), 6.53 (d, 1H), 7.14 (d, 2H, J =9.0 Hz), 7.19 (d, 1H), 7.66 (d, 2H).

TABLE 33 Comd. No. ¹H-NMR (Solvent)δ II-45 (DMSO-d6) 1.31 (d, J = 6.0Hz, 6H), 2.93-3.02 (m, 4H), 3.06-3.14 (m, 4H), 4.64 (s, 2H), 4.76 (m,1H), 6.80 (d, J = 8.7 Hz, 1H), 6.88 (d, J = 2.7 Hz, 1H), 6.96 (dd, J =2.7, 8.7 Hz, 1H), 7.15 (d-like, 2H), 7.67 (d-like, 2H), 13.01 (br, 1H)II-46 (CDCl3) 1.37 (d, 6H, J = 6.0 Hz), 3.17 (t, 4H), 3.46 (t, 4H), 4.63(m, 1H), 4.76 (s, 2H), 6.38 (d, 1H, J = 2.4 Hz), 6.62 (dd, 1H, J = 9.0,2.1 Hz), 6.98 (d, 2H), 7.67-7.75 (m, 3H), 8.39 (s, 1H). II-47 (DMSO-d6)1.30 (d, J = 6.0 Hz, 6H), 2.98 (brs, 4H), 3.20 (brs, 4H), 4.70-4.79 (m,1H), 4.85 (s, 2H), 6.55 (d, J = 9.0 Hz, 1H), 6.68 (s, 1H), 7.14 (d, J =8.7 Hz, 2H), 7.64-7.69 (m, 3H), 8.06 (d, J = 9.3 Hz, 1H), 8.16 (d, J =7.8 Hz, 1H), 8.24 (d, J = 7.8 Hz, 1H), 8.68 (d, J = 5.7 Hz, 1H), 10.40(s, 1H), 13.05 (brs, 1H) II-48 (DMSO-d6) 1.30 (d, J = 6.0 Hz, 6H), 2.98(brs, 4H), 3.22 (brs, 4H), 4.72-4.80 (m, 3H), 6.57 (dd, J = 2.1, 8.7 Hz,1H), 6.68 (d, J = 2.4 Hz, 1H), 7.15 (d, J = 9.0 Hz, 2H), 7.53-7.57 (m,1H), 7.64-7.70 (m, 3H), 8.29 (d, J = 8.1 Hz, 1H), 8.74 (s, 1H), 9.10 (s,1H), 9.79 (s, 1H), 13.10 (brs, 1H) II-49 (DMSO-d6) 1.30 (d, J = 6.3 Hz,6H), 2.98 (brs, 4H), 3.22 (brs, 4H), 4.73-4.80 (m, 3H), 6.57 (dd, J =2.4, 9.0 Hz, 1H), 6.69 (d, J = 1.8 Hz, 1H), 7.15 (d, J = 9.0 Hz, 2H),7.65-7.70 (m, 3H), 7.85 (d, J = 5.4 Hz, 2H), 8.76 (brs, 2H), 9.86 (brs,1H), 13.16 (brs, 1H) II-50 (DMSO-d6) 1.37 (d, J = 6.0 Hz, 6H), 2.08(quint, J = 5.7 Hz, 2H), 2.12 (br, 1H), 3.12-3.25 (m, 8H), 3.89 (t, J =5.7 Hz, 2H), 4.14 (t, J = 5.7 Hz, 2H), 4.63 (sept, J = 6.0 Hz, 1H), 6.41(dd, J = 2.7, 8.4 Hz, 1H), 6.47 (d, J = 2.7 Hz, 1H), 6.97 (d-like, 2H),7.19 (d, J = 8.4 Hz, 1H), 7.69 (d-like, 2H) II-51 (CDCl3) 1.37 (d, 6H, J= 6.0 Hz), 3.18-3.22 (m, 4H), 3.25-3.30 (m, 4H), 4.58-4.65 (m, 1H), 4.70(s, 2H), 6.41 (s, 1H), 6.65 (s, 1H), 6.77 (s, 1H), 6.98 (d, 2H, J = 8.6Hz), 7.03-7.10 (m, 1H), 7.26-7.30 (m, 2H), 7.70 (d, 2H, J = 8.6 Hz).II-52 (DMSO-d6) 1.30 (d, J = 6.0 Hz, 6H), 2.68 (t, J = 6.0, 2H),2.92-3.00 (m, 4H), 3.19-3.27 (m, 4H), 4.19 (t, J = 6.0 Hz, 2H), 4.75(sept, J = 6.0 Hz, 1H), 6.46 (dd, J = 2.4, 8.7 Hz, 1H), 6.66 (d, J = 2.4Hz, 1H), 7.14 (d-like, 2H), 7.17 (d, J = 8.7 Hz, 1H), 7.67 (d-like, 2H),12.37 (br, 1H) II-53 (DMSO-d6) 1.30 (d, J = 6.0 Hz, 6H), 2.99 (brs, 4H),3.26 (brs, 4H), 4.78 (s, 2H), 4.72-4.79 (m, 1H), 6.55-6.57 (m, 2H),7.14-7.17 (m, 3H), 7.23 (t, J = 7.2 Hz, 1H), 7.34 (t, J = 7.8 Hz, 2H),7.51 (d, J = 7.8 Hz, 2H), 7.68 (d, J = 9.0 Hz, 2H) II-54 (DMSO-d6) 1.29(d, J = 6.0 Hz, 6H), 2.97 (brs, 4H), 3.26 (brs, 4H), 4.79-4.70 (m, 3H),6.52 (d, J = 9.0 Hz, 1H), 6.55 (s, 1H), 6.97 (s, 1H), 7.14 (d, J = 9.0Hz, 2H), 7.44 (d, J = 9.0 Hz, 1H), 7.66 (s, 1H), 7.67 (d, J = 9.0 Hz,2H), 8.36 (s, 1H) II-55 (DMSO-d6) 1.33 (d, J = 6.0 Hz, 6H), 2.98-3.05(m, 4 H), 3.16-3.23 (m, 4H), 4.79 (s, 2H), 5.34 (sep, J = 6.0 Hz, 1H),6.48-6.56 (m, 2H), 6.97 (d, J = 8.7 Hz, 1H), 8.00 (dd, J = 2.4, 8.7 Hz,1H), 8.55 (d, J = 2.4 Hz, 1H), 13.09 (br, 1H)

TABLE 34 Comd. No. ¹H-NMR (Solvent)δ II-56 (DMSO-d6) 1.37 (d, J = 6.0Hz, 6H), 2.18 (br, 1H), 3.13-3.28 (m, 8H), 3.96 (brm, 2H), 4.10 (t, J =4.5 Hz, 2H), 4.63 (sept, J = 6.0 Hz, 1H), 6.47 (dd, J = 2.4, 8.7 Hz,1H), 6.54 (brs, 1H), 6.97 (d- like, 2H), 7.22 (d, J = 8.7 Hz, 1H), 7.69(d-like, 2H) II-57 (CDCl3) 1.37 (d, 6H, J = 6.0 Hz), 3.18-3.22 (m, 4H),3.25-3.30 (m, 4H), 4.58-4.65 (m, 1H), 4.70 (s, 2H), 6.53 (s, 1H), 6.65(s, 1H), 6.77 (s, 1H), 6.98 (d, 2H, J = 8.6 Hz), 7.34-7.43 (m, 3H),7.46-7.50 (m, 2H), 7.70 (d, 2H, J = 8.6 Hz). II-58 (DMSO-d6) 1.30 (d, J= 6.0 Hz, 6H), 2.97 (brs, 4H), 3.23 (brs, 4H), 4.70-4.80 (m, 3H),6.48-6.65 (m, 3H), 7.03-7.16 (m, 3H), 7.65-7.78 (m, 3H), 9.60 (s, 1H),12.98 (brs, 1H) II-59 (DMSO-d6) 1.30 (d, J = 6.0 Hz, 6H), 2.96 (brs,4H), 3.15 (brs, 4H), 3.61 (s, 3H), 4.66-4.80 (m, 3H), 6.49 (d, J = 8.1Hz, 1H), 6.58 (s, 1H), 7.14 (d, J = 9.0 Hz, 2H), 7.41 (s, 1H), 7.67 (d,J = 8.4 Hz, 2H), 8.29 (brs, 1H), 13.00 (brs, 1H) II-60 (DMSO-d6) 1.30(d, J = 5.4 Hz, 6H), 2.50 (s, 3H), 2.97 (brs, 4H), 3.20 (brs, 4H),4.65-4.85 (m, 3H), 6.54 (d, J = 7.5 Hz, 1H), 6.66-6.70 (m, 2H), 7.15 (d,J = 8.7 Hz, 2H), 7.68 (d, J = 8.4 Hz, 2H), 7.86 (d, J = 9.0 Hz, 1H),9.47 (s, 1H), 13.11 (brs, 1H) II-61 (CDCl3) 1.37 (d, 6H, J = 6.0 Hz),2.60 (s, 3H), 3.17 (t, 4H), 3.44 (t, 4H), 4.63 (m, 1H), 4.74 (s, 2H),6.38 (d, 1H, J = 2.1 Hz), 6.60 (dd, 1H, J = 8.4, 1.8 Hz), 6.98 (d, 2H, J= 9.0 Hz), 7.67-7.71 (m, 3H) II-62 (CDCl3) 1.37 (d, 6H, J = 6.0 Hz),3.21 (t, 4H), 3.41 (t, 4H), 4.63 (m, 1H), 4.79 (s, 2H), 6.37 (d, 1H),6.63 (dd, 1H), 6.99 (d, 2H), 7.09 (t, 1H), 7.32 (t, 1H), 7.69 (d, 1H, J= 9.0 Hz), 7.79 (d, 2H, J = 8.1 Hz), 8.09 (d, 1H), 9.80 (s, 1H). II-63(CDCl3) 1.24 (d, 6H, J = 6.3 Hz), 1.37 (d, 6H, J = 6.0 Hz), 3.14 (t,4H), 3.35 (t, 4H), 4.65 (m, 1H), 4.71 (s, 2H), 6.29 (d, 1H, J = 2.4 Hz),6.53 (dd, 1H, J = 8.7, 2.1 Hz), 6.97 (d, 2H, J = 3.0 Hz), 7.66-7.72 (m,3H), 7.84 (d, 1H, J = 8.7 Hz). II-64 (CDCl3) 1.22 (d, 6H, J = 6.0 Hz),1.37 (d, 6H, J = 6.0 Hz), 3.18-3.22 (m, 4H), 3.25-3.30 (m, 4H),4.28-4.36 (m, 1H), 4.58-4.65 (m, 1H), 4.65 (s, 2H), 6.01 (brs, 1H), 6.57(s, 1H), 6.75 (s, 1H), 6.89 (s, 1H), 6.98 (d, 2H, J = 8.6 Hz), 7.70 (d,2H, J = 8.6 Hz). II-65 (DMSO-d6) 1.29 (d, J = 6.0 Hz, 6H), 2.97 (brs,4H), 3.29 (brs, 4H), 4.71-4.80 (m, 3H), 6.52-6.57 (m, 3H), 7.11 (d, J =3.0 Hz, 1H), 7.14 (d, J = 9.0 Hz, 2H), 7.56 (d, J = 9.3 Hz, 1H), 7.61(d, J = 1.2 Hz, 1H), 7.67 (d, J = 9.0 Hz, 2H) II-66 (CDCl3) 1.37 (d, 6H,J = 6.0 Hz), 3.18-3.22 (m, 4H), 3.25-3.30 (m, 4H), 4.58-4.65 (m, 1H),4.73 (s, 2H), 6.64 (s, 1H), 6.98 (d, 2H, J = 8.6 Hz), 7.07 (s, 1H), 7.24(s, 1H), 7.28 (s, 1H), 7.70 (d, 2H, J = 8.6 Hz), 8.46 (s, 1H). II-67(DMSO-d6) 1.21 (d, J = 6.3 Hz, 6H), 1.30 (d, J = 6.0 Hz, 6H), 2.96 (brs,4H), 3.14 (brs, 4H), 4.62 (s, 2H), 4.71-4.85 (m, 2H), 6.48 (d, J = 9.9Hz, 1H), 6.59 (s, 1H), 7.14 (d, J = 8.7 Hz, 2H), 7.47 (brd, J = 6.6 Hz,1H), 7.67 (d, J = 8.7 Hz, 2H), 8.26 (brs, 1H)

TABLE 35 Comd. No. ¹H-NMR(Solvent)δ II-68 (DMSO-d6) 1.06 (d, J = 6.6 Hz,6H), 1.30 (d, J = 6.3 Hz, 6H), 2.96-2.97 (m, 4H), 3.06-3.08 (m, 4H),3.65-3.76 (m, 1H), 4.71- 4.79 (m, 3H), 6.39 (dd, J = 2.4, 8.7 Hz, 1H),6.50 (d, J = 2.4 Hz, 1H), 6.62 (d, J = 7.5 Hz, 1H), 7.14 (d, J = 9.0 Hz,2H), 7.52 (s, 1H), 7.67 (d, J = 9.0 Hz, 2H), 7.81 (d, J = 9.0 Hz, 1H),13.02 (brs, 1H) II-69 (DMSO-d6) 1.31 (d, J = 6.0 Hz, 6H), 3.02 (brs,8H), 4.67 (s, 1H), 4.73-4.80 (m, 2H), 6.59 (dd, J = 3.0, 9.0 Hz, 1H),6.70 (d, J = 2.7 Hz, 1H), 7.16 (d, J = 8.7 Hz, 2H), 7.27 (d, J = 9.0 Hz,1H), 7.68 (d, J = 8.7 Hz, 2H) II-70 (CDCl3) 1.35 (d, 6H, J = 6.0 Hz),1.37 (d, 6H, J = 6.0 Hz), 3.18- 3.22 (m, 8H), 4.48-4.56 (m, 1H), 4.52(s, 2H), 4.58-4.65 (m, 1H), 6.58 (d, 1H, J = 8.5 Hz), 6.60 (s, 1H), 6.83(d, 1H, J = 8.5 Hz), 6.96 (d, 2H, J = 8.5 Hz), 7.81 (d, 2H, J = 8.5 Hz)II-71 (CDCl3) 1.37 (d, 6H, J = 6.0 Hz), 3.18-3.22 (m, 8H), 4.52 (s, 2H),4.58-4.65 (m, 1H), 5.10 (s, 2H), 6.58 (d, 1H, J = 8.5 Hz), 6.70 (s, 1H),6.83 (d, 1H, J = 8.5 Hz), 6.96 (d, 2H, J = 8.5 Hz), 7.30-7.40 (m, 5H),7.81 (d, 2H, J = 8.5 Hz). II-72 (DMSO-d6) 1.30 (d, J = 6.3 Hz, 6H), 2.97(brs, 4H), 3.15 (s, 3H), 3.26 (brs, 4H), 4.58-4.80 (m, 3H), 5.71 (d, J =3.3 Hz, 1H), 6.29 (s, 1H), 6.45 (dd, J = 2.1, 8.7 Hz, 1H), 6.59 (s, 1H),6.99 (d, J = 8.4 Hz, 1H), 7.15 (d, J = 9.0 Hz, 2H), 7.62-7.69 (m, 3H)II-73 (CDCl3) 1.37 (d, 6H, J = 6.0 Hz), 2.43 (s, 3H), 3.16 (br, 4H),3.45 (br, 4H), 4.63 (m, 1H), 4.85 (s, 2H), 6.43 (br, 1H), 6.57 (br, 1H),6.96-7.01 (m, 3H), 7.68-7.75 (m, 3H). II-74 (CDCl3) 1.37 (d, 6H, J = 6.0Hz), 3.16 (t, 4H), 3.42 (t, 4H), 4.63 (m, 1H), 4.77 (s, 2H), 6.40 (d,1H, J = 2.7 Hz), 6.62 (dd, 1H, J = 9.0, 2.4 Hz), 6.98 (d, 2H, J = 3.0Hz), 7.27 (d, 1H), 7.67-7.72 (m, 3H), 7.79 (d, 1H, J = 3.0 Hz). II-75(CDCl3) 1.37 (d, 6H, J = 6.0 Hz), 2.79 (s, 3H), 3.16 (t, 4H), 3.43 (t,4H), 4.63 (m, 1H), 4.82 (s, 2H), 6.41 (d, 1H, J = 2.1 Hz), 6.57 (dd, 1H,J = 8.4, 2.4 Hz), 6.98 (d, 2H, J = 8.7 Hz), 7.62 (d, 1H, J = 8.4 Hz),7.69 (d, 2H). II-76 (DMSO-d6) 1.30 (d, 6H, J = 6.0 Hz), 3.18-3.22 (m,8H), 4.59 (s, 2H), 4.58-4.65 (m, 1H), 6.38 (d, 1H, J = 8.5 Hz), 6.50 (s,1H), 6.65 (d, 2H, J = 8.5 Hz), 7.12 (d, 1H, J = 8.5 Hz), 7.61 (d, 2H, J= 8.5 Hz). II-77 (CDCl3) 1.37 (d, 6H, J = 6.0 Hz), 3.18-3.22 (m, 8H),4.52 (s, 2H), 4.58-4.65 (m, 1H), 5.10 (s, 2H), 6.58 (d, 1H, J = 7.5 Hz),6.70 (s, 1H), 6.83 (d, 1H, J = 8.5 Hz), 6.96 (d, 2H, J = 8.5 Hz), 7.41(s, 1H), 7.48 (s, 1H), 7.81 (d, 2H, J = 8.5 Hz). II-78 (CDCl3) 1.03 (d,6H, J = 6.0 Hz), 1.37 (d, 6H, J = 6.0 Hz), 2.01- 2.11 (m, 1H), 3.18-3.22(m, 8H), 3.75 (d, 2H, J = 6.0), 4.62 (s, 2H), 4.60-4.69 (m, 1H), 6.58(d, 1H, J = 7.5 Hz), 6.65 (s, 1H), 6.83 (d, 1H, J = 7.5 Hz), 6.96 (d,2H, J = 8.5 Hz), 7.81 (d, 2H, J = 8.5 Hz).

TABLE 36 Comd. No. ¹H-NMR(Solvent)δ II-79 (DMSO-d6) 1.31 (d, J = 6.0 Hz,6H), 2.95-3.02 (m, 4H), 3.14-3.24 (m, 4H), 4.64 (s, 2H), 4.76 (sep, J =6.0 Hz, 1H), 6.44 (dd, J = 2.4, 8.7 Hz, 1H), 6.63 (d, J = 2.4 Hz, 1H),6.78-6.83 (m, 2H), 6.89 (d, J = 8.7 Hz, 1H), 6.96 (m, 1H), 7.15 (d-like,2H), 7.22- 7.29 (m, 2H), 7.68 (d-like, 2H), 12.88 (br, 1H) II-80(DMSO-d6) 1.29 (d, 6H, J = 6.0 Hz), 2.93 (t, 4H), 3.43 (t, 4H), 4.74 (m,1H), 4.83 (s, 2H), 6.50 (d, 1H), 6.54 (dd, 1H, J = 8.1, 1.8 Hz), 7.13(d, 2H, J = 8.7 Hz), 7.44 (d, 1H, J = 8.7 Hz), 7.65 (d, 1H). II-81(DMSO-d6) 1.30 (d, 6H, J = 6.0 Hz), 2.95 (t, 4H), 3.38 (t, 4H), 4.74 (m,1H), 4.79 (s, 2H), 6.50 (d, 1H), 6.55 (dd, 1H, J = 8.7 Hz), 7.13 (d, 2H,J = 9.0 Hz), 7.32 (br, 1H), 7.67 (d, 2H), 7.77 (d, 1H), 8.01 (br, 1H).II-82 (DMSO-d6) 1.29 (d, 6H, J = 6.0 Hz), 2.78 (d, 3H, 4.5 Hz), 2.95 (t,4H), 3.35 (t, 4H), 4.74 (m, 1H), 4.81 (s, 2H), 6.50 (d, 1H, J = 2.1 Hz),6.56 (dd, 1H, J = 9.0, 2.1 Hz), 7.13 (d, 2H, J = 9.0 Hz), 7.67 (d, 2H),7.75 (d, 1H), 8.54 (d, 1H). II-83 (DMSO-d6) 0.88 (t, 3H, J = 7.2 Hz),1.29 (d, 6H, J = 6.0 Hz), 1.54 (m, 2H), 2.95 (t, 4H), 3.36 (t, 4H), 4.74(m, 1H), 4.80 (s, 2H), 6.51 (d, 1H), 6.56 (dd, 1H, J = 8.4, 2.1 Hz),7.13 (d, 2H, J = 8.7 Hz), 7.66 (d, 2H), 7.76 (d, 1H), 8.58 (t, 1H).II-84 (DMSO-d6) 1.29 (d, J = 6.0 Hz, 6H), 2.97 (brs, 4H), 3.33 (brs,4H), 4.70-4.78 (m, 3H), 6.59-6.61 (m, 2H), 7.14 (d, J = 9.0 Hz, 2H),7.52 (d, J = 9.0 Hz, 1H), 7.67 (d, J = 9.0 Hz, 2H), 7.74 (s, 1H), 8.29(s, 1H) II-85 (DMSO-d6) 1.32 (d, J = 6.0 Hz, 6H), 3.05 (brs, 4H), 3.32(brs, 4H), 4.79 (s, 2H), 5.30-5.40 (m, 1H), 6.61-6.63(m, 2H), 6.96 (d, J= 8.7 Hz, 1H), 7.52 (d, J = 8.7 Hz, 1H), 7.73 (s, 1H), 8.00 (dd, J =2.7, 8.7 Hz, 1H), 8.29 (s, 1H), 8.55 (d, J = 2.4 Hz, 1H), 13.11 (brs,1H) II-86 (CDCl3) 1.37 (d, 6H, J = 6.0 Hz), 3.18-3.22 (m, 8H), 4.58-4.65(m, 1H), 6.58 (d, 1H, J = 15.5 Hz), 6.70-6.90 (m, 3H), 6.96 (d, 2H, J =8.5 Hz), 7.61 (d, 2H, J = 8.5 Hz), 8.96 (d, 1H, J = 15.5 Hz). II-87(CDCl3) 1.37 (d, 6H, J = 6.0 Hz), 3.18-3.22 (m, 8H), 4.58-4.65 (m, 1H),5.10 (s, 2H), 6.58 (d, 1H, J = 15.5 Hz), 6.70-6.90 (m, 3H), 6.96 (d, 2H,J = 8.5 Hz), 7.30-7.40 (m, 5H), 7.81 (d, 2H, J = 8.5 Hz), 8.96 (d, 1H, J= 15.5 Hz). II-88 (DMSO-d6) 1.29 (d, 6H, J = 6.0 Hz), 2.97 (t, 4H), 3.41(t, 4H), 4.74 (m, 1H), 4.91 (s, 2H), 6.64 (d, 1H), 6.68 (dd, 1H,J = 9.0Hz), 7.14 (d, 2H, J = 9.0 Hz), 7.67 (d, 2H), 8.14 (d, 1H), 1H).9.49 (s,1H). II-89 (DMSO-d6) 0.55 (m, 2H), 0.68 (m, 2H), 1.29 (d, 6H, J = 6.3Hz), 2.90 (t, 4H), 3.37 (t, 4H), 4.74 (m, 1H), 4.76 (s, 2H), 6.48 (d,1H, J = 1.8 Hz), 6.56 (dd, 1H, J = 9.0 Hz), 7.13 (d, 2H, J = 8.7 Hz),7.66 (d, 2H), 7.77 (d, 1H), 8.61 (d, 1H, J = 4.8 Hz). II-90 (DMSO-d6)1.28 (d, J = 6.0 Hz, 6H), 2.88 (brs, 4H), 3.53 (brs, 4H), 4.66-4.76 (m,3H), 6.30 (d, J = 8.4 Hz, 1H), 7.09 (d, J = 9.0 Hz, 2H), 7.64 (d, J =9.0 Hz, 3H)

TABLE 37 Comd. No. ¹H-NMR(Solvent)δ II-91 (DMSO-d6) 1.29 (d, J = 6.0 Hz,6H), 2.50 (s, 3H), 2.94 (brs, 4H), 3.42 (brs, 4H), 4.70-4.79 (m, 3H),6.45 (d, J = 2.4 Hz, 1H), 6.52 (dd, J = 2.4, 8.4 Hz, 1H), 7.13 (d, J =9.0 Hz, 2H), 7.55 (d, J = 9.0 Hz, 1H), 7.66 (d, J = 8.7 Hz, 2H), 13.07(brs, 1H) II-92 (DMSO-d6) 1.29 (d, 6H, J = 6.0 Hz), 2.97 (t, 4H), 3.38(t, 4H), 4.74 (m, 1H), 4.93 (s, 2H), 6.61 (d, 1H), 6.64 (dd, 1H, J = 9.3Hz), 7.14 (d, 2H, J = 9.0 Hz), 7.63-7.69 (m, 3H), 7.83 (d, 1H, J = 3.0Hz), 8.08 (d, 1H). II-93 (DMSO-d6) 1.29 (d, 6H, J = 6.0 Hz), 2.95 (t,4H), 3.23 (s, 3H), 3.43 (t, 4H), 4.74 (m, 1H), 4.86 (s, 2H), 6.54-6.59(m, 2H), 6.68 (dd, 1H, J = 9.0 Hz), 7.14 (d, 2H, J = 9.0 Hz), 7.54 (d,1H, J = 9.3 Hz), 7.67 (d, 2H). II-94 (DMSO-d6) 1.32 (d, J = 6.3 Hz, 6H),3.05 (brs, 4H), 3.39 (brs, 4H), 4.82 (s, 2H), 5.29-5.38 (m, 1H), 6.59(s, 1H), 6.64 (d, J = 8.4 Hz, 1H), 6.96 (d, J = 8.7 Hz, 1H), 7.37 (s,1H), 7.69 (d, J = 9.0 Hz, 1H), 8.00 (dd, J = 2.7, 8.7 Hz, 1H), 8.13 (s,1H), 8.55 (d, J = 2.7 Hz, 1H) II-95 1H NMR (DMSO-d6) 1.30 (d, J = 6.0Hz, 6H), 2.97 (brs, 4H), 3.25 (brs, 4H), 4.70-4.80 (m, 3H), 6.41(s, 1H),6.57 (d, 1H), 6.66 (s, 1H), 7.14 (d, J = 8.7 Hz, 2H), 7.47 (d, J = 8.4Hz, 1H), 7.61 (s, 1H), 7.67 (d, J = 8.7 Hz, 2H), 8.36 (s, 1H) II-96 1HNMR (DMSO-d6) 1.29 (d, J = 6.0 Hz, 6H), 2.96 (brs, 4H), 3.26 (brs, 4H),4.30 (s, 2H), 4.69-4.77 (m, 1H), 6.50 (s, 1H), 6.53 (d, J = 9.0 Hz, 1H),7.12 (d, J = 8.7 Hz, 2H), 7.65 (d, J = 9.0 Hz, 2H), 7.78 (d, J = 8.7 Hz,1H), 8.31 (s, 1H), 9.13 (s, 1H) II-99 1H NMR (CDCl3) 1.36 (d, 6H, J =6.0 Hz), 3.08-3.15 (m, 4H), 3.25-3.35 (m, 4H), 4.58-4.65 (m, 1H), 4.69(s, 2H), 4.78 (d, 2H, J = 6.0 Hz), 6.24 (s, 1H), 6.52 (d, 1H, J = 8.5Hz), 6.87-6.91 (m, 1H), 6.96 (d, 2H, J = 8.5 Hz), 6.96-6.98 (m, 1H),7.14 (d, 1H, J = 8.5 Hz), 7.68 (d, 2H, J = 8.5 Hz), 7.90 (d, 1H, J = 8.5Hz), 8.30-8.35 (m, 1H). II-100 1H NMR (DMSO-d6) 1.30 (d, 6H, J = 6.0Hz), 3.08-3.15 (m, 4H), 3.25-3.35 (m, 4H), 4.55 (d, 2H, J = 6.0 Hz),4.74-4.84 (m, 1H), 4.79 (s, 2H), 6.53 (s, 1H), 6.58 (d, 1H, J = 8.5 Hz),7.14 (d, 2H, J = 8.5 Hz), 7.20-7.24 (m, 1H), 7.32 (d, 1H, J = 8.5 Hz),7.64 (d, 2H, J = 8.5 Hz), 7.69-7.72 (m, 1H), 7.79 (d, 1H, J = 8.5 Hz),8.48 (d, 1H, J = 4.5 Hz), 9.30-9.35 (m, 1H).

TABLE 38 Comd. No. ¹H-NMR(Solvent)δ II-101 1H NMR (DMSO-d6) 1.30 (d, 6H,J = 6.0 Hz), 3.08-3.15 (m, 4H), 3.25-3.35 (m, 4H), 4.35 (s, 2H),4.74-4.84 (m, 1H), 6.12 (d, 1H, J = 8.5 Hz), 6.53 (s, 1H), 6.58-6.70 (m,2H), 7.00 (t, 1H, J = 7.6 Hz), 7.13 (t, 1H, J = 7.6 Hz), 7.15 (d, 2H, J= 8.5 Hz), 7.28 (d, 1H, J = 7.6 Hz), 7.64 (d, 2H, J = 8.5 Hz). II-1021H-NMR (DMSO-d6) 8.13 (1H, d, J = 0.8 Hz), 7.67 (2H, d, J = 8.9 Hz),7.51 (1H, dd, J = 8.2, 1.8 Hz), 7.30-7.30 (2H, m), 7.15 (2H, d, J = 9.0Hz), 7.01 (1H, d, J = 8.4 Hz), 4.77-4.75 (3H, m), 3.19-3.16 (4H, m),3.02-2.99 (4H, m), 1.31 (6H, d, J = 6.0 Hz). II-103 1H-NMR (CDCl3) 1.38(6H, d, J = 6.1 Hz), 3.20 (8H, s), 4.51 (2H, s), 4.61-4.69 (1H, m), 6.56(1H, s), 6.67 (1H, d, J = 9.0 Hz), 6.98 (2H, d, J = 8.9 Hz), 7.11 (1H,d, J = 9.0 Hz), 7.69 (2H, d, J = 8.9 Hz). II-105 1H-NMR (CDCl3) 8.04(0.5H, s), 7.85 (1H, d, J = 8.7 Hz), 7.73 (2H, d, J = 8.9 Hz), 7.01 (2H,d, J = 8.9 Hz), 6.64-6.61 (1H, m), 4.78 (2H, s), 4.71-4.63 (1H, m),4.12-4.04 (1H, m), 3.42-3.32 (6H, m), 3.23 (4H, brs), 1.41 (6H, d, J =6.0 Hz), 1.26 (6H, d, J = 6.0 Hz), 1.14-1.07 (1H, m), 0.58-0.53 (2H, m),0.32-0.24 (2H, m). II-106 1H NMR (DMSO-d6) 1.29 (d, 6H, J = 6.0 Hz),3.08-3.15 (m, 4H), 3.25-3.35 (m, 4H), 4.45 (d, 2H, J = 6.0 Hz),4.74-4.84 (m, 1H), 4.81 (s, 2H), 6.22 (d, 1H, J = 2.3 Hz), 6.32 (d, 1H,J = 2.3 Hz), 6.50 (s, 1H), 6.58 (d, 1H, J = 8.5 Hz), 7.14 (d, 2H, J =8.5 Hz), 7.52 (d, 1H, J = 2.3 Hz), 7.64 (d, 2H, J = 8.5 Hz), 7.76 (d,1H, J = 8.5 Hz), 8.90-8.95 (m, 1H). II-108 1H-NMR (DMSO-d6) 1.29 (6H, d,J = 6.0 Hz), 2.96 (4H, m), 3.48 (4H, m), 4.74 (1H, tt, J = 6.0, 6.0 Hz),4.96 (2H, s), 6.60 (1H, d, J = 2.1 Hz), 6.66 (1H, d, J = 2.1, 9.0 Hz),7.13 (2H, d, J = 9.0 Hz), 7.22 (1H, d, J = 3.6 Hz), 7.47 (1H, d, J = 3.6Hz), 7.66 (2H, d, J = 9.0 Hz), 7.84 (1H, d, J = 9.0 Hz), 11.56 (1H,brs). II-109 1H-NMR (DMSO-d6) 1.29 (6H, d, J = 6.0 Hz), 2.95 (4H, m),3.39 (4H, m), 4.74 (1H, tt, J = 6.0, 6.0 Hz), 4.77 (2H, s), 6.47 (1H, d,J = 2.4 Hz), 6.54 (1H, d, J = 2.4, 9.0 Hz), 7.13 (2H, d, J = 9.0 Hz),7.62 (1H, d, J = 9.0 Hz), 7.66 (2H, d, J = 9.0 Hz), 11.8 (1H, br), 13.0(1H, br). II-110 1H-NMR (DMSO-d6) 1.28 (6H, d, J = 6.0 Hz), 2.96 (4H,m), 3.50 (4H, m), 4.73 (1H, tt, J = 6.0, 6.0 Hz), 4.96 (2H, s), 6.61(1H, d, J = 2.1 Hz), 6.67 (1H, dd, J = 2.1, 9.0 Hz), 7.13 (2H, d, J =9.0 Hz), 7.67 (2H, d, J = 9.0 Hz), 7.84 (1H, d, J = 9.0 Hz), 9.16 (1H,s), 11.88 (1H, brs), 13.5 (1H, br).

TABLE 39 Comd. No. ¹H-NMR(Solvent)δ or [M + H]+ II-111 1H-NMR (DMSO-d6)1.28 (6H, d, J = 6.0 Hz), 2.96 (4H, m), 3.42 (4H, m), 3.73 (3H, s), 4.74(1H, tt, J = 6.0, 6.0 Hz), 4.93 (2H, s), 6.54 (1H, d, J = 2.4 Hz), 6.57(1H, d, J = 2.4 Hz), 6.61 (1H, dd, J = 2.4, 9.0 Hz), 7.13 (2H, d, J =9.0 Hz), 7.55 (1H, d, J = 2.4 Hz), 7.67 (2H, d, J = 9.0 Hz), 7.81 (1H,d, J = 9.0 Hz), 10.32 (1H, s), 13.35 (1H, brs). II-112 1H NMR (DMSO-d6)0.63-0.68 (m, 2H), 0.88-0.92 (m, 2H), 1.30 (d, 6H, J = 6.0 Hz),1.93-1.96 (m, 1H), 3.08-3.15 (m, 4H), 3.25- 3.35 (m, 4H), 4.74-4.84 (m,1H), 4.90 (s, 2H), 6.18 (s, 1H), 6.53 (s, 1H), 6.58 (d, 1H, J = 8.5 Hz),7.14 (d, 2H, J = 8.5 Hz), 7.64 (d, 2H, J = 8.5 Hz), 7.79 (d, 1H, J = 8.5Hz), 9.80-9.85 (m, 1H). II-113 1H-NMR (CDCl3) 7.69 (2H, d, J = 6.9 Hz),7.07 (1H, d, J = 9.0 Hz), 6.97 (2H, d, J = 6.9 Hz), 6.54 (2H, d, J = 6.7Hz), 4.77 (2H, s), 4.67-4.59 (1H, m), 3.72-3.60 (4H, m), 3.35-3.33 (4H,m), 3.18-3.16 (4H, m), 1.38 (6H, d, J = 6.1 Hz). II-114 1H-NMR (CDCl3)7.73 (2H, d, J = 8.9 Hz), 7.25 (1H, d, J = 9.1 Hz), 7.02 (2H, d, J = 8.9Hz), 6.60 (2H, s), 4.82 (2H, s), 4.72-4.64 (1H, m), 3.71 (4H, m),3.40-3.38 (4H, m), 3.24-3.22 (4H, m), 1.99 (4H, m), 1.42 (6H, d, J = 6.0Hz). II-115 1H-NMR (CDCl3) 7.73 (2H, d, J = 9.4 Hz), 7.16 (1H, d, J =9.1 Hz), 7.02 (2H, d, J = 8.9 Hz), 6.59-6.57 (2H, m), 4.81 (2H, s),4.72-4.64 (1H, m), 3.40-3.38 (4H, m), 3.22-3.17 (10H, m), 1.42 (6H, d, J= 6.0 Hz). II-116 [M + H]+ = 494 II-117 [M + H]+ = 480 II-118 1H NMR(CDCl3) 1.36 (d, 6H, J = 6.0 Hz), 3.08-3.15 (m, 4H), 3.25-3.35 (m, 4H),4.58-4.65 (m, 1H), 4.78 (s, 2H), 6.42 (s, 1H), 6.45 (d, 1H, J = 8.5 Hz),6.96 (d, 2H, J = 8.5 Hz), 7.32 (d, 1H, J = 8.5 Hz), 7.44 (t, 2H, J = 8.0Hz), 7.60 (t, 1H, J = 8.0 Hz), 7.74 (d, 2H, J = 8.5 Hz), 7.79 (d, 2H, J= 8.0 Hz).

TABLE 40 Comd. No. ¹H-NMR(Solvent)δ or [M + H]+ II-122 1H NMR (CDCl3)1.36 (d, 6H, J = 6.0 Hz), 3.15-3.35 (m, 8H), 3.94 (s, 2H), 4.52 (s, 2H),4.60-4.66 (m, 1H), 6.42 (s, 1H), 6.45 (d, 1H, J = 8.5 Hz), 6.96 (d, 2H,J = 8.5 Hz), 7.08 (d, 1H, J = 8.5 Hz), 7.16-7.30 (m, 5H), 7.74 (d, 2H, J= 8.5 Hz), 7.70 (d, 2H, J = 8.0 Hz). II-123 1H NMR (CDCl3) 1.36 (d, 6H,J = 6.0 Hz), 3.08-3.15 (m, 4H), 3.25-3.35 (m, 4H), 4.61-4.67 (m, 1H),4.78 (s, 2H), 6.45 (s, 1H), 6.52 (d, 1H, J = 8.5 Hz), 6.97 (d, 2H, J =8.5 Hz), 7.15 (t, 1H, J = 4.0 Hz), 7.56 (d, 2H, J = 8.5 Hz), 7.60 (s,1H), 7.74 (d, 2H, J = 8.5 Hz), 7.70 (d, 2H, J = 4.0 Hz). II-127 1H-NMR(CDCl3) 8.09 (0.5H, s), 7.80-7.69 (4H, m), 7.57-7.52 (1H, m), 7.45-7.39(3H, m), 7.00 (2H, d, J = 8.9 Hz), 6.59 (1H, d, J = 10.0 Hz), 6.39 (1H,s), 4.68-4.64 (1H, m), 4.36 (2H, s), 3.23 (8H, br s), 1.41 (6H, d, J =6.0 Hz). II-128 [M + H]+ = 440 II-129 1H NMR (CDCl3) 1.36 (d, 6H, J =6.0 Hz), 3.08-3.15 (m, 4H), 3.25-3.35 (m, 4H), 4.61-4.67 (m, 1H), 4.76(s, 2H), 6.40 (s, 1H), 6.52 (d, 1H, J = 8.5 Hz), 6.65 (d, 1H, J = 4.0Hz), 6.97 (d, 2H, J = 8.5 Hz), 7.20 (d, 2H, J = 4.0 Hz), 7.60-7.70 (m,3H). II-130 1H-NMR (DMSO-d6) 10.48 (1H, s), 7.65 (2H, d, J = 8.5 Hz),7.14 (2H, d, J = 8.4 Hz), 6.72 (1H, d, J = 7.8 Hz), 6.53-6.49 (2H, m),4.79-4.71 (1H, m), 4.48 (2H, s), 3.12-3.09 (4H, m), 2.96-2.93 (4H, m),1.30 (6H, d, J = 6.1 Hz). II-131 1H-NMR (CDCl3) 7.76-7.71 (2H, m),7.53-7.51 (1H, m), 7.03- 7.00 (2H, m), 6.66 (2H, td, J = 5.0, 2.6 Hz),4.74-4.62 (1H, m), 4.57 (2H, s), 3.55 (3H, s), 3.31-3.22 (8H, m), 1.42(6H, d, J = 6.0 Hz). II-133 1H-NMR (DMSO-d6) 8.31 (0.5H, s), 7.66 (2H,d, J = 8.9 Hz), 7.14 (2H, d, J = 8.9 Hz), 7.03 (1H, d, J = 8.7 Hz), 6.58(1H, d, J = 2.6 Hz), 6.50 (1H, dd, J = 8.8, 2.4 Hz), 4.79-4.71 (1H, m),4.48 (2H, s), 3.19-3.17 (4H, m), 2.97-2.94 (4H, m), 2.85 (3H, s), 1.30(6H, d, J = 6.0 Hz). II-134 [M + H]+ = 459 II-135 [M + H]+ = 479

TABLE 41 Comd. No. ¹H-NMR(Solvent)δ or [M + H]+ II-140 1H NMR (CDCl3)1.37 (d, J = 6.0 Hz, 6H), 3.23 (brs, 4H), 3.37 (brs, 4H), 4.09 (brs,2H), 4.63 (m, 1H), 6.16 (brs, 1H), 6.39 (m, 1H), 6.97 (d, J = 9.0 Hz,2H), 7.19 (s, 1H), 7.60 (s, 1H), 7.69 (d, J = 9.0 Hz, 2H), 7.80 (d, J =9.0 Hz, 1H) II-141 1H-NMR (CDCl3) 1.37 (6H, d, J = 6.0 Hz), 3.06-3.19(8H, m), 3.40-3.46 (4H, m), 3.69-3.75 (4H, m), 4.59-4.67 (1H, m), 4.70(2H, s), 6.27 (1H, d, J = 1.9 Hz), 6.53 (1H, dd, J = 8.9, 1.9 Hz), 6.98(2H, d, J = 8.8 Hz), 7.63 (1H, d, J = 8.9 Hz), 7.69 (2H, d, J = 8.8 Hz).II-142 1H-NMR (DMSO-d6) 1.33 (6H, d, J = 5.8 Hz), 2.96-3.02 (4H, m),3.11-3.16 (4H, m), 4.59 (2H, s), 4.62 (2H, s), 4.72-4.84 (1H, m), 6.56(1H, dd, J = 8.8, 2.2 Hz), 6.67 (1H, d, J = 2.2 Hz), 6.90 (1H, d, J =8.8 Hz), 7.17 (2H, d, J = 8.8 Hz), 7.70 (2H, d, J = 8.8 Hz). II-143 [M +H]+ = 492

Moreover, compounds in Tables 42-47 can be prepared in the same manneras set forth above.

TABLE 42 Comd. No. Structure IV-1

IV-2

IV-3

IV-4

IV-5

TABLE 43 Comd. No. Structure IV-6

IV-7

IV-8

IV-9

IV-10

TABLE 44 Comd. No. Structure IV-11

IV-12

IV-13

IV-14

IV-15

TABLE 45 Comp. No. Structure V-1

V-2

V-3

V-4

V-5

V-6

V-7

V-8

V-9

V-10

V-11

V-12

V-13

V-14

V-15

V-16

V-17

V-18

TABLE 46 Comp. No. Structure V-19

V-20

V-21

V-22

V-23

V-24

V-25

V-26

V-27

V-28

V-29

V-30

V-31

V-32

TABLE 47 Comp. No. Structure V-33

V-34

V-35

V-36

Also, compounds of the formula (IA):

wherein Z¹ is CR^(2B) or N; Z² is CR^(4B) or N; R^(2B), R^(2C), R^(2D)and R^(2E) are independently a hydrogen atom, a fluorine atom, achlorine atom, a bromine atom, methyl, ethyl, allyl, propargyl,trifluoromethyl, methyloxy, difluoromethyloxy, methylthio,methylsulfonyl, phenyl, phenoxy, phenylthio, amino, methylamino,dimethylamino, methylcarbonylamino, methylsulfonylamino, nitro, cyano,methylcarbonyl, N-methylcarbamoyl, N-phenylcarbamoyl, 2-furyl, 2-thenyl,2-pyridyl, 1,3-oxazol-2-yl, 1,3-oxazol-4-yl, 1,3-oxazol-5-yl,1,3-thiazol-2-yl, 1,3-thiazol-4-yl, 1,3-thiazol-5-yl,1,3,4-oxadiazol-2-yl, 1,3,4-thiadiazol-2-yl, imidazol-1-yl,pyrazol-1-yl, morpholino, pyrrolidino or piperizino; R³ is methyloxy,ethyloxy, isopropyloxy, sec-butyloxy, difluoromethyloxy,1-phenylethyloxy, phenoxy, methylthio, ethylthio, isopropylthio,sec-butylthio, difluoromethylthio, 1-phenylethylthio or phenylthio;R^(4A), R^(4B), Roc and R^(4D) are independently a hydrogen atom, afluorine atom, a chlorine atom, methyl or methyloxy; L³ is a singlebond, methylene, 1,1-dimethylmethylene, ethylene, CH═CH—CH₂ —,1-propylene-1,3-diynel, —O—CH₂—, —O—CH(Me)-, —O—C(Me)₂-, —S—CH₂— or—NH—CH₂—;

can be prepared in the same manner as set forth above.

A combination of Z¹, R^(2C), R^(2D) and R^(2E) (part A) is shown inTables 48-53. -L³-COOH (part B) is shown in Table 54. A combination ofR^(4A), Z², R^(4C), R^(4D) (part C) is shown in Tables 55-60.

TABLE 48 No. Z¹ R^(2C) R^(2D) R^(2E) A-1 CH H H H A-2 CH F H H A-3 CH ClH H A-4 CH Br H H A-5 CH Me H H A-6 CH Et H H A-7 CH allyl H H A-8 CHpropargyl H H A-9 CH CF3 H H A-10 CH OMe H H A-11 CH OCHF2 H H A-12 CHSMe H H A-13 CH SO2Me H H A-14 CH Ph H H A-15 CH OPh H H A-16 CH SPh H HA-17 CH NH2 H H A-18 CH NHMe H H A-19 CH NMe2 H H A-20 CH NHCOMe H HA-21 CH NHSO2Me H H A-22 CH NO2 H H A-23 CH CN H H A-24 CH COMe H H A-25CH CONHMe H H A-26 CH CONHPh H H A-27 CH 2-furyl H H A-28 CH 2-thienyl HH A-29 CH 2-pyridyl H H A-30 CH 1,3-oxazol-2-yl H H A-31 CH1,3-oxazol-4-yl H H A-32 CH 1,3-oxazol-5-yl H H A-33 CH 1,3-thiazol-2-ylH H A-34 CH 1,3-thiazol-4-yl H H A-35 CH 1,3-thiazol-5-yl H H A-36 CH1,3,4-oxadiazol-2-yl H H A-37 CH 1,3,4-thiadiazol-2-yl H H A-38 CHimidazol-1-yl H H A-39 CH pyrazol-1-yl H H A-40 CH morpholino H H A-41CH pyrrolidino H H A-42 CH piperidino H H A-43 CH piperazino H H A-44 CHH F H A-45 CH H Cl H

TABLE 49 No. Z¹ R^(2C) R^(2D) R^(2E) A-46 CH H Br H A-47 CH H Me H A-48CH H Et H A-49 CH H allyl H A-50 CH H propargyl H A-51 CH H CF3 H A-52CH H OMe H A-53 CH H OCHF2 H A-54 CH H SMe H A-55 CH H SO2Me H A-56 CH HPh H A-57 CH H OPh H A-58 CH H SPh H A-59 CH H NH2 H A-60 CH H NMe2 HA-61 CH H NHCOMe H A-62 CH H NHSO2Me H A-63 CH H NO2 H A-64 CH H CN HA-65 CH H COMe H A-66 CH H CONHMe H A-67 CH H CONHPh H A-68 CH H 2-furylH A-69 CH H 2-thienyl H A-70 CH H 2-pyridyl H A-71 CH H 1,3-oxazol-2-ylH A-72 CH H 1,3-oxazol-4-yl H A-73 CH H 1,3-oxazol-5-yl H A-74 CH H1,3-thiazol-2-yl H A-75 CH H 1,3-thiazol-4-yl H A-76 CH H1,3-thiazol-5-yl H A-77 CH H 1,3,4-oxadiazol-2-yl H A-78 CH H1,3,4-thiadiazol-2-yl H A-79 CH H imidazol-1-yl H A-80 CH H pyrazol-1-ylH A-81 CH H morpholino H A-82 CH H pyrrolidino H A-83 CH H piperidino HA-84 CH H piperazino H A-85 CH H H F A-86 CH H H Cl A-87 CH H H Br A-88CH H H Me A-89 CH H H Et A-90 CH H H allyl

TABLE 50 No. Z¹ R^(2C) R^(2D) R^(2E) A-91 CH H H propargyl A-92 CH H HCF3 A-93 CH H H OMe A-94 CH H H OCHF2 A-95 CH H H SMe A-96 CH H H SO2MeA-97 CH H H Ph A-98 CH H H OPh A-99 CH H H SPh A-100 CH H H NH2 A-101 CHH H NHMe A-102 CH H H NMe2 A-103 CH H H NHCOMe A-104 CH H H NHSO2MeA-105 CH H H NO2 A-106 CH H H CN A-107 CH H H COMe A-108 CH H H CONHMeA-109 CH H H CONHPh A-110 CH H H 2-furyl A-111 CH H H 2-thienyl A-112 CHH H 2-pyridyl A-113 CH H H 1,3-oxazol-2-yl A-114 CH H H 1,3-oxazol-4-ylA-115 CH H H 1,3-oxazol-5-yl A-116 CH H H 1,3-thiazol-2-yl A-117 CH H H1,3-thiazol-4-yl A-118 CH H H 1,3-thiazol-5-yl A-119 CH H H1,3,4-oxadiazol-2-yl A-120 CH H H 1,3,4-thiadiazol-2-yl A-121 CH H Himidazol-1-yl A-122 CH H H pyrazol-1-yl A-123 CH H H morpholino A-124 CHH H pyrrolidino A-125 CH H H piperidino A-126 CH H H piperazino A-127 NCl H H A-128 N Br H H A-129 N OMe H H A-130 N NO 2 H H A-131 N CN H HA-132 N CONHMe H H A-133 N 2-furyl H H A-134 N 2-thienyl H H A-135 N1,3-oxazol-2-yl H H

TABLE 51 No. Z¹ R^(2C) R^(2D) R^(2E) A-136 N 1,3-oxazol-4-yl H H A-137 N1,3-oxazol-5-yl H H A-138 N 1,3-thiazol-2-yl H H A-139 N1,3-thiazol-4-yl H H A-140 N 1,3-thiazol-5-yl H H A-141 N1,3,4-oxadiazol-2-yl H H A-142 N 1,3,4-thiadiazol-2-yl H H A-143 Nimidazol-1-yl H H A-144 N pyrazol-1-yl H H A-145 N morpholino H H A-146N pyrrolidino H H A-147 N piperidino H H A-148 N piperazino H H A-149 N2-thienyl H H A-150 N 2-pyridyl H H A-151 N morpholino H H A-152 Npyrrolidino H H A-153 N piperidino H H A-154 CH Cl Cl H A-155 CH Br Cl HA-156 CH OMe Cl H A-157 CH NO2 Cl H A-158 CH CN Cl H A-159 CH CONHMe ClH A-160 CH 2-furyl Cl H A-161 CH 2-thienyl Cl H A-162 CH 1,3-oxazol-2-ylCl H A-163 CH 1,3-oxazol-4-yl Cl H A-164 CH 1,3-oxazol-5-yl Cl H A-165CH 1,3-thiazol-2-yl Cl H A-166 CH 1,3-thiazol-4-yl Cl H A-167 CH1,3-thiazol-5-yl Cl H A-168 CH 1,3,4-oxadiazol-2-yl Cl H A-169 CH1,3,4-thiadiazol-2-yl Cl H A-170 CH imidazol-1-yl Cl H A-171 CHpyrazol-1-yl Cl H A-172 CH morpholino Cl H A-173 CH pyrrolidino Cl HA-174 CH piperidino Cl H A-175 CH piperazino Cl H A-176 CH Cl Cl H A-177CH Br Cl H A-178 CH OMe Cl H A-179 CH NO2 Cl A-180 CH CN Cl H

TABLE 52 No. Z¹ R^(2C) R^(2D) R^(2E) A-181 CH CONHMe Cl H A-182 CH2-furyl Cl H A-183 CH 2-thienyl Cl H A-184 CH 1,3-oxazol-2-yl Cl H A-185CH 1,3-oxazol-4-yl Cl H A-186 CH 1,3-oxazol-5-yl Cl H A-187 CH1,3-thiazol-2-yl Cl H A-188 CH 1,3-thiazol-4-yl Cl H A-189 CH1,3-thiazol-5-yl Cl H A-190 CH 1,3,4-oxadiazol-2-yl Cl H A-191 CH1,3,4-thiadiazol-2-yl Cl H A-192 CH imidazol-1-yl Cl H A-193 CHpyrazol-1-yl Cl H A-194 CH morpholino Cl H A-195 CH pyrrolidino Cl HA-196 CH piperidino Cl H A-197 CH piperazino Cl H A-198 CH Cl H Cl A-199CH Br H Cl A-200 CH OMe H Cl A-201 CH NO2 H Cl A-202 CH CN H Cl A-203 CHCONHMe H Cl A-204 CH 2-furyl H Cl A-205 CH 2-thienyl H Cl A-206 CH1,3-oxazol-2-yl H Cl A-207 CH 1,3-oxazol-4-yl H Cl A-208 CH1,3-oxazol-5-yl H Cl A-209 CH 1,3-thiazol-2-yl H Cl A-210 CH1,3-thiazol-4-yl H Cl A-211 CH 1,3-thiazol-5-yl H Cl A-212 CH1,3,4-oxadiazol-2-yl H Cl A-213 CH 1,3,4-thiadiazol-2-yl H Cl A-214 CHimidazol-1-yl H Cl A-215 CH pyrazol-1-yl H Cl A-216 CH morpholino H ClA-217 CH pyrrolidino H Cl A-218 CH piperidino H Cl A-219 CH piperazino HCl A-220 CH Cl Me H A-221 CH Br Me H A-222 CH OMe Me H A-223 CH NO2 Me HA-224 CH CN Me H A-225 CH CONHMe Me H

TABLE 53 No. Z¹ R^(2C) R^(2D) R^(2E) A-226 CH 2-furyl Me H A-227 CH2-thienyl Me H A-228 CH 1,3-oxazol-2-yl Me H A-229 CH 1,3-oxazol-4-yl MeH A-230 CH 1,3-oxazol-5-yl Me H A-231 CH 1,3-thiazol-2-yl Me H A-232 CH1,3-thiazol-4-yl Me H A-233 CH 1,3-thiazol-5-yl Me H A-234 CH1,3,4-oxadiazol-2-yl Me H A-235 CH 1,3,4-thiadiazol-2-yl Me H A-236 CHimidazol-1-yl Me H A-237 CH pyrazol-1-yl Me H A-238 CH morpholino Me HA-239 CH pyrrolidino Me H A-240 CH piperidino Me H A-241 CH piperazinoMe H A-242 CH Cl H Me A-243 CH Br H Me A-244 CH OMe H Me A-245 CH NO2 HMe A-246 CH CN H Me A-247 CH CONHMe H Me A-248 CH 2-furyl H Me A-249 CH2-thienyl H Me A-250 CH 1,3-oxazol-2-yl H Me A-251 CH 1,3-oxazol-4-yl HMe A-252 CH 1,3-oxazol-5-yl H Me A-253 CH 1,3-thiazol-2-yl H Me A-254 CH1,3-thiazol-4-yl H Me A-255 CH 1,3-thiazol-5-yl H Me A-256 CH1,3,4-oxadiazol-2-yl H Me A-257 CH 1,3,4-thiadiazol-2-yl H Me A-258 CHimidazol-1-yl H Me A-259 CH pyrazol-1-yl H Me A-260 CH morpholino H MeA-261 CH pyrrolidino H Me A-262 CH 4-Me-1,3-oxazol-2-yl H Me A-263 CH5-Me-1,3-oxazol-4-yl H Me A-264 CH 2-Me-1,3-oxazol-5-yl H Me A-265 CH4-Me-1,3-thiazol-2-yl H Me A-266 CH 5-Me-1,3-thiazol-4-yl H Me A-267 CH2-Me-1,3-thiazol-5-yl H Me A-268 CH 5-Me-1,3,4-oxadiazol-2-yl H Me A-269CH 5-Me1,3,4-thiadiazol-2-yl H Me A-270 CH 5-Me-1,3-oxazol-2-yl H Me

TABLE 54 No. L³-COOH No. L³-COOH B-1 —COOH B-2 —CH₂COOH B-3 —C(Me)₂COOHB-4 —CH₂CH₂COOH B-5 —CH═CH—COOH B-6 —C≡C—COOH B-7 —OCH₂COOH B-8—OC(Me)₂COOH B-9 —SCH₂COOH B-10 —NHCH₂COOH

TABLE 55 No. R³ R^(4A) Z² R^(4C) R^(4D) C-1 OMe H C—H H H C-2 OMe H C—HH F C-3 OMe H C—H H Cl C-4 OMe H C—H H Me C-5 OMe H C—H F H C-6 OMe HC—H Cl H C-7 OMe H C—H Me H C-8 OEt H C—H H H C-9 OEt H C—H H F C-10 OEtH C—H H Cl C-11 OEt H C—H H Me C-12 OEt H C—H F H C-13 OEt H C—H Cl HC-14 OEt H C—H Me H C-15 OCHMe₂ H C—H H H C-16 OCHMe₂ H C—H H F C-17OCHMe₂ H C—H H Cl C-18 OCHMe₂ H C—H H Me C-19 OCHMe₂ H C—H F H C-20OCHMe₂ H C—H F F C-21 OCHMe₂ H C—H F Cl C-22 OCHMe₂ H C—H F Me C-23OCHMe₂ H C—H Cl H C-24 OCHMe₂ H C—H Cl F C-25 OCHMe₂ H C—H Cl Cl C-26OCHMe₂ H C—H Cl Me C-27 OCHMe₂ H C—H Me H C-28 OCHMe₂ H C—H Me F C-29OCHMe₂ H C—H Me Cl C-30 OCHMe₂ H C—H Me Me C-31 OCHMe₂ H C—F H F C-32OCHMe₂ H C—F H Cl C-33 OCHMe₂ H C—F H Me C-34 OCHMe₂ H C—F F H C-35OCHMe₂ H C—F Cl H C-36 OCHMe₂ H C—F Me H C-37 OCHMe₂ H C—Cl H F C-38OCHMe₂ H C—Cl H Cl C-39 OCHMe₂ H C—Cl H Me C-40 OCHMe₂ H C—Cl Cl H

TABLE 56 No. R³ R^(4A) Z² R^(4C) R^(4D) C-41 OCHMe₂ H C—Cl Me H C-42OCHMe₂ H C—Me H F C-43 OCHMe₂ H C—Me H Cl C-44 OCHMe₂ H C—Me H Me C-45OCHMe₂ H C—Me Me H C-46 OCHMe₂ F C—H H F C-47 OCHMe₂ F C—H H Cl C-48OCHMe₂ F C—H H Me C-49 OCHMe₂ Cl C—H H Cl C-50 OCHMe₂ Cl C—H H Me C-51OCHMe₂ Me C—H H Me C-52 OCHMe₂ H N H H C-53 OCHMe₂ H N H F C-54 OCHMe₂ HN H Cl C-55 OCHMe₂ H N H Me C-56 OCHMe₂ H N F H C-57 OCHMe₂ H N Cl HC-58 OCHMe₂ H N Me H C-59 OCHMe₂ F N H H C-60 OCHMe₂ Cl N H H C-61OCHMe₂ Me N H H C-62 OCHMe(Et) H C—H H H C-63 OCHMe(Et) H C—H H F C-64OCHMe(Et) H C—H H Cl C-65 OCHMe(Et) H C—H H Me C-66 OCHMe(Et) H C—H F HC-67 OCHMe(Et) H C—H F F C-68 OCHMe(Et) H C—H F Cl C-69 OCHMe(Et) H C—HF Me C-70 OCHMe(Et) H C—H Cl H C-71 OCHMe(Et) H C—H Cl F C-72 OCHMe(Et)H C—H Cl Cl C-73 OCHMe(Et) H C—H Cl Me C-74 OCHMe(Et) H C—H Me H C-75OCHMe(Et) H C—H Me F C-76 OCHMe(Et) H C—H Me Cl C-77 OCHMe(Et) H C—H MeMe C-78 OCHMe(Et) H C—F H F C-79 OCHMe(Et) H C—F H Cl C-80 OCHMe(Et) HC—F H Me

TABLE 57 No. R³ R^(4A) Z² R^(4C) R^(4D) C-81 OCHMe(Et) H C—F F H C-82OCHMe(Et) H C—F Cl H C-83 OCHMe(Et) H C—F Me H C-84 OCHMe(Et) H C—Cl H FC-85 OCHMe(Et) H C—Cl H Cl C-86 OCHMe(Et) H C—Cl H Me C-87 OCHMe(Et) HC—Cl Cl H C-88 OCHMe(Et) H C—Cl Me H C-89 OCHMe(Et) H C—Me H F C-90OCHMe(Et) H C—Me H Cl C-91 OCHMe(Et) H C—Me H Me C-92 OCHMe(Et) H C—MeMe H C-93 OCHMe(Et) F C—H H F C-94 OCHMe(Et) F C—H H Cl C-95 OCHMe(Et) FC—H H Me C-96 OCHMe(Et) Cl C—H H Cl C-97 OCHMe(Et) Cl C—H H Me C-98OCHMe(Et) H C—H Me Cl C-99 OCHMe(Et) H C—H Me Me C-100 OCHMe(Et) H C—F HF C-101 OCHMe(Et) H C—F H Cl C-102 OCHMe(Et) H C—F H Me C-103 OCHMe(Et)H C—F F H C-104 OCHMe(Et) H C—F Cl H C-105 OCHMe(Et) H C—F Me H C-106OCHMe(Et) H C—Cl H F C-107 OCHMe(Et) H C—Cl H Cl C-108 OCHMe(Et) H C—ClH Me C-109 OCHMe(Et) H C—Cl Cl H C-110 OCHMe(Et) H C—Cl Me H C-111OCHMe(Et) H C—Me H F C-112 OCHMe(Et) H C—Me H Cl C-113 OCHMe(Et) H C—MeH Me C-114 OCHMe(Et) H C—Me Me H C-115 OCHMe(Et) F C—H H F C-116OCHMe(Et) F C—H H Cl C-117 OCHMe(Et) F C—H H Me C-118 OCHMe(Et) Cl C—H HCl C-119 OCHMe(Et) Cl C—H H Me C-120 OCHMe(Et) Me C—H H Me

TABLE 58 No. R³ R^(4A) Z² R^(4C) R^(4D) C-121 OCHMe(Et) H N H H C-122OCHMe(Et) H N H F C-123 OCHMe(Et) H N H Cl C-124 OCHMe(Et) H N H MeC-125 OCHMe(Et) H N F H C-126 OCHMe(Et) H N Cl H C-127 OCHMe(Et) H N MeH C-128 OCHMe(Et) F N H H C-129 OCHMe(Et) Cl N H H C-130 OCHMe(Et) Me NH H C-131 OCHF₂ H C—H H H C-132 OCHF₂ H C—H H F C-133 OCHF₂ H C—H H ClC-134 OCHF₂ H C—H H Me C-135 OCHF₂ H C—H F H C-136 OCHF₂ H C—H Cl HC-137 OCHF₂ H C—H Me H C-138 OCHMe(Ph) H C—H H H C-139 OCHMe(Ph) H C—H HF C-140 OCHMe(Ph) H C—H H Cl C-141 OCHMe(Ph) H C—H H Me C-142 OCHMe(Ph)H C—H F H C-143 OCHMe(Ph) H C—H Cl H C-144 OCHMe(Ph) H C—H Me H C-145OPh H C—H H H C-146 OPh H C—H H F C-147 OPh H C—H H Cl C-148 OPh H C—H HMe C-149 OPh H C—H F H C-150 OPh H C—H Cl H C-151 OPh H C—H Me H C-152SMe H C—H H H C-153 SMe H C—H H F C-154 SMe H C—H H Cl C-155 SMe H C—H HMe C-156 SMe H C—H F H C-157 SMe H C—H Cl H C-158 SMe H C—H Me H C-159SEt H C—H H H C-160 SEt H C—H H F

TABLE 59 No. R³ R^(4A) Z² R^(4C) R^(4D) C-161 SEt H C—H H Cl C-162 SEt HC—H H Me C-163 SEt H C—H F H C-164 SEt H C—H Cl H C-165 SEt H C—H Me HC-166 SCHMe₂ H C—H H H C-167 SCHMe₂ H C—H H F C-168 SCHMe₂ H C—H H ClC-169 SCHMe₂ H C—H H Me C-170 SCHMe₂ H C—H F H C-171 SCHMe₂ H C—H Cl HC-172 SCHMe₂ H C—H Me H C-173 SCHMe(Et) H C—H H H C-174 SCHMe(Et) H C—HH F C-175 SCHMe(Et) H C—H H Cl C-176 SCHMe(Et) H C—H H Me C-177SCHMe(Et) H C—H F H C-178 SCHMe(Et) H C—H Cl H C-179 SCHMe(Et) H C—H MeH C-180 SCHF₂ H C—H H H C-181 SCHF₂ H C—H H F C-182 SCHF₂ H C—H H ClC-183 SCHF₂ H C—H H Me C-184 SCHF₂ H C—H F H C-185 SCHF₂ H C—H Cl HC-186 SCHF₂ H C—H Me H C-187 SCHMe(Ph) H C—H H H C-188 SCHMe(Ph) H C—H HF C-189 SCHMe(Ph) H C—H H Cl C-190 SCHMe(Ph) H C—H H Me C-191 SCHMe(Ph)H C—H F H C-192 SCHMe(Ph) H C—H Cl H C-193 SCHMe(Ph) H C—H Me H C-194SPh H C—H H H C-195 SPh H C—H H F C-196 SPh H C—H H Cl C-197 SPh H C—H HMe C-198 SPh H C—H F H C-199 SPh H C—H Cl H C-200 SPh H C—H Me H

TABLE 60 No. R³ R^(4A) Z² R^(4C) R^(4D) C-201 OCHMe₂ H N H H C-202OCHMe₂ H N H F C-203 OCHMe₂ H N H Cl C-204 OCHMe₂ H N H Me C-205 OCHMe₂H N F H C-206 OCHMe₂ H N Cl H C-207 OCHMe₂ H N Me H C-208 SCHMe₂ H N H HC-209 SCHMe₂ H N H F C-210 SCHMe₂ H N H Cl C-211 SCHMe₂ H N H Me C-212SCHMe₂ H N F H C-213 SCHMe₂ H N Cl H C-214 SCHMe₂ H N Me H

A compound of the formula (IA) is shown below.

(Compound No., part A, part B, part C), (IA-1, A-1, B-7, C-15), (IA-2,A-1, B-7, C-52), (IA-3, A-1, B-10, C-15), (IA-4, A-1, B-10, C-52),(IA-5, A-2, B-7, C-15), (IA-6, A-2, B-7, C-52), (IA-7, A-2, B-10, C-15),(IA-8, A-2, B-10, C-52), (IA-9, A-3, B-7, C-15), (IA-10, A-15), (IA-14,A-4, B-7, C-52), (IA-15, A-4, B-10, C-15), (IA-16, A-4, B-10, C-52),(IA-17, A-5, B-7, C-15), (IA-18, A-5, B-7, C-52), (IA-19, A-5, B-10,C-15), (IA-20, A-5, B-10, C-52), (IA-21, A-6, B-7, C-15), (IA-22, A-6,B-7, C-52), (IA-23, A-6, B-10, C-15), (IA-24, A-6, B-10, C-52), (IA-25,A-7, B-7, C-15), (IA-26, A-7, B-7, C-52), (IA-27, A-7, B-10, C-15),(IA-28, A-7, B-10, C-52), (IA-29, A-8, B-7, C-15), (IA-30, A-8, B-7,C-52), (IA-31, A-8, B-10, C-15), (IA-32, A-8, B-10, C-52), (IA-33, A-9,B-7, C-15), (IA-34, A-9, B-7, C-52), (IA-35, A-9, B-10, C-15), (IA-36,A-9, B-10, C-52), (IA-37, A-10, B-7, C-15), (IA-38, A-10, B-7, C-52),(IA-39, A-10, B-10, C-15), (IA-40, A-10, B-10, C-52), (IA-41, A-11, B-7,C-15), (IA-42, A-11, B-7, C-52), (IA-43, A-11, B-10, C-15), (IA-44,A-11, B-10, C-52), (IA-45, A-12, B-7, C-15), (IA-46, A-12, B-7, C-52),(IA-47, A-12, B-10, C-15), (IA-48, A-12, B-10, C-52), (IA-49, A-13, B-7,C-15), (IA-50, A-13, B-7, C-52), (IA-51, A-13, B-10, C-15), (IA-52,A-13, B-10, C-52), (IA-53, A-14, B-7, C-15), (IA-54, A-14, B-7, C-52),(IA-55, A-14, B-10, C-15), (IA-56, A-14, B-10, C-52), (IA-57, A-15, B-7,C-15), (IA-58, A-15, B-7, C-52), (IA-59, A-15, B-10, C-15), (IA-60,A-15, B-10, C-52), (IA-61, A-16, B-7, C-15), (IA-62, A-16, B-7, C-52),(IA-63, A-16, B-10, C-15), (IA-64, A-16, B-10, C-52), (IA-65, A-17, B-7,C-15), (IA-66, A-17, B-7, C-52), (IA-67, A-17, B-10, C-15), (IA-68,A-17, B-10, C-52), (IA-69, A-18, B-7, C-15), (IA-70, A-18, B-7, C-52),(IA-71, A-18, B-10, C-15), (IA-72, A-18, B-10, C-52), (IA-73, A-19, B-7,C-15), (IA-74, A-19, B-7, C-52), (IA-75, A-19, B-10, C-15), (IA-76,A-19, B-10, C-52), (IA-77, A-20, B-7, C-15), (IA-78, A-20, B-7, C-52),(IA-79, A-20, B-10, C-15), (IA-80, A-20, B-10, C-52), (IA-81, A-21, B-7,C-15), (IA-82, A-21, B-7, C-52), (IA-83, A-21, B-10, C-15), (IA-84,A-21, B-10, C-52), (IA-85, A-22, B-7, C-15), (IA-86, A-22, B-7, C-52),(IA-87, A-22, B-10, C-15), (IA-88, A-22, B-10, C-52), (IA-89, A-23, B-7,C-15), (IA-90, A-23, B-7, C-52), (LA-91, A-23, B-10, C-15), (IA-92,A-23, B-10, C-52), (IA-93, A-24, B-7, C-15), (IA-94, A-24, B-7, C-52),(IA-95, A-24, B-10, C-15), (IA-96, A-24, B-10, C-52), (LA-97, A-25, B-7,C-15), (IA-98, A-25, B-7, C-52), (IA-99, A-25, B-10, C-15), (IA-100,A-25, B-10, C-52), (IA-101, A-26, B-7, C-15), (IA-102, A-26, B-7, C-52),(IA-103, A-26, B-10, C-15), (IA-104, A-26, B-10, C-52), (IA-105, A-27,B-7, C-15), (IA-106, A-27, B-7, C-52), (IA-107, A-27, B-10, C-15),(IA-108, A-27, B-10, C-52), (IA-109, A-28, B-7, C-15), (IA-110, A-28,B-7, C-52), (IA-111, A-28, B-10, C-15), (IA-112, A-28, B-10, C-52),(IA-113, A-29, B-7, C-15), (IA-114, A-29, B-7, C-52), (IA-115, A-29,B-10, C-15), (IA-116, A-29, B-10, C-52), (IA-117, A-30, B-7, C-15),(IA-118, A-30, B-7, C-52), (IA-119, A-30, B-10, C-15), (IA-120, A-30,B-10, C-52), (IA-121, A-31, B-7, C-15), (IA-122, A-31, B-7, C-52),(IA-123, A-31, B-10, C-15), (IA-124, A-31, B-10, C-52), (IA-125, A-32,B-7, C-15), (IA-126, A-32, B-7, C-52), (IA-127, A-32, B-10, C-15),(IA-128, A-32, B-10, C-52), (IA-129, A-33, B-7, C-15), (IA-130, A-33,B-7, C-52), (IA-131, A-33, B-10, C-15), (IA-132, A-33, B-10, C-52),(IA-133, A-34, B-7, C-15), (IA-134, A-34, B-7, C-52), (IA-135, A-34,B-10, C-15), (IA-136, A-34, B-10, C-52), (IA-137, A-35, B-7, C-15),(IA-138, A-35, B-7, C-52), (IA-139, A-35, B-10, C-15), (IA-140, A-35,B-10, C-52), (IA-141, A-36, B-7, C-15), (IA-142, A-36, B-7, C-52),(IA-143, A-36, B-10, C-15), (IA-144, A-36, B-10, C-52), (IA-145, A-37,B-7, C-15), (IA-146, A-37, B-7, C-52), (IA-147, A-37, B-10, C-15),(IA-148, A-37, B-10, C-52), (IA-149, A-38, B-7, C-15), (IA-150, A-38,B-7, C-52), (IA-151, A-38, B-10, C-15), (IA-152, A-38, B-10, C-52),(IA-153, A-39, B-7, C-15), (IA-154, A-39, B-7, C-52), (IA-155, A-39,B-10, C-15), (IA-156, A-39, B-10, C-52), (IA-157, A-40, B-7, C-15),(IA-158, A-40, B-7, C-52), (IA-159, A-40, B-10, C-15), (IA-160, A-40,B-10, C-52), (IA-161, A-41, B-7, C-15), (IA-162, A-41, B-7, C-52),(IA-163, A-41, B-10, C-15), (IA-164, A-41, B-10, C-52), (IA-165, A-42,B-7, C-15), (IA-166, A-42, B-7, C-52), (IA-167, A-42, B-10, C-15),(IA-168, A-42, B-10, C-52), (IA-169, A-43, B-7, C-15), (IA-170, A-43,B-7, C-52), (IA-171, A-43, B-10, C-15), (IA-172, A-43, B-10, C-52),(IA-173, A-44, B-7, C-15), (IA-174, A-44, B-10, C-15), (IA-175, A-45,B-7, C-15), (IA-176, A-45, B-10, C-15), (IA-177, A-46, B-7, C-15),(IA-178, A-46, B-10, C-15), (IA-179, A-47, B-7, C-15), (IA-180, A-47,B-10, C-15), (IA-181, A-48, B-7, C-15), (IA-182, A-48, B-10, C-15),(IA-183, A-49, B-7, C-15), (IA-184, A-49, B-10, C-15), (IA-185, A-50,B-7, C-15), (IA-186, A-50, B-10, C-15), (IA-187, A-51, B-7, C-15),(IA-188, A-51, B-10, C-15), (IA-189, A-52, B-7, C-15), (IA-190, A-52,B-10, C-15), (IA-191, A-53, B-7, C-15), (IA-192, A-53, B-10, C-15),(IA-193, A-54, B-7, C-15), (IA-194, A-54, B-10, C-15), (IA-195, A-55,B-7, C-15), (IA-196, A-55, B-10, C-15), (IA-197, A-56, B-7, C-15),(IA-198, A-56, B-10, C-15), (IA-199, A-57, B-7, C-15), (IA-200, A-57,B-10, C-15), (IA-201, A-58, B-7, C-15), (IA-202, A-58, B-10, C-15),(IA-203, A-59, B-7, C-15), (IA-204, A-59, B-10, C-15), (IA-205, A-60,B-7, C-15), (IA-206, A-60, B-10, C-15), (IA-207, A-61, B-7, C-15),(IA-208, A-61, B-10, C-15), (IA-209, A-62, B-7, C-15), (IA-210, A-62,B-10, C-15), (IA-211, A-63, B-7, C-15), (IA-212, A-63, B-10, C-15),(IA-213, A-64, B-7, C-15), (IA-214, A-64, B-10, C-15), (IA-215, A-65,B-7, C-15), (IA-216, A-65, B-10, C-15), (IA-217, A-66, B-7, C-15),(IA-218, A-66, B-10, C-15), (IA-219, A-67, B-7, C-15), (IA-220, A-67,B-10, C-15), (IA-221, A-68, B-7, C-15), (IA-222, A-68, B-10, C-15),(IA-223, A-69, B-7, C-15), (IA-224, A-69, B-10, C-15), (IA-225, A-70,B-7, C-15), (IA-226, A-70, B-10, C-15), (IA-227, A-71, B-7, C-15),(IA-228, A-71, B-10, C-15), (IA-229, A-72, B-7, C-15), (IA-230, A-72,B-10, C-15), (IA-231, A-73, B-7, C-15), (IA-232, A-73, B-10, C-15),(IA-233, A-74, B-7, C-15), (IA-234, A-74, B-10, C-15), (IA-235, A-75,B-7, C-15), (IA-236, A-75, B-10, C-15), (IA-237, A-76, B-7, C-15),(IA-238, A-76, B-10, C-15), (IA-239, A-77, B-7, C-15), (IA-240, A-77,B-10, C-15), (IA-241, A-78, B-7, C-15), (IA-242, A-78, B-10, C-15),(IA-243, A-79, B-7, C-15), (IA-244, A-79, B-10, C-15), (IA-245, A-80,B-7, C-15), (IA-246, A-80, B-10, C-15), (IA-247, A-81, B-7, C-15),(IA-248, A-81, B-10, C-15), (IA-249, A-82, B-7, C-15), (IA-250, A-82,B-10, C-15), (IA-251, A-83, B-7, C-15), (IA-252, A-83, B-10, C-15),(IA-253, A-84, B-7, C-15), (IA-254, A-84, B-10, C-15), (IA-255, A-85,B-7, C-15), (IA-256, A-85, B-10, C-15), (IA-257, A-86, B-7, C-15),(IA-258, A-86, B-10, C-15), (IA-259, A-87, B-7, C-15), (IA-260, A-87,B-10, C-15), (IA-261, A-88, B-7, C-15), (IA-262, A-88, B-10, C-15),(IA-263, A-89, B-7, C-15), (IA-264, A-89, B-10, C-15), (IA-265, A-90,B-7, C-15), (IA-266, A-90, B-10, C-15), (IA-267, A-91, B-7, C-15),(IA-268, A-91, B-10, C-15), (IA-269, A-92, B-7, C-15), (IA-270, A-92,B-10, C-15), (IA-271, A-93, B-7, C-15), (IA-272, A-93, B-10, C-15),(IA-273, A-94, B-7, C-15), (IA-274, A-94, B-10, C-15), (IA-275, A-95,B-7, C-15), (IA-276, A-95, B-10, C-15), (IA-277, A-96, B-7, C-15),(IA-278, A-96, B-10, C-15), (IA-279, A-97, B-7, C-15), (IA-280, A-97,B-10, C-15), (IA-281, A-98, B-7, C-15), (IA-282, A-98, B-10, C-15),(IA-283, A-99, B-7, C-15), (IA-284, A-99, B-10, C-15), (IA-285, A-100,B-7, C-15), (IA-286, A-100, B-10, C-15), (IA-287, A-101, B-7, C-15),(IA-288, A-101, B-10, C-15), (IA-289, A-102, B-7, C-15), (IA-290, A-102,B-10, C-15), (IA-291, A-103, B-7, C-15), (IA-292, A-103, B-10, C-15),(IA-293, A-104, B-7, C-15), (IA-294, A-104, B-10, C-15), (IA-295, A-105,B-7, C-15), (M-296, A-105, B-10, C-15), (IA-297, A-106, B-7, C-15),(IA-298, A-106, B-10, C-15), (IA-299, A-107, B-7, C-15), (IA-300, A-107,B-10, C-15), (IA-301, A-108, B-7, C-15), (IA-302, A-108, B-10, C-15),(IA-303, A-109, B-7, C-15), (IA-304, A-109, B-10, C-15), (IA-305, A-110,B-7, C-15), (IA-306, A-110, B-10, C-15), (IA-307, A-111, B-7, C-15),(IA-308, A-111, B-10, C-15), (IA-309, A-112, B-7, C-15), (IA-310, A-112,B-10, C-15), (IA-311, A-113, B-7, C-15), (IA-312, A-113, B-10, C-15),(IA-313, A-114, B-7, C-15), (IA-314, A-114, B-10, C-15), (IA-315, A-115,B-7, C-15), (IA-316, A-115, B-10, C-15), (IA-317, A-116, B-7, C-15),(IA-318, A-116, B-10, C-15), (IA-319, A-117, B-7, C-15), (IA-320, A-117,B-10, C-15), (IA-321, A-118, B-7, C-15), (IA-322, A-118, B-10, C-15),(IA-323, A-119, B-7, C-15), (IA-324, A-119, B-10, C-15), (IA-325, A-120,B-7, C-15), (IA-326, A-120, B-10, C-15), (IA-327, A-121, B-7, C-15),(IA-328, A-121, B-10, C-15), (IA-329, A-122, B-7, C-15), (IA-330, A-122,B-10, C-15), (IA-331, A-123, B-7, C-15), (IA-332, A-123, B-10, C-15),(IA-333, A-124, B-7, C-15), (IA-334, A-124, B-10, C-15), (IA-335, A-125,B-7, C-15), (IA-336, A-125, B-10, C-15), (IA-337, A-126, B-7, C-15),(IA-338, A-126, B-10, C-15), (IA-339, A-127, B-7, C-15), (IA-340, A-127,B-10, C-15), (IA-341, A-128, B-7, C-15), (IA-342, A-128, B-10, C-15),(IA-343, A-129, B-7, C-15), (IA-344, A-129, B-10, C-15), (IA-345, A-130,B-7, C-15), (IA-346, A-130, B-10, C-15), (IA-347, A-131, B-7, C-15),(IA-348, A-131, B-10, C-15), (IA-349, A-132, B-7, C-15), (IA-350, A-132,B-10, C-15), (IA-351, A-133, B-7, C-15), (IA-352, A-133, B-10, C-15),(IA-353, A-134, B-7, C-15), (IA-354, A-134, B-10, C-15), (IA-355, A-135,B-7, C-15), (IA-356, A-135, B-10, C-15), (IA-357, A-136, B-7, C-15),(IA-358, A-136, B-10, C-15), (IA-359, A-137, B-7, C-15), (IA-360, A-137,B-10, C-15), (IA-361, A-138, B-7, C-15), (IA-362, A-138, B-10, C-15),(IA-363, A-139, B-7, C-15), (IA-364, A-139, B-10, C-15), (IA-365, A-140,B-7, C-15), (IA-366, A-140, B-10, C-15), (IA-367, A-141, B-7, C-15),(IA-368, A-141, B-10, C-15), (IA-369, A-142, B-7, C-15), (IA-370, A-142,B-10, C-15), (IA-371, A-143, B-7, C-15), (IA-372, A-143, B-10, C-15),(IA-373, A-144, B-7, C-15), (IA-374, A-144, B-10, C-15), (IA-375, A-145,B-7, C-15), (IA-376, A-145, B-10, C-15), (IA-377, A-146, B-7, C-15),(IA-378, A-146, B-10, C-15), (IA-379, A-147, B-7, C-15), (IA-380, A-147,B-10, C-15), (IA-381, A-148, B-7, C-15), (IA-382, A-148, B-10, C-15),(IA-383, A-149, B-7, C-15), (IA-384, A-149, B-10, C-15), (IA-385, A-150,B-7, C-15), (IA-386, A-150, B-10, C-15), (IA-387, A-151, B-7, C-15),(IA-388, A-151, B-10, C-15), (IA-389, A-152, B-7, C-15), (IA-390, A-152,B-10, C-15), (IA-391, A-153, B-7, C-15), (IA-392, A-153, B-10, C-15),(IA-393, A-154, B-7, C-15), (IA-394, A-154, B-10, C-15), (IA-395, A-155,B-7, C-15), (IA-396, A-155, B-10, C-15), (IA-397, A-156, B-7, C-15),(IA-398, A-156, B-10, C-15), (IA-399, A-157, B-7, C-15), (IA-400, A-157,B-10, C-15), (IA-401, A-158, B-7, C-15), (IA-402, A-158, B-10, C-15),(IA-403, A-159, B-7, C-15), (IA-404, A-159, B-10, C-15), (IA-405, A-160,B-7, C-15), (IA-406, A-160, B-10, C-15), (IA-407, A-161, B-7, C-15),(IA-408, A-161, B-10, C-15), (IA-409, A-162, B-7, C-15), (IA-410, A-162,B-10, C-15), (IA-411, A-163, B-7, C-15), (IA-412, A-163, B-10, C-15),(IA-413, A-164, B-7, C-15), (IA-414, A-164, B-10, C-15), (IA-415, A-165,B-7, C-15), (IA-416, A-165, B-10, C-15), (IA-417, A-166, B-7, C-15),(IA-418, A-166, B-10, C-15), (IA-419, A-167, B-7, C-15), (IA-420, A-167,B-10, C-15), (IA-421, A-168, B-7, C-15), (IA-422, A-168, B-10, C-15),(IA-423, A-169, B-7, C-15), (IA-424, A-169, B-10, C-15), (IA-425, A-170,B-7, C-15), (IA-426, A-170, B-10, C-15), (IA-427, A-171, B-7, C-15),(IA-428, A-171, B-10, C-15), (IA-429, A-172, B-7, C-15), (IA-430, A-172,B-10, C-15), (IA-431, A-173, B-7, C-15), (IA-432, A-173, B-10, C-15),(IA-433, A-174, B-7, C-15), (IA-434, A-174, B-10, C-15), (IA-435, A-175,B-7, C-15), (IA-436, A-175, B-10, C-15), (IA-437, A-176, B-7, C-15),(IA-438, A-176, B-10, C-15), (IA-439, A-177, B-7, C-15), (IA-440, A-177,B-10, C-15), (IA-441, A-178, B-7, C-15), (IA-442, A-178, B-10, C-15),(IA-443, A-179, B-7, C-15), (IA-444, A-179, B-10, C-15), (IA-445, A-180,B-7, C-15), (IA-446, A-180, B-10, C-15), (IA-447, A-181, B-7, C-15),(IA-448, A-181, B-10, C-15), (IA-449, A-182, B-7, C-15), (IA-450, A-182,B-10, C-15), (IA-451, A-183, B-7, C-15), (IA-452, A-183, B-10, C-15),(IA-453, A-184, B-7, C-15), (IA-454, A-184, B-10, C-15), (IA-455, A-185,B-7, C-15), (IA-456, A-185, B-10, C-15), (IA-457, A-186, B-7, C-15),(IA-458, A-186, B-10, C-15), (IA-459, A-187, B-7, C-15), (IA-460, A-187,B-10, C-15), (IA-461, A-188, B-7, C-15), (IA-462, A-188, B-10, C-15),(IA-463, A-189, B-7, C-15), (IA-464, A-189, B-10, C-15), (IA-465, A-190,B-7, (IA-466, A-190, B-10, C-15), (IA-467, A-191, B-7, C-15), (IA-468,A-191, B-10, C-15), (IA-469, A-192, B-7, C-15), (IA-470, A-192, B-10,C-15), (IA-471, A-193, B-7, C-15), (IA-472, A-193, B-10, C-15), (IA-473,A-194, B-7, C-15), (IA-474, A-194, B-10, C-15), (IA-475, A-195, B-7,C-15), (IA-476, A-195, B-10, C-15), (IA-477, A-196, B-7, C-15), (IA-478,A-196, B-10, C-15), (IA-479, A-197, B-7, C-15), (IA-480, A-197, B-10,C-15), (IA-481, A-198, B-7, C-15), (IA-482, A-198, B-10, C-15), (IA-483,A-199, B-7, C-15), (IA-484, A-199, B-10, C-15), (IA-485, A-200, B-7,C-15), (IA-486, A-200, B-10, C-15), (IA-487, A-201, B-7, C-15), (IA-488,A-201, B-10, C-15), (IA-489, A-202, B-7, C-15), (IA-490, A-202, B-10,C-15), (IA-491, A-203, B-7, C-15), (IA-492, A-203, B-10, C-15), (IA-493,A-204, B-7, C-15), (IA-494, A-204, B-10, C-15), (IA-495, A-205, B-7,C-15), (IA-496, A-205, B-10, C-15), (IA-497, A-206, B-7, C-15), (IA-498,A-206, B-10, C-15), (IA-499, A-207, B-7, C-15), (IA-500, A-207, B-10,C-15), (IA-501, A-208, B-7, C-15), (IA-502, A-208, B-10, C-15), (IA-503,A-209, B-7, C-15), (IA-504, A-209, B-10, C-15), (IA-505, A-210, B-7,C-15), (IA-506, A-210, B-10, C-15), (IA-507, A-211, B-7, C-15), (IA-508,A-211, B-10, C-15), (IA-509, A-212, B-7, C-15), (IA-510, A-212, B-10,C-15), (IA-511, A-213, B-7, C-15), (IA-512, A-213, B-10, C-15), (IA-513,A-214, B-7, C-15), (IA-514, A-214, B-10, C-15), (IA-515, A-215, B-7,C-15), (IA-516, A-215, B-10, C-15), (IA-517, A-216, B-7, C-15), (IA-518,A-216, B-10, C-15), (IA-519, A-217, B-7, C-15), (IA-520, A-217, B-10,C-15), (IA-521, A-218, B-7, C-15), (IA-522, A-218, B-10, C-15), (IA-523,A-219, B-7, C-15), (IA-524, A-219, B-10, C-15), (IA-525, A-220, B-7,C-15), (IA-526, A-220, B-10, C-15), (IA-527, A-221, B-7, C-15), (IA-528,A-221, B-10, C-15), (IA-529, A-222, B-7, C-15), (IA-530, A-222, B-10,C-15), (IA-531, A-223, B-7, C-15), (IA-532, A-223, B-10, C-15), (IA-533,A-224, B-7, C-15), (IA-534, A-224, B-10, C-15), (IA-535, A-225, B-7,C-15), (IA-536, A-225, B-10, C-15), (IA-537, A-226, B-7, C-15), (IA-538,A-226, B-10, C-15), (IA-539, A-227, B-7, C-15), (IA-540, A-227, B-10,C-15), (IA-541, A-228, B-7, C-15), (IA-542, A-228, B-10, C-15), (IA-543,A-229, B-7, C-15), (IA-544, A-229, B-10, C-15), (IA-545, A-230, B-7,C-15), (IA-546, A-230, B-10, C-15), (IA-547, A-231, B-7, C-15), (IA-548,A-231, B-10, C-15), (IA-549, A-232, B-7, C-15), (IA-550, A-232, B-10,C-15), (IA-551, A-233, B-7, C-15), (IA-552, A-233, B-10, C-15), (IA-553,A-234, B-7, C-15), (IA-554, A-234, B-10, C-15), (IA-555, A-235, B-7,C-15), (IA-556, A-235, B-10, C-15), (IA-557, A-236, B-7, C-15), (IA-558,A-236, B-10, C-15), (IA-559, A-237, B-7, C-15), (IA-560, A-237, B-10,C-15), (IA-561, A-238, B-7, C-15), (IA-562, A-238, B-10, C-15), (IA-563,A-239, B-7, C-15), (IA-564, A-239, B-10, C-15), (IA-565, A-240, B-7,C-15), (IA-566, A-240, B-10, C-15), (IA-567, A-241, B-7, C-15), (IA-568,A-241, B-10, C-15), (IA-569, A-242, B-7, C-15), (IA-570, A-242, B-10,C-15), (IA-571, A-243, B-7, C-15), (IA-572, A-243, B-10, C-15), (IA-573,A-244, B-7, C-15), (IA-574, A-244, B-10, C-15), (IA-575, A-245, B-7,C-15), (IA-576, A-245, B-10, C-15), (IA-577, A-246, B-7, C-15), (IA-578,A-246, B-10, C-15), (IA-579, A-247, B-7, C-15), (IA-580, A-247, B-10,C-15), (IA-581, A-248, B-7, C-15), (IA-582, A-248, B-10, C-15), (IA-583,A-249, B-7, C-15), (IA-584, A-249, B-10, C-15), (IA-585, A-250, B-7,C-15), (IA-586, A-250, B-10, C-15), (IA-587, A-251, B-7, C-15), (IA-588,A-251, B-10, C-15), (IA-589, A-252, B-7, C-15), (IA-590, A-252, B-10,C-15), (IA-591, A-253, B-7, C-15), (IA-592, A-253, B-10, C-15), (IA-593,A-254, B-7, C-15), (IA-594, A-254, B-10, C-15), (IA-595, A-255, B-7,C-15), (IA-596, A-255, B-10, C-15), (IA-597, A-256, B-7, C-15), (IA-598,A-256, B-10, C-15), (IA-599, A-257, B-7, C-15), (IA-600, A-257, B-10,C-15), (IA-601, A-258, B-7, C-15), (IA-602, A-258, B-10, C-15), (IA-603,A-259, B-7, C-15), (IA-604, A-259, B-10, C-15), (IA-605, A-260, B-7,C-15), (IA-606, A-260, B-10, C-15), (IA-607, A-261, B-7, C-15), (IA-608,A-261, B-10, C-15), (IA-609, A-262, B-7, C-15), (IA-610, A-262, B-10,C-15), (IA-611, A-263, B-7, C-15), (IA-612, A-263, B-10, C-15), (IA-613,A-264, B-7, C-15), (IA-614, A-264, B-10, C-15), (IA-615, A-265, B-7,C-15), (IA-616, A-265, B-10, C-15), (IA-617, A-266, B-7, C-15), (IA-618,A-266, B-10, C-15), (IA-619, A-267, B-7, C-15), (IA-620, A-267, B-10,C-15), (IA-621, A-268, B-7, C-15), (IA-622, A-268, B-10, C-15), (IA-623,A-269, B-7, C-15), (IA-624, A-269, B-10, C-15), (IA-625, A-270, B-7,C-15), (IA-626, A-270, B-10, C-15)

A compound of the formula (IB)

wherein Z¹ is CR^(2B) or N; Z² is CR^(4B) or N; R^(2B), R^(2C), R^(2D)and R^(2E) are independently a hydrogen atom, a fluorine atom, achlorine atom, a bromine atom, a iodine atom, methyl, ethyl, allyl,propargyl, trifluoromethyl, methyloxy, difluoromethyloxy, methylthio,methylsulfonyl, phenyl, phenoxy, phenylthio, amino, methylamino,dimethylamino, methylcarbonylamino, methylsulfonylamino, nitro, cyano,2-furyl, 2-thenyl, 2-pyridyl, 1,3-oxazol-2-yl, 1,3-oxazol-4-yl,1,3-oxazol-5-yl, 1,3-thiazol-2-yl, 1,3-thiazol-4-yl, 1,3-thiazol-5-yl,1,3,4-oxdiazol-2-yl, 1,3,4-thiadiazol-2-yl, imidazol-1-yl, pyrazol-1-yl,morpholino, pyrrolidino or piperizino; R³ is methyloxy, ethyloxy,isopropyloxy, sec-butyloxy, difluoromethyloxy, 1-phenylethyloxy,phenoxy, methylthio, ethylthio, isopropylthio, sec-butylthio,difluoromethylthio, 1-phenylethylthio or phenylthio; R^(4A), R^(4B),R^(4C) and R^(4D) are independently a hydrogen atom, a fluorine atom, achlorine atom, methyl or methyloxy; L³ is a single bond, methylene,1,1-dimethylmethylene, ethylene, CH═CH—CH₂ —, 1-propylene-1,3-diynel,—O—CH₂—, —O—CH(Me)-, —O—C(Me)₂-, —S—CH₂— or —NH—CH₂—;

can be prepared in the same manner as set forth above.

Hereinafter, a table for combination of part A, part B and part C is thesame as that of the formula (IA).

A compound of the formula (IB) is shown below;

(Compound No., part A, part B, part C), (IB-1, A-1, B-1, C-15), (IB-2,A-1, B-2, C-15), (IB-3, A-1, B-3, C-15), (IB-4, A-1, B-4, C-15), (IB-5,A-1, B-5, C-15), (IB-6, A-1, B-6, C-15), (IB-7, A-1, B-7, C-15), (IB-8,A-1, B-7, C-52), (IB-9, A-1, B-8, C-15), (IB-10, A-1, B-9, C-15),(IB-11, A-1, B-10, C-15), (IB-12, A-1, B-10, C-52), (IB-13, A-2, B-1,C-15), (IB-14, A-2, B-2, C-15), (IB-15, A-2, B-3, C-15), (IB-16, A-2,B-4, C-15), (IB-17, A-2, B-5, C-15), (IB-18, A-2, B-6, C-15), (IB-19,A-2, B-7, C-15), (IB-20, A-2, B-7, C-52), (IB-21, A-2, B-8, C-15),(IB-22, A-2, B-9, C-15), (IB-23, A-2, B-10, C-15), (IB-24, A-2, B-10,C-52), (IB-25, A-3, B-1, C-15), (IB-26, A-3, B-2, C-15), (IB-27, A-3,B-3, C-15), (IB-28, A-3, B-4, C-15), (IB-29, A-3, B-5, C-15), (IB-30,A-3, B-6, C-15), (IB-31, A-3, B-7, C-1), (IB-32, A-3, B-7, C-2), (IB-33,A-3, B-7, C-3), (IB-34, A-3, B-7, C-4), (IB-35, A-3, B-7, C-5), (IB-36,A-3, B-7, C-6), (IB-37, A-3, B-7, C-7), (IB-38, A-3, B-7, C-8), (IB-39,A-3, B-7, C-9), (IB-40, A-3, B-7, C-10), (IB-41, A-3, B-7, C-11),(IB-42, A-3, B-7, C-12), (IB-43, A-3, B-7, C-13), (IB-44, A-3, B-7,C-14), (IB-45, A-3, B-7, C-15), (IB-46, A-3, B-7, C-16), (IB-47, A-3,B-7, C-17), (IB-48, A-3, B-7, C-18), (IB-49, A-3, B-7, C-19), (IB-50,A-3, B-7, C-20), (IB-51, A-3, B-7, C-21), (IB-52, A-3, B-7, C-22),(IB-53, A-3, B-7, C-23), (IB-54, A-3, B-7, C-24), (IB-55, A-3, B-7,C-25), (IB-56, A-3, B-7, C-26), (IB-57, A-3, B-7, C-27), (IB-58, A-3,B-7, C-28), (IB-59, A-3, B-7, C-29), (IB-60, A-3, B-7, C-30), (IB-61,A-3, B-7, C-31), (IB-62, A-3, B-7, C-32), (IB-63, A-3, B-7, C-33),(IB-64, A-3, B-7, C-34), (IB-65, A-3, B-7, C-35), (IB-66, A-3, B-7,C-36), (IB-67, A-3, B-7, C-37), (IB-68, A-3, B-7, C-38), (IB-69, A-3,B-7, C-39), (IB-70, A-3, B-7, C-40), (IB-71, A-3, B-7, C-41), (IB-72,A-3, B-7, C-42), (IB-73, A-3, B-7, C-43), (IB-74, A-3, B-7, C-44),(IB-75, A-3, B-7, C-45), (IB-76, A-3, B-7, C-46), (IB-77, A-3, B-7,C-47), (IB-78, A-3, B-7, C-48), (IB-79, A-3, B-7, C-49), (IB-80, A-3,B-7, C-50), (IB-81, A-3, B-7, C-51), (IB-82, A-3, B-7, C-52), (IB-83,A-3, B-7, C-53), (IB-84, A-3, B-7, C-54), (IB-85, A-3, B-7, C-55),(IB-86, A-3, B-7, C-56), (IB-87, A-3, B-7, C-57), (IB-88, A-3, B-7,C-58), (IB-89, A-3, B-7, C-59), (IB-90, A-3, B-7, C-60), (IB-91, A-3,B-7, C-61), (IB-92, A-3, B-7, C-62), (IB-93, A-3, B-7, C-63), (IB-94,A-3, B-7, C-64), (IB-95, A-3, B-7, C-65), (IB-96, A-3, B-7, C-66),(IB-97, A-3, B-7, C-67), (IB-98, A-3, B-7, C-68), (IB-99, A-3, B-7,C-69), (IB-100, A-3, B-7, C-70), (IB-101, A-3, B-7, C-71), (IB-102, A-3,B-7, C-72), (IB-103, A-3, B-7, C-73), (IB-104, A-3, B-7, C-74), (IB-105,A-3, B-7, C-75), (IB-106, A-3, B-7, C-76), (IB-107, A-3, B-7, C-77),(IB-108, A-3, B-7, C-78), (IB-109, A-3, B-7, C-79), (IB-110, A-3, B-7,C-80), (IB-111, A-3, B-7, C-81), (IB-112, A-3, B-7, C-82), (IB-113, A-3,B-7, C-83), (IB-114, A-3, B-7, C-84), (IB-115, A-3, B-7, C-85), (IB-116,A-3, B-7, C-86), (IB-117, A-3, B-7, C-87), (IB-118, A-3, B-7, C-88),(IB-119, A-3, B-7, C-89), (IB-120, A-3, B-7, C-90), (IB-121, A-3, B-7,C-91), (IB-122, A-3, B-7, C-92), (M-123, A-3, B-7, C-93), (IB-124, A-3,B-7, C-94), (IB-125, A-3, B-7, C-95), (IB-126, A-3, B-7, C-96), (IB-127,A-3, B-7, C-97), (IB-128, A-3, B-7, C-98), (IB-129, A-3, B-7, C-99),(IB-130, A-3, B-7, C-100), (IB-131, A-3, B-7, C-101), (IB-132, A-3, B-7,C-102), (IB-133, A-3, B-7, C-103), (IB-134, A-3, B-7, C-104), (IB-135,A-3, B-7, C-105), (IB-136, A-3, B-7, C-106), (IB-137, A-3, B-7, C-107),(IB-138, A-3, B-7, C-108), (IB-139, A-3, B-7, C-109), (IB-140, A-3, B-7,C-110), (IB-141, A-3, B-7, C-111), (IB-142, A-3, B-7, C-112), (IB-143,A-3, B-7, C-113), (IB-144, A-3, B-7, C-114), (IB-145, A-3, B-7, C-115),(IB-146, A-3, B-7, C-116), (IB-147, A-3, B-7, C-117), (IB-148, A-3, B-7,C-118), (IB-149, A-3, B-7, C-119), (IB-150, A-3, B-7, C-120), (IB-151,A-3, B-7, C-121), (IB-152, A-3, B-7, C-122), (IB-153, A-3, B-7, C-123),(IB-154, A-3, B-7, C-124), (IB-155, A-3, B-7, C-125), (IB-156, A-3, B-7,C-126), (IB-157, A-3, B-7, C-127), (IB-158, A-3, B-7, C-128), (IB-159,A-3, B-7, C-129), (IB-160, A-3, B-7, C-130), (IB-161, A-3, B-7, C-131),(IB-162, A-3, B-7, C-132), (IB-163, A-3, B-7, C-133), (IB-164, A-3, B-7,C-134), (IB-165, A-3, B-7, C-135), (IB-166, A-3, B-7, C-136), (IB-167,A-3, B-7, C-137), (IB-168, A-3, B-7, C-138), (IB-169, A-3, B-7, C-139),(IB-170, A-3, B-7, C-140), (IB-171, A-3, B-7, C-141), (IB-172, A-3, B-7,C-142), (IB-173, A-3, B-7, C-143), (IB-174, A-3, B-7, C-144), (IB-175,A-3, B-7, C-145), (IB-176, A-3, B-7, C-146), (IB-177, A-3, B-7, C-147),(IB-178, A-3, B-7, C-148), (IB-179, A-3, B-7, C-149), (IB-180, A-3, B-7,C-150), (IB-181, A-3, B-7, C-151), (IB-182, A-3, B-7, C-152), (IB-183,A-3, B-7, C-153), (IB-184, A-3, B-7, C-154), (IB-185, A-3, B-7, C-155),(IB-186, A-3, B-7, C-156), (IB-187, A-3, B-7, C-157), (IB-188, A-3, B-7,C-158), (IB-189, A-3, B-7, C-159), (IB-190, A-3, B-7, C-160), (IB-191,A-3, B-7, C-161), (IB-192, A-3, B-7, C-162), (IB-193, A-3, B-7, C-163),(IB-194, A-3, B-7, C-164), (IB-195, A-3, B-7, C-165), (IB-196, A-3, B-7,C-166), (IB-197, A-3, B-7, C-167), (IB-198, A-3, B-7, C-168), (IB-199,A-3, B-7, C-169), (IB-200, A-3, B-7, C-170), (IB-201, A-3, B-7, C-171),(IB-202, A-3, B-7, C-172), (IB-203, A-3, B-7, C-173), (IB-204, A-3, B-7,C-174), (IB-205, A-3, B-7, C-175), (IB-206, A-3, B-7, C-176), (IB-207,A-3, B-7, C-177), (IB-208, A-3, B-7, C-178), (IB-209, A-3, B-7, C-179),(IB-210, A-3, B-7, C-180), (IB-211, A-3, B-7, C-181), (IB-212, A-3, B-7,C-182), (IB-213, A-3, B-7, C-183), (IB-214, A-3, B-7, C-184), (IB-215,A-3, B-7, C-185), (IB-216, A-3, B-7, C-186), (IB-217, A-3, B-7, C-187),(IB-218, A-3, B-7, C-188), (IB-219, A-3, B-7, C-189), (IB-220, A-3, B-7,C-190), (IB-221, A-3, B-7, C-191), (IB-222, A-3, B-7, C-192), (IB-223,A-3, B-7, C-193), (IB-224, A-3, B-7, C-194), (IB-225, A-3, B-7, C-195),(IB-226, A-3, B-7, C-196), (IB-227, A-3, B-7, C-197), (IB-228, A-3, B-7,C-198), (IB-229, A-3, B-7, C-199), (IB-230, A-3, B-7, C-200), (IB-231,A-3, B-7, C-201), (IB-232, A-3, B-7, C-202), (IB-233, A-3, B-7, C-203),(IB-234, A-3, B-7, C-204), (IB-235, A-3, B-7, C-205), (IB-236, A-3, B-7,C-206), (IB-237, A-3, B-7, C-207), (IB-238, A-3, B-7, C-208), (IB-239,A-3, B-7, C-209), (IB-240, A-3, B-7, C-210), (IB-241, A-3, B-7, C-211),(IB-242, A-3, B-7, C-212), (IB-243, A-3, B-7, C-213), (IB-244, A-3, B-7,C-214), (IB-245, A-3, B-8, C-15), (IB-246, A-3, B-9, C-15), (IB-247,A-3, B-10, C-15), (IB-248, A-3, B-10, C-52), (IB-249, A-4, B-1, C-15),(IB-250, A-4, B-2, C-15), (IB-251, A-4, B-3, C-15), (IB-252, A-4, B-4,C-15), (IB-253, A-4, B-5, C-15), (IB-254, A-4, B-6, C-15), (IB-255, A-4,B-7, C-1), (IB-256, A-4, B-7, C-2), (IB-257, A-4, B-7, C-3), (IB-258,A-4, B-7, C-4), (IB-259, A-4, B-7, C-5), (IB-260, A-4, B-7, C-6),(IB-261, A-4, B-7, C-7), (IB-262, A-4, B-7, C-8), (IB-263, A-4, B-7,C-9), (IB-264, A-4, B-7, C-10), (IB-265, A-4, B-7, C-11), (IB-266, A-4,B-7, C-12), (IB-267, A-4, B-7, C-13), (IB-268, A-4, B-7, C-14), (IB-269,A-4, B-7, C-15), (IB-270, A-4, B-7, C-16), (IB-271, A-4, B-7, C-17),(IB-272, A-4, B-7, C-18), (IB-273, A-4, B-7, C-19), (IB-274, A-4, B-7,C-20), (IB-275, A-4, B-7, C-21), (IB-276, A-4, B-7, C-22), (IB-277, A-4,B-7, C-23), (IB-278, A-4, B-7, C-24), (IB-279, A-4, B-7, C-25), (IB-280,A-4, B-7, C-26), (IB-281, A-4, B-7, C-27), (IB-282, A-4, B-7, C-28),(IB-283, A-4, B-7, C-29), (IB-284, A-4, B-7, C-30), (IB-285, A-4, B-7,C-31), (IB-286, A-4, B-7, C-32), (IB-287, A-4, B-7, C-33), (IB-288, A-4,B-7, C-34), (IB-289, A-4, B-7, C-35), (IB-290, A-4, B-7, C-36), (IB-291,A-4, B-7, C-37), (IB-292, A-4, B-7, C-38), (IB-293, A-4, B-7, C-39),(IB-294, A-4, B-7, C-40), (IB-295, A-4, B-7, C-41), (IB-296, A-4, B-7,C-42), (IB-297, A-4, B-7, C-43), (IB-298, A-4, B-7, C-44), (IB-299, A-4,B-7, C-45), (IB-300, A-4, B-7, C-46), (IB-301, A-4, B-7, C-47), (IB-302,A-4, B-7, C-48), (IB-303, A-4, B-7, C-49), (IB-304, A-4, B-7, C-50),(IB-305, A-4, B-7, C-51), (IB-306, A-4, B-7, C-52), (IB-307, A-4, B-7,C-53), (IB-308, A-4, B-7, C-54), (IB-309, A-4, B-7, C-55), (IB-310, A-4,B-7, C-56), (IB-311, A-4, B-7, C-57), (IB-312, A-4, B-7, C-58), (IB-313,A-4, B-7, C-59), (IB-314, A-4, B-7, C-60), (IB-315, A-4, B-7, C-61),(IB-316, A-4, B-7, C-62), (IB-317, A-4, B-7, C-63), (IB-318, A-4, B-7,C-64), (IB-319, A-4, B-7, C-65), (IB-320, A-4, B-7, C-66), (IB-321, A-4,B-7, C-67), (IB-322, A-4, B-7, C-68), (IB-323, A-4, B-7, C-69), (IB-324,A-4, B-7, C-70), (IB-325, A-4, B-7, C-71), (IB-326, A-4, B-7, C-72),(IB-327, A-4, B-7, C-73), (IB-328, A-4, B-7, C-74), (IB-329, A-4, B-7,C-75), (IB-330, A-4, B-7, C-76), (IB-331, A-4, B-7, C-77), (IB-332, A-4,B-7, C-78), (IB-333, A-4, B-7, C-79), (IB-334, A-4, B-7, C-80), (IB-335,A-4, B-7, C-81), (IB-336, A-4, B-7, C-82), (IB-337, A-4, B-7, C-83),(IB-338, A-4, B-7, C-84), (IB-339, A-4, B-7, C-85), (IB-340, A-4, B-7,C-86), (IB-341, A-4, B-7, C-87), (IB-342, A-4, B-7, C-88), (IB-343, A-4,B-7, C-89), (IB-344, A-4, B-7, C-90), (IB-345, A-4, B-7, C-91), (IB-346,A-4, B-7, C-92), (IB-347, A-4, B-7, C-93), (IB-348, A-4, B-7, C-94),(IB-349, A-4, B-7, C-95), (IB-350, A-4, B-7, C-96), (IB-351, A-4, B-7,C-97), (IB-352, A-4, B-7, C-98), (IB-353, A-4, B-7, C-99), (IB-354, A-4,B-7, C-100), (IB-355, A-4, B-7, C-101), (IB-356, A-4, B-7, C-102),(IB-357, A-4, B-7, C-103), (IB-358, A-4, B-7, C-104), (IB-359, A-4, B-7,C-105), (IB-360, A-4, B-7, C-106), (IB-361, A-4, B-7, C-107), (IB-362,A-4, B-7, C-108), (IB-363, A-4, B-7, C-109), (IB-364, A-4, B-7, C-110),(IB-365, A-4, B-7, C-111), (IB-366, A-4, B-7, C-112), (IB-367, A-4, B-7,C-113), (IB-368, A-4, B-7, C-114), (IB-369, A-4, B-7, C-115), (IB-370,A-4, B-7, C-116), (IB-371, A-4, B-7, C-117), (IB-372, A-4, B-7, C-118),(IB-373, A-4, B-7, C-119), (IB-374, A-4, B-7, C-120), (IB-375, A-4, B-7,C-121), (IB-376, A-4, B-7, C-122), (IB-377, A-4, B-7, C-123), (IB-378,A-4, B-7, C-124), (IB-379, A-4, B-7, C-125), (IB-380, A-4, B-7, C-126),(IB-381, A-4, B-7, C-127), (IB-382, A-4, B-7, C-128), (IB-383, A-4, B-7,C-129), (IB-384, A-4, B-7, C-130), (IB-385, A-4, B-7, C-131), (IB-386,A-4, B-7, C-132), (IB-387, A-4, B-7, C-133), (IB-388, A-4, B-7, C-134),(IB-389, A-4, B-7, C-135), (IB-390, A-4, B-7, C-136), (IB-391, A-4, B-7,C-137), (IB-392, A-4, B-7, C-138), (IB-393, A-4, B-7, C-139), (IB-394,A-4, B-7, C-140), (IB-395, A-4, B-7, C-141), (IB-396, A-4, B-7, C-142),(IB-397, A-4, B-7, C-143), (IB-398, A-4, B-7, C-144), (IB-399, A-4, B-7,C-145), (IB-400, A-4, B-7, C-146), (IB-401, A-4, B-7, C-147), (IB-402,A-4, B-7, C-148), (IB-403, A-4, B-7, C-149), (IB-404, A-4, B-7, C-150),(IB-405, A-4, B-7, C-151), (IB-406, A-4, B-7, C-152), (IB-407, A-4, B-7,C-153), (IB-408, A-4, B-7, C-154), (IB-409, A-4, B-7, C-155), (IB-410,A-4, B-7, C-156), (IB-411, A-4, B-7, C-157), (IB-412, A-4, B-7, C-158),(IB-413, A-4, B-7, C-159), (IB-414, A-4, B-7, C-160), (IB-415, A-4, B-7,C-161), (IB-416, A-4, B-7, C-162), (IB-417, A-4, B-7, C-163), (IB-418,A-4, B-7, C-164), (IB-419, A-4, B-7, C-165), (IB-420, A-4, B-7, C-166),(IB-421, A-4, B-7, C-167), (IB-422, A-4, B-7, C-168), (IB-423, A-4, B-7,C-169), (IB-424, A-4, B-7, C-170), (IB-425, A-4, B-7, C-171), (IB-426,A-4, B-7, C-172), (IB-427, A-4, B-7, C-173), (IB-428, A-4, B-7, C-174),(IB-429, A-4, B-7, C-175), (IB-430, A-4, B-7, C-176), (IB-431, A-4, B-7,C-177), (IB-432, A-4, B-7, C-178), (IB-433, A-4, B-7, C-179), (IB-434,A-4, B-7, C-180), (IB-435, A-4, B-7, C-181), (IB-436, A-4, B-7, C-182),(IB-437, A-4, B-7, C-183), (IB-438, A-4, B-7, C-184), (IB-439, A-4, B-7,C-185), (IB-440, A-4, B-7, C-186), (IB-441, A-4, B-7, C-187), (IB-442,A-4, B-7, C-188), (IB-443, A-4, B-7, C-189), (IB-444, A-4, B-7, C-190),(IB-445, A-4, B-7, C-191), (IB-446, A-4, B-7, C-192), (IB-447, A-4, B-7,C-193), (IB-448, A-4, B-7, C-194), (IB-449, A-4, B-7, C-195), (IB-450,A-4, B-7, C-196), (IB-451, A-4, B-7, C-197), (IB-452, A-4, B-7, C-198),(IB-453, A-4, B-7, C-199), (IB-454, A-4, B-7, C-200), (IB-455, A-4, B-7,C-201), (IB-456, A-4, B-7, C-202), (IB-457, A-4, B-7, C-203), (IB-458,A-4, B-7, C-204), (IB-459, A-4, B-7, C-205), (IB-460, A-4, B-7, C-206),(IB-461, A-4, B-7, C-207), (IB-462, A-4, B-7, C-208), (IB-463, A-4, B-7,C-209), (IB-464, A-4, B-7, C-210), (IB-465, A-4, B-7, C-211), (IB-466,A-4, B-7, C-212), (IB-467, A-4, B-7, C-213), (IB-468, A-4, B-7, C-214),(IB-469, A-4, B-8, C-15), (IB-470, A-4, B-9, C-15), (IB-471, A-4, B-10,C-15), (IB-472, A-4, B-10, C-52), (IB-473, A-5, B-1, C-15), (IB-474,A-5, B-2, C-15), (IB-475, A-5, B-3, C-15), (IB-476, A-5, B-4, C-15),(IB-477, A-5, B-5, C-15), (IB-478, A-5, B-6, C-15), (IB-479, A-5, B-7,C-15), (IB-480, A-5, B-7, C-52), (IB-481, A-5, B-8, C-15), (IB-482, A-5,B-9, C-15), (IB-483, A-5, B-10, C-15), (IB-484, A-5, B-10, C-52),(IB-485, A-6, B-1, C-15), (IB-486, A-6, B-2, C-15), (IB-487, A-6, B-3,C-15), (IB-488, A-6, B-4, C-15), (IB-489, A-6, B-5, C-15), (IB-490, A-6,B-6, C-15), (IB-491, A-6, B-7, C-15), (IB-492, A-6, B-7, C-52), (IB-493,A-6, B-8, C-15), (IB-494, A-6, B-9, C-15), (IB-495, A-6, B-10, C-15),(IB-496, A-6, B-10, C-52), (IB-497, A-7, B-1, C-15), (IB-498, A-7, B-2,C-15), (IB-499, A-7, B-3, C-15), (IB-500, A-7, B-4, C-15), (IB-501, A-7,B-5, C-15), (IB-502, A-7, B-6, C-15), (IB-503, A-7, B-7, C-15), (IB-504,A-7, B-7, C-52), (IB-505, A-7, B-8, C-15), (IB-506, A-7, B-9, C-15),(IB-507, A-7, B-10, C-15), (IB-508, A-7, B-10, C-52), (IB-509, A-8, B-1,C-15), (IB-510, A-8, B-2, C-15), (IB-511, A-8, B-3, C-15), (IB-512, A-8,B-4, C-15), (IB-513, A-8, B-5, C-15), (IB-514, A-8, B-6, C-15), (IB-515,A-8, B-7, C-15), (IB-516, A-8, B-7, C-52), (IB-517, A-8, B-8, C-15),(IB-518, A-8, B-9, C-15), (IB-519, A-8, B-10, C-15), (IB-520, A-8, B-10,C-52), (IB-521, A-9, B-1, C-15), (IB-522, A-9, B-2, C-15), (IB-523, A-9,B-3, C-15), (IB-524, A-9, B-4, C-15), (IB-525, A-9, B-5, C-15), (IB-526,A-9, B-6, C-15), (IB-527, A-9, B-7, C-15), (IB-528, A-9, B-7, C-52),(IB-529, A-9, B-8, C-15), (IB-530, A-9, B-9, C-15), (IB-531, A-9, B-10,C-15), (IB-532, A-9, B-10, C-52), (IB-533, A-10, B-1, C-15), (IB-534,A-10, B-2, C-15), (IB-535, A-10, B-3, C-15), (IB-536, A-10, B-4, C-15),(IB-537, A-10, B-5, C-15), (IB-538, A-10, B-6, C-15), (IB-539, A-10,B-7, C-1), (IB-540, A-10, B-7, C-2), (IB-541, A-10, B-7, C-3), (IB-542,A-10, B-7, C-4), (IB-543, A-10, B-7, C-5), (IB-544, A-10, B-7, C-6),(IB-545, A-10, B-7, C-7), (IB-546, A-10, B-7, C-8), (IB-547, A-10, B-7,C-9), (IB-548, A-10, B-7, C-10), (IB-549, A-10, B-7, C-11), (IB-550,A-10, B-7, C-12), (IB-551, A-10, B-7, C-13), (IB-552, A-10, B-7, C-14),(IB-553, A-10, B-7, C-15), (IB-554, A-10, B-7, C-16), (IB-555, A-10,B-7, C-17), (IB-556, A-10, B-7, C-18), (IB-557, A-10, B-7, C-19),(IB-558, A-10, B-7, C-20), (IB-559, A-10, B-7, C-21), (IB-560, A-10,B-7, C-22), (IB-561, A-10, B-7, C-23), (IB-562, A-10, B-7, C-24),(IB-563, A-10, B-7, C-25), (IB-564, A-10, B-7, C-26), (IB-565, A-10,B-7, C-27), (IB-566, A-10, B-7, C-28), (IB-567, A-10, B-7, C-29),(IB-568, A-10, B-7, C-30), (IB-569, A-10, B-7, C-31), (IB-570, A-10,B-7, C-32), (IB-571, A-10, B-7, C-33), (IB-572, A-10, B-7, C-34),(IB-573, A-10, B-7, C-35), (IB-574, A-10, B-7, C-36), (IB-575, A-10,B-7, C-37), (IB-576, A-10, B-7, C-38), (IB-577, A-10, B-7, C-39),(IB-578, A-10, B-7, C-40), (IB-579, A-10, B-7, C-41), (IB-580, A-10,B-7, C-42), (IB-581, A-10, B-7, C-43), (IB-582, A-10, B-7, C-44),(IB-583, A-10, B-7, C-45), (IB-584, A-10, B-7, C-46), (IB-585, A-10,B-7, C-47), (IB-586, A-10, B-7, C-48), (IB-587, A-10, B-7, C-49),(IB-588, A-10, B-7, C-50), (IB-589, A-10, B-7, C-51), (IB-590, A-10,B-7, C-52), (IB-591, A-10, B-7, C-53), (IB-592, A-10, B-7, C-54),(IB-593, A-10, B-7, C-55), (IB-594, A-10, B-7, C-56), (IB-595, A-10,B-7, C-57), (IB-596, A-10, B-7, C-58), (IB-597, A-10, B-7, C-59),(IB-598, A-10, B-7, C-60), (IB-599, A-10, B-7, C-61), (IB-600, A-10,B-7, C-62), (IB-601, A-10, B-7, C-63), (IB-602, A-10, B-7, C-64),(IB-603, A-10, B-7, C-65), (IB-604, A-10, B-7, C-66), (IB-605, A-10,B-7, C-67), (IB-606, A-10, B-7, C-68), (IB-607, A-10, B-7, C-69),(IB-608, A-10, B-7, C-70), (IB-609, A-10, B-7, C-71), (IB-610, A-10,B-7, C-72), (IB-611, A-10, B-7, C-73), (IB-612, A-10, B-7, C-74),(IB-613, A-10, B-7, C-75), (IB-614, A-10, B-7, C-76), (IB-615, A-10,B-7, C-77), (IB-616, A-10, B-7, C-78), (IB-617, A-10, B-7, C-79),(IB-618, A-10, B-7, C-80), (IB-619, A-10, B-7, C-81), (IB-620, A-10,B-7, C-82), (IB-621, A-10, B-7, C-83), (IB-622, A-10, B-7, C-84),(IB-623, A-10, B-7, C-85), (IB-624, A-10, B-7, C-86), (IB-625, A-10,B-7, C-87), (IB-626, A-10, B-7, C-88), (IB-627, A-10, B-7, C-89),(IB-628, A-10, B-7, C-90), (IB-629, A-10, B-7, C-91), (IB-630, A-10,B-7, C-92), (IB-631, A-10, B-7, C-93), (IB-632, A-10, B-7, C-94),(IB-633, A-10, B-7, C-95), (IB-634, A-10, B-7, C-96), (IB-635, A-10,B-7, C-97), (IB-636, A-10, B-7, C-98), (IB-637, A-10, B-7, C-99),(IB-638, A-10, B-7, C-100), (IB-639, A-10, B-7, C-101), (IB-640, A-10,B-7, C-102), (IB-641, A-10, B-7, C-103), (IB-642, A-10, B-7, C-104),(IB-643, A-10, B-7, C-105), (IB-644, A-10, B-7, C-106), (IB-645, A-10,B-7, C-107), (IB-646, A-10, B-7, C-108), (IB-647, A-10, B-7, C-109),(IB-648, A-10, B-7, C-110), (IB-649, A-10, B-7, C-111), (IB-650, A-10,B-7, C-112), (IB-651, A-10, B-7, C-113), (IB-652, A-10, B-7, C-114),(IB-653, A-10, B-7, C-115), (IB-654, A-10, B-7, C-116), (IB-655, A-10,B-7, C-117), (IB-656, A-10, B-7, C-118), (IB-657, A-10, B-7, C-119),(IB-658, A-10, B-7, C-120), (IB-659, A-10, B-7, C-121), (IB-660, A-10,B-7, C-122), (IB-661, A-10, B-7, C-123), (IB-662, A-10, B-7, C-124),(IB-663, A-10, B-7, C-125), (IB-664, A-10, B-7, C-126), (IB-665, A-10,B-7, C-127), (IB-666, A-10, B-7, C-128), (IB-667, A-10, B-7, C-129),(IB-668, A-10, B-7, C-130), (IB-669, A-10, B-7, C-131), (IB-670, A-10,B-7, C-132), (IB-671, A-10, B-7, C-133), (IB-672, A-10, B-7, C-134),(IB-673, A-10, B-7, C-135), (IB-674, A-10, B-7, C-136), (IB-675, A-10,B-7, C-137), (IB-676, A-10, B-7, C-138), (IB-677, A-10, B-7, C-139),(IB-678, A-10, B-7, C-140), (IB-679, A-10, B-7, C-141), (IB-680, A-10,B-7, C-142), (IB-681, A-10, B-7, C-143), (IB-682, A-10, B-7, C-144),(IB-683, A-10, B-7, C-145), (IB-684, A-10, B-7, C-146), (IB-685, A-10,B-7, C-147), (IB-686, A-10, B-7, C-148), (IB-687, A-10, B-7, C-149),(IB-688, A-10, B-7, C-150), (IB-689, A-10, B-7, C-151), (IB-690, A-10,B-7, C-152), (IB-691, A-10, B-7, C-153), (IB-692, A-10, B-7, C-154),(IB-693, A-10, B-7, C-155), (IB-694, A-10, B-7, C-156), (IB-695, A-10,B-7, C-157), (IB-696, A-10, B-7, C-158), (IB-697, A-10, B-7, C-159),(IB-698, A-10, B-7, C-160), (IB-699, A-10, B-7, C-161), (IB-700, A-10,B-7, C-162), (IB-701, A-10, B-7, C-163), (IB-702, A-10, B-7, C-164),(IB-703, A-10, B-7, C-165), (IB-704, A-10, B-7, C-166), (IB-705, A-10,B-7, C-167), (IB-706, A-10, B-7, C-168), (IB-707, A-10, B-7, C-169),(IB-708, A-10, B-7, C-170), (IB-709, A-10, B-7, C-171), (IB-710, A-10,B-7, C-172), (IB-711, A-10, B-7, C-173), (IB-712, A-10, B-7, C-174),(IB-713, A-10, B-7, C-175), (IB-714, A-10, B-7, C-176), (IB-715, A-10,B-7, C-177), (IB-716, A-10, B-7, C-178), (IB-717, A-10, B-7, C-179),(IB-718, A-10, B-7, C-180), (IB-719, A-10, B-7, C-181), (IB-720, A-10,B-7, C-182), (IB-721, A-10, B-7, C-183), (IB-722, A-10, B-7, C-184),(IB-723, A-10, B-7, C-185), (IB-724, A-10, B-7, C-186), (IB-725, A-10,B-7, C-187), (IB-726, A-10, B-7, C-188), (IB-727, A-10, B-7, C-189),(IB-728, A-10, B-7, C-190), (IB-729, A-10, B-7, C-191), (IB-730, A-10,B-7, C-192), (IB-731, A-10, B-7, C-193), (IB-732, A-10, B-7, C-194),(IB-733, A-10, B-7, C-195), (IB-734, A-10, B-7, C-196), (IB-735, A-10,B-7, C-197), (IB-736, A-10, B-7, C-198), (IB-737, A-10, B-7, C-199),(IB-738, A-10, B-7, C-200), (IB-739, A-10, B-7, C-201), (IB-740, A-10,B-7, C-202), (IB-741, A-10, B-7, C-203), (IB-742, A-10, B-7, C-204),(IB-743, A-10, B-7, C-205), (IB-744, A-10, B-7, C-206), (IB-745, A-10,B-7, C-207), (IB-746, A-10, B-7, C-208), (IB-747, A-10, B-7, C-209),(IB-748, A-10, B-7, C-210), (IB-749, A-10, B-7, C-211), (IB-750, A-10,B-7, C-212), (IB-751, A-10, B-7, C-213), (IB-752, A-10, B-7, C-214),(IB-753, A-11, B-1, C-15), (IB-754, A-11, B-2, C-15), (IB-755, A-11,B-3, C-15), (IB-756, A-11, B-4, C-15), (IB-757, A-11, B-5, C-15),(IB-758, A-11, B-6, C-15), (IB-759, A-11, B-7, C-15), (IB-760, A-11,B-7, C-52), (IB-761, A-11, B-8, C-15), (IB-762, A-11, B-9, C-15),(IB-763, A-11, B-10, C-15), (IB-764, A-11, B-10, C-52), (IB-765, A-12,B-1, C-15), (IB-766, A-12, B-2, C-15), (IB-767, A-12, B-3, C-15),(IB-768, A-12, B-4, C-15), (IB-769, A-12, B-5, C-15), (IB-770, A-12,B-6, C-15), (IB-771, A-12, B-7, C-15), (IB-772, A-12, B-7, C-52),(IB-773, A-12, B-8, C-15), (IB-774, A-12, B-9, C-15), (IB-775, A-12,B-10, C-15), (IB-776, A-12, B-10, C-52), (IB-777, A-13, B-1, C-15),(IB-778, A-13, B-2, C-15), (IB-779, A-13, B-3, C-15), (IB-780, A-13,B-4, C-15), (IB-781, A-13, B-5, C-15), (IB-782, A-13, B-6, C-15),(IB-783, A-13, B-7, C-15), (IB-784, A-13, B-7, C-52), (IB-785, A-13,B-8, C-15), (IB-786, A-13, B-9, C-15), (IB-787, A-13, B-10, C-15),(IB-788, A-13, B-10, C-52), (IB-789, A-14, B-1, C-15), (IB-790, A-14,B-2, C-15), (IB-791, A-14, B-3, C-15), (IB-792, A-14, B-4, C-15),(IB-793, A-14, B-5, C-15), (IB-794, A-14, B-6, C-15), (IB-795, A-14,B-7, C-15), (IB-796, A-14, B-7, C-52), (IB-797, A-14, B-8, C-15),(IB-798, A-14, B-9, C-15), (IB-799, A-14, B-10, C-15), (IB-800, A-14,B-10, C-52), (IB-801, A-15, B-1, C-15), (IB-802, A-15, B-2, C-15),(IB-803, A-15, B-3, C-15), (IB-804, A-15, B-4, C-15), (IB-805, A-15,B-5, C-15), (IB-806, A-15, B-6, C-15), (IB-807, A-15, B-7, C-15),(IB-808, A-15, B-7, C-52), (IB-809, A-15, B-8, C-15), (IB-810, A-15,B-9, C-15), (IB-811, A-15, B-10, C-15), (IB-812, A-15, B-10, C-52),(IB-813, A-16, B-1, C-15), (IB-814, A-16, B-2, C-15), (IB-815, A-16,B-3, C-15), (IB-816, A-16, B-4, C-15), (IB-817, A-16, B-5, C-15),(IB-818, A-16, B-6, C-15), (IB-819, A-16, B-7, C-15), (IB-820, A-16,B-7, C-52), (IB-821, A-16, B-8, C-15), (IB-822, A-16, B-9, C-15),(IB-823, A-16, B-10, C-15), (IB-824, A-16, B-10, C-52), (IB-825, A-17,B-1, C-15), (IB-826, A-17, B-2, C-15), (IB-827, A-17, B-3, C-15),(IB-828, A-17, B-4, C-15), (IB-829, A-17, B-5, C-15), (IB-830, A-17,B-6, C-15), (IB-831, A-17, B-7, C-15), (IB-832, A-17, B-7, C-52),(IB-833, A-17, B-8, C-15), (IB-834, A-17, B-9, C-15), (IB-835, A-17,B-10, C-15), (IB-836, A-17, B-10, C-52), (IB-837, A-18, B-1, C-15),(IB-838, A-18, B-2, C-15), (IB-839, A-18, B-3, C-15), (IB-840, A-18,B-4, C-15), (IB-841, A-18, B-5, C-15), (IB-842, A-18, B-6, C-15),(IB-843, A-18, B-7, C-15), (IB-844, A-18, B-7, C-52), (IB-845, A-18,B-8, C-15), (IB-846, A-18, B-9, C-15), (IB-847, A-18, B-10, C-15),(IB-848, A-18, B-10, C-52), (IB-849, A-19, B-1, C-15), (IB-850, A-19,B-2, C-15), (IB-851, A-19, B-3, C-15), (IB-852, A-19, B-4, C-15),(IB-853, A-19, B-5, C-15), (IB-854, A-19, B-6, C-15), (IB-855, A-19,B-7, C-15), (IB-856, A-19, B-7, C-52), (IB-857, A-19, B-8, C-15),(IB-858, A-19, B-9, C-15), (IB-859, A-19, B-10, C-15), (IB-860, A-19,B-10, C-52), (IB-861, A-20, B-1, C-15), (IB-862, A-20, B-2, C-15),(IB-863, A-20, B-3, C-15), (IB-864, A-20, B-4, C-15), (IB-865, A-20,B-5, C-15), (IB-866, A-20, B-6, C-15), (IB-867, A-20, B-7, C-1),(IB-868, A-20, B-7, C-2), (IB-869, A-20, B-7, C-3), (IB-870, A-20, B-7,C-4), (IB-875, A-20, B-7, C-9), (IB-876, A-20, B-7, C-10), (IB-877,A-20, B-7, C-11), (IB-878, A-20, B-7, C-12), (IB-879, A-20, B-7, C-13),(IB-880, A-20, B-7, C-14), (IB-881, A-20, B-7, C-15), (IB-882, A-20,B-7, C-16), (IB-883, A-20, B-7, C-17), (IB-884, A-20, B-7, C-18),(IB-885, A-20, B-7, C-19), (IB-886, A-20, B-7, C-20), (IB-887, A-20,B-7, C-21), (IB-888, A-20, B-7, C-22), (IB-889, A-20, B-7, C-23),(IB-890, A-20, B-7, C-24), (IB-891, A-20, B-7, C-25), (IB-892, A-20,B-7, C-26), (IB-893, A-20, B-7, C-27), (IB-894, A-20, B-7, C-28),(IB-895, A-20, B-7, C-29), (IB-896, A-20, B-7, C-30), (IB-897, A-20,B-7, C-31), (IB-898, A-20, B-7, C-32), (IB-899, A-20, B-7, C-33),(IB-900, A-20, B-7, C-34), (IB-901, A-20, B-7, C-35), (IB-902, A-20,B-7, C-36), (IB-903, A-20, B-7, C-37), (IB-904, A-20, B-7, C-38),(IB-905, A-20, B-7, C-39), (IB-906, A-20, B-7, C-40), (IB-907, A-20,B-7, C-41), (IB-908, A-20, B-7, C-42), (IB-909, A-20, B-7, C-43),(IB-910, A-20, B-7, C-44), (IB-911, A-20, B-7, C-45), (IB-912, A-20,B-7, C-46), (IB-913, A-20, B-7, C-47), (IB-914, A-20, B-7, C-48),(IB-915, A-20, B-7, C-49), (IB-916, A-20, B-7, C-50), (IB-917, A-20,B-7, C-51), (IB-918, A-20, B-7, C-52), (IB-919, A-20, B-7, C-53),(IB-920, A-20, B-7, C-54), (IB-921, A-20, B-7, C-55), (IB-922, A-20,B-7, C-56), (IB-923, A-20, B-7, C-57), (IB-924, A-20, B-7, C-58),(IB-925, A-20, B-7, C-59), (IB-926, A-20, B-7, C-60), (IB-927, A-20,B-7, C-61), (IB-928, A-20, B-7, C-62), (IB-929, A-20, B-7, C-63),(IB-930, A-20, B-7, C-64), (IB-931, A-20, B-7, C-65), (IB-932, A-20,B-7, C-66), (IB-933, A-20, B-7, C-67), (IB-934, A-20, B-7, C-68),(IB-935, A-20, B-7, C-69), (IB-936, A-20, B-7, C-70), (IB-937, A-20,B-7, C-71), (IB-938, A-20, B-7, C-72), (IB-939, A-20, B-7, C-73),(IB-940, A-20, B-7, C-74), (IB-941, A-20, B-7, C-75), (IB-942, A-20,B-7, C-76), (IB-943, A-20, B-7, C-77), (IB-944, A-20, B-7, C-78),(IB-945, A-20, B-7, C-79), (IB-946, A-20, B-7, C-80), (IB-947, A-20,B-7, C-81), (IB-948, A-20, B-7, C-82), (IB-949, A-20, B-7, C-83),(IB-950, A-20, B-7, C-84), (IB-951, A-20, B-7, C-85), (IB-952, A-20,B-7, C-86), (IB-953, A-20, B-7, C-87), (IB-954, A-20, B-7, C-88),(IB-955, A-20, B-7, C-89), (IB-956, A-20, B-7, C-90), (IB-957, A-20,B-7, C-91), (IB-958, A-20, B-7, C-92), (IB-959, A-20, B-7, C-93),(IB-960, A-20, B-7, C-94), (IB-961, A-20, B-7, C-95), (IB-962, A-20,B-7, C-96), (IB-963, A-20, B-7, C-97), (IB-964, A-20, B-7, C-98),(IB-965, A-20, B-7, C-99), (IB-966, A-20, B-7, C-100), (IB-967, A-20,B-7, C-101), (IB-968, A-20, B-7, C-102), (IB-969, A-20, B-7, C-103),(IB-970, A-20, B-7, C-104), (IB-971, A-20, B-7, C-105), (IB-972, A-20,B-7, C-106), (IB-973, A-20, B-7, C-107), (IB-974, A-20, B-7, C-108),(IB-975, A-20, B-7, C-109), (IB-976, A-20, B-7, C-110), (IB-977, A-20,B-7, C-111), (IB-978, A-20, B-7, C-112), (IB-979, A-20, B-7, C-113),(IB-980, A-20, B-7, C-114), (IB-981, A-20, B-7, C-115), (IB-982, A-20,B-7, C-116), (IB-983, A-20, B-7, C-117), (IB-984, A-20, B-7, C-118),(IB-985, A-20, B-7, C-119), (IB-986, A-20, B-7, C-120), (IB-987, A-20,B-7, C-121), (IB-988, A-20, B-7, C-122), (IB-989, A-20, B-7, C-123),(IB-990, A-20, B-7, C-124), (IB-991, A-20, B-7, C-125), (IB-992, A-20,B-7, C-126), (IB-993, A-20, B-7, C-127), (IB-994, A-20, B-7, C-128),(IB-995, A-20, B-7, C-129), (IB-996, A-20, B-7, C-130), (IB-997, A-20,B-7, C-131), (IB-998, A-20, B-7, C-132), (IB-999, A-20, B-7, C-133),(IB-1000, A-20, B-7, C-134), (IB-1001, A-20, B-7, C-135), (IB-1002,A-20, B-7, C-136), (IB-1003, A-20, B-7, C-137), (IB-1004, A-20, B-7,C-138), (IB-1005, A-20, B-7, C-139), (IB-1006, A-20, B-7, C-140),(IB-1007, A-20, B-7, C-141), (IB-1008, A-20, B-7, C-142), (IB-1009,A-20, B-7, C-143), (IB-1010, A-20, B-7, C-144), (IB-1011, A-20, B-7,C-145), (IB-1012, A-20, B-7, C-146), (IB-1013, A-20, B-7, C-147),(IB-1014, A-20, B-7, C-148), (IB-1015, A-20, B-7, C-149), (IB-1016,A-20, B-7, C-150), (IB-1017, A-20, B-7, C-151), (IB-1018, A-20, B-7,C-152), (IB-1019, A-20, B-7, C-153), (IB-1020, A-20, B-7, C-154),(IB-1021, A-20, B-7, C-155), (IB-1022, A-20, B-7, C-156), (IB-1023,A-20, B-7, C-157), (IB-1024, A-20, B-7, C-158), (IB-1025, A-20, B-7,C-159), (IB-1026, A-20, B-7, C-160), (IB-1027, A-20, B-7, C-161),(IB-1028, A-20, B-7, C-162), (IB-1029, A-20, B-7, C-163), (IB-1030,A-20, B-7, C-164), (IB-1031, A-20, B-7, C-165), (IB-1032, A-20, B-7,C-166), (IB-1033, A-20, B-7, C-167), (IB-1034, A-20, B-7, C-168),(IB-1035, A-20, B-7, C-169), (IB-1036, A-20, B-7, C-170), (IB-1037,A-20, B-7, C-171), (IB-1038, A-20, B-7, C-172), (IB-1039, A-20, B-7,C-173), (IB-1040, A-20, B-7, C-174), (IB-1041, A-20, B-7, C-175),(IB-1042, A-20, B-7, C-176), (IB-1043, A-20, B-7, C-177), (IB-1044,A-20, B-7, C-178), (IB-1045, A-20, B-7, C-179), (IB-1046, A-20, B-7,C-180), (IB-1047, A-20, B-7, C-181), (IB-1048, A-20, B-7, C-182),(IB-1049, A-20, B-7, C-183), (IB-1050, A-20, B-7, C-184), (IB-1051,A-20, B-7, C-185), (IB-1052, A-20, B-7, C-186), (IB-1053, A-20, B-7,C-187), (IB-1054, A-20, B-7, C-188), (IB-1055, A-20, B-7, C-189),(IB-1056, A-20, B-7, C-190), (IB-1057, A-20, B-7, C-191), (IB-1058,A-20, B-7, C-192), (IB-1059, A-20, B-7, C-193), (IB-1060, A-20, B-7,C-194), (IB-1061, A-20, B-7, C-195), (IB-1062, A-20, B-7, C-196),(IB-1063, A-20, B-7, C-197), (IB-1064, A-20, B-7, C-198), (IB-1065,A-20, B-7, C-199), (IB-1066, A-20, B-7, C-200), (IB-1067, A-20, B-7,C-201), (IB-1068, A-20, B-7, C-202), (IB-1069, A-20, B-7, C-203),(IB-1070, A-20, B-7, C-204), (IB-1071, A-20, B-7, C-205), (IB-1072,A-20, B-7, C-206), (IB-1073, A-20, B-7, C-207), (IB-1074, A-20, B-7,C-208), (IB-1075, A-20, B-7, C-209), (IB-1076, A-20, B-7, C-210),(IB-1077, A-20, B-7, C-211), (IB-1078, A-20, B-7, C-212), (IB-1079,A-20, B-7, C-213), (IB-1080, A-20, B-7, C-214), (IB-1081, A-21, B-1,C-15), (IB-1082, A-21, B-2, C-15), (IB-1083, A-21, B-3, C-15), (IB-1084,A-21, B-4, C-15), (IB-1085, A-21, B-5, C-15), (IB-1086, A-21, B-6,C-15), (IB-1087, A-21, B-7, C-15), (IB-1088, A-21, B-7, C-52), (IB-1089,A-21, B-8, C-15), (IB-1090, A-21, B-9, C-15), (IB-1091, A-21, B-10,C-15), (IB-1092, A-21, B-10, C-52), (IB-1093, A-22, B-1, C-15),(IB-1094, A-22, B-2, C-15), (IB-1095, A-22, B-3, C-15), (IB-1096, A-22,B-4, C-15), (IB-1097, A-22, B-5, C-15), (IB-1098, A-22, B-6, C-15),(IB-1099, A-22, B-7, C-1), (IB-1100, A-22, B-7, C-2), (IB-1101, A-22,B-7, C-3), (IB-1102, A-22, B-7, C-4), (IB-1103, A-22, B-7, C-5),(IB-1104, A-22, B-7, C-6), (IB-1105, A-22, B-7, C-7), (IB-1106, A-22,B-7, C-8), (IB-1107, A-22, B-7, C-9), (IB-1108, A-22, B-7, C-10),(IB-1109, A-22, B-7, C-11), (IB-1110, A-22, B-7, C-12), (IB-1111, A-22,B-7, C-13), (IB-1112, A-22, B-7, C-14), (IB-1113, A-22, B-7, C-15),(IB-1114, A-22, B-7, C-16), (IB-1115, A-22, B-7, C-17), (IB-1116, A-22,B-7, C-18), (IB-1117, A-22, B-7, C-19), (IB-1118, A-22, B-7, C-20),(IB-1119, A-22, B-7, C-21), (IB-1120, A-22, B-7, C-22), (IB-1121, A-22,B-7, C-23), (IB-1122, A-22, B-7, C-24), (IB-1123, A-22, B-7, C-25),(IB-1124, A-22, B-7, C-26), (IB-1125, A-22, B-7, C-27), (IB-1126, A-22,B-7, C-28), (IB-1127, A-22, B-7, C-29), (IB-1128, A-22, B-7, C-30),(IB-1129, A-22, B-7, C-31), (IB-1130, A-22, B-7, C-32), (IB-1131, A-22,B-7, C-33), (IB-1132, A-22, B-7, C-34), (IB-1133, A-22, B-7, C-35),(IB-1134, A-22, B-7, C-36), (IB-1135, A-22, B-7, C-37), (IB-1136, A-22,B-7, C-38), (IB-1137, A-22, B-7, C-39), (IB-1138, A-22, B-7, C-40),(IB-1139, A-22, B-7, C-41), (IB-1140, A-22, B-7, C-42), (IB-1141, A-22,B-7, C-43), (IB-1142, A-22, B-7, C-44), (IB-1143, A-22, B-7, C-45),(IB-1144, A-22, B-7, C-46), (IB-1145, A-22, B-7, C-47), (IB-1146, A-22,B-7, C-48), (IB-1147, A-22, B-7, C-49), (IB-1148, A-22, B-7, C-50),(IB-1149, A-22, B-7, C-51), (IB-1150, A-22, B-7, C-52), (IB-1151, A-22,B-7, C-53), (IB-1152, A-22, B-7, C-54), (IB-1153, A-22, B-7, C-55),(IB-1154, A-22, B-7, C-56), (IB-1155, A-22, B-7, C-57), (IB-1156, A-22,B-7, C-58), (IB-1157, A-22, B-7, C-59), (IB-1158, A-22, B-7, C-60),(IB-1159, A-22, B-7, C-61), (IB-1160, A-22, B-7, C-62), (IB-1161, A-22,B-7, C-63), (IB-1162, A-22, B-7, C-64), (IB-1163, A-22, B-7, C-65),(IB-1164, A-22, B-7, C-66), (IB-1165, A-22, B-7, C-67), (IB-1166, A-22,B-7, C-68), (IB-1167, A-22, B-7, C-69), (IB-1168, A-22, B-7, C-70),(IB-1169, A-22, B-7, C-71), (IB-1170, A-22, B-7, C-72), (IB-1171, A-22,B-7, C-73), (IB-1172, A-22, B-7, C-74), (IB-1173, A-22, B-7, C-75),(IB-1174, A-22, B-7, C-76), (IB-1175, A-22, B-7, C-77), (IB-1176, A-22,B-7, C-78), (IB-1177, A-22, B-7, C-79), (IB-1178, A-22, B-7, C-80),(IB-1179, A-22, B-7, C-81), (IB-1180, A-22, B-7, C-82), (IB-1181, A-22,B-7, C-83), (IB-1182, A-22, B-7, C-84), (IB-1183, A-22, B-7, C-85),(IB-1184, A-22, B-7, C-86), (IB-1185, A-22, B-7, C-87), (IB-1186, A-22,B-7, C-88), (IB-1187, A-22, B-7, C-89), (IB-1188, A-22, B-7, C-90),(IB-1189, A-22, B-7, C-91), (IB-1190, A-22, B-7, C-92), (IB-1191, A-22,B-7, C-93), (IB-1192, A-22, B-7, C-94), (IB-1193, A-22, B-7, C-95),(IB-1200, A-22, B-7, C-102), (IB-1201, A-22, B-7, C-103), (IB-1202,A-22, B-7, C-104), (IB-1203, A-22, B-7, C-105), (IB-1204, A-22, B-7,C-106), (IB-1205, A-22, B-7, C-107), (IB-1206, A-22, B-7, C-108),(IB-1207, A-22, B-7, C-109), (IB-1208, A-22, B-7, C-110), (IB-1209,A-22, B-7, C-111), (IB-1210, A-22, B-7, C-112), (IB-1211, A-22, B-7,C-113), (IB-1212, A-22, B-7, C-114), (IB-1213, A-22, B-7, C-115),(IB-1214, A-22, B-7, C-116), (IB-1215, A-22, B-7, C-117), (IB-1216,A-22, B-7, C-118), (IB-1217, A-22, B-7, C-119), (IB-1218, A-22, B-7,C-120), (IB-1219, A-22, B-7, C-121), (IB-1220, A-22, B-7, C-122),(IB-1221, A-22, B-7, C-123), (IB-1222, A-22, B-7, C-124), (IB-1223,A-22, B-7, C-125), (IB-1224, A-22, B-7, C-127), (IB-1226, A-22, B-7,C-128), (IB-1227, A-22, B-7, C-129), (IB-1228, A-22, B-7, C-130),(IB-1229, A-22, B-7, C-131), (IB-1230, A-22, B-7, C-132), (IB-1231,A-22, B-7, C-133), (IB-1232, A-22, B-7, C-134), (IB-1233, A-22, B-7,C-135), (IB-1234, A-22, B-7, C-136), (IB-1235, A-22, B-7, C-137),(IB-1236, A-22, B-7, C-138), (IB-1237, A-22, B-7, C-139), (IB-1238,A-22, B-7, C-140), (IB-1239, A-22, B-7, C-141), (IB-1240, A-22, B-7,C-142), (IB-1241, A-22, B-7, C-143), (IB-1242, A-22, B-7, C-144),(IB-1243, A-22, B-7, C-145), (IB-1244, A-22, B-7, C-146), (IB-1245,A-22, B-7, C-147), (IB-1246, A-22, B-7, C-148), (IB-1247, A-22, B-7,C-149), (IB-1248, A-22, B-7, C-150), (IB-1249, A-22, B-7, C-151),(IB-1250, A-22, B-7, C-152), (IB-1251, A-22, B-7, C-153), (IB-1252,A-22, B-7, C-154), (IB-1253, A-22, B-7, C-155), (IB-1254, A-22, B-7,C-156), (IB-1255, A-22, B-7, C-157), (IB-1256, A-22, B-7, C-158),(IB-1257, A-22, B-7, C-159), (IB-1258, A-22, B-7, C-160), (IB-1259,A-22, B-7, C-161), (IB-1260, A-22, B-7, C-162), (IB-1261, A-22, B-7,C-163), (IB-1262, A-22, B-7, C-164), (IB-1263, A-22, B-7, C-165),(IB-1264, A-22, B-7, C-166), (IB-1265, A-22, B-7, C-167), (IB-1266,A-22, B-7, C-168), (IB-1267, A-22, B-7, C-169), (IB-1268, A-22, B-7,C-170), (IB-1269, A-22, B-7, C-171), (IB-1270, A-22, B-7, C-172),(IB-1271, A-22, B-7, C-173), (IB-1272, A-22, B-7, C-174), (IB-1273,A-22, B-7, C-175), (IB-1274, A-22, B-7, C-176), (IB-1275, A-22, B-7,C-177), (IB-1276, A-22, B-7, C-178), (IB-1277, A-22, B-7, C-179),(IB-1278, A-22, B-7, C-180), (IB-1279, A-22, B-7, C-181), (IB-1280,A-22, B-7, C-182), (IB-1281, A-22, B-7, C-183), (IB-1282, A-22, B-7,C-184), (IB-1283, A-22, B-7, C-185), (IB-1284, A-22, B-7, C-186),(IB-1285, A-22, B-7, C-187), (IB-1286, A-22, B-7, C-188), (IB-1287,A-22, B-7, C-189), (IB-1288, A-22, B-7, C-190), (IB-1289, A-22, B-7,C-191), (IB-1290, A-22, B-7, C-192), (IB-1291, A-22, B-7, C-193),(IB-1292, A-22, B-7, C-194), (IB-1293, A-22, B-7, C-195), (IB-1294,A-22, B-7, C-196), (IB-1295, A-22, B-7, C-197), (IB-1296, A-22, B-7,C-198), (IB-1297, A-22, B-7, C-199), (IB-1298, A-22, B-7, C-200),(IB-1299, A-22, B-7, C-201), (IB-1300, A-22, B-7, C-202), (IB-1301,A-22, B-7, C-203), (IB-1302, A-22, B-7, C-204), (IB-1303, A-22, B-7,C-205), (IB-1304, A-22, B-7, C-206), (IB-1305, A-22, B-7, C-207),(IB-1306, A-22, B-7, C-208), (IB-1307, A-22, B-7, C-209), (IB-1308,A-22, B-7, C-210), (IB-1309, A-22, B-7, C-211), (IB-1310, A-22, B-7,C-212), (IB-1311, A-22, B-7, C-213), (IB-1312, A-22, B-7, C-214),(IB-1313, A-23, B-1, C-15), (IB-1314, A-23, B-2, C-15), (IB-1315, A-23,B-3, C-15), (IB-1316, A-23, B-4, C-15), (IB-1317, A-23, B-5, C-15),(IB-1318, A-23, B-6, C-15), (IB-1319, A-23, B-7, C-15), (IB-1320, A-23,B-7, C-52), (IB-1321, A-23, B-8, C-15), (IB-1322, A-23, B-9, C-15),(IB-1323, A-23, B-10, C-15), (IB-1324, A-23, B-10, C-52), (IB-1325,A-24, B-1, C-15), (IB-1326, A-24, B-2, C-15), (IB-1327, A-24, B-3,C-15), (IB-1328, A-24, B-4, C-15), (IB-1329, A-24, B-5, C-15), (IB-1330,A-24, B-6, C-15), (IB-1331, A-24, B-7, C-15), (IB-1332, A-24, B-7,C-52), (IB-1333, A-24, B-8, C-15), (IB-1334, A-24, B-9, C-15), (IB-1335,A-24, B-10, C-15), (IB-1336, A-24, B-10, C-52), (IB-1337, A-25, B-1,C-15), (IB-1338, A-25, B-2, C-15), (IB-1339, A-25, B-3, C-15), (IB-1340,A-25, B-4, C-15), (IB-1341, A-25, B-5, C-15), (IB-1342, A-25, B-6,C-15), (IB-1343, A-25, B-7, C-15), (IB-1344, A-25, B-7, C-52), (IB-1345,A-25, B-8, C-15), (IB-1346, A-25, B-9, C-15), (IB-1347, A-25, B-10,C-15), (IB-1348, A-25, B-10, C-52), (IB-1349, A-26, B-1, C-15),(IB-1350, A-26, B-2, C-15), (IB-1351, A-26, B-3, C-15), (IB-1352, A-26,B-4, C-15), (IB-1353, A-26, B-5, C-15), (IB-1354, A-26, B-6, C-15),(IB-1355, A-26, B-7, C-15), (IB-1356, A-26, B-7, C-52), (IB-1357, A-26,B-8, C-15), (IB-1358, A-26, B-9, C-15), (IB-1359, A-26, B-10, C-15),(IB-1360, A-26, B-10, C-52), (IB-1361, A-27, B-1, C-15), (IB-1362, A-27,B-2, C-15), (IB-1363, A-27, B-3, C-15), (IB-1364, A-27, B-4, C-15),(IB-1365, A-27, B-5, C-15), (IB-1366, A-27, B-6, C-15), (IB-1367, A-27,B-7, C-1), (IB-1368, A-27, B-7, C-2), (IB-1369, A-27, B-7, C-3),(IB-1370, A-27, B-7, C-4), (IB-1371, A-27, B-7, C-5), (IB-1372, A-27,B-7, C-6), (IB-1373, A-27, B-7, C-7), (IB-1374, A-27, B-7, C-8),(IB-1375, A-27, B-7, C-9), (IB-1376, A-27, B-7, C-10), (IB-1377, A-27,B-7, C-11), (IB-1378, A-27, B-7, C-12), (IB-1379, A-27, B-7, C-13),(IB-1380, A-27, B-7, C-14), (IB-1381, A-27, B-7, C-15), (IB-1382, A-27,B-7, C-16), (IB-1383, A-27, B-7, C-17), (IB-1384, A-27, B-7, C-18),(IB-1385, A-27, B-7, C-19), (IB-1386, A-27, B-7, C-20), (IB-1387, A-27,B-7, C-21), (IB-1388, A-27, B-7, C-22), (IB-1389, A-27, B-7, C-23),(IB-1390, A-27, B-7, C-24), (IB-1391, A-27, B-7, C-25), (IB-1392, A-27,B-7, C-26), (IB-1393, A-27, B-7, C-27), (IB-1394, A-27, B-7, C-28),(IB-1395, A-27, B-7, C-29), (IB-1396, A-27, B-7, C-30), (IB-1397, A-27,B-7, C-31), (IB-1398, A-27, B-7, C-32), (IB-1399, A-27, B-7, C-33),(IB-1400, A-27, B-7, C-34), (IB-1401, A-27, B-7, C-35), (IB-1402, A-27,B-7, C-36), (IB-1403, A-27, B-7, C-37), (IB-1404, A-27, B-7, C-38),(IB-1405, A-27, B-7, C-39), (IB-1406, A-27, B-7, C-40), (IB-1407, A-27,B-7, C-41), (IB-1408, A-27, B-7, C-42), (IB-1409, A-27, B-7, C-43),(IB-1410, A-27, B-7, C-44), (IB-1411, A-27, B-7, C-45), (IB-1412, A-27,B-7, C-46), (IB-1413, A-27, B-7, C-47), (IB-1414, A-27, B-7, C-48),(IB-1415, A-27, B-7, C-49), (IB-1416, A-27, B-7, C-50), (IB-1417, A-27,B-7, C-51), (IB-1418, A-27, B-7, C-52), (IB-1419, A-27, B-7, C-53),(IB-1420, A-27, B-7, C-54), (IB-1421, A-27, B-7, C-55), (IB-1422, A-27,B-7, C-56), (IB-1423, A-27, B-7, C-57), (IB-1424, A-27, B-7, C-58),(IB-1425, A-27, B-7, C-59), (IB-1426, A-27, B-7, C-60), (IB-1427, A-27,B-7, C-61), (IB-1428, A-27, B-7, C-62), (IB-1429, A-27, B-7, C-63),(IB-1430, A-27, B-7, C-64), (IB-1431, A-27, B-7, C-65), (IB-1432, A-27,B-7, C-66), (IB-1433, A-27, B-7, C-67), (IB-1434, A-27, B-7, C-68),(IB-1435, A-27, B-7, C-69), (IB-1436, A-27, B-7, C-70), (IB-1437, A-27,B-7, C-71), (IB-1438, A-27, B-7, C-72), (IB-1439, A-27, B-7, C-73),(IB-1440, A-27, B-7, C-74), (IB-1441, A-27, B-7, C-75), (IB-1442, A-27,B-7, C-76), (IB-1443, A-27, B-7, C-77), (IB-1444, A-27, B-7, C-78),(IB-1445, A-27, B-7, C-79), (IB-1446, A-27, B-7, C-80), (IB-1447, A-27,B-7, C-81), (IB-1448, A-27, B-7, C-82), (IB-1449, A-27, B-7, C-83),(IB-1450, A-27, B-7, C-84), (IB-1451, A-27, B-7, C-85), (IB-1452, A-27,B-7, C-86), (IB-1453, A-27, B-7, C-87), (IB-1454, A-27, B-7, C-88),(IB-1455, A-27, B-7, C-89), (IB-1456, A-27, B-7, C-90), (IB-1457, A-27,B-7, C-91), (IB-1458, A-27, B-7, C-92), (IB-1459, A-27, B-7, C-93),(IB-1460, A-27, B-7, C-94), (IB-1461, A-27, B-7, C-95), (IB-1462, A-27,B-7, C-96), (IB-1463, A-27, B-7, C-97), (IB-1464, A-27, B-7, C-98),(IB-1465, A-27, B-7, C-99), (IB-1466, A-27, B-7, C-100), (IB-1467, A-27,B-7, C-101), (IB-1468, A-27, B-7, C-102), (IB-1469, A-27, B-7, C-103),(IB-1470, A-27, B-7, C-104), (IB-1471, A-27, B-7, C-105), (IB-1472,A-27, B-7, C-106), (IB-1473, A-27, B-7, C-107), (IB-1474, A-27, B-7,C-108), (IB-1475, A-27, B-7, C-109), (IB-1476, A-27, B-7, C-110),(IB-1477, A-27, B-7, C-111), (IB-1478, A-27, B-7, C-112), (IB-1479,A-27, B-7, C-113), (IB-1480, A-27, B-7, C-114), (IB-1481, A-27, B-7,C-115), (IB-1482, A-27, B-7, C-116), (IB-1483, A-27, B-7, C-117),(IB-1484, A-27, B-7, C-118), (IB-1485, A-27, B-7, C-119), (IB-1486,A-27, B-7, C-120), (IB-1487, A-27, B-7, C-121), (IB-1488, A-27, B-7,C-122), (IB-1489, A-27, B-7, C-123), (IB-1490, A-27, B-7, C-124),(IB-1491, A-27, B-7, C-125), (IB-1492, A-27, B-7, C-126), (IB-1493,A-27, B-7, C-127), (IB-1494, A-27, B-7, C-128), (IB-1495, A-27, B-7,C-129), (IB-1496, A-27, B-7, C-130), (IB-1497, A-27, B-7, C-131),(IB-1498, A-27, B-7, C-132), (IB-1499, A-27, B-7, C-133), (IB-1500,A-27, B-7, C-134), (IB-1501, A-27, B-7, C-135), (IB-1502, A-27, B-7,C-136), (IB-1503, A-27, B-7, C-137), (IB-1504, A-27, B-7, C-138),(IB-1505, A-27, B-7, C-139), (IB-1506, A-27, B-7, C-140), (IB-1507,A-27, B-7, C-141), (IB-1508, A-27, B-7, C-142), (IB-1509, A-27, B-7,C-143), (IB-1510, A-27, B-7, C-144), (IB-1511, A-27, B-7, C-145),(IB-1512, A-27, B-7, C-146), (IB-1513, A-27, B-7, C-147), (IB-1514,A-27, B-7, C-148), (IB-1515, A-27, B-7, C-149), (IB-1516, A-27, B-7,C-150), (IB-1517, A-27, B-7, C-151), (IB-1518, A-27, B-7, C-152),(IB-1519, A-27, B-7, C-153), (IB-1520, A-27, B-7, C-154), (IB-1521,A-27, B-7, C-155), (IB-1522, A-27, B-7, C-156), (IB-1523, A-27, B-7,C-157), (IB-1524, A-27, B-7, C-158), (IB-1525, A-27, B-7, C-159),(IB-1526, A-27, B-7, C-160), (IB-1527, A-27, B-7, C-161), (IB-1528,A-27, B-7, C-162), (IB-1529, A-27, B-7, C-163), (IB-1530, A-27, B-7,C-164), (IB-1531, A-27, B-7, C-165), (IB-1532, A-27, B-7, C-166),(IB-1533, A-27, B-7, C-167), (IB-1534, A-27, B-7, C-168), (IB-1535,A-27, B-7, C-169), (IB-1536, A-27, B-7, C-170), (IB-1537, A-27, B-7,C-171), (IB-1538, A-27, B-7, C-172), (IB-1539, A-27, B-7, C-173),(IB-1540, A-27, B-7, C-174), (IB-1541, A-27, B-7, C-175), (IB-1542,A-27, B-7, C-176), (IB-1543, A-27, B-7, C-177), (IB-1544, A-27, B-7,C-178), (IB-1545, A-27, B-7, C-179), (IB-1546, A-27, B-7, C-180),(IB-1547, A-27, B-7, C-181), (IB-1548, A-27, B-7, C-182), (IB-1549,A-27, B-7, C-183), (IB-1550, A-27, B-7, C-184), (IB-1551, A-27, B-7,C-185), (IB-1552, A-27, B-7, C-186), (IB-1553, A-27, B-7, C-187),(IB-1554, A-27, B-7, C-188), (IB-1555, A-27, B-7, C-189), (IB-1556,A-27, B-7, C-190), (IB-1557, A-27, B-7, C-191), (IB-1558, A-27, B-7,C-192), (IB-1559, A-27, B-7, C-193), (IB-1560, A-27, B-7, C-194),(IB-1561, A-27, B-7, C-195), (IB-1562, A-27, B-7, C-196), (IB-1563,A-27, B-7, C-197), (IB-1564, A-27, B-7, C-198), (IB-1565, A-27, B-7,C-199), (IB-1566, A-27, B-7, C-200), (IB-1567, A-27, B-7, C-201),(IB-1568, A-27, B-7, C-202), (IB-1569, A-27, B-7, C-203), (IB-1570,A-27, B-7, C-204), (IB-1571, A-27, B-7, C-205), (IB-1572, A-27, B-7,C-206), (IB-1573, A-27, B-7, C-207), (IB-1574, A-27, B-7, C-208),(IB-1575, A-27, B-7, C-209), (IB-1576, A-27, B-7, C-210), (IB-1577,A-27, B-7, C-211), (IB-1578, A-27, B-7, C-212), (IB-1579, A-27, B-7,C-213), (IB-1580, A-27, B-7, C-214), (IB-1581, A-27, B-8, C-15),(IB-1582, A-27, B-9, C-15), (IB-1583, A-27, B-10, C-15), (IB-1584, A-27,B-10, C-52), (IB-1585, A-28, B-1, C-15), (IB-1586, A-28, B-2, C-15),(IB-1587, A-28, B-3, C-15), (IB-1588, A-28, B-4, C-15), (IB-1589, A-28,B-5, C-15), (IB-1590, A-28, B-6, C-15), (IB-1591, A-28, B-7, C-1),(IB-1592, A-28, B-7, C-2), (IB-1593, A-28, B-7, C-3), (IB-1594, A-28,B-7, C-4), (IB-1595, A-28, B-7, C-5), (IB-1596, A-28, B-7, C-6),(IB-1597, A-28, B-7, C-7), (IB-1598, A-28, B-7, C-8), (IB-1599, A-28,B-7, C-9), (IB-1600, A-28, B-7, C-10), (IB-1601, A-28, B-7, C-11),(IB-1602, A-28, B-7, C-12), (IB-1603, A-28, B-7, C-13), (IB-1604, A-28,B-7, C-14), (IB-1605, A-28, B-7, C-15), (IB-1606, A-28, B-7, C-16),(IB-1607, A-28, B-7, C-17), (IB-1608, A-28, B-7, C-18), (IB-1609, A-28,B-7, C-19), (IB-1610, A-28, B-7, C-20), (IB-1611, A-28, B-7, C-21),(IB-1612, A-28, B-7, C-22), (IB-1613, A-28, B-7, C-23), (IB-1614, A-28,B-7, C-24), (IB-1615, A-28, B-7, C-25), (IB-1616, A-28, B-7, C-26),(IB-1617, A-28, B-7, C-27), (IB-1618, A-28, B-7, C-28), (IB-1619, A-28,B-7, C-29), (IB-1620, A-28, B-7, C-30), (IB-1621, A-28, B-7, C-31),(IB-1622, A-28, B-7, C-32), (IB-1623, A-28, B-7, C-33), (IB-1624, A-28,B-7, C-34), (IB-1625, A-28, B-7, C-35), (IB-1626, A-28, B-7, C-36),(IB-1627, A-28, B-7, C-37), (IB-1628, A-28, B-7, C-38), (IB-1629, A-28,B-7, C-39), (IB-1630, A-28, B-7, C-40), (IB-1631, A-28, B-7, C-41),(IB-1632, A-28, B-7, C-42), (IB-1633, A-28, B-7, C-43), (IB-1634, A-28,B-7, C-44), (IB-1635, A-28, B-7, C-45), (IB-1636, A-28, B-7, C-46),(IB-1637, A-28, B-7, C-47), (IB-1638, A-28, B-7, C-48), (IB-1639, A-28,B-7, C-49), (IB-1640, A-28, B-7, C-50), (IB-1641, A-28, B-7, C-51),(IB-1642, A-28, B-7, C-52), (IB-1643, A-28, B-7, C-53), (IB-1644, A-28,B-7, C-54), (IB-1645, A-28, B-7, C-55), (IB-1646, A-28, B-7, C-56),(IB-1647, A-28, B-7, C-57), (IB-1648, A-28, B-7, C-58), (IB-1649, A-28,B-7, C-59), (IB-1650, A-28, B-7, C-60), (IB-1651, A-28, B-7, C-61),(IB-1652, A-28, B-7, C-62), (IB-1653, A-28, B-7, C-63), (IB-1654, A-28,B-7, C-64), (IB-1655, A-28, B-7, C-65), (IB-1656, A-28, B-7, C-66),(IB-1657, A-28, B-7, C-67), (IB-1658, A-28, B-7, C-68), (IB-1659, A-28,B-7, C-69), (IB-1660, A-28, B-7, C-70), (IB-1661, A-28, B-7, C-71),(IB-1662, A-28, B-7, C-72), (IB-1663, A-28, B-7, C-73), (IB-1664, A-28,B-7, C-74), (IB-1665, A-28, B-7, C-75), (IB-1666, A-28, B-7, C-76),(IB-1667, A-28, B-7, C-77), (IB-1668, A-28, B-7, C-78), (IB-1669, A-28,B-7, C-79), (IB-1670, A-28, B-7, C-80), (IB-1671, A-28, B-7, C-81),(IB-1672, A-28, B-7, C-82), (IB-1673, A-28, B-7, C-83), (IB-1674, A-28,B-7, C-84), (IB-1675, A-28, B-7, C-85), (IB-1676, A-28, B-7, C-86),(IB-1677, A-28, B-7, C-87), (IB-1678, A-28, B-7, C-88), (IB-1679, A-28,B-7, C-89), (IB-1680, A-28, B-7, C-90), (IB-1681, A-28, B-7, C-91),(IB-1682, A-28, B-7, C-92), (IB-1683, A-28, B-7, C-93), (IB-1684, A-28,B-7, C-94), (IB-1685, A-28, B-7, C-95), (IB-1686, A-28, B-7, C-96),(IB-1687, A-28, B-7, C-97), (IB-1688, A-28, B-7, C-98), (IB-1689, A-28,B-7, C-99), (IB-1690, A-28, B-7, C-100), (IB-1691, A-28, B-7, C-101),(IB-1692, A-28, B-7, C-102), (IB-1693, A-28, B-7, C-103), (IB-1694,A-28, B-7, C-104), (IB-1695, A-28, B-7, C-105), (IB-1696, A-28, B-7,C-106), (IB-1697, A-28, B-7, C-107), (IB-1698, A-28, B-7, C-108),(IB-1699, A-28, B-7, C-109), (IB-1700, A-28, B-7, C-110), (IB-1701,A-28, B-7, C-111), (IB-1702, A-28, B-7, C-112), (IB-1703, A-28, B-7,C-113), (IB-1704, A-28, B-7, C-114), (IB-1705, A-28, B-7, C-115),(IB-1706, A-28, B-7, C-116), (IB-1707, A-28, B-7, C-117), (IB-1708,A-28, B-7, C-118), (IB-1709, A-28, B-7, C-119), (IB-1710, A-28, B-7,C-120), (IB-1711, A-28, B-7, C-121), (IB-1712, A-28, B-7, C-122),(IB-1713, A-28, B-7, C-123), (IB-1714, A-28, B-7, C-124), (IB-1715,A-28, B-7, C-125), (IB-1716, A-28, B-7, C-126), (IB-1717, A-28, B-7,C-127), (IB-1718, A-28, B-7, C-128), (IB-1719, A-28, B-7, C-129),(IB-1720, A-28, B-7, C-130), (IB-1721, A-28, B-7, C-131), (IB-1722,A-28, B-7, C-132), (IB-1723, A-28, B-7, C-133), (IB-1724, A-28, B-7,C-134), (IB-1725, A-28, B-7, C-135), (IB-1726, A-28, B-7, C-136),(IB-1727, A-28, B-7, C-137), (IB-1728, A-28, B-7, C-138), (IB-1729,A-28, B-7, C-139), (IB-1730, A-28, B-7, C-140), (IB-1731, A-28, B-7,C-141), (IB-1732, A-28, B-7, C-142), (IB-1733, A-28, B-7, C-143),(IB-1734, A-28, B-7, C-144), (IB-1735, A-28, B-7, C-145), (IB-1736,A-28, B-7, C-146), (IB-1737, A-28, B-7, C-147), (IB-1738, A-28, B-7,C-148), (IB-1739, A-28, B-7, C-149), (IB-1740, A-28, B-7, C-150),(IB-1741, A-28, B-7, C-151), (IB-1742, A-28, B-7, C-152), (IB-1743,A-28, B-7, C-153), (IB-1744, A-28, B-7, C-154), (IB-1745, A-28, B-7,C-155), (IB-1746, A-28, B-7, C-156), (IB-1747, A-28, B-7, C-157),(IB-1748, A-28, B-7, C-158), (IB-1749, A-28, B-7, C-159), (IB-1750,A-28, B-7, C-160), (IB-1751, A-28, B-7, C-161), (IB-1752, A-28, B-7,C-162), (IB-1753, A-28, B-7, C-163), (IB-1754, A-28, B-7, C-164),(IB-1755, A-28, B-7, C-165), (IB-1756, A-28, B-7, C-166), (IB-1757,A-28, B-7, C-167), (IB-1758, A-28, B-7, C-168), (IB-1759, A-28, B-7,C-169), (IB-1760, A-28, B-7, C-170), (IB-1761, A-28, B-7, C-171),(IB-1762, A-28, B-7, C-172), (IB-1763, A-28, B-7, C-173), (IB-1764,A-28, B-7, C-174), (IB-1765, A-28, B-7, C-175), (IB-1766, A-28, B-7,C-176), (IB-1767, A-28, B-7, C-177), (IB-1768, A-28, B-7, C-178),(IB-1769, A-28, B-7, C-179), (IB-1770, A-28, B-7, C-180), (IB-1771,A-28, B-7, C-181), (IB-1772, A-28, B-7, C-182), (IB-1773, A-28, B-7,C-183), (IB-1774, A-28, B-7, C-184), (IB-1775, A-28, B-7, C-185),(IB-1776, A-28, B-7, C-186), (IB-1777, A-28, B-7, C-187), (IB-1778,A-28, B-7, C-188), (IB-1779, A-28, B-7, C-189), (IB-1780, A-28, B-7,C-190), (IB-1781, A-28, B-7, C-191), (IB-1782, A-28, B-7, C-192),(IB-1783, A-28, B-7, C-193), (IB-1784, A-28, B-7, C-194), (IB-1785,A-28, B-7, C-195), (IB-1786, A-28, B-7, C-196), (IB-1787, A-28, B-7,C-197), (IB-1788, A-28, B-7, C-198), (IB-1789, A-28, B-7, C-199),(IB-1790, A-28, B-7, C-200), (IB-1791, A-28, B-7, C-201), (IB-1792,A-28, B-7, C-202), (IB-1793, A-28, B-7, C-203), (IB-1794, A-28, B-7,C-204), (IB-1795, A-28, B-7, C-205), (IB-1796, A-28, B-7, C-206),(IB-1797, A-28, B-7, C-207), (IB-1798, A-28, B-7, C-208), (IB-1799,A-28, B-7, C-209), (IB-1800, A-28, B-7, C-210), (IB-1801, A-28, B-7,C-211), (IB-1802, A-28, B-7, C-212), (IB-1803, A-28, B-7, C-213),(IB-1804, A-28, B-7, C-214), (IB-1805, A-28, B-8, C-15), (IB-1806, A-28,B-9, C-15), (IB-1807, A-28, B-10, C-15), (IB-1808, A-28, B-10, C-52),(IB-1809, A-29, B-1, C-15), (IB-1810, A-29, B-2, C-15), (IB-1811, A-29,B-3, C-15), (IB-1812, A-29, B-4, C-15), (IB-1813, A-29, B-5, C-15),(IB-1814, A-29, B-6, C-15), (IB-1815, A-29, B-7, C-1), (IB-1816, A-29,B-7, C-2), (IB-1817, A-29, B-7, C-3), (IB-1818, A-29, B-7, C-4),(IB-1819, A-29, B-7, C-5), (IB-1820, A-29, B-7, C-6), (IB-1821, A-29,B-7, C-7), (IB-1822, A-29, B-7, C-8), (IB-1823, A-29, B-7, C-9),(IB-1824, A-29, B-7, C-10), (IB-1825, A-29, B-7, C-11), (IB-1826, A-29,B-7, C-12), (IB-1827, A-29, B-7, C-13), (IB-1828, A-29, B-7, C-14),(IB-1829, A-29, B-7, C-15), (IB-1830, A-29, B-7, C-16), (IB-1831, A-29,B-7, C-17), (IB-1832, A-29, B-7, C-18), (IB-1833, A-29, B-7, C-19),(IB-1834, A-29, B-7, C-20), (IB-1835, A-29, B-7, C-21), (IB-1836, A-29,B-7, C-22), (IB-1837, A-29, B-7, C-23), (IB-1838, A-29, B-7, C-24),(IB-1839, A-29, B-7, C-25), (IB-1840, A-29, B-7, C-26), (IB-1841, A-29,B-7, C-27), (IB-1842, A-29, B-7, C-28), (IB-1843, A-29, B-7, C-29),(IB-1844, A-29, B-7, C-30), (IB-1845, A-29, B-7, C-31), (IB-1846, A-29,B-7, C-32), (IB-1847, A-29, B-7, C-33), (IB-1848, A-29, B-7, C-34),(IB-1849, A-29, B-7, C-35), (IB-1850, A-29, B-7, C-36), (IB-1851, A-29,B-7, C-37), (IB-1852, A-29, B-7, C-38), (IB-1853, A-29, B-7, C-39),(IB-1854, A-29, B-7, C-40), (IB-1855, A-29, B-7, C-41), (IB-1856, A-29,B-7, C-42), (IB-1857, A-29, B-7, C-43), (IB-1858, A-29, B-7, C-44),(IB-1859, A-29, B-7, C-45), (IB-1860, A-29, B-7, C-46), (IB-1861, A-29,B-7, C-47), (IB-1862, A-29, B-7, C-48), (IB-1863, A-29, B-7, C-49),(IB-1864, A-29, B-7, C-50), (IB-1865, A-29, B-7, C-51), (IB-1866, A-29,B-7, C-52), (IB-1867, A-29, B-7, C-53), (IB-1868, A-29, B-7, C-54),(IB-1869, A-29, B-7, C-55), (IB-1870, A-29, B-7, C-55), (IB-1871, A-29,B-7, C-57), (IB-1872, A-29, B-7, C-58), (IB-1873, A-29, B-7, C-59),(IB-1874, A-29, B-7, C-60), (IB-1875, A-29, B-7, C-61), (IB-1876, A-29,B-7, C-62), (IB-1877, A-29, B-7, C-63), (IB-1878, A-29, B-7, C-64),(IB-1879, A-29, B-7, C-65), (IB-1880, A-29, B-7, C-66), (IB-1881, A-29,B-7, C-67), (IB-1882, A-29, B-7, C-68), (IB-1883, A-29, B-7, C-69),(IB-1884, A-29, B-7, C-70), (IB-1885, A-29, B-7, C-71), (IB-1886, A-29,B-7, C-72), (IB-1887, A-29, B-7, C-73), (IB-1888, A-29, B-7, C-74),(IB-1889, A-29, B-7, C-75), (IB-1890, A-29, B-7, C-76), (IB-1891, A-29,B-7, C-77), (IB-1892, A-29, B-7, C-78), (IB-1893, A-29, B-7, C-79),(IB-1894, A-29, B-7, C-80), (IB-1895, A-29, B-7, C-81), (IB-1896, A-29,B-7, C-82), (IB-1897, A-29, B-7, C-83), (IB-1898, A-29, B-7, C-84),(IB-1899, A-29, B-7, C-85), (IB-1900, A-29, B-7, C-86), (IB-1901, A-29,B-7, C-87), (IB-1902, A-29, B-7, C-88), (IB-1903, A-29, B-7, C-89),(IB-1904, A-29, B-7, C-90), (IB-1905, A-29, B-7, C-91), (IB-1906, A-29,B-7, C-92), (IB-1907, A-29, B-7, C-93), (IB-1908, A-29, B-7, C-94),(IB-1909, A-29, B-7, C-95), (IB-1910, A-29, B-7, C-96), (IB-1911, A-29,B-7, C-97), (IB-1912, A-29, B-7, C-98), (IB-1913, A-29, B-7, C-99),(IB-1914, A-29, B-7, C-100), (IB-1915, A-29, B-7, C-101), (IB-1916,A-29, B-7, C-102), (IB-1917, A-29, B-7, C-103), (IB-1918, A-29, B-7,C-104), (IB-1919, A-29, B-7, C-105), (IB-1920, A-29, B-7, C-106),(IB-1921, A-29, B-7, C-107), (IB-1922, A-29, B-7, C-108), (IB-1923,A-29, B-7, C-109), (IB-1924, A-29, B-7, C-110), (IB-1925, A-29, B-7,C-111), (IB-1926, A-29, B-7, C-112), (IB-1927, A-29, B-7, C-113),(IB-1928, A-29, B-7, C-114), (IB-1929, A-29, B-7, C-115), (IB-1930,A-29, B-7, C-116), (IB-1931, A-29, B-7, C-117), (IB-1932, A-29, B-7,C-118), (IB-1933, A-29, B-7, C-119), (IB-1934, A-29, B-7, C-120),(IB-1935, A-29, B-7, C-121), (IB-1936, A-29, B-7, C-122), (IB-1937,A-29, B-7, C-123), (IB-1938, A-29, B-7, C-124), (IB-1939, A-29, B-7,C-125), (IB-1940, A-29, B-7, C-126), (IB-1941, A-29, B-7, C-127),(IB-1942, A-29, B-7, C-128), (IB-1943, A-29, B-7, C-129), (IB-1944,A-29, B-7, C-130), (IB-1945, A-29, B-7, C-131), (IB-1946, A-29, B-7,C-132), (IB-1947, A-29, B-7, C-133), (IB-1948, A-29, B-7, C-134),(IB-1949, A-29, B-7, C-135), (IB-1950, A-29, B-7, C-136), (IB-1951,A-29, B-7, C-137), (IB-1952, A-29, B-7, C-138), (IB-1953, A-29, B-7,C-139), (IB-1954, A-29, B-7, C-140), (IB-1955, A-29, B-7, C-141),(IB-1956, A-29, B-7, C-142), (IB-1957, A-29, B-7, C-143), (IB-1958,A-29, B-7, C-144), (IB-1959, A-29, B-7, C-145), (IB-1960, A-29, B-7,C-146), (IB-1961, A-29, B-7, C-147), (IB-1962, A-29, B-7, C-148),(IB-1963, A-29, B-7, C-149), (IB-1964, A-29, B-7, C-150), (IB-1965,A-29, B-7, C-151), (IB-1966, A-29, B-7, C-152), (IB-1967, A-29, B-7,C-153), (IB-1968, A-29, B-7, C-154), (IB-1969, A-29, B-7, C-155),(IB-1970, A-29, B-7, C-156), (IB-1971, A-29, B-7, C-157), (IB-1972,A-29, B-7, C-158), (IB-1973, A-29, B-7, C-159), (IB-1974, A-29, B-7,C-160), (IB-1975, A-29, B-7, C-161), (IB-1976, A-29, B-7, C-162),(IB-1977, A-29, B-7, C-163), (IB-1978, A-29, B-7, C-164), (IB-1979,A-29, B-7, C-165), (IB-1980, A-29, B-7, C-166), (IB-1981, A-29, B-7,C-167), (IB-1982, A-29, B-7, C-168), (IB-1983, A-29, B-7, C-169),(IB-1984, A-29, B-7, C-170), (IB-1985, A-29, B-7, C-171), (IB-1986,A-29, B-7, C-172), (IB-1987, A-29, B-7, C-173), (IB-1988, A-29, B-7,C-174), (IB-1989, A-29, B-7, C-175), (IB-1990, A-29, B-7, C-176),(IB-1991, A-29, B-7, C-177), (IB-1992, A-29, B-7, C-178), (IB-1993,A-29, B-7, C-179), (IB-1994, A-29, B-7, C-180), (IB-1995, A-29, B-7,C-181), (IB-1996, A-29, B-7, C-182), (IB-1997, A-29, B-7, C-183),(IB-1998, A-29, B-7, C-184), (IB-1999, A-29, B-7, C-185), (IB-2000,A-29, B-7, C-186), (IB-2001, A-29, B-7, C-187), (IB-2002, A-29, B-7,C-188), (IB-2003, A-29, B-7, C-189), (IB-2004, A-29, B-7, C-190),(IB-2005, A-29, B-7, C-191), (IB-2006, A-29, B-7, C-192), (IB-2007,A-29, B-7, C-193), (IB-2008, A-29, B-7, C-194), (IB-2009, A-29, B-7,C-195), (IB-2010, A-29, B-7, C-196), (IB-2011, A-29, B-7, C-197),(IB-2012, A-29, B-7, C-198), (IB-2013, A-29, B-7, C-199), (IB-2014,A-29, B-7, C-200), (IB-2015, A-29, B-7, C-201), (IB-2016, A-29, B-7,C-202), (IB-2017, A-29, B-7, C-203), (IB-2018, A-29, B-7, C-204),(IB-2019, A-29, B-7, C-205), (IB-2020, A-29, B-7, C-206), (IB-2021,A-29, B-7, C-207), (IB-2022, A-29, B-7, C-208), (IB-2023, A-29, B-7,C-209), (IB-2024, A-29, B-7, C-210), (IB-2025, A-29, B-7, C-211),(IB-2026, A-29, B-7, C-212), (IB-2027, A-29, B-7, C-213), (IB-2028,A-29, B-7, C-214), (IB-2029, A-29, B-8, C-15), (IB-2030, A-29, B-9,C-15), (IB-2031, A-29, B-10, C-15), (IB-2032, A-29, B-10, C-52),(IB-2033, A-30, B-1, C-15), (IB-2034, A-30, B-2, C-15), (IB-2035, A-30,B-3, C-15), (IB-2036, A-30, B-4, C-15), (IB-2037, A-30, B-5, C-15),(IB-2038, A-30, B-6, C-15), (IB-2039, A-30, B-7, C-1), (IB-2040, A-30,B-7, C-2), (IB-2041, A-30, B-7, C-3), (IB-2042, A-30, B-7, C-4),(IB-2043, A-30, B-7, C-5), (IB-2044, A-30, B-7, C-6), (IB-2045, A-30,B-7, C-7), (IB-2046, A-30, B-7, C-8), (IB-2047, A-30, B-7, C-9),(IB-2048, A-30, B-7, C-10), (IB-2049, A-30, B-7, C-11), (IB-2050, A-30,B-7, C-12), (IB-2051, A-30, B-7, C-13), (IB-2052, A-30, B-7, C-14),(IB-2053, A-30, B-7, C-15), (IB-2054, A-30, B-7, C-16), (IB-2055, A-30,B-7, C-17), (IB-2056, A-30, B-7, C-18), (IB-2057, A-30, B-7, C-19),(IB-2058, A-30, B-7, C-20), (IB-2059, A-30, B-7, C-21), (IB-2060, A-30,B-7, C-22), (IB-2061, A-30, B-7, C-23), (IB-2062, A-30, B-7, C-24),(IB-2063, A-30, B-7, C-25), (IB-2064, A-30, B-7, C-26), (IB-2065, A-30,B-7, C-27), (IB-2066, A-30, B-7, C-28), (IB-2067, A-30, B-7, C-29),(IB-2068, A-30, B-7, C-30), (IB-2069, A-30, B-7, C-31), (IB-2070, A-30,B-7, C-32), (IB-2071, A-30, B-7, C-33), (IB-2072, A-30, B-7, C-34),(IB-2073, A-30, B-7, C-35), (IB-2074, A-30, B-7, C-36), (IB-2075, A-30,B-7, C-37), (IB-2076, A-30, B-7, C-38), (IB-2077, A-30, B-7, C-39),(IB-2078, A-30, B-7, C-40), (IB-2079, A-30, B-7, C-41), (IB-2080, A-30,B-7, C-42), (IB-2081, A-30, B-7, C-43), (IB-2082, A-30, B-7, C-44),(IB-2083, A-30, B-7, C-45), (IB-2084, A-30, B-7, C-46), (IB-2085, A-30,B-7, C-47), (IB-2086, A-30, B-7, C-48), (IB-2087, A-30, B-7, C-49),(IB-2088, A-30, B-7, C-50), (IB-2089, A-30, B-7, C-51), (IB-2090, A-30,B-7, C-52), (IB-2091, A-30, B-7, C-53), (IB-2092, A-30, B-7, C-54),(IB-2093, A-30, B-7, C-55), (IB-2094, A-30, B-7, C-56), (IB-2095, A-30,B-7, C-57), (IB-2096, A-30, B-7, C-58), (IB-2097, A-30, B-7, C-59),(IB-2098, A-30, B-7, C-60), (IB-2099, A-30, B-7, C-61), (IB-2100, A-30,B-7, C-62), (IB-2101, A-30, B-7, C-63), (IB-2102, A-30, B-7, C-64),(IB-2103, A-30, B-7, C-65), (IB-2104, A-30, B-7, C-66), (IB-2105, A-30,B-7, C-67), (IB-2106, A-30, B-7, C-68), (IB-2107, A-30, B-7, C-69),(IB-2108, A-30, B-7, C-70), (IB-2109, A-30, B-7, C-71), (IB-2110, A-30,B-7, C-72), (IB-2111, A-30, B-7, C-73), (IB-2112, A-30, B-7, C-74),(IB-2113, A-30, B-7, C-75), (IB-2114, A-30, B-7, C-76), (IB-2115, A-30,B-7, C-77), (IB-2116, A-30, B-7, C-78), (IB-2117, A-30, B-7, C-79),(IB-2118, A-30, B-7, C-80), (IB-2119, A-30, B-7, C-81), (IB-2120, A-30,B-7, C-82), (IB-2121, A-30, B-7, C-83), (IB-2122, A-30, B-7, C-84),(IB-2123, A-30, B-7, C-85), (IB-2124, A-30, B-7, C-86), (IB-2125, A-30,B-7, C-87), (IB-2126, A-30, B-7, C-88), (IB-2127, A-30, B-7, C-89),(IB-2128, A-30, B-7, C-90), (IB-2129, A-30, B-7, C-91), (IB-2130, A-30,B-7, C-92), (IB-2131, A-30, B-7, C-93), (IB-2132, A-30, B-7, C-94),(IB-2133, A-30, B-7, C-95), (IB-2134, A-30, B-7, C-96), (IB-2135, A-30,B-7, C-97), (IB-2136, A-30, B-7, C-98), (IB-2137, A-30, B-7, C-99),(IB-2138, A-30, B-7, C-100), (IB-2139, A-30, B-7, C-101), (IB-2140,A-30, B-7, C-102), (IB-2141, A-30, B-7, C-103), (IB-2142, A-30, B-7,C-104), (IB-2143, A-30, B-7, C-105), (IB-2144, A-30, B-7, C-106),(IB-2145, A-30, B-7, C-107), (IB-2146, A-30, B-7, C-108), (IB-2147,A-30, B-7, C-109), (IB-2148, A-30, B-7, C-110), (IB-2149, A-30, B-7,C-111), (IB-2150, A-30, B-7, C-112), (IB-2151, A-30, B-7, C-113),(IB-2152, A-30, B-7, C-114), (IB-2153, A-30, B-7, C-115), (IB-2154,A-30, B-7, C-116), (IB-2155, A-30, B-7, C-117), (IB-2156, A-30, B-7,C-118), (IB-2157, A-30, B-7, C-119), (IB-2158, A-30, B-7, C-120),(IB-2159, A-30, B-7, C-121), (IB-2160, A-30, B-7, C-122), (IB-2161,A-30, B-7, C-123), (IB-2162, A-30, B-7, C-124), (IB-2163, A-30, B-7,C-125), (IB-2164, A-30, B-7, C-126), (IB-2165, A-30, B-7, C-127),(IB-2166, A-30, B-7, C-128), (IB-2167, A-30, B-7, C-129), (IB-2168,A-30, B-7, C-130), (IB-2169, A-30, B-7, C-131), (IB-2170, A-30, B-7,C-132), (IB-2171, A-30, B-7, C-133), (IB-2172, A-30, B-7, C-134),(IB-2173, A-30, B-7, C-135), (IB-2174, A-30, B-7, C-136), (IB-2175,A-30, B-7, C-137), (IB-2176, A-30, B-7, C-138), (IB-2177, A-30, B-7,C-139), (IB-2178, A-30, B-7, C-140), (IB-2179, A-30, B-7, C-141),(IB-2180, A-30, B-7, C-142), (IB-2181, A-30, B-7, C-143), (IB-2182,A-30, B-7, C-144), (IB-2183, A-30, B-7, C-145), (IB-2184, A-30, B-7,C-146), (IB-2185, A-30, B-7, C-147), (IB-2186, A-30, B-7, C-148),(IB-2187, A-30, B-7, C-149), (IB-2188, A-30, B-7, C-150), (IB-2189,A-30, B-7, C-151), (IB-2190, A-30, B-7, C-152), (IB-2191, A-30, B-7,C-153), (IB-2192, A-30, B-7, C-154), (IB-2193, A-30, B-7, C-155),(IB-2194, A-30, B-7, C-156), (IB-2195, A-30, B-7, C-157), (IB-2196,A-30, B-7, C-158), (IB-2197, A-30, B-7, C-159), (IB-2198, A-30, B-7,C-160), (IB-2199, A-30, B-7, C-161), (IB-2200, A-30, B-7, C-162),(IB-2201, A-30, B-7, C-163), (IB-2202, A-30, B-7, C-164), (IB-2203,A-30, B-7, C-165), (IB-2204, A-30, B-7, C-166), (IB-2205, A-30, B-7,C-167), (IB-2206, A-30, B-7, C-168), (IB-2207, A-30, B-7, C-169),(IB-2208, A-30, B-7, C-170), (IB-2209, A-30, B-7, C-171), (IB-2210,A-30, B-7, C-172), (IB-2211, A-30, B-7, C-173), (IB-2212, A-30, B-7,C-174), (IB-2213, A-30, B-7, C-175), (IB-2214, A-30, B-7, C-176),(IB-2215, A-30, B-7, C-177), (IB-2216, A-30, B-7, C-178), (IB-2217,A-30, B-7, C-179), (IB-2218, A-30, B-7, C-180), (IB-2219, A-30, B-7,C-181), (IB-2220, A-30, B-7, C-182), (IB-2221, A-30, B-7, C-183),(IB-2222, A-30, B-7, C-184), (IB-2223, A-30, B-7, C-185), (IB-2224,A-30, B-7, C-186), (IB-2225, A-30, B-7, C-187), (IB-2226, A-30, B-7,C-188), (IB-2227, A-30, B-7, C-189), (IB-2228, A-30, B-7, C-190),(IB-2229, A-30, B-7, C-191), (IB-2230, A-30, B-7, C-192), (IB-2231,A-30, B-7, C-193), (IB-2232, A-30, B-7, C-194), (IB-2233, A-30, B-7,C-195), (IB-2234, A-30, B-7, C-196), (IB-2235, A-30, B-7, C-197),(IB-2236, A-30, B-7, C-198), (IB-2237, A-30, B-7, C-199), (IB-2238,A-30, B-7, C-200), (IB-2239, A-30, B-7, C-201), (IB-2240, A-30, B-7,C-202), (IB-2241, A-30, B-7, C-203), (IB-2242, A-30, B-7, C-204),(IB-2243, A-30, B-7, C-205), (IB-2244, A-30, B-7, C-206), (IB-2245,A-30, B-7, C-207), (IB-2246, A-30, B-7, C-208), (IB-2247, A-30, B-7,C-209), (IB-2248, A-30, B-7, C-210), (IB-2249, A-30, B-7, C-211),(IB-2250, A-30, B-7, C-212), (IB-2251, A-30, B-7, C-213), (IB-2252,A-30, B-7, C-214), (IB-2253, A-30, B-8, C-15), (IB-2254, A-30, B-9,C-15), (IB-2255, A-30, B-10, C-15), (IB-2256, A-30, B-10, C-52),(IB-2257, A-31, B-1, C-15), (IB-2258, A-31, B-2, C-15), (IB-2259, A-31,B-3, C-15), (IB-2260, A-31, B-4, C-15), (IB-2261, A-31, B-5, C-15),(IB-2262, A-31, B-6, C-15), (IB-2263, A-31, B-7, C-1), (IB-2264, A-31,B-7, C-2), (IB-2265, A-31, B-7, C-3), (IB-2266, A-31, B-7, C-4),(IB-2267, A-31, B-7, C-5), (IB-2268, A-31, B-7, C-6), (IB-2269, A-31,B-7, C-7), (IB-2270, A-31, B-7, C-8), (IB-2271, A-31, B-7, C-9),(IB-2272, A-31, B-7, C-10), (IB-2273, A-31, B-7, C-11), (IB-2274, A-31,B-7, C-12), (IB-2275, A-31, B-7, C-13), (IB-2276, A-31, B-7, C-14),(IB-2277, A-31, B-7, C-15), (IB-2278, A-31, B-7, C-16), (IB-2279, A-31,B-7, C-17), (IB-2280, A-31, B-7, C-18), (IB-2281, A-31, B-7, C-19),(IB-2282, A-31, B-7, C-20), (IB-2283, A-31, B-7, C-21), (IB-2284, A-31,B-7, C-22), (IB-2285, A-31, B-7, C-23), (IB-2286, A-31, B-7, C-24),(IB-2287, A-31, B-7, C-25), (IB-2288, A-31, B-7, C-26), (IB-2289, A-31,B-7, C-27), (IB-2290, A-31, B-7, C-28), (IB-2291, A-31, B-7, C-29),(IB-2292, A-31, B-7, C-30), (IB-2293, A-31, B-7, C-31), (IB-2294, A-31,B-7, C-32), (IB-2295, A-31, B-7, C-33), (IB-2296, A-31, B-7, C-33),(IB-2296, A-30, B-6, C-34), (IB-2297, A-30, B-6, C-35), (IB-2298, A-30,B-6, C-36), (IB-2299, A-30, B-7, C-38), (IB-2301, A-31, B-7, C-39),(IB-2302, A-31, B-7, C-40), (IB-2303, A-31, B-7, C-41), (IB-2304, A-31,B-7, C-42), (IB-2305, A-31, B-7, C-43), (IB-2306, A-31, B-7, C-44),(IB-2307, A-31, B-7, C-45), (IB-2308, A-31, B-7, C-46), (IB-2309, A-31,B-7, C-47), (IB-2310, A-31, B-7, C-48), (IB-2311, A-31, B-7, C-49),(IB-2312, A-31, B-7, C-50), (IB-2313, A-31, B-7, C-51), (IB-2314, A-31,B-7, C-52), (IB-2315, A-31, B-7, C-53), (IB-2316, A-31, B-7, C-54),(IB-2317, A-31, B-7, C-55), (IB-2318, A-31, B-7, C-56), (IB-2319, A-31,B-7, C-57), (IB-2320, A-31, B-7, C-58), (IB-2321, A-31, B-7, C-59),(IB-2322, A-31, B-7, C-60), (IB-2323, A-31, B-7, C-61), (IB-2324, A-31,B-7, C-62), (IB-2325, A-31, B-7, C-63), (IB-2326, A-31, B-7, C-64),(IB-2327, A-31, B-7, C-65), (IB-2328, A-31, B-7, C-66), (IB-2329, A-31,B-7, C-67), (IB-2330, A-31, B-7, C-68), (IB-2331, A-31, B-7, C-69),(IB-2332, A-31, B-7, C-70), (IB-2333, A-31, B-7, C-71), (IB-2334, A-31,B-7, C-72), (IB-2335, A-31, B-7, C-73), (IB-2336, A-31, B-7, C-74),(IB-2337, A-31, B-7, C-75), (IB-2338, A-31, B-7, C-76), (IB-2339, A-31,B-7, C-77), (IB-2340, A-31, B-7, C-78), (IB-2341, A-31, B-7, C-79),(IB-2342, A-31, B-7, C-80), (IB-2343, A-31, B-7, C-81), (IB-2344, A-31,B-7, C-82), (IB-2345, A-31, B-7, C-83), (IB-2346, A-31, B-7, C-84),(IB-2347, A-31, B-7, C-85), (IB-2348, A-31, B-7, C-86), (IB-2349, A-31,B-7, C-87), (IB-2350, A-31, B-7, C-88), (IB-2351, A-31, B-7, C-89),(IB-2352, A-31, B-7, C-90), (IB-2353, A-31, B-7, C-91), (IB-2354, A-31,B-7, C-92), (IB-2355, A-31, B-7, C-93), (IB-2356, A-31, B-7, C-94),(IB-2357, A-31, B-7, C-95), (IB-2358, A-31, B-7, C-96), (IB-2359, A-31,B-7, C-97), (IB-2360, A-31, B-7, C-98), (IB-2361, A-31, B-7, C-99),(IB-2362, A-31, B-7, C-100), (IB-2363, A-31, B-7, C-101), (IB-2364,A-31, B-7, C-102), (IB-2365, A-31, B-7, C-103), (IB-2366, A-31, B-7,C-104), (IB-2367, A-31, B-7, C-105), (IB-2368, A-31, B-7, C-106),(IB-2369, A-31, B-7, C-107), (IB-2370, A-31, B-7, C-108), (IB-2371,A-31, B-7, C-109), (IB-2372, A-31, B-7, C-110), (IB-2373, A-31, B-7,C-111), (IB-2374, A-31, B-7, C-112), (IB-2375, A-31, B-7, C-113),(IB-2376, A-31, B-7, C-114), (IB-2377, A-31, B-7, C-115), (IB-2378,A-31, B-7, C-116), (IB-2379, A-31, B-7, C-117), (IB-2380, A-31, B-7,C-118), (IB-2381, A-31, B-7, C-119), (IB-2382, A-31, B-7, C-120),(IB-2383, A-31, B-7, C-121), (IB-2384, A-31, B-7, C-122), (IB-2385,A-31, B-7, C-123), (IB-2386, A-31, B-7, C-124), (IB-2387, A-31, B-7,C-125), (IB-2388, A-31, B-7, C-126), (IB-2389, A-31, B-7, C-127),(IB-2390, A-31, B-7, C-128), (IB-2391, A-31, B-7, C-129), (IB-2392,A-31, B-7, C-130), (IB-2393, A-31, B-7, C-131), (IB-2394, A-31, B-7,C-132), (IB-2395, A-31, B-7, C-133), (IB-2396, A-31, B-7, C-134),(IB-2397, A-31, B-7, C-135), (IB-2398, A-31, B-7, C-136), (IB-2399,A-31, B-7, C-137), (IB-2400, A-31, B-7, C-138), (IB-2401, A-31, B-7,C-139), (IB-2402, A-31, B-7, C-140), (IB-2403, A-31, B-7, C-141),(IB-2404, A-31, B-7, C-142), (IB-2405, A-31, B-7, C-143), (IB-2406,A-31, B-7, C-144), (IB-2407, A-31, B-7, C-145), (IB-2408, A-31, B-7,C-146), (IB-2409, A-31, B-7, C-147), (IB-2410, A-31, B-7, C-148),(IB-2411, A-31, B-7, C-149), (IB-2412, A-31, B-7, C-150), (IB-2413,A-31, B-7, C-151), (IB-2414, A-31, B-7, C-152), (IB-2415, A-31, B-7,C-153), (IB-2416, A-31, B-7, C-154), (IB-2417, A-31, B-7, C-155),(IB-2418, A-31, B-7, C-156), (IB-2419, A-31, B-7, C-157), (IB-2420,A-31, B-7, C-158), (IB-2421, A-31, B-7, C-159), (IB-2422, A-31, B-7,C-160), (IB-2423, A-31, B-7, C-161), (IB-2424, A-31, B-7, C-162),(IB-2425, A-31, B-7, C-163), (IB-2426, A-31, B-7, C-164), (IB-2427,A-31, B-7, C-165), (IB-2428, A-31, B-7, C-166), (IB-2429, A-31, B-7,C-167), (IB-2430, A-31, B-7, C-168), (IB-2431, A-31, B-7, C-169),(IB-2432, A-31, B-7, C-170), (IB-2433, A-31, B-7, C-171), (IB-2434,A-31, B-7, C-172), (IB-2435, A-31, B-7, C-173), (IB-2436, A-31, B-7,C-174), (IB-2437, A-31, B-7, C-175), (IB-2438, A-31, B-7, C-176),(IB-2439, A-31, B-7, C-177), (IB-2440, A-31, B-7, C-178), (IB-2441,A-31, B-7, C-179), (IB-2442, A-31, B-7, C-180), (IB-2443, A-31, B-7,C-181), (IB-2444, A-31, B-7, C-182), (IB-2445, A-31, B-7, C-183),(IB-2446, A-31, B-7, C-184), (IB-2447, A-31, B-7, C-185), (IB-2448,A-31, B-7, C-186), (IB-2449, A-31, B-7, C-187), (IB-2450, A-31, B-7,C-188), (IB-2451, A-31, B-7, C-189), (IB-2452, A-31, B-7, C-190),(IB-2453, A-31, B-7, C-191), (IB-2454, A-31, B-7, C-192), (IB-2455,A-31, B-7, C-193), (IB-2456, A-31, B-7, C-194), (IB-2457, A-31, B-7,C-195), (IB-2458, A-31, B-7, C-196), (IB-2459, A-31, B-7, C-197),(IB-2460, A-31, B-7, C-198), (IB-2461, A-31, B-7, C-199), (IB-2462,A-31, B-7, C-200), (IB-2463, A-31, B-7, C-201), (IB-2464, A-31, B-7,C-202), (IB-2465, A-31, B-7, C-203), (IB-2466, A-31, B-7, C-204),(IB-2467, A-31, B-7, C-205), (IB-2468, A-31, B-7, C-206), (IB-2469,A-31, B-7, C-207), (IB-2470, A-31, B-7, C-208), (IB-2471, A-31, B-7,C-209), (IB-2472, A-31, B-7, C-210), (IB-2473, A-31, B-7, C-211),(IB-2474, A-31, B-7, C-212), (IB-2475, A-31, B-7, C-213), (IB-2476,A-31, B-7, C-214), (IB-2477, A-31, B-8, C-15), (IB-2478, A-31, B-9,C-15), (IB-2479, A-31, B-10, C-15), (IB-2480, A-31, B-10, C-52),(IB-2481, A-32, B-1, C-15), (IB-2482, A-32, B-2, C-15), (IB-2483, A-32,B-3, C-15), (IB-2484, A-32, B-4, C-15), (IB-2485, A-32, B-5, C-15),(IB-2486, A-32, B-6, C-15), (IB-2487, A-32, B-7, C-1), (IB-2488, A-32,B-7, C-2), (IB-2489, A-32, B-7, C-3), (IB-2490, A-32, B-7, C-4),(IB-2491, A-32, B-7, C-5), (IB-2492, A-32, B-7, C-6), (IB-2493, A-32,B-7, C-7), (IB-2494, A-32, B-7, C-8), (IB-2495, A-32, B-7, C-9),(IB-2496, A-32, B-7, C-10), (IB-2497, A-32, B-7, C-11), (IB-2498, A-32,B-7, C-12), (IB-2499, A-32, B-7, C-13), (IB-2500, A-32, B-7, C-14),(IB-2501, A-32, B-7, C-15), (IB-2502, A-32, B-7, C-16), (IB-2503, A-32,B-7, C-17), (IB-2504, A-32, B-7, C-18), (IB-2505, A-32, B-7, C-19),(IB-2506, A-32, B-7, C-20), (IB-2507, A-32, B-7, C-21), (IB-2508, A-32,B-7, C-22), (IB-2509, A-32, B-7, C-23), (IB-2510, A-32, B-7, C-24),(IB-2511, A-32, B-7, C-25), (IB-2512, A-32, B-7, C-26), (IB-2513, A-32,B-7, C-27), (IB-2514, A-32, B-7, C-28), (IB-2515, A-32, B-7, C-29),(IB-2516, A-32, B-7, C-30), (IB-2517, A-32, B-7, C-31), (IB-2518, A-32,B-7, C-32), (IB-2519, A-32, B-7, C-33), (IB-2520, A-32, B-7, C-34),(IB-2521, A-32, B-7, C-36), (IB-2523, A-32, B-7, C-37), (IB-2524, A-32,B-7, C-38), (IB-2525, A-32, B-7, C-39), (IB-2526, A-32, B-7, C-40),(IB-2527, A-32, B-7, C-41), (IB-2528, A-32, B-7, C-42), (IB-2529, A-32,B-7, C-43), (IB-2530, A-32, B-7, C-44), (IB-2531, A-32, B-7, C-45),(IB-2532, A-32, B-7, C-46), (IB-2533, A-32, B-7, C-47), (IB-2534, A-32,B-7, C-48), (IB-2535, A-32, B-7, C-49), (IB-2536, A-32, B-7, C-50),(IB-2537, A-32, B-7, C-51), (IB-2538, A-32, B-7, C-52), (IB-2539, A-32,B-7, C-53), (IB-2540, A-32, B-7, C-54), (IB-2541, A-32, B-7, C-55),(IB-2542, A-32, B-7, C-56), (IB-2543, A-32, B-7, C-57), (IB-2544, A-32,B-7, C-58), (IB-2545, A-32, B-7, C-59), (IB-2546, A-32, B-7, C-60),(IB-2547, A-32, B-7, C-61), (IB-2548, A-32, B-7, C-62), (IB-2549, A-32,B-7, C-63), (IB-2550, A-32, B-7, C-64), (IB-2551, A-32, B-7, C-65),(IB-2552, A-32, B-7, C-66), (IB-2553, A-32, B-7, C-67), (IB-2554, A-32,B-7, C-68), (IB-2555, A-32, B-7, C-69), (IB-2556, A-32, B-7, C-70),(IB-2557, A-32, B-7, C-71), (IB-2558, A-32, B-7, C-72), (IB-2559, A-32,B-7, C-73), (IB-2560, A-32, B-7, C-74), (IB-2561, A-32, B-7, C-75),(IB-2562, A-32, B-7, C-76), (IB-2563, A-32, B-7, C-77), (IB-2564, A-32,B-7, C-78), (IB-2565, A-32, B-7, C-79), (IB-2566, A-32, B-7, C-80),(IB-2567, A-32, B-7, C-81), (IB-2568, A-32, B-7, C-82), (IB-2569, A-32,B-7, C-83), (IB-2570, A-32, B-7, C-84), (IB-2571, A-32, B-7, C-85),(IB-2572, A-32, B-7, C-86), (IB-2573, A-32, B-7, C-87), (IB-2574, A-32,B-7, C-88), (IB-2575, A-32, B-7, C-89), (IB-2576, A-32, B-7, C-90),(IB-2577, A-32, B-7, C-91), (IB-2578, A-32, B-7, C-92), (IB-2579, A-32,B-7, C-93), (IB-2580, A-32, B-7, C-94), (IB-2581, A-32, B-7, C-95),(IB-2582, A-32, B-7, C-96), (IB-2583, A-32, B-7, C-97), (IB-2584, A-32,B-7, C-98), (IB-2585, A-32, B-7, C-99), (IB-2586, A-32, B-7, C-100),(IB-2587, A-32, B-7, C-101), (IB-2588, A-32, B-7, C-102), (IB-2589,A-32, B-7, C-103), (IB-2590, A-32, B-7, C-104), (IB-2591, A-32, B-7,C-105), (IB-2592, A-32, B-7, C-106), (IB-2593, A-32, B-7, C-107),(IB-2594, A-32, B-7, C-108), (IB-2595, A-32, B-7, C-109), (IB-2596,A-32, B-7, C-110), (IB-2597, A-32, B-7, C-111), (IB-2598, A-32, B-7,C-112), (IB-2599, A-32, B-7, C-113), (IB-2600, A-32, B-7, C-114),(IB-2601, A-32, B-7, C-115), (IB-2602, A-32, B-7, C-116), (IB-2603,A-32, B-7, C-117), (IB-2604, A-32, B-7, C-118), (IB-2605, A-32, B-7,C-119), (IB-2606, A-32, B-7, C-120), (IB-2607, A-32, B-7, C-121),(IB-2608, A-32, B-7, C-122), (IB-2609, A-32, B-7, C-123), (IB-2610,A-32, B-7, C-124), (IB-2611, A-32, B-7, C-125), (IB-2612, A-32, B-7,C-126), (IB-2613, A-32, B-7, C-127), (IB-2614, A-32, B-7, C-128),(IB-2615, A-32, B-7, C-129), (IB-2616, A-32, B-7, C-130), (IB-2617,A-32, B-7, C-131), (IB-2618, A-32, B-7, C-132), (IB-2619, A-32, B-7,C-133), (IB-2620, A-32, B-7, C-134), (IB-2621, A-32, B-7, C-135),(IB-2622, A-32, B-7, C-136), (IB-2623, A-32, B-7, C-137), (IB-2624,A-32, B-7, C-138), (IB-2625, A-32, B-7, C-139), (IB-2626, A-32, B-7,C-140), (IB-2627, A-32, B-7, C-141), (IB-2628, A-32, B-7, C-142),(IB-2629, A-32, B-7, C-143), (IB-2630, A-32, B-7, C-144), (IB-2631,A-32, B-7, C-145), (IB-2632, A-32, B-7, C-146), (IB-2633, A-32, B-7,C-147), (IB-2634, A-32, B-7, C-148), (IB-2635, A-32, B-7, C-149),(IB-2636, A-32, B-7, C-150), (IB-2637, A-32, B-7, C-151), (IB-2638,A-32, B-7, C-152), (IB-2639, A-32, B-7, C-153), (IB-2640, A-32, B-7,C-154), (IB-2641, A-32, B-7, C-155), (IB-2642, A-32, B-7, C-156),(IB-2643, A-32, B-7, C-157), (IB-2644, A-32, B-7, C-158), (IB-2645,A-32, B-7, C-159), (IB-2646, A-32, B-7, C-160), (IB-2647, A-32, B-7,C-161), (IB-2648, A-32, B-7, C-162), (IB-2649, A-32, B-7, C-163),(IB-2650, A-32, B-7, C-164), (IB-2651, A-32, B-7, C-165), (IB-2652,A-32, B-7, C-166), (IB-2653, A-32, B-7, C-167), (IB-2654, A-32, B-7,C-168), (IB-2655, A-32, B-7, C-169), (IB-2656, A-32, B-7, C-170),(IB-2657, A-32, B-7, C-171), (IB-2658, A-32, B-7, C-172), (IB-2659,A-32, B-7, C-173), (IB-2660, A-32, B-7, C-174), (IB-2661, A-32, B-7,C-175), (IB-2662, A-32, B-7, C-176), (IB-2663, A-32, B-7, C-177),(IB-2664, A-32, B-7, C-178), (IB-2665, A-32, B-7, C-179), (IB-2666,A-32, B-7, C-180), (IB-2667, A-32, B-7, C-181), (IB-2668, A-32, B-7,C-182), (IB-2669, A-32, B-7, C-183), (IB-2670, A-32, B-7, C-184),(IB-2671, A-32, B-7, C-185), (IB-2672, A-32, B-7, C-186), (IB-2673,A-32, B-7, C-187), (IB-2674, A-32, B-7, C-188), (IB-2675, A-32, B-7,C-189), (IB-2676, A-32, B-7, C-190), (IB-2677, A-32, B-7, C-191),(IB-2678, A-32, B-7, C-192), (IB-2679, A-32, B-7, C-193), (IB-2680,A-32, B-7, C-194), (IB-2681, A-32, B-7, C-195), (IB-2682, A-32, B-7,C-196), (IB-2683, A-32, B-7, C-197), (IB-2684, A-32, B-7, C-198),(IB-2685, A-32, B-7, C-199), (IB-2686, A-32, B-7, C-200), (IB-2687,A-32, B-7, C-201), (IB-2688, A-32, B-7, C-202), (IB-2689, A-32, B-7,C-203), (IB-2690, A-32, B-7, C-204), (IB-2691, A-32, B-7, C-205),(IB-2692, A-32, B-7, C-206), (IB-2693, A-32, B-7, C-207), (IB-2694,A-32, B-7, C-208), (IB-2695, A-32, B-7, C-209), (IB-2696, A-32, B-7,C-210), (IB-2697, A-32, B-7, C-211), (IB-2698, A-32, B-7, C-212),(IB-2699, A-32, B-7, C-213), (IB-2700, A-32, B-7, C-214), (IB-2701,A-32, B-8, C-15), (IB-2702, A-32, B-9, C-15), (IB-2703, A-32, B-10,C-15), (IB-2704, A-32, B-10, C-52), (IB-2705, A-33, B-1, C-15),(IB-2706, A-33, B-2, C-15), (IB-2707, A-33, B-3, C-15), (IB-2708, A-33,B-4, C-15), (IB-2709, A-33, B-5, C-15), (IB-2710, A-33, B-6, C-15),(IB-2711, A-33, B-7, C-1), (IB-2712, A-33, B-7, C-2), (IB-2713, A-33,B-7, C-3), (IB-2714, A-33, B-7, C-4), (IB-2715, A-33, B-7, C-5),(IB-2716, A-33, B-7, C-6), (IB-2717, A-33, B-7, C-7), (IB-2718, A-33,B-7, C-8), (IB-2719, A-33, B-7, C-9), (IB-2720, A-33, B-7, C-10),(IB-2721, A-33, B-7, C-11), (IB-2722, A-33, B-7, C-12), (IB-2723, A-33,B-7, C-13), (IB-2724, A-33, B-7, C-14), (IB-2725, A-33, B-7, C-15),(IB-2726, A-33, B-7, C-16), (IB-2727, A-33, B-7, C-17), (IB-2728, A-33,B-7, C-18), (IB-2729, A-33, B-7, C-19), (IB-2730, A-33, B-7, C-20),(IB-2731, A-33, B-7, C-21), (IB-2732, A-33, B-7, C-22), (IB-2733, A-33,B-7, C-23), (IB-2734, A-33, B-7, C-24), (IB-2735, A-33, B-7, C-25),(IB-2736, A-33, B-7, C-26), (IB-2737, A-33, B-7, C-27), (IB-2738, A-33,B-7, C-28), (IB-2739, A-33, B-7, C-29), (IB-2740, A-33, B-7, C-30),(IB-2741, A-33, B-7, C-31), (IB-2742, A-33, B-7, C-32), (IB-2743, A-33,B-7, C-33), (IB-2744, A-33, B-7, C-34), (IB-2745, A-33, B-7, C-35),(IB-2746, A-33, B-7, C-36), (IB-2747, A-33, B-7, C-37), (IB-2748, A-33,B-7, C-38), (IB-2749, A-33, B-7, C-39), (IB-2750, A-33, B-7, C-40),(IB-2751, A-33, B-7, C-41), (IB-2752, A-33, B-7, C-42), (IB-2753, A-33,B-7, C-43), (IB-2754, A-33, B-7, C-44), (IB-2755, A-33, B-7, C-45),(IB-2756, A-33, B-7, C-46), (IB-2757, A-33, B-7, C-47), (IB-2758, A-33,B-7, C-48), (IB-2759, A-33, B-7, C-49), (IB-2760, A-33, B-7, C-50),(IB-2761, A-33, B-7, C-51), (IB-2762, A-33, B-7, C-52), (IB-2763, A-33,B-7, C-53), (IB-2764, A-33, B-7, C-54), (IB-2765, A-33, B-7, C-55),(IB-2766, A-33, B-7, C-56), (IB-2767, A-33, B-7, C-57), (IB-2768, A-33,B-7, C-58), (IB-2769, A-33, B-7, C-59), (IB-2770, A-33, B-7, C-60),(IB-2771, A-33, B-7, C-61), (IB-2772, A-33, B-7, C-62), (IB-2773, A-33,B-7, C-63), (IB-2774, A-33, B-7, C-64), (IB-2775, A-33, B-7, C-65),(IB-2776, A-33, B-7, C-66), (IB-2777, A-33, B-7, C-67), (IB-2778, A-33,B-7, C-68), (IB-2779, A-33, B-7, C-69), (IB-2780, A-33, B-7, C-70),(IB-2781, A-33, B-7, C-71), (IB-2782, A-33, B-7, C-72), (IB-2783, A-33,B-7, C-73), (IB-2784, A-33, B-7, C-74), (IB-2785, A-33, B-7, C-75),(IB-2786, A-33, B-7, C-76), (IB-2787, A-33, B-7, C-77), (IB-2788, A-33,B-7, C-78), (IB-2789, A-33, B-7, C-79), (IB-2790, A-33, B-7, C-80),(IB-2791, A-33, B-7, C-81), (IB-2792, A-33, B-7, C-82), (IB-2793, A-33,B-7, C-83), (IB-2794, A-33, B-7, C-84), (IB-2795, A-33, B-7, C-85),(IB-2796, A-33, B-7, C-86), (IB-2797, A-33, B-7, C-87), (IB-2798, A-33,B-7, C-88), (IB-2799, A-33, B-7, C-89), (IB-2800, A-33, B-7, C-90),(IB-2801, A-33, B-7, C-91), (IB-2802, A-33, B-7, C-92), (IB-2803, A-33,B-7, C-93), (IB-2804, A-33, B-7, C-94), (IB-2805, A-33, B-7, C-95),(IB-2806, A-33, B-7, C-96), (IB-2807, A-33, B-7, C-97), (IB-2808, A-33,B-7, C-98), (IB-2809, A-33, B-7, C-99), (IB-2810, A-33, B-7, C-100),(IB-2811, A-33, B-7, C-101), (IB-2812, A-33, B-7, C-102), (IB-2813,A-33, B-7, C-103), (IB-2814, A-33, B-7, C-104), (IB-2815, A-33, B-7,C-105), (IB-2816, A-33, B-7, C-106), (IB-2817, A-33, B-7, C-107),(IB-2818, A-33, B-7, C-108), (IB-2819, A-33, B-7, C-109), (IB-2820,A-33, B-7, C-110), (IB-2821, A-33, B-7, C-111), (IB-2822, A-33, B-7,C-112), (IB-2823, A-33, B-7, C-113), (IB-2824, A-33, B-7, C-114),(IB-2825, A-33, B-7, C-115), (IB-2826, A-33, B-7, C-116), (IB-2827,A-33, B-7, C-117), (IB-2828, A-33, B-7, C-118), (IB-2829, A-33, B-7,C-119), (IB-2830, A-33, B-7, C-120), (IB-2831, A-33, B-7, C-121),(IB-2832, A-33, B-7, C-122), (IB-2833, A-33, B-7, C-123), (IB-2834,A-33, B-7, C-124), (IB-2835, A-33, B-7, C-125), (IB-2836, A-33, B-7,C-126), (IB-2837, A-33, B-7, C-127), (IB-2838, A-33, B-7, C-128),(IB-2839, A-33, B-7, C-129), (IB-2840, A-33, B-7, C-130), (IB-2841,A-33, B-7, C-131), (IB-2842, A-33, B-7, C-132), (IB-2843, A-33, B-7,C-133), (IB-2844, A-33, B-7, C-134), (IB-2845, A-33, B-7, C-135),(IB-2846, A-33, B-7, C-136), (IB-2847, A-33, B-7, C-137), (IB-2848,A-33, B-7, C-138), (IB-2849, A-33, B-7, C-139), (IB-2850, A-33, B-7,C-140), (IB-2851, A-33, B-7, C-141), (IB-2852, A-33, B-7, C-142),(IB-2853, A-33, B-7, C-143), (IB-2854, A-33, B-7, C-144), (IB-2855,A-33, B-7, C-145), (IB-2856, A-33, B-7, C-146), (IB-2857, A-33, B-7,C-147), (IB-2858, A-33, B-7, C-148), (IB-2859, A-33, B-7, C-149),(IB-2860, A-33, B-7, C-150), (IB-2861, A-33, B-7, C-151), (IB-2862,A-33, B-7, C-152), (IB-2863, A-33, B-7, C-153), (IB-2864, A-33, B-7,C-154), (IB-2865, A-33, B-7, C-155), (IB-2866, A-33, B-7, C-156),(IB-2867, A-33, B-7, C-157), (IB-2868, A-33, B-7, C-158), (IB-2869,A-33, B-7, C-159), (IB-2870, A-33, B-7, C-160), (IB-2871, A-33, B-7,C-161), (IB-2872, A-33, B-7, C-162), (IB-2873, A-33, B-7, C-163),(IB-2874, A-33, B-7, C-164), (IB-2875, A-33, B-7, C-165), (IB-2876,A-33, B-7, C-166), (IB-2877, A-33, B-7, C-167), (IB-2878, A-33, B-7,C-168), (IB-2879, A-33, B-7, C-169), (IB-2880, A-33, B-7, C-170),(IB-2881, A-33, B-7, C-171), (IB-2882, A-33, B-7, C-172), (IB-2883,A-33, B-7, C-173), (IB-2884, A-33, B-7, C-174), (IB-2885, A-33, B-7,C-175), (IB-2886, A-33, B-7, C-176), (IB-2887, A-33, B-7, C-177),(IB-2888, A-33, B-7, C-178), (IB-2889, A-33, B-7, C-179), (IB-2890,A-33, B-7, C-180), (IB-2891, A-33, B-7, C-181), (IB-2892, A-33, B-7,C-182), (IB-2893, A-33, B-7, C-183), (IB-2894, A-33, B-7, C-184),(IB-2895, A-33, B-7, C-185), (IB-2896, A-33, B-7, C-186), (IB-2897,A-33, B-7, C-187), (IB-2898, A-33, B-7, C-188), (IB-2899, A-33, B-7,C-189), (IB-2900, A-33, B-7, C-190), (IB-2901, A-33, B-7, C-191),(IB-2902, A-33, B-7, C-192), (IB-2903, A-33, B-7, C-193), (IB-2904,A-33, B-7, C-194), (IB-2905, A-33, B-7, C-195), (IB-2906, A-33, B-7,C-196), (IB-2907, A-33, B-7, C-197), (IB-2908, A-33, B-7, C-198),(IB-2909, A-33, B-7, C-199), (IB-2910, A-33, B-7, C-200), (IB-2911,A-33, B-7, C-201), (IB-2912, A-33, B-7, C-202), (IB-2913, A-33, B-7,C-203), (IB-2914, A-33, B-7, C-204), (IB-2915, A-33, B-7, C-205),(IB-2916, A-33, B-7, C-206), (IB-2917, A-33, B-7, C-207), (IB-2918,A-33, B-7, C-208), (IB-2919, A-33, B-7, C-209), (IB-2920, A-33, B-7,C-210), (IB-2921, A-33, B-7, C-211), (IB-2922, A-33, B-7, C-212),(IB-2923, A-33, B-7, C-213), (IB-2924, A-33, B-7, C-214), (IB-2925,A-33, B-8, C-15), (IB-2926, A-33, B-9, C-15), (IB-2927, A-33, B-10,C-15), (IB-2928, A-33, B-10, C-52), (IB-2929, A-34, B-1, C-15),(IB-2930, A-34, B-2, C-15), (IB-2931, A-34, B-3, C-15), (IB-2932, A-34,B-4, C-15), (IB-2933, A-34, B-5, C-15), (IB-2934, A-34, B-6, C-15),(IB-2935, A-34, B-7, C-1), (IB-2936, A-34, B-7, C-2), (IB-2937, A-34,B-7, C-3), (IB-2938, A-34, B-7, C-4), (IB-2939, A-34, B-7, C-5),(IB-2940, A-34, B-7, C-6), (IB-2941, A-34, B-7, C-7), (IB-2942, A-34,B-7, C-8), (IB-2943, A-34, B-7, C-9), (IB-2944, A-34, B-7, C-10),(IB-2945, A-34, B-7, C-11), (IB-2946, A-34, B-7, C-12), (IB-2947, A-34,B-7, C-13), (IB-2948, A-34, B-7, C-14), (IB-2949, A-34, B-7, C-15),(IB-2950, A-34, B-7, C-16), (IB-2951, A-34, B-7, C-17), (IB-2952, A-34,B-7, C-18), (IB-2953, A-34, B-7, C-19), (IB-2954, A-34, B-7, C-20),(IB-2955, A-34, B-7, C-21), (IB-2956, A-34, B-7, C-22), (IB-2957, A-34,B-7, C-23), (IB-2958, A-34, B-7, C-24), (IB-2959, A-34, B-7, C-25),(IB-2960, A-34, B-7, C-26), (IB-2961, A-34, B-7, C-27), (IB-2962, A-34,B-7, C-28), (IB-2963, A-34, B-7, C-29), (IB-2964, A-34, B-7, C-30),(IB-2965, A-34, B-7, C-31), (IB-2966, A-34, B-7, C-32), (IB-2967, A-34,B-7, C-33), (IB-2968, A-34, B-7, C-34), (IB-2969, A-34, B-7, C-35),(IB-2970, A-34, B-7, C-36), (IB-2971, A-34, B-7, C-37), (IB-2972, A-34,B-7, C-38), (IB-2973, A-34, B-7, C-39), (IB-2974, A-34, B-7, C-40),(IB-2975, A-34, B-7, C-41), (IB-2976, A-34, B-7, C-42), (IB-2977, A-34,B-7, C-43), (IB-2978, A-34, B-7, C-44), (IB-2979, A-34, B-7, C-45),(IB-2980, A-34, B-7, C-46), (IB-2981, A-34, B-7, C-47), (IB-2982, A-34,B-7, C-48), (IB-2983, A-34, B-7, C-49), (IB-2984, A-34, B-7, C-50),(IB-2985, A-34, B-7, C-51), (IB-2986, A-34, B-7, C-52), (IB-2987, A-34,B-7, C-53), (IB-2988, A-34, B-7, C-54), (IB-2989, A-34, B-7, C-55),(IB-2990, A-34, B-7, C-56), (IB-2991, A-34, B-7, C-57), (IB-2992, A-34,B-7, C-58), (IB-2993, A-34, B-7, C-59), (IB-2994, A-34, B-7, C-60),(IB-2995, A-34, B-7, C-61), (IB-2996, A-34, B-7, C-62), (IB-2997, A-34,B-7, C-63), (IB-2998, A-34, B-7, C-64), (IB-2999, A-34, B-7, C-65),(IB-3000, A-34, B-7, C-66), (IB-3001, A-34, B-7, C-67), (IB-3002, A-34,B-7, C-68), (IB-3003, A-34, B-7, C-69), (IB-3004, A-34, B-7, C-70),(IB-3005, A-34, B-7, C-71), (IB-3006, A-34, B-7, C-72), (IB-3007, A-34,B-7, C-73), (IB-3008, A-34, B-7, C-74), (IB-3009, A-34, B-7, C-75),(IB-3010, A-34, B-7, C-76), (IB-3011, A-34, B-7, C-77), (IB-3012, A-34,B-7, C-78), (IB-3013, A-34, B-7, C-79), (IB-3014, A-34, B-7, C-80),(IB-3015, A-34, B-7, C-81), (IB-3016, A-34, B-7, C-82), (IB-3017, A-34,B-7, C-83), (IB-3018, A-34, B-7, C-84), (IB-3019, A-34, B-7, C-85),(IB-3020, A-34, B-7, C-86), (IB-3021, A-34, B-7, C-87), (IB-3022, A-34,B-7, C-88), (IB-3023, A-34, B-7, C-89), (IB-3024, A-34, B-7, C-90),(IB-3025, A-34, B-7, C-91), (IB-3026, A-34, B-7, C-92), (IB-3027, A-34,B-7, C-93), (IB-3028, A-34, B-7, C-94), (IB-3029, A-34, B-7, C-95),(IB-3030, A-34, B-7, C-96), (IB-3031, A-34, B-7, C-97), (IB-3032, A-34,B-7, C-98), (IB-3033, A-34, B-7, C-99), (IB-3034, A-34, B-7, C-100),(IB-3035, A-34, B-7, C-101), (IB-3036, A-34, B-7, C-102), (IB-3037,A-34, B-7, C-103), (IB-3038, A-34, B-7, C-104), (IB-3039, A-34, B-7,C-105), (IB-3040, A-34, B-7, C-106), (IB-3041, A-34, B-7, C-107),(IB-3042, A-34, B-7, C-108), (IB-3043, A-34, B-7, C-109), (IB-3044,A-34, B-7, C-110), (IB-3045, A-34, B-7, C-111), (IB-3046, A-34, B-7,C-112), (IB-3047, A-34, B-7, C-113), (IB-3048, A-34, B-7, C-114),(IB-3049, A-34, B-7, C-115), (IB-3050, A-34, B-7, C-116), (IB-3051,A-34, B-7, C-117), (IB-3052, A-34, B-7, C-118), (IB-3053, A-34, B-7,C-119), (IB-3054, A-34, B-7, C-120), (IB-3055, A-34, B-7, C-121),(IB-3056, A-34, B-7, C-122), (IB-3057, A-34, B-7, C-123), (IB-3058,A-34, B-7, C-124), (IB-3059, A-34, B-7, C-125), (IB-3060, A-34, B-7,C-126), (IB-3061, A-34, B-7, C-127), (IB-3062, A-34, B-7, C-128),(IB-3063, A-34, B-7, C-129), (IB-3064, A-34, B-7, C-130), (IB-3065,A-34, B-7, C-131), (IB-3066, A-34, B-7, C-132), (IB-3067, A-34, B-7,C-133), (IB-3068, A-34, B-7, C-134), (IB-3069, A-34, B-7, C-135),(IB-3070, A-34, B-7, C-136), (IB-3071, A-34, B-7, C-137), (IB-3072,A-34, B-7, C-138), (IB-3073, A-34, B-7, C-139), (IB-3074, A-34, B-7,C-140), (IB-3075, A-34, B-7, C-141), (IB-3076, A-34, B-7, C-142),(IB-3077, A-34, B-7, C-143), (IB-3078, A-34, B-7, C-144), (IB-3079,A-34, B-7, C-145), (IB-3080, A-34, B-7, C-146), (IB-3081, A-34, B-7,C-147), (IB-3082, A-34, B-7, C-148), (IB-3083, A-34, B-7, C-149),(IB-3084, A-34, B-7, C-150), (IB-3085, A-34, B-7, C-151), (IB-3086,A-34, B-7, C-152), (IB-3087, A-34, B-7, C-153), (IB-3088, A-34, B-7,C-154), (IB-3089, A-34, B-7, C-155), (IB-3090, A-34, B-7, C-156),(IB-3091, A-34, B-7, C-157), (IB-3092, A-34, B-7, C-158), (IB-3093,A-34, B-7, C-159), (IB-3094, A-34, B-7, C-160), (IB-3095, A-34, B-7,C-161), (IB-3096, A-34, B-7, C-162), (IB-3097, A-34, B-7, C-163),(IB-3098, A-34, B-7, C-164), (IB-3099, A-34, B-7, C-165), (IB-3100,A-34, B-7, C-166), (IB-3101, A-34, B-7, C-167), (IB-3102, A-34, B-7,C-168), (IB-3103, A-34, B-7, C-169), (IB-3104, A-34, B-7, C-170),(IB-3105, A-34, B-7, C-171), (IB-3106, A-34, B-7, C-172), (IB-3107,A-34, B-7, C-173), (IB-3108, A-34, B-7, C-174), (IB-3109, A-34, B-7,C-175), (IB-3110, A-34, B-7, C-176), (IB-3111, A-34, B-7, C-177),(IB-3112, A-34, B-7, C-178), (IB-3113, A-34, B-7, C-179), (IB-3114,A-34, B-7, C-180), (IB-3115, A-34, B-7, C-181), (IB-3116, A-34, B-7,C-182), (IB-3117, A-34, B-7, C-183), (IB-3118, A-34, B-7, C-184),(IB-3119, A-34, B-7, C-185), (IB-3120, A-34, B-7, C-186), (IB-3121,A-34, B-7, C-187), (IB-3122, A-34, B-7, C-188), (IB-3123, A-34, B-7,C-189), (IB-3124, A-34, B-7, C-190), (IB-3125, A-34, B-7, C-191),(IB-3126, A-34, B-7, C-192), (IB-3127, A-34, B-7, C-193), (IB-3128,A-34, B-7, C-194), (IB-3129, A-34, B-7, C-195), (IB-3130, A-34, B-7,C-196), (IB-3131, A-34, B-7, C-197), (IB-3132, A-34, B-7, C-198),(IB-3133, A-34, B-7, C-199), (IB-3134, A-34, B-7, C-200), (IB-3135,A-34, B-7, C-201), (IB-3136, A-34, B-7, C-202), (IB-3137, A-34, B-7,C-203), (IB-3138, A-34, B-7, C-204), (IB-3139, A-34, B-7, C-205),(IB-3140, A-34, B-7, C-206), (IB-3141, A-34, B-7, C-207), (IB-3142,A-34, B-7, C-208), (IB-3143, A-34, B-7, C-209), (IB-3144, A-34, B-7,C-210), (IB-3145, A-34, B-7, C-211), (IB-3146, A-34, B-7, C-212),(IB-3147, A-34, B-7, C-213), (IB-3148, A-34, B-7, C-214), (IB-3149,A-34, B-8, C-15), (IB-3150, A-34, B-9, C-15), (IB-3151, A-34, B-10,C-15), (IB-3152, A-34, B-10, C-52), (IB-3153, A-35, B-1, C-15),(IB-3154, A-35, B-2, C-15), (IB-3155, A-35, B-3, C-15), (IB-3156, A-35,B-4, C-15), (IB-3157, A-35, B-5, C-15), (IB-3158, A-35, B-6, C-15),(IB-3159, A-35, B-7, C-1), (IB-3160, A-35, B-7, C-2), (IB-3161, A-35,B-7, C-3), (IB-3162, A-35, B-7, C-4), (IB-3163, A-35, B-7, C-5),(IB-3164, A-35, B-7, C-6), (IB-3165, A-35, B-7, C-7), (IB-3166, A-35,B-7, C-8), (IB-3167, A-35, B-7, C-9), (IB-3168, A-35, B-7, C-10),(IB-3169, A-35, B-7, C-11), (IB-3170, A-35, B-7, C-12), (IB-3171, A-35,B-7, C-13), (IB-3172, A-35, B-7, C-14), (IB-3173, A-35, B-7, C-15),(IB-3174, A-35, B-7, C-16), (IB-3175, A-35, B-7, C-17), (IB-3176, A-35,B-7, C-18), (IB-3177, A-35, B-7, C-19), (IB-3178, A-35, B-7, C-20),(IB-3179, A-35, B-7, C-21), (IB-3180, A-35, B-7, C-22), (IB-3181, A-35,B-7, C-23), (IB-3182, A-35, B-7, C-24), (IB-3183, A-35, B-7, C-25),(IB-3184, A-35, B-7, C-26), (IB-3185, A-35, B-7, C-27), (IB-3186, A-35,B-7, C-28), (IB-3187, A-35, B-7, C-29), (IB-3188, A-35, B-7, C-30),(IB-3189, A-35, B-7, C-31), (IB-3190, A-35, B-7, C-32), (IB-3191, A-35,B-7, C-33), (IB-3192, A-35, B-7, C-34), (IB-3193, A-35, B-7, C-35),(IB-3194, A-35, B-7, C-36), (IB-3195, A-35, B-7, C-37), (IB-3196, A-35,B-7, C-38), (IB-3197, A-35, B-7, C-39), (IB-3198, A-35, B-7, C-40),(IB-3199, A-35, B-7, C-41), (IB-3200, A-35, B-7, C-42), (IB-3201, A-35,B-7, C-43), (IB-3202, A-35, B-7, C-44), (IB-3203, A-35, B-7, C-45),(IB-3204, A-35, B-7, C-46), (IB-3205, A-35, B-7, C-47), (IB-3206, A-35,B-7, C-48), (IB-3207, A-35, B-7, C-49), (IB-3208, A-35, B-7, C-50),(IB-3209, A-35, B-7, C-51), (IB-3210, A-35, B-7, C-52), (IB-3211, A-35,B-7, C-53), (IB-3212, A-35, B-7, C-54), (IB-3213, A-35, B-7, C-55),(IB-3214, A-35, B-7, C-56), (IB-3215, A-35, B-7, C-57), (IB-3216, A-35,B-7, C-58), (IB-3217, A-35, B-7, C-59), (IB-3218, A-35, B-7, C-60),(IB-3219, A-35, B-7, C-61), (IB-3220, A-35, B-7, C-62), (IB-3221, A-35,B-7, C-63), (IB-3222, A-35, B-7, C-64), (IB-3223, A-35, B-7, C-65),(IB-3224, A-35, B-7, C-66), (IB-3225, A-35, B-7, C-67), (IB-3226, A-35,B-7, C-68), (IB-3227, A-35, B-7, C-69), (IB-3228, A-35, B-7, C-70),(IB-3229, A-35, B-7, C-71), (IB-3230, A-35, B-7, C-72), (IB-3231, A-35,B-7, C-73), (IB-3232, A-35, B-7, C-74), (IB-3233, A-35, B-7, C-75),(IB-3234, A-35, B-7, C-76), (IB-3235, A-35, B-7, C-77), (IB-3236, A-35,B-7, C-78), (IB-3237, A-35, B-7, C-79), (IB-3238, A-35, B-7, C-80),(IB-3239, A-35, B-7, C-81), (IB-3240, A-35, B-7, C-82), (IB-3241, A-35,B-7, C-83), (IB-3242, A-35, B-7, C-84), (IB-3243, A-35, B-7, C-85),(IB-3244, A-35, B-7, C-86), (IB-3245, A-35, B-7, C-87), (IB-3246, A-35,B-7, C-88), (IB-3247, A-35, B-7, C-89), (IB-3248, A-35, B-7, C-90),(IB-3249, A-35, B-7, C-91), (IB-3250, A-35, B-7, C-92), (IB-3251, A-35,B-7, C-93), (IB-3252, A-35, B-7, C-94), (IB-3253, A-35, B-7, C-95),(IB-3254, A-35, B-7, C-96), (IB-3255, A-35, B-7, C-97), (IB-3256, A-35,B-7, C-98), (IB-3257, A-35, B-7, C-99), (IB-3258, A-35, B-7, C-100),(IB-3259, A-35, B-7, C-101), (IB-3260, A-35, B-7, C-102), (IB-3261,A-35, B-7, C-103), (IB-3262, A-35, B-7, C-104), (IB-3263, A-35, B-7,C-105), (IB-3264, A-35, B-7, C-106), (IB-3265, A-35, B-7, C-107),(IB-3266, A-35, B-7, C-108), (IB-3267, A-35, B-7, C-109), (IB-3268,A-35, B-7, C-110), (18-3269, A-35, B-7, C-111), (IB-3270, A-35, B-7,C-112), (IB-3271, A-35, B-7, C-113), (IB-3272, A-35, B-7, C-114),(IB-3273, A-35, B-7, C-115), (IB-3274, A-35, B-7, C-116), (IB-3275,A-35, B-7, C-117), (IB-3276, A-35, B-7, C-118), (IB-3277, A-35, B-7,C-119), (IB-3278, A-35, B-7, C-120), (IB-3279, A-35, B-7, C-121),(IB-3280, A-35, B-7, C-122), (IB-3281, A-35, B-7, C-123), (IB-3282,A-35, B-7, C-124), (IB-3283, A-35, B-7, C-125), (IB-3284, A-35, B-7,C-126), (IB-3285, A-35, B-7, C-127), (IB-3286, A-35, B-7, C-128),(IB-3287, A-35, B-7, C-129), (IB-3288, A-35, B-7, C-130), (IB-3289,A-35, B-7, C-131), (IB-3290, A-35, B-7, C-132), (IB-3291, A-35, B-7,C-133), (IB-3292, A-35, B-7, C-134), (IB-3293, A-35, B-7, C-135),(IB-3294, A-35, B-7, C-136), (IB-3295, A-35, B-7, C-137), (IB-3296,A-35, B-7, C-138), (IB-3297, A-35, B-7, C-139), (IB-3298, A-35, B-7,C-140), (IB-3299, A-35, B-7, C-141), (IB-3300, A-35, B-7, C-142),(IB-3301, A-35, B-7, C-143), (IB-3302, A-35, B-7, C-144), (IB-3303,A-35, B-7, C-145), (IB-3304, A-35, B-7, C-146), (IB-3305, A-35, B-7,C-147), (IB-3306, A-35, B-7, C-148), (IB-3307, A-35, B-7, C-149),(IB-3308, A-35, B-7, C-150), (IB-3309, A-35, B-7, C-151), (IB-3310,A-35, B-7, C-152), (IB-3311, A-35, B-7, C-153), (IB-3312, A-35, B-7,C-154), (IB-3313, A-35, B-7, C-155), (IB-3314, A-35, B-7, C-156),(IB-3315, A-35, B-7, C-157), (IB-3316, A-35, B-7, C-158), (IB-3317,A-35, B-7, C-159), (IB-3318, A-35, B-7, C-160), (IB-3319, A-35, B-7,C-161), (IB-3320, A-35, B-7, C-162), (IB-3321, A-35, B-7, C-163),(IB-3322, A-35, B-7, C-164), (IB-3323, A-35, B-7, C-165), (IB-3324,A-35, B-7, C-166), (IB-3325, A-35, B-7, C-167), (IB-3326, A-35, B-7,C-168), (IB-3327, A-35, B-7, C-169), (IB-3328, A-35, B-7, C-170),(IB-3329, A-35, B-7, C-171), (IB-3330, A-35, B-7, C-172), (IB-3331,A-35, B-7, C-173), (IB-3332, A-35, B-7, C-174), (IB-3333, A-35, B-7,C-175), (IB-3334, A-35, B-7, C-176), (IB-3335, A-35, B-7, C-177),(IB-3336, A-35, B-7, C-178), (IB-3337, A-35, B-7, C-179), (IB-3338,A-35, B-7, C-180), (IB-3339, A-35, B-7, C-181), (IB-3340, A-35, B-7,C-182), (IB-3341, A-35, B-7, C-183), (IB-3342, A-35, B-7, C-184),(IB-3343, A-35, B-7, C-185), (IB-3344, A-35, B-7, C-186), (IB-3345,A-35, B-7, C-187), (IB-3346, A-35, B-7, C-188), (IB-3347, A-35, B-7,C-189), (IB-3348, A-35, B-7, C-190), (IB-3349, A-35, B-7, C-191),(IB-3350, A-35, B-7, C-192), (IB-3351, A-35, B-7, C-193), (IB-3352,A-35, B-7, C-194), (IB-3353, A-35, B-7, C-195), (IB-3354, A-35, B-7,C-196), (IB-3355, A-35, B-7, C-197), (IB-3356, A-35, B-7, C-198),(IB-3357, A-35, B-7, C-199), (IB-3358, A-35, B-7, C-200), (IB-3359,A-35, B-7, C-201), (IB-3360, A-35, B-7, C-202), (IB-3361, A-35, B-7,C-203), (IB-3362, A-35, B-7, C-204), (IB-3363, A-35, B-7, C-205),(IB-3364, A-35, B-7, C-206), (IB-3364, A-35, B-7, C-207), (IB-3366,A-35, B-7, C-208), (IB-3367, A-35, B-7, C-209), (IB-3368, A-35, B-7,C-210), (IB-3369, A-35, B-7, C-211), (IB-3370, A-35, B-7, C-212),(IB-3371, A-35, B-7, C-213), (IB-3372, A-35, B-7, C-214), (IB-3373,A-35, B-8, C-15), (IB-3374, A-35, B-9, C-15), (IB-3375, A-35, B-10,C-15), (IB-3376, A-35, B-10, C-52), (IB-3377, A-36, B-1, C-15),(IB-3378, A-36, B-2, C-15), (IB-3379, A-36, B-3, C-15), (IB-3380, A-36,B-4, C-15), (IB-3381, A-36, B-5, C-15), (IB-3382, A-36, B-6, C-15),(IB-3383, A-36, B-7, C-1), (IB-3384, A-36, B-7, C-2), (IB-3385, A-36,B-7, C-3), (IB-3386, A-36, B-7, C-4), (IB-3387, A-36, B-7, C-5),(IB-3388, A-36, B-7, C-6), (IB-3389, A-36, B-7, C-7), (IB-3390, A-36,B-7, C-8), (IB-3391, A-36, B-7, C-9), (IB-3392, A-36, B-7, C-10),(IB-3393, A-36, B-7, C-11), (IB-3394, A-36, B-7, C-12), (IB-3395, A-36,B-7, C-13), (IB-3396, A-36, B-7, C-14), (IB-3397, A-36, B-7, C-15),(IB-3398, A-36, B-7, C-16), (IB-3399, A-36, B-7, C-17), (IB-3400, A-36,B-7, C-18), (IB-3401, A-36, B-7, C-19), (IB-3402, A-36, B-7, C-20),(IB-3403, A-36, B-7, C-21), (IB-3404, A-36, B-7, C-22), (IB-3405, A-36,B-7, C-23), (IB-3406, A-36, B-7, C-24), (IB-3407, A-36, B-7, C-25),(IB-3408, A-36, B-7, C-26), (IB-3409, A-36, B-7, C-27), (IB-3410, A-36,B-7, C-28), (IB-3411, A-36, B-7, C-29), (IB-3412, A-36, B-7, C-30),(IB-3413, A-36, B-7, C-31), (IB-3414, A-36, B-7, C-32), (IB-3415, A-36,B-7, C-33), (IB-3416, A-36, B-7, C-34), (IB-3417, A-36, B-7, C-35),(IB-3418, A-36, B-7, C-36), (IB-3419, A-36, B-7, C-37), (IB-3420, A-36,B-7, C-38), (IB-3421, A-36, B-7, C-39), (IB-3422, A-36, B-7, C-40),(IB-3423, A-36, B-7, C-41), (IB-3424, A-36, B-7, C-42), (IB-3425, A-36,B-7, C-43), (IB-3426, A-36, B-7, C-44), (IB-3427, A-36, B-7, C-45),(IB-3428, A-36, B-7, C-46), (IB-3429, A-36, B-7, C-47), (IB-3430, A-36,B-7, C-48), (IB-3431, A-36, B-7, C-49), (IB-3432, A-36, B-7, C-50),(IB-3433, A-36, B-7, C-51), (IB-3434, A-36, B-7, C-52), (IB-3435, A-36,B-7, C-53), (IB-3436, A-36, B-7, C-54), (IB-3437, A-36, B-7, C-55),(IB-3438, A-36, B-7, C-56), (IB-3439, A-36, B-7, C-57), (IB-3440, A-36,B-7, C-58), (IB-3441, A-36, B-7, C-59), (IB-3442, A-36, B-7, C-60),(IB-3443, A-36, B-7, C-61), (IB-3444, A-36, B-7, C-62), (IB-3445, A-36,B-7, C-63), (IB-3446, A-36, B-7, C-64), (IB-3447, A-36, B-7, C-65),(IB-3448, A-36, B-7, C-66), (IB-3449, A-36, B-7, C-67), (IB-3450, A-36,B-7, C-68), (IB-3451, A-36, B-7, C-69), (IB-3452, A-36, B-7, C-70),(IB-3453, A-36, B-7, C-71), (IB-3454, A-36, B-7, C-72), (IB-3455, A-36,B-7, C-73), (IB-3456, A-36, B-7, C-74), (IB-3457, A-36, B-7, C-75),(IB-3458, A-36, B-7, C-76), (IB-3459, A-36, B-7, C-77), (IB-3460, A-36,B-7, C-78), (IB-3461, A-36, B-7, C-79), (IB-3462, A-36, B-7, C-80),(IB-3463, A-36, B-7, C-81), (IB-3464, A-36, B-7, C-82), (IB-3465, A-36,B-7, C-83), (IB-3466, A-36, B-7, C-84), (IB-3467, A-36, B-7, C-85),(IB-3468, A-36, B-7, C-86), (IB-3469, A-36, B-7, C-87), (IB-3470, A-36,B-7, C-88), (IB-3471, A-36, B-7, C-89), (IB-3472, A-36, B-7, C-90),(IB-3473, A-36, B-7, C-91), (IB-3474, A-36, B-7, C-92), (IB-3475, A-36,B-7, C-93), (IB-3476, A-36, B-7, C-94), (IB-3477, A-36, B-7, C-95),(IB-3478, A-36, B-7, C-96), (IB-3479, A-36, B-7, C-97), (IB-3480, A-36,B-7, C-98), (IB-3481, A-36, B-7, C-99), (IB-3482, A-36, B-7, C-100),(IB-3483, A-36, B-7, C-101), (IB-3484, A-36, B-7, C-102), (IB-3485,A-36, B-7, C-103), (IB-3486, A-36, B-7, C-104), (IB-3487, A-36, B-7,C-105), (IB-3488, A-36, B-7, C-106), (IB-3489, A-36, B-7, C-107),(IB-3490, A-36, B-7, C-108), (IB-3491, A-36, B-7, C-109), (IB-3492,A-36, B-7, C-110), (IB-3493, A-36, B-7, C-111), (IB-3494, A-36, B-7,C-112), (IB-3495, A-36, B-7, C-113), (IB-3496, A-36, B-7, C-114),(IB-3497, A-36, B-7, C-115), (IB-3498, A-36, B-7, C-116), (IB-3499,A-36, B-7, C-117), (IB-3500, A-36, B-7, C-118), (IB-3501, A-36, B-7,C-119), (IB-3502, A-36, B-7, C-120), (IB-3503, A-36, B-7, C-121),(IB-3504, A-36, B-7, C-122), (IB-3505, A-36, B-7, C-123), (IB-3506,A-36, B-7, C-124), (IB-3507, A-36, B-7, C-125), (IB-3508, A-36, B-7,C-126), (IB-3509, A-36, B-7, C-127), (IB-3510, A-36, B-7, C-128),(IB-3511, A-36, B-7, C-129), (IB-3512, A-36, B-7, C-130), (IB-3513,A-36, B-7, C-131), (IB-3514, A-36, B-7, C-132), (IB-3515, A-36, B-7,C-133), (IB-3516, A-36, B-7, C-134), (IB-3517, A-36, B-7, C-135),(IB-3518, A-36, B-7, C-136), (IB-3519, A-36, B-7, C-137), (IB-3520,A-36, B-7, C-138), (IB-3521, A-36, B-7, C-139), (IB-3522, A-36, B-7,C-140), (IB-3523, A-36, B-7, C-141), (IB-3524, A-36, B-7, C-142),(IB-3525, A-36, B-7, C-143), (IB-3526, A-36, B-7, C-144), (IB-3527,A-36, B-7, C-145), (IB-3528, A-36, B-7, C-146), (IB-3529, A-36, B-7,C-147), (IB-3530, A-36, B-7, C-148), (IB-3531, A-36, B-7, C-149),(IB-3532, A-36, B-7, C-150), (IB-3533, A-36, B-7, C-151), (IB-3534,A-36, B-7, C-152), (IB-3535, A-36, B-7, C-153), (IB-3536, A-36, B-7,C-154), (IB-3537, A-36, B-7, C-155), (IB-3538, A-36, B-7, C-156),(IB-3539, A-36, B-7, C-157), (IB-3540, A-36, B-7, C-158), (IB-3541,A-36, B-7, C-159), (IB-3542, A-36, B-7, C-160), (IB-3543, A-36, B-7,C-161), (IB-3544, A-36, B-7, C-162), (IB-3545, A-36, B-7, C-163),(IB-3546, A-36, B-7, C-164), (IB-3547, A-36, B-7, C-165), (IB-3548,A-36, B-7, C-166), (IB-3549, A-36, B-7, C-167), (IB-3550, A-36, B-7,C-168), (IB-3551, A-36, B-7, C-169), (IB-3552, A-36, B-7, C-170),(IB-3553, A-36, B-7, C-171), (IB-3554, A-36, B-7, C-172), (IB-3555,A-36, B-7, C-173), (IB-3556, A-36, B-7, C-174), (IB-3557, A-36, B-7,C-175), (IB-3558, A-36, B-7, C-176), (IB-3559, A-36, B-7, C-177),(IB-3560, A-36, B-7, C-178), (IB-3561, A-36, B-7, C-179), (IB-3562,A-36, B-7, C-180), (IB-3563, A-36, B-7, C-181), (IB-3564, A-36, B-7,C-182), (IB-3565, A-36, B-7, C-183), (IB-3566, A-36, B-7, C-184),(IB-3567, A-36, B-7, C-185), (IB-3568, A-36, B-7, C-186), (IB-3569,A-36, B-7, C-187), (IB-3570, A-36, B-7, C-188), (IB-3571, A-36, B-7,C-189), (IB-3572, A-36, B-7, C-190), (IB-3573, A-36, B-7, C-191),(IB-3574, A-36, B-7, C-192), (IB-3575, A-36, B-7, C-193), (IB-3576,A-36, B-7, C-194), (IB-3577, A-36, B-7, C-195), (IB-3578, A-36, B-7,C-196), (IB-3579, A-36, B-7, C-197), (IB-3580, A-36, B-7, C-198),(IB-3581, A-36, B-7, C-199), (IB-3582, A-36, B-7, C-200), (IB-3583,A-36, B-7, C-201), (IB-3584, A-36, B-7, C-202), (IB-3585, A-36, B-7,C-203), (IB-3586, A-36, B-7, C-204), (IB-3587, A-36, B-7, C-205),(IB-3588, A-36, B-7, C-206), (IB-3589, A-36, B-7, C-207), (IB-3590,A-36, B-7, C-208), (IB-3591, A-36, B-7, C-209), (IB-3592, A-36, B-7,C-210), (IB-3593, A-36, B-7, C-211), (IB-3594, A-36, B-7, C-212),(IB-3595, A-36, B-7, C-213), (IB-3596, A-36, B-7, C-214), (IB-3597,A-36, B-8, C-15), (IB-3598, A-36, B-9, C-15), (IB-3599, A-36, B-10,C-15), (IB-3600, A-36, B-10, C-52), (IB-3601, A-37, B-1, C-15),(IB-3602, A-37, B-2, C-15), (IB-3603, A-37, B-3, C-15), (IB-3604, A-37,B-4, C-15), (IB-3605, A-37, B-5, C-15), (IB-3606, A-37, B-6, C-15),(IB-3607, A-37, B-7, C-1), (IB-3608, A-37, B-7, C-2), (IB-3609, A-37,B-7, C-3), (IB-3610, A-37, B-7, C-4), (IB-3611, A-37, B-7, C-5),(IB-3612, A-37, B-7, C-6), (IB-3613, A-37, B-7, C-7), (IB-3614, A-37,B-7, C-8), (IB-3615, A-37, B-7, C-9), (IB-3616, A-37, B-7, C-10),(IB-3617, A-37, B-7, C-11), (IB-3618, A-37, B-7, C-12), (IB-3619, A-37,B-7, C-13), (IB-3620, A-37, B-7, C-14), (IB-3621, A-37, B-7, C-15),(IB-3622, A-37, B-7, C-16), (IB-3623, A-37, B-7, C-17), (IB-3624, A-37,B-7, C-18), (IB-3625, A-37, B-7, C-19), (IB-3626, A-37, B-7, C-20),(IB-3627, A-37, B-7, C-21), (IB-3628, A-37, B-7, C-22), (IB-3629, A-37,B-7, C-23), (IB-3630, A-37, B-7, C-24), (IB-3631, A-37, B-7, C-25),(IB-3632, A-37, B-7, C-26), (IB-3633, A-37, B-7, C-27), (IB-3634, A-37,B-7, C-28), (IB-3635, A-37, B-7, C-29), (IB-3636, A-37, B-7, C-30),(IB-3637, A-37, B-7, C-31), (IB-3638, A-37, B-7, C-32), (IB-3639, A-37,B-7, C-33), (IB-3640, A-37, B-7, C-34), (IB-364 LA-37, B-7, C-35),(IB-3642, A-37, B-7, C-36), (IB-3643, A-37, B-7, C-37), (IB-3644, A-37,B-7, C-38), (IB-3645, A-37, B-7, C-39), (IB-3646, A-37, B-7, C-40),(IB-3647, A-37, B-7, C-41), (IB-3648, A-37, B-7, C-42), (IB-3649, A-37,B-7, C-43), (IB-3650, A-37, B-7, C-44), (IB-3651, A-37, B-7, C-45),(IB-3652, A-37, B-7, C-46), (IB-3653, A-37, B-7, C-47), (IB-3654, A-37,B-7, C-48), (IB-3655, A-37, B-7, C-49), (IB-3656, A-37, B-7, C-50),(IB-3657, A-37, B-7, C-51), (IB-3658, A-37, B-7, C-52), (IB-3659, A-37,B-7, C-53), (IB-3660, A-37, B-7, C-54), (IB-3661, A-37, B-7, C-55),(IB-3662, A-37, B-7, C-56), (IB-3663, A-37, B-7, C-57), (IB-3664, A-37,B-7, C-58), (IB-3665, A-37, B-7, C-59), (IB-3666, A-37, B-7, C-60),(IB-3667, A-37, B-7, C-61), (IB-3668, A-37, B-7, C-62), (IB-3669, A-37,B-7, C-63), (IB-3670, A-37, B-7, C-64), (IB-3671, A-37, B-7, C-65),(IB-3672, A-37, B-7, C-66), (IB-3673, A-37, B-7, C-67), (IB-3674, A-37,B-7, C-68), (IB-3675, A-37, B-7, C-69), (IB-3676, A-37, B-7, C-70),(IB-3677, A-37, B-7, C-71), (IB-3678, A-37, B-7, C-72), (IB-3679, A-37,B-7, C-73), (IB-3680, A-37, B-7, C-74), (IB-3681, A-37, B-7, C-75),(IB-3682, A-37, B-7, C-76), (IB-3683, A-37, B-7, C-77), (IB-3684, A-37,B-7, C-78), (IB-3685, A-37, B-7, C-79), (IB-3686, A-37, B-7, C-80),(IB-3687, A-37, B-7, C-81), (IB-3688, A-37, B-7, C-82), (IB-3689, A-37,B-7, C-83), (IB-3690, A-37, B-7, C-84), (IB-3691, A-37, B-7, C-85),(IB-3692, A-37, B-7, C-86), (IB-3693, A-37, B-7, C-87), (IB-3694, A-37,B-7, C-88), (IB-3695, A-37, B-7, C-89), (IB-3696, A-37, B-7, C-90),(IB-3697, A-37, B-7, C-91), (IB-3698, A-37, B-7, C-92), (IB-3699, A-37,B-7, C-93), (IB-3700, A-37, B-7, C-94), (IB-3701, A-37, B-7, C-95),(IB-3702, A-37, B-7, C-96), (IB-3703, A-37, B-7, C-97), (IB-3704, A-37,B-7, C-98), (IB-3705, A-37, B-7, C-99), (IB-3706, A-37, B-7, C-100),(IB-3707, A-37, B-7, C-101), (IB-3708, A-37, B-7, C-102), (IB-3709,A-37, B-7, C-103), (IB-3710, A-37, B-7, C-104), (IB-3711, A-37, B-7,C-105), (IB-3712, A-37, B-7, C-106), (IB-3713, A-37, B-7, C-107),(IB-3714, A-37, B-7, C-108), (IB-3715, A-37, B-7, C-109), (IB-3716,A-37, B-7, C-110), (IB-3717, A-37, B-7, C-111), (IB-3718, A-37, B-7,C-112), (IB-3719, A-37, B-7, C-113), (IB-3720, A-37, B-7, C-114),(IB-3721, A-37, B-7, C-115), (IB-3722, A-37, B-7, C-116), (IB-3723,A-37, B-7, C-117), (IB-3724, A-37, B-7, C-118), (IB-3725, A-37, B-7,C-119), (IB-3726, A-37, B-7, C-120), (IB-3727, A-37, B-7, C-121),(IB-3728, A-37, B-7, C-122), (IB-3729, A-37, B-7, C-123), (IB-3730,A-37, B-7, C-124), (IB-3731, A-37, B-7, C-125), (IB-3732, A-37, B-7,C-126), (IB-3733, A-37, B-7, C-127), (IB-3734, A-37, B-7, C-128),(IB-3735, A-37, B-7, C-129), (IB-3736, A-37, B-7, C-130), (IB-3737,A-37, B-7, C-131), (IB-3738, A-37, B-7, C-132), (IB-3739, A-37, B-7,C-133), (IB-3740, A-37, B-7, C-134), (IB-3741, A-37, B-7, C-135),(IB-3742, A-37, B-7, C-136), (IB-3743, A-37, B-7, C-137), (IB-3744,A-37, B-7, C-138), (IB-3745, A-37, B-7, C-139), (IB-3746, A-37, B-7,C-140), (IB-3747, A-37, B-7, C-141), (IB-3748, A-37, B-7, C-142),(IB-3749, A-37, B-7, C-143), (IB-3750, A-37, B-7, C-144), (IB-3751,A-37, B-7, C-145), (IB-3752, A-37, B-7, C-146), (IB-3753, A-37, B-7,C-147), (IB-3754, A-37, B-7, C-148), (IB-3755, A-37, B-7, C-149),(IB-3756, A-37, B-7, C-150), (IB-3757, A-37, B-7, C-151), (IB-3758,A-37, B-7, C-152), (IB-3759, A-37, B-7, C-153), (IB-3760, A-37, B-7,C-154), (IB-3761, A-37, B-7, C-155), (IB-3762, A-37, B-7, C-156),(IB-3763, A-37, B-7, C-157), (IB-3764, A-37, B-7, C-158), (IB-3765,A-37, B-7, C-159), (IB-3766, A-37, B-7, C-160), (IB-3767, A-37, B-7,C-161), (IB-3768, A-37, B-7, C-162), (IB-3769, A-37, B-7, C-163),(IB-3770, A-37, B-7, C-164), (IB-3771, A-37, B-7, C-165), (IB-3772,A-37, B-7, C-166), (IB-3773, A-37, B-7, C-167), (IB-3774, A-37, B-7,C-168), (IB-3775, A-37, B-7, C-169), (IB-3776, A-37, B-7, C-170),(IB-3777, A-37, B-7, C-171), (IB-3778, A-37, B-7, C-172), (IB-3779,A-37, B-7, C-173), (IB-3780, A-37, B-7, C-174), (IB-3781, A-37, B-7,C-175), (IB-3782, A-37, B-7, C-176), (IB-3783, A-37, B-7, C-177),(IB-3784, A-37, B-7, C-178), (IB-3785, A-37, B-7, C-179), (IB-3786,A-37, B-7, C-180), (IB-3787, A-37, B-7, C-181), (IB-3788, A-37, B-7,C-182), (IB-3789, A-37, B-7, C-183), (IB-3790, A-37, B-7, C-184),(IB-3791, A-37, B-7, C-185), (IB-3792, A-37, B-7, C-186), (IB-3793,A-37, B-7, C-187), (IB-3794, A-37, B-7, C-188), (IB-3795, A-37, B-7,C-189), (IB-3796, A-37, B-7, C-190), (IB-3797, A-37, B-7, C-191),(IB-3798, A-37, B-7, C-192), (IB-3799, A-37, B-7, C-193), (IB-3800,A-37, B-7, C-194), (IB-3801, A-37, B-7, C-195), (IB-3802, A-37, B-7,C-196), (IB-3803, A-37, B-7, C-197), (IB-3804, A-37, B-7, C-198),(IB-3805, A-37, B-7, C-199), (IB-3806, A-37, B-7, C-200), (IB-3807,A-37, B-7, C-201), (IB-3808, A-37, B-7, C-202), (IB-3809, A-37, B-7,C-203), (IB-3810, A-37, B-7, C-204), (IB-3811, A-37, B-7, C-205),(IB-3812, A-37, B-7, C-206), (IB-3813, A-37, B-7, C-207), (IB-3814,A-37, B-7, C-208), (IB-3815, A-37, B-7, C-209), (IB-3816, A-37, B-7,C-210), (IB-3817, A-37, B-7, C-211), (IB-3818, A-37, B-7, C-212),(IB-3819, A-37, B-7, C-213), (IB-3820, A-37, B-7, C-214), (IB-3821,A-37, B-8, C-15), (IB-3822, A-37, B-9, C-15), (IB-3823, A-37, B-10,C-15), (IB-3824, A-37, B-10, C-52), (IB-3825, A-38, B-1, C-15),(IB-3826, A-38, B-2, C-15), (IB-3827, A-38, B-3, C-15), (IB-3828, A-38,B-4, C-15), (IB-3829, A-38, B-5, C-15), (IB-3830, A-38, B-6, C-15),(IB-3831, A-38, B-7, C-1), (IB-3832, A-38, B-7, C-2), (IB-3833, A-38,B-7, C-3), (IB-3834, A-38, B-7, C-4), (IB-3835, A-38, B-7, C-5),(IB-3836, A-38, B-7, C-6), (IB-3837, A-38, B-7, C-7), (IB-3838, A-38,B-7, C-8), (IB-3839, A-38, B-7, C-9), (IB-3840, A-38, B-7, C-10),(IB-3841, A-38, B-7, C-11), (IB-3842, A-38, B-7, C-12), (IB-3843, A-38,B-7, C-13), (IB-3844, A-38, B-7, C-14), (IB-3845, A-38, B-7, C-15),(IB-3846, A-38, B-7, C-16), (IB-3847, A-38, B-7, C-17), (IB-3848, A-38,B-7, C-18), (IB-3849, A-38, B-7, C-19), (IB-3850, A-38, B-7, C-20),(IB-3851, A-38, B-7, C-21), (IB-3852, A-38, B-7, C-22), (IB-3853, A-38,B-7, C-23), (IB-3854, A-38, B-7, C-24), (IB-3855, A-38, B-7, C-25),(IB-3856, A-38, B-7, C-26), (IB-3857, A-38, B-7, C-27), (IB-3858, A-38,B-7, C-28), (IB-3859, A-38, B-7, C-29), (IB-3860, A-38, B-7, C-30),(IB-3861, A-38, B-7, C-31), (IB-3862, A-38, B-7, C-32), (IB-3863, A-38,B-7, C-33), (IB-3864, A-38, B-7, C-34), (IB-3865, A-38, B-7, C-35),(IB-3866, A-38, B-7, C-36), (IB-3867, A-38, B-7, C-37), (IB-3868, A-38,B-7, C-38), (IB-3869, A-38, B-7, C-39), (IB-3870, A-38, B-7, C-40),(IB-3871, A-38, B-7, C-41), (IB-3872, A-38, B-7, C-42), (IB-3873, A-38,B-7, C-43), (IB-3874, A-38, B-7, C-44), (IB-3875, A-38, B-7, C-45),(IB-3876, A-38, B-7, C-46), (IB-3877, A-38, B-7, C-47), (IB-3878, A-38,B-7, C-48), (IB-3879, A-38, B-7, C-49), (IB-3880, A-38, B-7, C-50),(IB-3881, A-38, B-7, C-51), (IB-3882, A-38, B-7, C-52), (IB-3883, A-38,B-7, C-53), (IB-3884, A-38, B-7, C-54), (IB-3885, A-38, B-7, C-55),(IB-3886, A-38, B-7, C-56), (IB-3887, A-38, B-7, C-57), (IB-3888, A-38,B-7, C-58), (IB-3889, A-38, B-7, C-59), (IB-3890, A-38, B-7, C-60),(IB-3891, A-38, B-7, C-61), (IB-3892, A-38, B-7, C-62), (IB-3893, A-38,B-7, C-63), (IB-3894, A-38, B-7, C-64), (IB-3895, A-38, B-7, C-65),(IB-3896, A-38, B-7, C-66), (IB-3897, A-38, B-7, C-67), (IB-3898, A-38,B-7, C-68), (IB-3899, A-38, B-7, C-69), (IB-3900, A-38, B-7, C-70),(IB-3901, A-38, B-7, C-71), (IB-3902, A-38, B-7, C-72), (IB-3903, A-38,B-7, C-73), (IB-3904, A-38, B-7, C-74), (IB-3905, A-38, B-7, C-75),(IB-3906, A-38, B-7, C-76), (IB-3907, A-38, B-7, C-77), (IB-3908, A-38,B-7, C-78), (IB-3909, A-38, B-7, C-79), (IB-3910, A-38, B-7, C-80),(IB-3911, A-38, B-7, C-81), (IB-3912, A-38, B-7, C-82), (IB-3913, A-38,B-7, C-83), (IB-3914, A-38, B-7, C-84), (IB-3915, A-38, B-7, C-85),(IB-3916, A-38, B-7, C-86), (IB-3917, A-38, B-7, C-87), (IB-3918, A-38,B-7, C-88), (IB-3919, A-38, B-7, C-89), (IB-3920, A-38, B-7, C-90),(IB-3921, A-38, B-7, C-91), (IB-3922, A-38, B-7, C-92), (IB-3923, A-38,B-7, C-93), (IB-3924, A-38, B-7, C-94), (IB-3925, A-38, B-7, C-95),(IB-3926, A-38, B-7, C-96), (IB-3927, A-38, B-7, C-97), (IB-3928, A-38,B-7, C-98), (IB-3929, A-38, B-7, C-99), (IB-3930, A-38, B-7, C-100),(IB-3931, A-38, B-7, C-101), (IB-3932, A-38, B-7, C-102), (IB-3933,A-38, B-7, C-103), (IB-3934, A-38, B-7, C-104), (IB-3935, A-38, B-7,C-105), (IB-3936, A-38, B-7, C-106), (IB-3937, A-38, B-7, C-107),(IB-3938, A-38, B-7, C-108), (IB-3939, A-38, B-7, C-109), (IB-3940,A-38, B-7, C-110), (IB-3941, A-38, B-7, C-111), (IB-3942, A-38, B-7,C-112), (IB-3943, A-38, B-7, C-113), (IB-3944, A-38, B-7, C-114),(IB-3945, A-38, B-7, C-115), (IB-3946, A-38, B-7, C-116), (IB-3947,A-38, B-7, C-117), (IB-3948, A-38, B-7, C-118), (IB-3949, A-38, B-7,C-119), (IB-3950, A-38, B-7, C-120), (IB-3951, A-38, B-7, C-121),(IB-3952, A-38, B-7, C-122), (IB-3953, A-38, B-7, C-123), (IB-3954,A-38, B-7, C-124), (IB-3955, A-38, B-7, C-125), (IB-3956, A-38, B-7,C-126), (IB-3957, A-38, B-7, C-127), (IB-3958, A-38, B-7, C-128),(IB-3959, A-38, B-7, C-129), (IB-3960, A-38, B-7, C-130), (IB-3961,A-38, B-7, C-131), (IB-3962, A-38, B-7, C-132), (IB-3963, A-38, B-7,C-133), (IB-3964, A-38, B-7, C-134), (IB-3965, A-38, B-7, C-135),(IB-3966, A-38, B-7, C-136), (IB-3967, A-38, B-7, C-137), (IB-3968,A-38, B-7, C-138), (IB-3969, A-38, B-7, C-139), (IB-3970, A-38, B-7,C-140), (IB-3971, A-38, B-7, C-141), (IB-3972, A-38, B-7, C-142),(IB-3973, A-38, B-7, C-143), (IB-3974, A-38, B-7, C-144), (IB-3975,A-38, B-7, C-145), (IB-3976, A-38, B-7, C-146), (IB-3977, A-38, B-7,C-147), (IB-3978, A-38, B-7, C-148), (IB-3979, A-38, B-7, C-149),(IB-3980, A-38, B-7, C-150), (IB-3981, A-38, B-7, C-151), (IB-3982,A-38, B-7, C-152), (IB-3983, A-38, B-7, C-153), (IB-3984, A-38, B-7,C-154), (IB-3985, A-38, B-7, C-155), (IB-3986, A-38, B-7, C-156),(IB-3987, A-38, B-7, C-157), (IB-3988, A-38, B-7, C-158), (IB-3989,A-38, B-7, C-159), (IB-3990, A-38, B-7, C-160), (IB-3991, A-38, B-7,C-161), (IB-3992, A-38, B-7, C-162), (IB-3993, A-38, B-7, C-163),(IB-3994, A-38, B-7, C-164), (IB-3995, A-38, B-7, C-165), (IB-3996,A-38, B-7, C-166), (IB-3997, A-38, B-7, C-167), (IB-3998, A-38, B-7,C-168), (IB-3999, A-38, B-7, C-169), (IB-4000, A-38, B-7, C-170),(IB-4001, A-38, B-7, C-171), (IB-4002, A-38, B-7, C-172), (IB-4003,A-38, B-7, C-173), (IB-4004, A-38, B-7, C-174), (IB-4005, A-38, B-7,C-175), (IB-4006, A-38, B-7, C-176), (IB-4007, A-38, B-7, C-177),(IB-4008, A-38, B-7, C-178), (IB-4009, A-38, B-7, C-179), (IB-4010,A-38, B-7, C-180), (IB-4011, A-38, B-7, C-181), (IB-4012, A-38, B-7,C-182), (IB-4013, A-38, B-7, C-183), (IB-4014, A-38, B-7, C-184),(IB-4015, A-38, B-7, C-185), (IB-4016, A-38, B-7, C-186), (IB-4017,A-38, B-7, C-187), (IB-4018, A-38, B-7, C-188), (IB-4019, A-38, B-7,C-189), (IB-4020, A-38, B-7, C-190), (IB-4021, A-38, B-7, C-191),(IB-4022, A-38, B-7, C-192), (IB-4023, A-38, B-7, C-193), (IB-4024,A-38, B-7, C-194), (IB-4025, A-38, B-7, C-195), (IB-4026, A-38, B-7,C-196), (IB-4027, A-38, B-7, C-197), (IB-4028, A-38, B-7, C-198),(IB-4029, A-38, B-7, C-199), (IB-4030, A-38, B-7, C-200), (IB-4031,A-38, B-7, C-201), (IB-4032, A-38, B-7, C-202), (IB-4033, A-38, B-7,C-203), (IB-4034, A-38, B-7, C-204), (IB-4035, A-38, B-7, C-205),(IB-4036, A-38, B-7, C-206), (IB-4037, A-38, B-7, C-207), (IB-4038,A-38, B-7, C-208), (IB-4039, A-38, B-7, C-209), (IB-4040, A-38, B-7,C-210), (IB-4041, A-38, B-7, C-211), (IB-4042, A-38, B-7, C-212),(IB-4043, A-38, B-7, C-213), (IB-4044, A-38, B-7, C-214), (IB-4045,A-38, B-8, C-15), (IB-4046, A-38, B-9, C-15), (IB-4047, A-38, B-10,C-15), (IB-4048, A-38, B-10, C-52), (IB-4049, A-39, B-1, C-15),(IB-4050, A-39, B-2, C-15), (IB-4051, A-39, B-3, C-15), (IB-4052, A-39,B-4, C-15), (IB-4053, A-39, B-5, C-15), (IB-4054, A-39, B-6, C-15),(IB-4055, A-39, B-7, C-1), (IB-4056, A-39, B-7, C-2), (IB-4057, A-39,B-7, C-3), (IB-4058, A-39, B-7, C-4), (IB-4059, A-39, B-7, C-5),(IB-4060, A-39, B-7, C-6), (IB-4061, A-39, B-7, C-7), (IB-4062, A-39,B-7, C-8), (IB-4063, A-39, B-7, C-9), (IB-4064, A-39, B-7, C-10),(IB-4065, A-39, B-7, C-11), (IB-4066, A-39, B-7, C-12), (IB-4067, A-39,B-7, C-13), (IB-4068, A-39, B-7, C-14), (IB-4069, A-39, B-7, C-15),(IB-4070, A-39, B-7, C-16), (IB-4071, A-39, B-7, C-17), (IB-4072, A-39,B-7, C-18), (IB-4073, A-39, B-7, C-19), (IB-4074, A-39, B-7, C-20),(IB-4075, A-39, B-7, C-21), (IB-4076, A-39, B-7, C-22), (IB-4077, A-39,B-7, C-23), (IB-4078, A-39, B-7, C-24), (IB-4079, A-39, B-7, C-25),(IB-4080, A-39, B-7, C-26), (IB-4081, A-39, B-7, C-27), (IB-4082, A-39,B-7, C-28), (IB-4083, A-39, B-7, C-29), (IB-4084, A-39, B-7, C-30),(IB-4085, A-39, B-7, C-31), (IB-4086, A-39, B-7, C-32), (IB-4087, A-39,B-7, C-33), (IB-4088, A-39, B-7, C-34), (IB-4089, A-39, B-7, C-35),(IB-4090, A-39, B-7, C-36), (IB-4091, A-39, B-7, C-37), (IB-4092, A-39,B-7, C-38), (IB-4093, A-39, B-7, C-39), (IB-4094, A-39, B-7, C-40),(IB-4095, A-39, B-7, C-41), (IB-4096, A-39, B-7, C-42), (IB-4097, A-39,B-7, C-43), (IB-4098, A-39, B-7, C-44), (IB-4099, A-39, B-7, C-45),(IB-4100, A-39, B-7, C-46), (IB-4101, A-39, B-7, C-47), (IB-4102, A-39,B-7, C-48), (IB-4103, A-39, B-7, C-49), (IB-4104, A-39, B-7, C-50),(IB-4105, A-39, B-7, C-51), (IB-4106, A-39, B-7, C-52), (IB-4107, A-39,B-7, C-53), (IB-4108, A-39, B-7, C-54), (IB-4109, A-39, B-7, C-55),(IB-4110, A-39, B-7, C-56), (IB-4111, A-39, B-7, C-57), (IB-4112, A-39,B-7, C-58), (IB-4113, A-39, B-7, C-59), (IB-4114, A-39, B-7, C-60),(IB-4115, A-39, B-7, C-61), (IB-4116, A-39, B-7, C-62), (IB-4117, A-39,B-7, C-63), (IB-4118, A-39, B-7, C-64), (IB-4119, A-39, B-7, C-65),(IB-4120, A-39, B-7, C-66), (IB-4121, A-39, B-7, C-67), (IB-4122, A-39,B-7, C-68), (IB-4123, A-39, B-7, C-69), (IB-4124, A-39, B-7, C-70),(IB-4125, A-39, B-7, C-71), (IB-4126, A-39, B-7, C-72), (IB-4127, A-39,B-7, C-73), (IB-4128, A-39, B-7, C-74), (IB-4129, A-39, B-7, C-75),(IB-4130, A-39, B-7, C-76), (IB-4131, A-39, B-7, C-77), (IB-4132, A-39,B-7, C-78), (IB-4133, A-39, B-7, C-79), (IB-4134, A-39, B-7, C-80),(IB-4135, A-39, B-7, C-81), (IB-4136, A-39, B-7, C-82), (IB-4137, A-39,B-7, C-83), (IB-4138, A-39, B-7, C-84), (IB-4139, A-39, B-7, C-85),(IB-4140, A-39, B-7, C-86), (IB-4141, A-39, B-7, C-87), (IB-4142, A-39,B-7, C-88), (IB-4143, A-39, B-7, C-89), (IB-4144, A-39, B-7, C-90),(IB-4145, A-39, B-7, C-91), (IB-4146, A-39, B-7, C-92), (IB-4147, A-39,B-7, C-93), (IB-4148, A-39, B-7, C-94), (IB-4149, A-39, B-7, C-95),(IB-4150, A-39, B-7, C-96), (IB-4151, A-39, B-7, C-97), (IB-4152, A-39,B-7, C-98), (IB-4153, A-39, B-7, C-99), (IB-4154, A-39, B-7, C-100),(IB-4155, A-39, B-7, C-101), (IB-4156, A-39, B-7, C-102), (IB-4157,A-39, B-7, C-103), (IB-4158, A-39, B-7, C-104), (IB-4159, A-39, B-7,C-105), (IB-4160, A-39, B-7, C-106), (IB-4161, A-39, B-7, C-107),(IB-4162, A-39, B-7, C-108), (IB-4163, A-39, B-7, C-109), (IB-4164,A-39, B-7, C-110), (IB-4165, A-39, B-7, C-111), (IB-4166, A-39, B-7,C-112), (IB-4167, A-39, B-7, C-113), (IB-4168, A-39, B-7, C-114),(IB-4169, A-39, B-7, C-115), (IB-4170, A-39, B-7, C-116), (IB-4171,A-39, B-7, C-117), (IB-4172, A-39, B-7, C-118), (IB-4173, A-39, B-7,C-119), (IB-4174, A-39, B-7, C-120), (IB-4175, A-39, B-7, C-121),(IB-4176, A-39, B-7, C-122), (IB-4177, A-39, B-7, C-123), (IB-4178,A-39, B-7, C-124), (IB-4179, A-39, B-7, C-125), (IB-4180, A-39, B-7,C-126), (IB-4181, A-39, B-7, C-127), (IB-4182, A-39, B-7, C-128),(IB-4183, A-39, B-7, C-129), (IB-4184, A-39, B-7, C-130), (IB-4185,A-39, B-7, C-131), (IB-4186, A-39, B-7, C-132), (IB-4187, A-39, B-7,C-133), (IB-4188, A-39, B-7, C-134), (IB-4189, A-39, B-7, C-135),(IB-4190, A-39, B-7, C-136), (IB-4191, A-39, B-7, C-137), (IB-4192,A-39, B-7, C-138), (IB-4193, A-39, B-7, C-139), (IB-4194, A-39, B-7,C-140), (IB-4195, A-39, B-7, C-141), (IB-4196, A-39, B-7, C-142),(IB-4197, A-39, B-7, C-143), (IB-4198, A-39, B-7, C-144), (IB-4199,A-39, B-7, C-145), (IB-4200, A-39, B-7, C-146), (IB-4201, A-39, B-7,C-147), (IB-4202, A-39, B-7, C-148), (IB-4203, A-39, B-7, C-149),(IB-4204, A-39, B-7, C-150), (IB-4205, A-39, B-7, C-151), (IB-4206,A-39, B-7, C-152), (IB-4207, A-39, B-7, C-153), (IB-4208, A-39, B-7,C-154), (IB-4209, A-39, B-7, C-155), (IB-4210, A-39, B-7, C-156),(IB-4211, A-39, B-7, C-157), (IB-4212, A-39, B-7, C-158), (IB-4213,A-39, B-7, C-159), (IB-4214, A-39, B-7, C-160), (IB-4215, A-39, B-7,C-161), (IB-4216, A-39, B-7, C-162), (IB-4217, A-39, B-7, C-163),(IB-4218, A-39, B-7, C-164), (IB-4219, A-39, B-7, C-165), (IB-4220,A-39, B-7, C-166), (IB-4221, A-39, B-7, C-167), (IB-4222, A-39, B-7,C-168), (IB-4223, A-39, B-7, C-169), (IB-4224, A-39, B-7, C-170),(IB-4225, A-39, B-7, C-171), (IB-4226, A-39, B-7, C-172), (IB-4227,A-39, B-7, C-173), (IB-4228, A-39, B-7, C-174), (IB-4229, A-39, B-7,C-175), (IB-4230, A-39, B-7, C-176), (IB-4231, A-39, B-7, C-177),(IB-4232, A-39, B-7, C-178), (IB-4233, A-39, B-7, C-179), (IB-4234,A-39, B-7, C-180), (IB-4235, A-39, B-7, C-181), (IB-4236, A-39, B-7,C-182), (IB-4237, A-39, B-7, C-183), (IB-4238, A-39, B-7, C-184),(IB-4239, A-39, B-7, C-185), (IB-4240, A-39, B-7, C-186), (IB-4241,A-39, B-7, C-187), (IB-4242, A-39, B-7, C-188), (IB-4243, A-39, B-7,C-189), (IB-4244, A-39, B-7, C-190), (IB-4245, A-39, B-7, C-191),(IB-4246, A-39, B-7, C-192), (IB-4247, A-39, B-7, C-193), (IB-4248,A-39, B-7, C-194), (IB-4249, A-39, B-7, C-195), (IB-4250, A-39, B-7,C-196), (IB-4251, A-39, B-7, C-197), (IB-4252, A-39, B-7, C-198),(IB-4253, A-39, B-7, C-199), (IB-4254, A-39, B-7, C-200), (IB-4255,A-39, B-7, C-201), (IB-4256, A-39, B-7, C-202), (IB-4257, A-39, B-7,C-203), (IB-4258, A-39, B-7, C-204), (IB-4259, A-39, B-7, C-205),(IB-4260, A-39, B-7, C-206), (IB-4261, A-39, B-7, C-207), (IB-4262,A-39, B-7, C-208), C-209), (IB-4264, A-39, B-7, C-210), (IB-4265, A-39,B-7, C-211), (IB-4266, A-39, B-7, C-212), (IB-4267, A-39, B-7, C-213),(IB-4268, A-39, B-7, C-214), (IB-4269, A-39, B-8, C-15), (IB-4270, A-39,B-9, C-15), (IB-4271, A-39, B-10, C-15), (IB-4272, A-39, B-10, C-52),(IB-4273, A-40, B-1, C-15), (IB-4274, A-40, B-2, C-15), (IB-4275, A-40,B-3, C-15), (IB-4276, A-40, B-4, C-15), (IB-4277, A-40, B-5, C-15),(IB-4278, A-40, B-6, C-15), (IB-4279, A-40, B-7, C-15), (IB-4280, A-40,B-7, C-52), (IB-4281, A-40, B-8, C-15), (IB-4282, A-40, B-9, C-15),(IB-4283, A-40, B-10, C-15), (IB-4284, A-40, B-10, C-52), (IB-4285,A-41, B-1, C-15), (IB-4286, A-41, B-2, C-15), (IB-4287, A-41, B-3,C-15), (IB-4288, A-41, B-4, C-15), (IB-4289, A-41, B-5, C-15), (IB-4290,A-41, B-6, C-15), (IB-4291, A-41, B-7, C-15), (IB-4292, A-41, B-7,C-52), (IB-4293, A-41, B-8, C-15), (IB-4294, A-41, B-9, C-15), (IB-4295,A-41, B-10, C-15), (IB-4296, A-41, B-10, C-52), (IB-4297, A-42, B-1,C-15), (IB-4298, A-42, B-2, C-15), (IB-4299, A-42, B-3, C-15), (IB-4300,A-42, B-4, C-15), (IB-4301, A-42, B-5, C-15), (IB-4302, A-42, B-6,C-15), (IB-4303, A-42, B-7, C-15), (IB-4304, A-42, B-7, C-52), (IB-4305,A-42, B-8, C-15), (IB-4306, A-42, B-9, C-15), (IB-4307, A-42, B-10,C-15), (IB-4308, A-42, B-10, C-52), (IB-4309, A-43, B-1, C-15),(IB-4310, A-43, B-2, C-15), (IB-4311, A-43, B-3, C-15), (IB-4312, A-43,B-4, C-15), (IB-4313, A-43, B-5, C-15), (IB-4314, A-43, B-6, C-15),(IB-4315, A-43, B-7, C-15), (IB-4316, A-43, B-7, C-52), (IB-4317, A-43,B-8, C-15), (IB-4318, A-43, B-9, C-15), (IB-4319, A-43, B-10, C-15),(IB-4320, A-43, B-10, C-52), (IB-4321, A-44, B-7, C-15), (IB-4322, A-44,B-10, C-15), (IB-4323, A-45, B-7, C-15), (IB-4324, A-45, B-10, C-15),(IB-4325, A-46, B-7, C-15), (IB-4326, A-46, B-10, C-15), (IB-4327, A-47,B-7, C-15), (IB-4328, A-47, B-10, C-15), (IB-4329, A-48, B-7, C-15),(IB-4330, A-48, B-10, C-15), (IB-4331, A-49, B-7, C-15), (IB-4332, A-49,B-10, C-15), (IB-4333, A-50, B-7, C-15), (IB-4334, A-50, B-10, C-15),(IB-4335, A-51, B-7, C-15), (IB-4336, A-51, B-10, C-15), (IB-4337, A-52,B-7, C-15), (IB-4338, A-52, B-10, C-15), (IB-4339, A-53, B-7, C-15),(IB-4340, A-53, B-10, C-15), (IB-4341, A-54, B-7, C-15), (IB-4342, A-54,B-10, C-15), (IB-4343, A-55, B-7, C-15), (IB-4344, A-55, B-10, C-15),(IB-4345, A-56, B-7, C-15), (IB-4346, A-56, B-10, C-15), (IB-4347, A-57,B-7, C-15), (IB-4348, A-57, B-10, C-15), (IB-4349, A-58, B-7, C-15),(IB-4350, A-58, B-10, C-15), (IB-4351, A-59, B-7, C-15), (IB-4352, A-59,B-10, C-15), (IB-4353, A-60, B-7, C-15), (IB-4354, A-60, B-10, C-15),(IB-4355, A-61, B-7, C-15), (IB-4356, A-61, B-10, C-15), (IB-4357, A-62,B-7, C-15), (IB-4358, A-62, B-10, C-15), (IB-4359, A-63, B-7, C-15),(IB-4360, A-63, B-10, C-15), (IB-4361, A-64, B-7, C-15), (IB-4362, A-64,B-10, C-15), (IB-4363, A-65, B-7, C-15), (IB-4364, A-65, B-10, C-15),(IB-4365, A-66, B-7, C-15), (IB-4366, A-66, B-10, C-15), (IB-4367, A-67,B-7, C-15), (IB-4368, A-67, B-10, C-15), (IB-4369, A-68, B-7, C-15),(IB-4370, A-68, B-10, C-15), (IB-4371, A-69, B-7, C-15), (IB-4372, A-69,B-10, C-15), (IB-4373, A-70, B-7, C-15), (IB-4374, A-70, B-10, C-15),(IB-4375, A-71, B-7, C-15), (IB-4376, A-71, B-10, C-15), (IB-4377, A-72,B-7, C-15), (IB-4378, A-72, B-10, C-15), (IB-4379, A-73, B-7, C-15),(IB-4380, A-73, B-10, C-15), (IB-4381, A-74, B-7, C-15), (IB-4382, A-74,B-10, C-15), (IB-4383, A-75, B-7, C-15), (IB-4384, A-75, B-10, C-15),(IB-4385, A-76, B-7, C-15), (IB-4386, A-76, B-10, C-15), (IB-4387, A-77,B-7, C-15), (IB-4388, A-77, B-10, C-15), (IB-4389, A-78, B-7, C-15),(IB-4390, A-78, B-10, C-15), (IB-4391, A-79, B-7, C-15), (IB-4392, A-79,B-10, C-15), (IB-4393, A-80, B-7, C-15), (IB-4394, A-80, B-10, C-15),(IB-4395, A-81, B-7, C-15), (IB-4396, A-81, B-10, C-15), (IB-4397, A-82,B-7, C-15), (IB-4398, A-82, B-10, C-15), (IB-4399, A-83, B-7, C-15),(IB-4400, A-83, B-10, C-15), (IB-4401, A-84, B-7, C-15), (IB-4402, A-84,B-10, C-15), (IB-4403, A-85, B-7, C-15), (IB-4404, A-85, B-10, C-15),(IB-4405, A-86, B-7, C-15), (IB-4406, A-86, B-10, C-15), (IB-4407, A-87,B-7, C-15), (IB-4408, A-87, B-10, C-15), (IB-4409, A-88, B-7, C-15),(IB-4410, A-88, B-10, C-15), (IB-4411, A-89, B-7, C-15), (IB-4412, A-89,B-10, C-15), (IB-4413, A-90, B-7, C-15), (IB-4414, A-90, B-10, C-15),(IB-4415, A-91, B-7, C-15), (IB-4416, A-91, B-10, C-15), (IB-4417, A-92,B-7, C-15), (IB-4418, A-92, B-10, C-15), (IB-4419, A-93, B-7, C-15),(IB-4420, A-93, B-10, C-15), (IB-4421, A-94, B-7, C-15), (IB-4422, A-94,B-10, C-15), (IB-4423, A-95, B-7, C-15), (IB-4424, A-95, B-10, C-15),(IB-4425, A-96, B-7, C-15), (IB-4426, A-96, B-10, C-15), (IB-4427, A-97,B-7, C-15), (IB-4428, A-97, B-10, C-15), (IB-4429, A-98, B-7, C-15),(IB-4430, A-98, B-10, C-15), (IB-4431, A-99, B-7, C-15), (IB-4432, A-99,B-10, C-15), (IB-4433, A-100, B-7, C-15), (IB-4434, A-100, B-10, C-15),(IB-4435, A-101, B-7, C-15), (IB-4436, A-101, B-10, C-15), (IB-4437,A-102, B-7, C-15), (IB-4438, A-102, B-10, C-15), (IB-4439, A-103, B-7,C-15), (IB-4440, A-103, B-10, C-15), (IB-4441, A-104, B-7, C-15),(IB-4442, A-104, B-10, C-15), (IB-4443, A-105, B-7, C-15), (IB-4444,A-105, B-10, C-15), (IB-4445, A-106, B-7, C-15), (IB-4446, A-106, B-10,C-15), (IB-4447, A-107, B-7, C-15), (IB-4448, A-107, B-10, C-15),(IB-4449, A-108, B-7, C-15), (IB-4450, A-108, B-10, C-15), (IB-4451,A-109, B-7, C-15), (IB-4452, A-109, B-10, C-15), (IB-4453, A-110, B-7,C-15), (IB-4454, A-110, B-10, C-15), (IB-4455, A-111, B-7, C-15),(IB-4456, A-111, B-10, C-15), (IB-4457, A-112, B-7, C-15), (IB-4458,A-112, B-10, C-15), (IB-4459, A-113, B-7, C-15), (IB-4460, A-113, B-10,C-15), (IB-4461, A-114, B-7, C-15), (IB-4462, A-114, B-10, C-15),(IB-4463, A-115, B-7, C-15), (IB-4464, A-115, B-10, C-15), (IB-4465,A-116, B-7, C-15), (IB-4466, A-116, B-10, C-15), (IB-4467, A-117, B-7,C-15), (IB-4468, A-117, B-10, C-15), (IB-4469, A-118, B-7, C-15),(IB-4470, A-118, B-10, C-15), (IB-4471, A-119, B-7, C-15), (IB-4472,A-119, B-10, C-15), (IB-4473, A-120, B-7, C-15), (IB-4474, A-120, B-10,C-15), (IB-4475, A-121, B-7, C-15), (IB-4476, A-121, B-10, C-15),(IB-4477, A-122, B-7, C-15), (IB-4478, A-122, B-10, C-15), (IB-4479,A-123, B-7, C-15), (IB-4480, A-123, B-10, C-15), (IB-4481, A-124, B-7,C-15), (IB-4482, A-124, B-10, C-15), (IB-4483, A-125, B-7, C-15),(IB-4484, A-125, B-10, C-15), (IB-4485, A-126, B-7, C-15), (IB-4486,A-126, B-10, C-15), (IB-4487, A-127, B-7, C-15), (IB-4488, A-127, B-10,C-15), (IB-4489, A-128, B-7, C-15), (IB-4490, A-128, B-10, C-15),(IB-4491, A-129, B-7, C-15), (IB-4492, A-129, B-10, C-15), (IB-4493,A-130, B-7, C-15), (IB-4494, A-130, B-10, C-15), (IB-4495, A-131, B-7,C-15), (IB-4496, A-131, B-10, C-15), (IB-4497, A-132, B-7, C-15),(IB-4498, A-132, B-10, C-15), (IB-4499, A-133, B-7, C-15), (IB-4500,A-133, B-10, C-15), (IB-4501, A-134, B-7, C-15), (IB-4502, A-134, B-10,C-15), (IB-4503, A-135, B-7, C-15), (IB-4504, A-135, B-10, C-15),(IB-4505, A-136, B-7, C-15), (IB-4506, A-136, B-10, C-15), (IB-4507,A-137, B-7, C-15), (IB-4508, A-137, B-10, C-5), (IB-4509, A-138, B-7,C-15), (IB-4510, A-138, B-10, C-15), (IB-4511, A-139, B-7, C-15),(IB-4512, A-139, B-10, C-15), (IB-4513, A-140, B-7, C-15), (IB-4514,A-140, B-10, C-15), (IB-4515, A-141, B-7, C-15), (IB-4516, A-141, B-10,C-15), (IB-4517, A-142, B-7, C-15), (IB-4518, A-142, B-10, C-15),(IB-4519, A-143, B-10, C-15), (IB-4520, A-143, B-10, C-15), (IB-4521,A-144, B-7, C-15), (IB-4522, A-144, B-10, C-15), (IB-4523, A-145, B-7,C-15), (IB-4524, A-145, B-10, C-15), (IB-4525, A-146, B-7, C-15),(IB-4526, A-146, B-10, C-15), (IB-4527, A-147, B-7, C-15), (IB-4528,A-147, B-10, C-15), (IB-4529, A-148, B-7, C-15), (IB-4530, A-148, B-10,C-15), (IB-4531, A-149, B-7, C-15), (IB-4532, A-149, B-10, C-15),(IB-4533, A-150, B-7, C-15), (IB-4534, A-150, B-10, C-15), (IB-4535,A-151, B-7, C-15), (IB-4536, A-151, B-10, C-15), (IB-4537, A-152, B-7,C-15), (IB-4538, A-152, B-10, C-15), (IB-4539, A-153, B-7, C-15),(IB-4540, A-153, B-10, C-15), (IB-4541, A-154, B-7, C-15), (IB-4542,A-154, B-10, C-15), (IB-4543, A-155, B-7, C-15), (IB-4544, A-155, B-10,C-15), (IB-4545, A-156, B-7, C-15), (IB-4546, A-156, B-10, C-15),(IB-4547, A-157, B-7, C-15), (IB-4548, A-157, B-10, C-15), (IB-4549,A-158, B-7, C-15), (IB-4550, A-158, B-10, C-15), (IB-4551, A-159, B-7,C-15), (IB-4552, A-159, B-10, C-15), (IB-4553, A-160, B-7, C-15),(IB-4554, A-160, B-10, C-15), (IB-4555, A-161, B-7, C-15), (IB-4556,A-161, B-10, C-15), (IB-4557, A-162, B-7, C-15), (IB-4558, A-162, B-10,C-15), (IB-4559, A-163, B-7, C-15), (IB-4560, A-163, B-10, C-15),(IB-4561, A-164, B-7, C-15), (IB-4562, A-164, B-10, C-15), (IB-4563,A-165, B-7, C-15), (IB-4564, A-165, B-10, C-15), (IB-4565, A-166, B-7,C-15), (IB-4566, A-166, B-10, C-15), (IB-4567, A-167, B-7, C-15),(IB-4568, A-167, B-10, C-15), (IB-4569, A-168, B-7, C-15), (IB-4570,A-168, B-10, C-15), (IB-4571, A-169, B-7, C-15), (IB-4572, A-169, B-10,C-15), (IB-4573, A-170, B-7, C-15), (IB-4574, A-170, B-10, C-15),(IB-4575, A-171, B-7, C-15), (IB-4576, A-171, B-10, C-15), (IB-4577,A-172, B-7, C-15), (IB-4578, A-172, B-10, C-15), (IB-4579, A-173, B-7,C-15), (IB-4580, A-173, B-10, C-15), (IB-4581, A-174, B-7, C-15),(IB-4582, A-174, B-10, C-15), (IB-4583, A-175, B-7, C-15), (IB-4584,A-175, B-10, C-15), (IB-4585, A-176, B-7, C-15), (IB-4586, A-176, B-10,C-15), (IB-4587, A-177, B-7, C-15), (IB-4588, A-177, B-10, C-15),(IB-4589, A-178, B-7, C-15), (IB-4590, A-178, B-10, C-15), (IB-4591,A-179, B-7, C-15), (IB-4592, A-179, B-10, C-15), (IB-4593, A-180, B-7,C-15), (IB-4594, A-180, B-10, C-15), (IB-4595, A-181, B-7, C-15),(IB-4596, A-181, B-10, C-15), (IB-4597, A-182, B-7, C-15), (IB-4598,A-182, B-10, C-15), (IB-4599, A-183, B-7, C-15), (IB-4600, A-183, B-10,C-15), (IB-4601, A-184, B-7, C-15), (IB-4602, A-184, B-10, C-15),(IB-4603, A-185, B-7, C-15), (IB-4604, A-185, B-10, C-15), (IB-4605,A-186, B-7, C-15), (IB-4606, A-186, B-10, C-15), (IB-4607, A-187, B-7,C-15), (IB-4608, A-187, B-10, C-15), (IB-4609, A-188, B-7, C-15),(IB-4610, A-188, B-10, C-15), (IB-4611, A-189, B-7, C-15), (IB-4612,A-189, B-10, C-15), (IB-4613, A-190, B-7, C-15), (IB-4614, A-190, B-10,C-15), (IB-4615, A-191, B-7, C-15), (IB-4616, A-191, B-10, C-15),(IB-4617, A-192, B-7, C-15), (IB-4618, A-192, B-10, C-15), (IB-4619,A-193, B-7, C-15), (IB-4620, A-193, B-10, C-15), (IB-4621, A-194, B-7,C-15), (IB-4622, A-194, B-10, C-15), (IB-4623, A-195, B-7, C-15),(IB-4624, A-195, B-10, C-15), (IB-4625, A-196, B-7, C-15), (IB-4626,A-196, B-10, C-15), (IB-4627, A-197, B-7, C-15), (IB-4628, A-197, B-10,C-15), (IB-4629, A-198, B-7, C-15), (IB-4630, A-198, B-10, C-15),(IB-4631, A-199, B-7, C-15), (IB-4632, A-199, B-10, C-15), (IB-4633,A-200, B-7, C-15), (IB-4634, A-200, B-10, C-15), (IB-4635, A-201, B-7,C-15), (IB-4636, A-201, B-10, C-15), (IB-4637, A-202, B-7, C-15),(IB-4638, A-202, B-10, C-15), (IB-4639, A-203, B-7, C-15), (IB-4640,A-203, B-10, C-15), (IB-4641, A-204, B-7, C-15), (IB-4642, A-204, B-10,C-15), (IB-4643, A-205, B-7, C-15), (IB-4644, A-205, B-10, C-15),(IB-4645, A-206, B-7, C-15), (IB-4646, A-206, B-10, C-15), (IB-4647,A-207, B-7, C-15), (IB-4648, A-207, B-10, C-15), (IB-4649, A-208, B-7,C-15), (IB-4650, A-208, B-10, C-15), (IB-4651, A-209, B-7, C-15),(IB-4652, A-209, B-10, C-15), (IB-4653, A-210, B-7, C-15), (IB-4654,A-210, B-10, C-15), (IB-4655, A-211, B-7, C-15), (IB-4656, A-211, B-10,C-15), (IB-4657, A-212, B-7, C-15), (IB-4658, A-212, B-10, C-15),(IB-4659, A-213, B-7, C-15), (IB-4660, A-213, B-10, C-15), (IB-4661,A-214, B-7, C-15), (IB-4662, A-214, B-10, C-15), (IB-4663, A-215, B-7,C-15), (IB-4664, A-215, B-10, C-15), (IB-4665, A-216, B-7, C-15),(IB-4666, A-216, B-10, C-15)(IB-4667, A-217, B-7, C-15), (IB-4668,A-217, B-10, C-15), (IB-4669, A-218, B-7, C-15), (IB-4670, A-218, B-10,C-15), (IB-4671, A-219, B-7, C-15), (IB-4672, A-219, B-10, C-15),(IB-4673, A-220, B-7, C-15), (IB-4674, A-220, B-10, C-15), (IB-4675,A-221, B-7, C-15), (IB-4676, A-221, B-10, C-15), (IB-4677, A-222, B-7,C-15), (IB-4678, A-222, B-10, C-15), (IB-4679, A-223, B-7, C-15),(IB-4680, A-223, B-10, C-15), (IB-4681, A-224, B-7, C-15), (IB-4682,A-224, B-10, C-15), (IB-4683, A-225, B-7, C-15), (IB-4684, A-225, B-10,C-15), (IB-4685, A-226, B-7, C-15), (IB-4686, A-226, B-10, C-15),(IB-4687, A-227, B-7, C-15), (IB-4688, A-227, B-10, C-15), (IB-4689,A-228, B-7, C-15), (IB-4690, A-228, B-10, C-15), (IB-4691, A-229, B-7,C-15), (IB-4692, A-229, B-10, C-15), (IB-4693, A-230, B-7, C-15),(IB-4694, A-230, B-10, C-15), (IB-4695, A-231, B-7, C-15), (IB-4696,A-231, B-10, C-15), (IB-4697, A-232, B-7, C-15), (IB-4698, A-232, B-10,C-15), (IB-4699, A-233, B-7, C-15), (IB-4700, A-233, B-10, C-15),(IB-4701, A-234, B-7, C-15), (IB-4702, A-234, B-10, C-15), (IB-4703,A-235, B-7, C-15), (IB-4704, A-235, B-10, C-15), (IB-4705, A-236, B-7,C-15), (IB-4706, A-236, B-10, C-15), (IB-4707, A-237, B-7, C-15),(IB-4708, A-237, B-10, C-15), (IB-4709, A-238, B-7, C-15), (IB-4710,A-238, B-10, C-15), (IB-4711, A-239, B-7, C-15), (IB-4712, A-239, B-10,C-15), (IB-4713, A-240, B-7, C-15), (IB-4714, A-240, B-10, C-15),(IB-4715, A-241, B-7, C-15), (IB-4716, A-241, B-10, C-15), (IB-4717,A-242, B-7, C-15), (IB-4718, A-242, B-10, C-15), (IB-4719, A-243, B-7,C-15), (IB-4720, A-243, B-10, C-15), (IB-4721, A-244, B-7, C-15),(IB-4722, A-244, B-10, C-15), (IB-4723, A-245, B-7, C-15), (IB-4724,A-245, B-10, C-15), (IB-4725, A-246, B-7, C-15), (IB-4726, A-246, B-10,C-15), (IB-4727, A-247, B-7, C-15), (IB-4728, A-247, B-10, C-15),(IB-4729, A-248, B-7, C-15), (IB-4730, A-248, B-10, C-15), (IB-4731,A-249, B-7, C-15), (IB-4732, A-249, B-10, C-15), (IB-4733, A-250, B-7,C-15), (IB-4734, A-250, B-10, C-15), (IB-4735, A-251, B-7, C-15),(IB-4736, A-251, B-10, C-15), (IB-4737, A-252, B-7, C-15), (IB-4738,A-252, B-10, C-15), (IB-4739, A-253, B-7, C-15), (IB-4740, A-253, B-10,C-15), (IB-4741, A-254, B-7, C-15), (IB-4742, A-254, B-10, C-15),(IB-4743, A-255, B-7, C-15), (IB-4744, A-255, B-10, C-15), (IB-4745,A-256, B-7, C-15), (IB-4746, A-256, B-10, C-15), (IB-4747, A-257, B-7,C-15), (IB-4748, A-257, B-10, C-15), (IB-4749, A-258, B-7, C-15),(IB-4750, A-258, B-10, C-15), (IB-4751, A-259, B-7, C-15), (IB-4752,A-259, B-10, C-15), (IB-4753, A-260, B-7, C-15), (IB-4754, A-260, B-10,C-15), (IB-4755, A-261, B-7, C-15), (IB-4756, A-261, B-10, C-15),(IB-4757, A-262, B-7, C-15), (IB-4758, A-262, B-10, C-15), (IB-4759,A-263, B-7, C-15), (IB-4760, A-263, B-10, C-15), (IB-4761, A-264, B-7,C-15), (IB-4762, A-264, B-10, C-15), (IB-4763, A-265, B-7, C-15),(IB-4764, A-265, B-10, C-15), (IB-4765, A-266, B-7, C-15), (IB-4766,A-266, B-10, C-15), (IB-4767, A-267, B-7, C-15), (IB-4768, A-267, B-10,C-15), (IB-4769, A-268, B-7, C-15), (IB-4770, A-268, B-10, C-15),(IB-4771, A-269, B-7, C-15), (IB-4772, A-269, B-10, C-15), (IB-4773,A-270, B-7, C-15), (IB-4774, A-270, B-10, C-15)

Test Example 1 DP Inhibitory Activity In Vitro

1) Preparation of Platelet and a Method of cAMP Assay

30 mL of peripheral blood was collected from a healthy volunteer using asyringe containing one ninth amount of 3.8% sodium citrate. After beingcentrifuged at 180 g for 10 minutes at room temperature, a supernatantwas collected and used as Platelet Rich Plasma (PRP). The resulting PRPwas washed with wash buffer and centrifuged three times (WashedPlatelet: WP) and platelets were counted by a microcell counter. WP wasadded to a plate in amount of 1.5×10⁸/assay and the plate was treatedwith 3-isobutyl-1-methylxanthin (IBMX; 0.5 mM) for 5 minutes. A reactionwas initiated by adding 100 nM of PGD2 5 min after an addition of a testcompound. The reaction was terminated with an addition of 1Nhydrochloric acid after 2 minutes and the cells were destructed using12% triton X-100. An amount of cAMP in the supernatant was assayed byHomogeneous Trangient Fluorescence (HTRF)

2) Receptor Binding Assay

A prepared WP was homogenated and a membrane fraction was collected withhigh-speed centrifugation. A compound of the present invention or areference compound A (No. IC-73 in WO 2003/097598) was added to theplate and [³H]-PGD2 was also added. A platelet membrane, a proteinconcentration is 2 mg/mL, was added and mixed in the plate, and placedon ice for 2 hours. The reaction solution was transferred to a lowprotein-adsorptive filter and washed with a wash solution eight timesusing a cell harvester. After the final washing, water was removedsufficiently, and scintillator was added. DP inhibitory activity wasinvestigated by measuring [³H] by using Micro Beta.

50% DP-inhibitory concentrations (IC50) in the cAMP assay and Ki valuesin the receptor binding assay were shown in Table 61.

3) Prostanoid Agonist and Antagonist Assay

Agonistic and antagonistic activities of the compounds of the presentinvention against prostanoid receptors were evaluated based onintracellular calcium flux or cAMP-production as an indicator using HEK293 cells expressing human EP1, EP2, EP3, EP4, FP, TP and IPrespectively. Any compounds did not show an agonistic activity againsteach prostanoid. In the other hand, more than twenty times potentantagonistic activity (IC50) was found in every compound compared withIC50 of cAMP assay with WP.

TABLE 61 Comd. No. IC50 (μM) Ki (μM) I-7 2.4 I-8 2.1 I-10 2.7 30 I-113.0 I-12 4.2 I-18 1.6 I-30 0.51 I-31 0.16 3.6 II-8 4.6 II-10 0.41 0.65II-11 2.3 II-13 0.28 0.81 II-16 0.25 0.87 II-17 0.23 0.57 II-18 4.9II-19 1.1 2.0 II-20 4.3 II-24 0.51 1.7 II-25 0.67 1.6 II-26 0.43 0.63II-27 1.0 1.4 II-28 2.5 3.8 II-29 0.38 0.74 II-31 0.81 3.7 II-33 0.301.9 II-35 0.47 3.1 II-37 1.5 II-38 0.65 0.25 II-41 3.5 II-43 0.74 2.3II-44 0.69 1.6 II-46 0.79 0.87 II-47 3.1 2.2 II-48 4.6 II-51 0.64 0.52II-53 2.3 II-54 0.42 0.27 II-55 3.0 II-57 1.2 II-58 3.5 II-59 4.3 II-600.88 2.6 II-61 2.1 1.4 II-62 1.1 4.7 II-65 0.14 16 II-67 1.7 II-68 17II-69 1.4 II-71 4.1 II-73 1.0 1.1 II-74 0.52 0.24 II-75 0.58 0.58 II-773.6 II-79 2.3 II-80 0.20 0.23 II-81 1.8 2.6 II-82 1.1 5.0 II-83 2.0 20II-84 0.18 0.33 II-85 0.51 1.7 II-88 0.23 1.5 II-89 2.1 20 II-90 0.59II-91 1.3 II-92 0.36 0.58 II-94 2.0 1.7 II-95 2.4 4.7 II-96 0.29 0.33II-99 0.59 11 II-100 2.4 12.8 II-101 0.21 22 II-105 1.5 16 II-106 1.6 19II-108 0.13 13 II-110 0.36 9.8 II-111 0.70 36 II-112 0.12 9.3 II-134 2.78.5 II-135 0.13 0.49

Test Example 2 Test Using OVA Asthma Model of Rat

Brown Norway (BN) Rats were sensitized by i.p. administration of 0.1mg/mL of ovalbumin (OVA) and 1 mg of aluminum hydroxide gel. A solutionof 1% OVA was aerosolized by ultrasonic nebulizer (NE-U17) and the ratswere subjected to inhalation exposure of the aerosol for 30 minutes inan exposing chamber 12, 19, 26 and 33 days after the sensitization. Onehour before the 4th exposure of the antigen, compounds of the presentinvention were administered in a dose of 10 mg/kg p.o. once a day forthree days consecutively. In a control group, 0.5% of methyl cellulosewas administered in place of the compound of the present invention.

Under pentobarbital anesthesia (80 mg/kg, i.p.), acetylcholine (3.9,7.8, 15.6, 31.3, 62.5, 125, 250 and 500 μg/kg) was injected to jugularvein of the rats successively from a lower dose at intervals of 5minutes three days after the fourth exposure to the antigen, andimmediate contractile reaction of airways (an increase of insufflationpressure) was measured by a modified method of Konnzett & Ririssler.Inhibition rate of airway hyperresponsiveness against the control groupwas calculated based on area under the curve (AUC) obtained fromconcentration-response curve of acetylcholine.

After the measurement of increased hyperresponsive airway was completed,bronchoalveoli of the rats were washed with 5 mL of saline three times.Total cell number in the washings was counted by a hemacytometer underlight microscope, and inhibition rates of infiltration of inflammatorycells against the control group were calculated. Further, mucin in theairway lavage fluid was measured by ELISA method using jacalin, amucin-binding lectin, and the inhibition rates of mucus-secretionagainst the control group were calculated.

Results were shown in Table 62.

TABLE 62 inhibition rate (%) infiltration of Comd. dose airwayinflammatory mucus- No. (mg/kg) hyperresponsiveness cells secretion II-110 59 76 79 II-3 10 50 78 78 II-13 10 99 46 47 II-16 10 131 67 76 II-1710 89 53 49 II-19 10 54 51 59 II-24 10 77 67 89 II-26 10 97 37 121 II-2710 49 49 118 II-29 10 89 60 110 II-33 10 72 57 76 II-35 10 88 60 84II-38 10 39 69 71 II-43 10 56 33 98 II-54 10 119 39 106 II-63 10 41 5979 II-74 10 111 65 92 II-80 10 39 57 82 II-84 10 82 54 56 II-92 10 53 4644 II-96 10 105 46 52

Test Example 3 Test Using Nasal Congestion Model of Guinea Pig

Methods of measuring nasal airway resistance and evaluating anti-nasalcongestion activity using a guinea pig were illustrated below.

A 1% solution of ovalbumin (OVA) was aerosolized by ultrasonicnebulizer, male Hartley guinea pigs were sensitized by inhalation of theaerosol for 10 minutes twice at an interval of a week and a reaction wasinitiated by exposure to the antigen 7 days later. Trachea of the guineapig was incised under pentobarbital anesthesia (30 mg/kg, i.p.), andcannulae were fitted at the sides of nasal cavity and lung respectively.To the lung side, a ventilator supplying 4 mL of air every time at arate of 60 times/min was connected. Spontaneous breathing of the guineapig was stopped by the administration of gallamine (2 mg/kg, i.v.) and 4mL of air every time was supplied at a rate of 70 times/minute torostrum of nose through the cannula of the nasal side using aventilator. Air pressure necessary for supplying the air was measured bya transducer fitted at the side branch and used as an indicator forresistance of nasal cavity. Exposure to the antigen was performed bygenerating the aerosol of 3% OVA solution between the ventilator and thenasal cavity cannula for three minutes. Compounds of the presentinvention were administered intravenously 10 minutes before the exposureto the antigen. Resistance of nasal cavity was continuously measuredduring a period from 0 to 30 minutes, and the inhibition rate againstthe vehicle was obtained based on AUC of the 30 minutes, which wasrecorded with resistance of nasal cavity (cm H₂O) as a longitudinalaxis, and time (from 0 to 30 min.) as an abscissa axis.

Formulation Example

The following formulating examples 1-8 are just for illustrativepurposes and not intended to limit the range of the present invention. Aterm of “active ingredient” means the compounds of the presentinvention, pharmaceutically acceptable salt or hydrate thereof.

Formulation Example 1

A hard-gelatin capsule is prepared with the following ingredients;

Amount (mg/capsule) active ingredient 250 starch (dried) 200 magnesiumstearate 10 Total 460 mg

Formulation Example 2

A tablet is prepared with the following ingredients;

Amount (mg/tablet) active ingredient 250 cellulose (micro crystalline)400 silicon dioxide (fume) 10 stearic acid 5 Total 665 mg

The ingredients above are mixed and compressed to give a tablet weighing665 mg/tablet.

Formulation Example 3

An aerosol solution is prepared with the following ingredients;

weight active ingredient 0.25 ethanol 25.75 propellant22(chlorodifluoroethane) 74.00 Total 100.00

The active ingredient and ethanol are mixed and the mixture is added toa part of propellant 22, and the resulting solution is transferred to afilling apparatus after being cooled to −30° C. Next, the necessaryamount is provided to a stainless-steel vessel and the content isdiluted with the remaining propellant. A valve unit is fitted to thevessel.

Formulation Example 4

A tablet containing 60 mg of an active ingredient is prepared asfollows;

active ingredient 60 mg starch 45 mg microcrystalline cellulose 35 mgpolyvinylpyrrolidone (10% aq. solution) 4 mg sodium carboxymethylstarch4.5 mg magnesium stearate 0.5 mg talc 1 mg Total 150 mg

The active ingredient, starch and cellulose are put through a sieve ofNo. 45 mesh US and mixed sufficiently. The resulting powder is mixedwith a solution containing polyvinylpyrrolidone and the mixture is putthrough a sieve of No. 14 mesh US. The granulated powder is dried at 50°C. and put through a sieve of No. 18 mesh US. Sodiumcarboxymethylstarch, magnesium stearate and talc are put through a sieveof No. 60 mesh US in advance and added to the granulated powder, mixedand compressed by a tableting machine to give a tablet weighing 150mg/tablet.

Formulation Example 5

A capsule containing 80 mg of an active ingredient is prepared asfollows;

active ingredient 80 mg starch 59 mg microcrystalline cellulose 59 mgmagnesium stearate 2 mg Total 200 mg

The active ingredient, starch, cellulose and magnesium stearate aremixed, put through a sieve of No. 45 mesh US and filled in hard-gelatincapsules to give a capsule formulation containing 200 mg/capsule.

Formulation Example 6

A suppository containing 225 mg of an active ingredient is prepared asfollows;

active ingredient  225 mg saturated fatty acid gliceride 2000 mg Total2225 mg

The active ingredient is put through a sieve of No. 60 mesh US andsuspended in the saturated fatty acid gliceride melted by the leastamount of heating. Then, the mixture was cooled in a mold of 2 g inappearance.

Formulation Example 7

A suspension containing 50 mg of an active ingredient is prepared asfollows;

active ingredient 50 mg sodium carboxymethylcellulose 50 mg syrup 1.25ml solution of benzoic acid 0.10 ml flavor q.v. pigment q.v. Total(adding purified water) 5 ml

The active ingredient is put through a sieve of No. 45 mesh US and mixedwith sodium carboxymethylcellulose and syrup to give a smooth paste. Thesolution of benzoic acid and flavor are diluted with a part of water andadded to the paste and stirred. A necessary amount of water is added togive the objective suspension.

Formulation Example 8

A formulation for i.v. injection is prepared as follows;

active ingredient 100 mg saturated fatty acid gliceride 1000 ml

The solution containing the active ingredient above is usually injectedintravenously to a patient at a rate of 1 ml/min.

INDUSTRIAL APPLICABILITY

It was found that a novel sulfonamide derivative had a DP receptorantagonistic activity and was effective on treating allergic diseases.

The invention claimed is:
 1. A compound of formula (I),

wherein R^(2A) and R^(2B) are each independently a hydrogen atom or−OCH₂COOH, wherein at least one of R^(2A) and R^(2B) is −OCH₂COOH,R^(2C) is heteroaryl optionally substituted with alkyl optionallysubstituted with a substituent selected from Substituent Group D at oneto three position(s); cycloalkyl; alkenyl; alkynyl; hydroxy; alkyloxyoptionally substituted with a substituent selected from SubstituentGroup A at one to three position(s); aryloxy optionally substituted witha substituent selected from Substituent Group B at one to threeposition(s); mercapto; alkylthio; a halogen atom; nitro; cyano; carboxy;alkyloxycarbonyl; acyl; alkylsulfanyl; an amino optionally substitutedwith one or two substituents selected from the group consisting ofalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkynyl, aryl, heteroaryl,acyl, alkyloxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, alkylsulfonyl, alkenyl sulfonyl, alkynyl sulfonyl, aryl sulfonyl andheteroaryl sulfonyl; carbamoyl; N-methylcarbamoyl;N,N-dimethylcarbamoyl; N-ethyl-N-methylcarbamoyl; N,N-diethylcarbamoyl;N-phenylcarbamoyl; N-benzylcarbamoyl; N-acetylcarbamoyl;N-methylsulfonylcarbamoyl; aryl optionally substituted with asubstituent selected from Substituent Group B at one to threeposition(s); heteroaryl optionally substituted with a substituentselected from Substituent Group C at one to three position(s); or anon-aromatic heterocyclic group optionally substituted with asubstituent selected from Substituent Group C at one to threeposition(s), Substituent Group A is selected from the group consistingof a halogen atom and a phenyl optionally substituted with one to threesubstituent(s) selected from Substituent Group B, Substituent Group B isselected from the group consisting of a halogen atom, alkyl, alkyloxy,cyano and nitro, Substituent Group C is selected from the groupconsisting of a halogen atom and alkyl, Substituent Group D is selectedfrom the group consisting of a halogen atom and alkyloxy, R^(2D) is ahydrogen atom, R^(2E) is a hydrogen atom, R³ is alkoxy or alkylthio,wherein the alkoxy and alkylthio are each optionally substituted withcycloalkyl; alkylene optionally having one or two heteroatom(s);hydroxy; oxo; alkyloxy optionally substituted with a substituentselected from Substituent Group A at one to three position(s); mercapto;alkylthio; a halogen atom; nitro; cyano; carboxy; alkyloxycarbonyl; anamino optionally substituted with one or two substituents selected fromthe group consisting of alkyl, alkenyl, alkynyl, cycloalkyl,cycloalkynyl, aryl, heteroaryl, acyl, alkyloxycarbonyl,alkenyloxycarbonyl, alkynyloxycarbonyl, alkyl sulfonyl, alkenylsulfonyl,alkynyl sulfonyl, arylsulfonyl and heteroarylsulfonyl; carbamoyl;N-methylcarbamoyl; N,N-dimethylcarbamoyl; N-ethyl-N-methylcarbamoyl;N,N-diethylcarbamoyl; N-phenylcarbamoyl; N-benzylcarbamoyl;N-acetylcarbamoyl; N-methylsulfonylcarbamoyl; acyl; aryl optionallysubstituted with a substituent selected from Substituent Group B at oneto three position(s); heteroaryl optionally substituted with asubstituent selected from Substituent Group C at one to threeposition(s); an optionally substituted non-aromatic heterocyclic ringgroup which may be substituted with a substituent selected fromSubstituent Group C at one to three position(s); aryloxy optionallysubstituted with a substituent selected from Substituent Group B at oneto three position(s); or alkylsulfonyl, R⁵ is an alkyl group, and n is 0or 1, with the proviso that the following compound is excluded:

or a pharmaceutically acceptable salt thereof.
 2. The compound accordingto claim 1, wherein R^(2C) is heteroaryl optionally substituted with asubstituent group selected from the group consisting of alkyl, alkenyland alkynyl, or a pharmaceutically acceptable salt thereof.
 3. Thecompound according to claim 1, wherein R^(2C) is

or a pharmaceutically acceptable salt thereof.
 4. The compound accordingto claim 1, wherein the compound is selected from the group consistingof: (1) compound II-61,

or a pharmaceutically acceptable salt thereof: and (2) compound II-75,

or a pharmaceutically acceptable salt thereof.